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Results for “Sodium Fluoride”

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At least 19 recordsLinked to original sources
PubMed1979

Comparative uptake of fluoride from sodium fluoride, ammonium fluoride, and barium fluoride in rat teeth when predominantly administered in the pre-eruptive stage of development.

A comparative study was undertaken which focused on the systemic uptake of sodium fluoride (NaF), ammonium fluoride (NH4F), and barium fluoride (BaF2) in rat pups. Two critical achievements made this comparative study possible: (a) the demonstration of significant increases in fluoride (F) uptake-deposition in the treatment group pups relative to control group rats as a result of stomach tube feeding; and (b) the demonstration of clear-cut differences in F concentration levels between the treatment groups as a result of this stomach tube-systemic uptake. Data were reliable and significant enough to suggest that, of the 3 compounds in question, NH4F is absorbed most successfully in a systemic fashion, whereas BaF2 is the least absorbed.

Ammonia↗
PubMed1977

Effect of high-concentration ammonium and sodium fluoride rinses on dental caries in schoolchildren.

A double-blind clinical trial was conducted in a non-fluoridated community to determine the effect on enamel fluoride and caries experience of daily rinsing in school with 1,000 parts/10(6) solutions of ammonium fluoride or sodium fluoride at pH 4.4. Subjects were 10- to 12-year-old children (n approximately equal to 200/group at baseline), about one-half of whom reported the usage of fluoride supplements. Dental caries (DFS index) and enamel fluoride (in vivo biopsy) were evaluated at baseline, 12 months, and 24 months. Supplement users had higher enamel fluoride levels and less caries experience initially, as well as generally lower caries increments over the study. In year 1, the overall caries reductions (supplement users and non-users combined) were 23 % (ammonium fluoride) and 33 % (sodium fluoride), P less than 0.01. For year 2, treatment effects were significantly greater: 54 % (ammonium fluoride) and 47 % (sodium fluoride). In newly erupted teeth, the effects of the ammonium fluoride (70 % DFS reduction) was significantly greater (P = 0.013) than that of the sodium fluoride (48 % DFS reduction). Enamel fluoride levels at the end of 2 years were 3,124 parts/10(6) (ammonium fluoride), 2,771 parts/10(6) (sodium fluoride), and 2,603 parts/10(6) (placebo), P = 0.025.

Child↗
PubMedDate not supplied

[Effect of sodium fluoride on DNA metabolism during therapy for osteoporosis].

The influence of sodium fluoride therapy on semiconservative DNA-synthesis and DNA-excision repair was investigated in lymphocytes of the peripheral blood of 6 patients with osteoporosis. The daily dose of sodium fluoride was 25 mg in the first week, and subsequent 50 mg during a period of 15 to 37 weeks. No significant effect on the tested parameters was found in 5 subjects. One patient showed significantly inhibited DNA-repair in the lymphocytes up to the ninth week, but during subsequent therapy normal values were obtained in this patient also. In conclusion sodium fluoride seems to have no effect on DNA-metabolism in lymphocytes of patients with osteoporosis.

DNA↗
PubMed1975

A clinical evaluation of a sodium fluoride dentifrice.

A double-blind study to determine the anticaries efficacy of a neutral pH dentifrice containing sodium fluoride and a high Beta-phase calcium pyrophosphate was conducted among elementary school children in Kansas City, Missouri. A sample of 567 children ages 8-13 were recruited and randomly assigned to test and control groups: the test group received a sodium fluoride high Beta-phase calcium pyrophosphate dentifrice, and the control group received a calcium pyrophosphate dentifrice without the active ingredient. The sodium fluoride dentifrice contained fluoride at the level of 1000 ppm. Caried examinations were conducted at initiation, after 12 months, and again after 24 months at the study's termination. All examinations (clinical and radiographic) were performed by the same investigator. At 12 months the sodium fluoride dentifrice demonstrated a caries reduction of 24.1% (DMFS). At 24 months the reduction demonstrated was 30.1% (DMFS); this reduction is significant at alpha = 0.05.

Adolescent↗
PubMedDate not supplied

Influence of an experimental sodium fluoride dentifrice on dental caries incidence in children.

Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a nonfluoride dentifrice for home use. About half the children provided each type of dentifrice were also given an initial prophylaxis. Combining the data with regard to the type of dentifrice indicated that the sodium fluoride dentifrice resulted in dental caries reductions of 24 and 26% as noted by the two examiners, respectively.

Adolescent↗
PubMed1979

[Therapy of senile osteoporosis using sodium fluoride--continuous and intermittent long-term therapy].

To evaluate a therapeutic effect, biochemical parameters of bone metabolism and photonabsorption densitometry have been compared in patients with senile osteoporosis under long-term continuous or intermittent sodium fluoride treatment. A comparable increase of trabecular bone density is found after continuous and intermittent therapy for at least one year. The well-known effect of defective mineralization under long-term continuous therapy with sodium fluoride corresponds to a statistically significant increase in urinary hydroxyproline and calcium excretion and a trend towards a rise in serum alkaline phosphatase in this study. Similar findings cannot be observed in patients on intermittent sodium fluoride treatment. The increase in bone density without concomitant changes in biochemical parameters suggests a beneficial therapeutic effect without biochemical evidence for defective mineralization.

Age Factors↗
PubMed1978

Histologic response of replanted teeth pretreated with acidulated sodium fluoride.

Central incisors in the vervet monkey were extracted, endodontically treated, and replanted into their original sockets after immersion in a 2 per cent acidulated sodium fluoride solution (pH 5.5) for 30 minutes. Histologic examination at 1, 2, 4, and 8 weeks postoperatively showed that by the second week resorption had taken place and that ankylosis, first seen by the fourth week, along both the buccal and palatal root surfaces, was well established by the eighth week. Under the conditions of the study, pretreatment of the tooth roots with 2 per cent acidulated sodium fluoride did not reduce root resorption and ankylosis.

Acids↗
PubMed1977

Effect of sodium fluoride rinsing on dental plaque accumulation.

1. Daily rinsing with water does not prevent plaque accumulation and leads to increased levels of gingival inflammation. 2. Toothbrushing or mouth rinsing with sodium fluoride alone decreases plaque accumulation and improves gingival health. 3. The combined method (toothbrushing and rinsing with sodium fluoride) is the most effective. Confirmation of the above results and conclusions requires additional experiments carried out over a longer period of time.

Adult↗
PubMed1979

The determination of aluminium in antacid formulations by Gran's Plot titration with sodium fluoride.

The aluminium content of a number of proprietary antacid formulations has been determined by titration with sodium fluoride, using the fluoride activity electrode as an end-point detector. Results compared favourably with the official method. The fluoride titration, however, involved less sample manipulation and was more rapid to carry out. End-point detection was made easier by treating titration data by the Gran's Plot method.

Aluminum↗
PubMed1979

[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)].

25 female patients with different forms of osteoporosis (progredient form in elderly patients, steroid osteoporosis, involutive osteoporosis) treated during a period varying between 1 to 24 months with a new compound preparation containing 25 mg sodium fluoride and 200 mg L-ascorbic acid per tablet. The daily dose amounts to 2 tablets. Clinical success was observed in 18 patients, X-ray controls showed increase of bone density in 8 patients. In 3 cases it was necessary to discontinue treatment because of side effects (2 patients with pains in the bones and joints, 1 patient with stomach troubles). Late side effects have not been observed. At present the treatment of certain forms of osteoporosis with sodium fluoride is the only effective therapy of this disease.

Aged↗
PubMed1978

[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)].

Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months. Mean total dose was 21 g fluoride. Symptoms, body size, biochemical results, radiological changes and skeletal mineral content as well as bone histomorphometry were evaluated in assessing results of treatment. Accordingly, no advance in the disease process was demonstrable in 13 patients, while there was definite improvement in six, but in four there was further progression.

Body Height↗
PubMed1979

Effect of sodium fluoride on protein and DNA synthesis, ornithine decarboxylase activity, and polyamine content in LS cells.

Sodium fluoride exhibited a dose dependent inhibitory effect on protein and DNA synthesis at concentrations from 1.3 mM in growing LS cells. The activity of ornithine decarboxylase (ODC) was slightly stimulated by 0.5 mM-NAF, but inhibited at 1.3 mM and above. The reduced enzyme activity seemed to be due to a reduced de novo formation of the enzyme caused by an inhibition of the protein synthesis. In spite of a reduction of ODC-activity, fluoride had no effect on the cellular polyamine content during the experimental period (10 hours).

Animals↗