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At least 19 recordsLinked to original sources
PubMed1983

Scintigraphic detection of occult hemorrhage using RBCs labeled in vitro with technetium Tc 99m sodium pertechnetate.

Scintigraphy with RBCs labeled with technetium Tc 99m sodium pertechnetate effectively located the source of hemorrhage in a patient receiving long-term anticoagulant therapy. (The patient was initially seen with a large hematoma on the flank.) More important, the procedure was used to monitor activity in this otherwise-occult bleeding site. Scintigraphic studies may be useful in the management of these difficult clinical problems.

Aged↗
PubMed1993

Effect of source and age of sodium pertechnetate Tc 99m on radiochemical purity of technetium Tc 99m exametazime.

The radiochemical purities of technetium Tc 99m exametazime prepared with one-hour-old or six-hour-old sodium pertechnetate Tc 99m from two manufacturers' generators were compared. Eluates from each manufacturer's generators were diluted immediately to provide two solutions of sodium pertechnetate Tc 99m. For the one-hour-old solution, eluate was diluted with 0.9% sodium chloride injection to a concentration of radioactivity of 38 mCi in 5.5 mL and used one hour later. For the six-hour-old solution, eluate was diluted to 65 mCi in 5.5 mL and used six hours later. Technetium Tc 99m exametazime was prepared by injecting 5.0 mL of one of the solutions into an exametazime kit to provide 30 mCi of technetium Tc 99m in 5.0 mL. At 2, 30, and 60 minutes after reconstitution of each kit, the radiochemical purity was measured by high-performance liquid chromatography with radiation detection. At two minutes, all the preparations retained high radiochemical purities. However, at 30 and 60 minutes, the radiochemical purities of technetium Tc 99m exametazime prepared with six-hour-old sodium pertechnetate Tc 99m were significantly lower than those of technetium Tc 99m exametazime prepared with one-hour-old sodium pertechnetate Tc 99m. Similar results were found for each manufacturer's generators. The radiochemical purity of technetium Tc 99m exametazime was affected by the age of the sodium pertechnetate Tc 99m from which it was prepared but not by the generator from which the sodium pertechnetate Tc 99m was obtained.

Humans↗
PubMed1994

Clinical application of spontaneous red blood cell labeling with Tc-99m sodium pertechnetate.

Red blood cells (RBC) may be labeled with Tc-99m after Tc-99m sodium pertechnetate is injected in the presence of a reducing agent, such as stannous chloride. Thus, spontaneous RBC labeling with Tc-99m is expected to be seen in patients with a high plasma concentration of tin. Spontaneous RBC labeling with Tc-99m was obtained in a 73-year-old woman who was clinically diagnosed with tin intoxication and proved to have a high concentration of plasma tin. The RBC labeling rate was calculated as 96% with blood sampling. Spontaneous RBC labeling with Tc-99m is a very simple method for proving a high plasma tin concentration and is adaptable to clinical diagnosis.

Aged↗
PubMed1981

Avid thyroid uptake of [Tc-99m] sodium pertechnetate in children with goitrous cretinism.

Three children with goitrous hypothyroidism had thyroid scans with [Tc-99m] sodium pertechnetate, which showed symmetrically enlarged thyroid glands with uniformly increased activities compared to little activities in the salivary glands and low body background activities. These scan findings, simulating those of Graves' disease, reflect acid trapping of this tracer, analogous to that seen with I-131. Perchlorate discharge test was positive in two patients, indicating an organification defect.

Adolescent↗
PubMed1991

Papillary thyroid carcinoma concentrating both Tc-99m sodium pertechnetate and I-131 iodide. Case report and review of the literature.

Thyroid carcinoma concentrating both Tc-99m sodium pertechnetate and radioactive iodine is a rare occurrence. This report describes such a case. It is somewhat different from previous reports in that the carcinoma had tracer uptake equal to that of the remaining normal thyroid gland on both isotope studies. It also occurred in the pediatric age group and followed external radiation therapy. A review of the pertinent literature is presented.

Adolescent↗
PubMed1989

Thyroid carcinoma in solitary hot thyroid lesions on Tc-99m sodium pertechnetate scans.

Sixteen patients with nonsuppressible solitary hot thyroid lesions (SHTL) identified on T3 suppression images using Tc-99m sodium pertechnetate were studied over a period of 5 years. Of the 16 patients, 7 (44%) had papillary adenocarcinoma (PAC) and 9 (56%) had follicular adenoma (FA). Of the 7 patients with PAC, 3 were toxic and 4 nontoxic. Of the 9 patients with FA, 2 were toxic and 7 nontoxic. The Tl-201 chloride thyroid scans were useful in locating SHTL and revealing extranodular thyroid tissue. The echography was sensitive to visualization of the nodule structures. However, there were no significant differences between the clinical findings, radionuclide images, and echograms between for PAC and FA. All patients with PAC were treated by partial thyroidectomy and there were neither regional nor distant metastasis in any of them. In conclusion, our study provided the following extremely interesting result: SHTL in the present series have a higher incidence of malignancy than previously reported autonomously functioning thyroid lesions (AFTL). Histological examination is necessary for the diagnosis and management of SHTL and surgical treatment should be considered.

Adenocarcinoma, Papillary↗
PubMed1975

The sodium pertechnetate Tc 99m scan: an aid in the evaluation of gastrointestinal bleeding.

Twenty pediatric patients presenting primarily with unexplained gastrointestinal bleeding were evaluated with sodium pertechnetate Tc 99m imaging. Three patients had normal barium enemas and scans consistent with Meckel's diverticulum. These three patients and three additional patients with normal scans underwent surgical exploration. Meckel's diverticula containing gastric mucosa were found in all three patients with positive scans. No diverticula were found in the three patients with normal scans. Four other patients had scans that were considered abnormal but not felt to represent Meckel's diverticula. In one of these patients a radiographic gastrointestinent, a nonspecific terminal ilial ulcer without gastric mucosa was found at surgery. The two other patients had normal radiographic gastrointestinal studies and no further evaluation was carried out. The etiology of gastrointestinal bleeding in pediatric patients is frequently unexplained even after thorough evaluation including celiotomy. The sodium pertechnetate Tc 99m scan is a safe, simple, non-invasive procedure that can demonstrate Meckel's diverticula with greater certainty than the barium enema and can suggest suspicious areas that can then be evaluated by more definitive procedures.

Adolescent↗
PubMed1995

Transcolonic sodium pertechnetate Tc 99m scintigraphy for diagnosis of macrovascular portosystemic shunts in dogs, cats, and potbellied pigs: 176 cases (1988-1992).

Medical records of 176 animals that underwent transcolonic sodium pertechnetate Tc 99m scintigraphy between September 1988 and June 1992 were reviewed. The study included 162 dogs, 10 cats, and 4 potbellied pigs. Whenever possible, scan results were confirmed during exploratory surgery or necropsy. For animals that did not undergo surgery or necropsy, additional medical information, (ie, results of histologic examination of hepatic biopsy specimens, clinicopathologic testing, abdominal ultrasonography, and clinical outcome) was evaluated to estimate the likelihood that the scan interpretation was correct. Interpretations were classified as confirmed true, probable true, possible false, or unconfirmed results. Of the 97 scans interpreted as positive for portosystemic shunting, 85 were classified as confirmed true-positive results, 5 were classified as probable true-positive results, and 7 were classified as unconfirmed results. None were classified as confirmed or possible false-positive results. Of the 79 scans interpreted as negative for portosystemic shunting, 3 were classified as confirmed true-negative results, 54 were classified as probable true-negative results, 1 was classified as a possible false-negative result, and 21 were classified as unconfirmed results. Our results suggest that transcolonic pertechnetate scintigraphy has satisfactory performance as a diagnostic test for macrovascular portosystemic shunting.

Animals↗
PubMed2005

Association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate Tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002).

OBJECTIVE: To assess whether the risk of development of hypothyroidism after treatment with iodine 131 (131I) was associated with the pattern of sodium pertechnetate Tc 99m activity in the thyroid gland detected via scintigraphy before treatment in cats with hyperthyroidism. DESIGN: Retrospective study. ANIMALS: 165 cats. PROCEDURE: Medical records of cats with hyperthyroidism that had been treated with 131I (from 1990 to 2002) and had undergone scintigraphy of the thyroid gland before treatment were reviewed; data regarding signalment, scintigraphic findings (classified as unilateral, bilateral-asymmetric, bilateral-symmetric, or multifocal patterns), serum total thyroxine (T4) concentrations before treatment and prior to hospital discharge, and 131I treatment were collected. A questionnaire was sent to each referring veterinarian to obtain additional data including whether the cats subsequently developed hypothyroidism (defined as serum total T4 concentration less than the lower reference limit > or = 3 months after treatment). RESULTS: 50 of 165 (30.3%) 131I-treated cats developed hypothyroidism. Hypothyroidism developed in 39 of 109 cats with bilateral, 10 of 50 cats with unilateral, and 1 of 6 cats with multifocal scintigraphic patterns of their thyroid glands. Cats with a bilateral scintigraphic pattern were approximately 2 times as likely to develop hypothyroidism after 131I treatment than were cats with a unilateral scintigraphic pattern (hazard ratio, 2.1; 95% confidence interval, 1.04 to 4.2). CONCLUSIONS AND CLINICAL RELEVANCE: Cats with hyperthyroidism that have a bilateral scintigraphic pattern in the thyroid gland before 131I treatment appear to have a significantly higher risk of subsequently developing hypothyroidism, compared with cats with a unilateral scintigraphic pattern.

Animals↗
PubMed1984

Sodium pertechnetate Tc 99m antral scan in the diagnosis of retained gastric antrum.

Retained gastric antrum (RGA) is a major factor in recurrent peptic ulcer. We studied 121 patients with proven anastomotic ulcers following subtotal gastrectomy and Billroth II reconstruction with sodium pertechnetate Tc 99m to determine the presence of RGA. Of the patients, 59 required surgery, 22 had RGA, and 16 had a positive scan for RGA. This noninvasive examination has 100% specificity. If RGA is identified before operation, minimal time is wasted in exploration of the abdomen, which is especially important in dealing with emergency cases. When an antral scan is negative for RGA, the surgeon is still advised to search for this condition.

Diagnosis, Differential↗
PubMed1976

Diagnosis of Meckel diverticulum by sodium pertechnetate Tc 99m scan.

Meckel diverticulum was diagnosed preoperatively as the cause of recurrent rectal bleeding in a 2-year-old child by means of a sodium pertechnetate Tc 99m scan. Although false-negative scans have been reported to occur in approximately 50% of all cases of Meckel diverticulum, the procedure should be considered in any case of unexplained, painless rectal bleeding, especially in pediatric patients.

Hemorrhage↗
PubMed1976

Thyroid scintigram. Sensitivity with sodium pertechnetate Tc 99m and gamma camera with pinhole collimator.

To evaluate the reliability of thyroid scintigraphy in the diagnosis of nodular growth, scintigrams of patients who later underwent thyroidectomy were reviewed and correlated with pathologic findings. The scintigrams were all obtained with a 5-mm single-hole collimator-equipped gamma-scintillation camera after intravenous injection of 5 millicuries of sodium pertechnetate Tc 99m. In the group of 92 patients, six of whom had two histologically different lesions, 149 nodules were identified pathologically. There were 26 nodules 2 to 5 mm in diameter, of which 22 were benign and four were malignant. None of the 22 benign nodules were delineated scintigraphically. Superior image quality and resolution, low radiation dose, technical simplicity, and speed make 99mTc pinhole-camera scintigraphy the best procedure available for routine thyroid imaging.

Adenocarcinoma↗