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Results for “Skin infections”

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At least 19 recordsLinked to original sources
PubMed1977

Cutaneous microflora of patients with repeated skin infections.

The microflora of normal skin in 16 patients with repeated staphylococcal and streptococcal skin infections was examined to determine whether abnormalities existed which would indicate a protective role for the indigenous flora against colonization by pathogens. Five sites-hands, feet, axilla, groin and back-were examined quantitatively and qualitatively and compared with a control group. Total populations of indigenous flora were significantly higher from patients with repeated skin infections of the back, axillae and feet. The frequency of isolation of different species from normal skin was comparable between the control and experimental groups, with the exception of the incidence of Staphylococcus aureus and Proteus species which were isolated only from patients with repeated skin infections. Gram-negative bacteria were isolated with comparable frequency between the two groups, but patients with repeated skin infections tended to carry gram-negative bacteria on multiple sites. It was concluded from the high population of indigenous flora and the types of microogranisms present that the microflora of normal skin did not appear to protect patients with repeated skin infections against colonization by pathogens. The presence of high populations of Staphylococcus aureus on the normal skin of patients with repeated skin infections would appear to be the most important contributing factor.

Bacteria↗
PubMed1978

Occlusion, carbon dioxide, and fungal skin infections.

Occlusion of the skin renders it susceptible to acute fungal skin infections (dermatophytosis and candidiasis). Occlusion also raised carbon-dioxide (CO2) tensions at the skin's surface. Comparable CO2 tnesions have a pronounced effect on the morphology and metabolism of dermatophytes in vitro. It is postulated that dermatophyte conida and hyphae produce infective units under conditions of raised CO2 tensions, and that occlusion of the skin produces the concentrations of CO2 required for the conversion. Fungal skin infections might be prevented or controlled by interference with the action of CO2 or by prevention of its accumulation under wet, occlusive clothing.

Acute Disease↗
PubMed1975

Skin infections and the epidemiology of diphtheria: acquisition and persistence of C diphtheriae infections.

Acquisition and persistence of C. diphtheriae infections of skin lesions and of the respiratory tract were observed in households exposed to C. diphtheriae carriers in a community experiencing a diphtheria outbreak and in households in two communities free of the disease. Acquisition of C. diphtheriae was more frequent in epidemic households, apparently due to a greater frequency of respiratory tract acquisition. Skin lesion acquisition was constant in both situations. The pattern of persistence appeared to be the same in both types of households, although skin lesion C. diphtheriae infections had a greater tendency to persist than respiratory tract infections. Acquisition occurred more frequently following exposure to a skin lesion C. diphtheriae carrier than following a respiratory carrier exposure.

Carrier State↗
PubMed2026

Host Proteome Remodeling During Group A Streptococcus Skin Infection.

Group A Streptococcus (Streptococcus pyogenes, GAS) is a bacterial pathogen that commonly causes local infections in humans and can lead to invasive diseases. GAS infections trigger complex host immune and tissue responses, yet how these processes are coordinated over time and across different tissues remains poorly understood. To explore the spectrum of GAS infection, we examined responses in a skin infection model at multiple proteome levels, characterizing local and distant tissues with variable infection responses. We map changes in canonical innate and adaptive immune signaling while uncovering new mechanisms in the context of skin infection. We uncover the robust and time-dependent expression of one family of proteins, chitinase-like proteins, that coincides with immune cell infiltration of local tissues. Because immunomodulatory networks are tightly regulated through post-translational modifications, we integrated global proteomic data with cytokine signaling and key phosphoproteome changes. This analysis revealed correlations between mTOR and kinase signaling pathways that diverge at local and systemic tissues. Our systems-based approach provides a rigorous evaluation of a GAS skin infection, characterizing host proteome remodeling across experimental groups and individual mice.

Animals↗
PubMedDate not supplied

[Interactions of Shope papilloma virus with SV40 in adult domestic rabbit cell lines derived from normal skin or from Shope papilloma virus infected skin (author's transl)].

Three cell lines from adult domestic rabbit are infected with SV40: LP 17 and LP 45 derived from normal skin and LP 42 PS derived from skin infected for 24 h with Shope papilloma virus. The fibroblastic morphology of the cultures is not changed. SV40 is not recovered and T antigen is only detected in LP 42 PS cell line after 29 passages. To know if Shope papilloma virus facilitates penetration of SV40, cultures of LP 45 are first infected with Shope papilloma virus for 2 h and for 24 h, then superinfected with SV40. There is no cellular alteration, and T antigen induced by SV40 is only detected in cells pretreated for 24 h with Shope papilloma virus, after 20 passages. When cultures LP 45 are infected with Shope papilloma virus neutralized with a high titer antiserum and superinfected with SV40, T antigen is not detected. Superinfected cells containing specific SV40 T antigen do not induce tumors either in new born hamsters or in rabbits but they are able to grow in colonies in soft agar. LP 42 PS cell line and LP 45 cells infected with Shope papilloma virus for 24 h containe Shope papilloma virus genome which is able to modify the permissivity of rabbit cells to SV40.

Animals↗
PubMed1979

Topical versus systemic antibiotics in the treatment of acute superficial skin infections.

Use of antibiotics in some superficial skin infections is examined. The choice of a route of administration is dependent on a number of factors, including the site and extent of skin lesions, frequency of recurrence, and clinical and immunological state of the host. However, the consensus of various studies on the subject seem to indicate a preference for the systemic route in acute infectious dermatoses.

Adult↗
PubMed1979

Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.

Topical treatment with 3% phosphonoformate of herpes simplex virus type 1 (HSV)-induced skin infections of hairless mice reduced the severity of skin lesions when the treatment was initiated 3 h after virus inoculation in the lumbosacral area or 3 and 24 h after inoculation in the orofacial area. The mortality was significantly reduced in lumbosacral-infected mice and was completely prevented in orofacial-infected mice when the treatment was initiated with a delay of 24 h after virus inoculation. However, phosphonoformate did not prevent the establishment of latent herpes simplex virus type 1 infections in the spinal and trigeminal ganglia, even when treatment was initiated as early as 3 h after infection.

Animals↗
PubMed1976

Effects of local corticosteroids in skin infections.

Glucocorticoids exert valuable therapeutic activities in skin infections, although their use is limited by the occurrence of undesiderable effects: glucocorticoids depress the local defense mechanisms and in low concentrations, stimulate microbiol metabolism. For these reasons, combined preparations containing an antimicrobiol substance besides the glucocorticoid are recommended. However, interactions between the steroids and the antimicrobiols must be ruled out beforehand, i.e. the unimpaired activity of both steroid and antimicrobial must be assured. Examples of such investigations are reported for the most widely used compounds for topical therapy. The simultaneous use of a glucocorticoid and an antimicrobial is not recommended in only a few instances.

Administration, Topical↗
PubMed1976

The treatment of equine skin infections using topical Trichlorocarbanilide.

Skin scrapings from clinical cases of equine skin disorder were examined by culture to determine the micro-organisms involved. In-vitro and in-vivo studies were then made to determine the efficacy of Trichloro-carbanilide as a topical treatment for these cases. The laboratory findings and results of treatment are described, and the value of Trichlorocarbanilide in cases of bacterial, actinomycete and fungal infection assessed.

Actinomycetales Infections↗
PubMed1975

Bacterial skin infections in preschool and school children in coastal Tanzania.

In coastal Tanzania, 1,855 preschool and school children were studied for pyoderma (superficial bacterial infections of the skin exclusive of secondarily infected scabies) and for scabies. The predisposing personal, socleoeconomic, and hygienic variables for both conditions were studied also. Pyoderma lesions and some secondarily infected scabies were cultured aerobically for bacterial isolates and the predisposing factors were determined by interviews, home visits, and physical examinations. Pyoderma was present in 6.9% and scabies in 16.6% of the children; both combined totalled 23.5% of the children. Both conditions were more common in rural than in urban environments, but scabies was most common in populations with poor socioeconomic and hygienic conditions. The predisposing factors included trauma, insect bites, hot and damp coastal weather, and poor socioeconomic and hygienic conditions.

Adolescent↗
PubMed1979

An outbreak of skin infections caused by group A beta-hemolytic streptococci probably originating from wild moose.

An outbreak of about 20 recorded cases of impetiginous skin infections occurred during the moose (Alces alces) hunting season in October and November 1976 in persons having been in contact with moose from Hailuoto Island, Northern Finland. Samples for bacteriological studies werre obtained from 4 patients, and beta-hemolytic streptococci group A were isolated from all. The strains were biochemically identical. Epidemiological data strongly support a moose origin of the streptococci, even though none were isolated from the animals.

Adult↗
PubMed1976

A double-blind study comparing Daktacort, miconazole and hydrocortisone in inflammatory skin infections.

In a 4-week double-blind trial, Daktacort cream was compared with each of its constituents (i.e. miconazole 2% and hydrocortisone 1%) in a total of 63 patients (aged 12-60 years) with inflamed skin infections of bacterial or mycotic origin. Daktacort treatment induced a significant improvement of all symptoms within 1 week and was superior to both miconazole and hydrocortisone in suppressing the inflammation. This tendency persisted throughout the trial but at the end miconazole treatment proved also superior to hydrocortisone.

Administration, Topical↗
PubMed1977

A familial defect of neutrophil chemotaxis with asthma, eczema, and recurrent skin infections.

A defect in chemotaxis of peripheral blood polymorphonuclear leukocytes (PMN's) was demonstrated in both parents and three of four children in a single family afflicted with varying degrees of respiratory allergy, unusual onset of severe eczema in the first month of life, and recurrent bacterial skin infections. Of great interest was the identification of HLA-B12 at the B locus in all affected members but not in the unaffected child. The two children known since infancy to be most severely affected with eczema and recurrent infections are HLA identical and homozygous for HLA-B12. The child without eczema and infections had an intermediate cellular chemotactic defect most apparent on kinetic studies.

Adolescent↗
PubMed1977

Skin infections in Kaimai Rail Tunnel construction workers.

Skin lesions in Kaimai Rail Tunnel workers were noted to respond poorly to treatment and investigations revealed that this was because the lesions were either gram-negative infections or Trichophyton rubrum infections.

Enterobacteriaceae Infections↗