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Results for “Shwartzman Phenomenon”

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At least 19 recordsLinked to original sources
PubMed1984

Effect of zinc on the local Shwartzman phenomenon.

Local Shwartzman reaction is substantially reduced in intensity by zinc administered locally before and after preparation of the reaction. The endotoxin-induced accumulation of PMN leukocytes is inhibited by zinc rubbed in the skin.

Animals↗
PubMed1951

Studies on the mechanism of the Shwartzman-phenomenon; evidence for the participation of polymorphonuclear leucocytes in the phenomenon.

The inhibition of the Shwartzman phenomenon by nitrogen mustard and benzene has been confirmed and investigated further. This inhibition can be correlated with the leucopenia induced by these agents. Evidence is presented indicating that polymorphonuclear leucocytes play an essential role in the preparation of the skin for the Shwartzman phenomenon.

Leukopenia↗
PubMed1982

Role of the acute phase response in the Shwartzman phenomenon.

Following elicitation of the local Shwartzman reaction by intradermal injection of Salmonella enteritidis lipopolysaccharide (LPS) in mice, there was a marked acute phase response which was monitored by measuring the serum levels of serum amyloid P component (SAP) and C3. Prednisolone therapy had no effect on either the cutaneous lesion or the accompanying acute phase response. Also, in vivo complement depletion with cobra factor did not affect the lesion or the SAP response despite gross reduction in serum C3 levels. In contrast, administration of colchicine at the same time as LPS suppressed both the acute phase response and the Shwartzman reaction. Inhibition of the cutaneous reaction by colchicine was abrogated by injecting mice with casein, and unrelated acute phase stimulus, the day before challenge with LPS. These observations suggest that acute phase proteins may participate in pathogenesis of the Shwartzman phenomenon.

Amyloid↗
PubMed1950

Production of the shwartzman phenomenon by a single injection technic.

In the hypersensitive animal a single inoculation of homologous antigen mixed with Shwartzman preparatory toxin may lead to the production of a Shwartzman reaction which functions as an amplifier of the antigen-antibody tissue response. The combination of antigen and bacterial toxin does not alter the antigenicity of purified bovine gamma globulin. This form of the Shwartzman phenomenon may be useful in the investigation of hyperergic tissue reactions.

Animals↗
PubMed1991

[Sudden death in Sanarelli-Shwartzman phenomenon with an unusual pathogen].

The classical generalized Sanarelli-Shwartzman phenomenon (SSP) in animal experiments is induced by two conservative endotoxin injections. The experimental animals mostly die within 24 hours in irreversible shock. They show numerous microthrombi with as high fibrin content in the peripheral vessels of many organs (especially the kidneys) in the context of a consumption coagulopathy. In a 49-year-old man who died within one day of a condition associated with high fever, the clinical picture could be defined on the basis of the clinical and morphological findings as a human equivalent of SSP. The detection of a gram-positive bacterium (Diplococcus pneumoniae), which has been described as the causative organism of SSP only in a few exceptional cases, was noteworthy. The special features of the pathophysiology are described.

Death, Sudden↗
PubMed1951

Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis.

Evidence is presented to indicate that a profound thrombocytopenia and granulocytopenia occur during the second stage of the Shwartzman phenomenon, prior to the actual onset of hemorrhage in the prepared skin areas. These hematologic alterations appear to be due to accumulation of the cells mentioned in the capillary bed of the lungs and perhaps other internal organs. This seems to be consequent on certain changes in the platelets and polymorphonuclear leucocytes, which result in the formation of clumps of these elements. In skin areas prepared for the Shwartzman phenomenon, the capillaries and small veins become occluded by masses of platelets and granulocytes after the intravenous challenging injection has been given. Following the interruption of blood supply necrosis of the involved vessels takes place, and hemorrhage occurs later where the vessel walls have lost their integrity.

Blood Platelets↗
PubMed1965

PLATELETS AND THE SHWARTZMAN PHENOMENON.

Studies are reported on the effect of immunologically induced thrombocytopenia upon the local and generalized Shwartzman phenomena. Intravenous injection of antiplatelet serum to rabbits produced profound but transient thrombocytopenia unaccompanied by significant changes in circulating leucocytes. Platelet antiserum alone given to rabbits prepared with thorotrast produced renal lesions characteristic of the Shwartzman reaction. Thrombocytopenia induced by platelet antiserum did not inhibit the cutaneous hemorrhagic lesion of the local Shwartzman phenomenon produced by sequential injections of endotoxin intracutaneously and intravenously. The implications of these observations in the pathogenesis of the local cutaneous and generalized Shwartzman reaction are discussed.

Aminosalicylic Acid↗