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At least 19 recordsLinked to original sources

Alcohol consumption and self-reported drinking-related problem behaviors as related to sex, work environment, and level of education.

This study examined the relation of sex, work environment, and level of education to self-reported alcohol-related problem behaviors and estimates of weekly consumption. 216 employees of various establishments located in the eastern United States participated in the study, which involved answering a 17-item questionnaire. It was hypothesized that men would report more problems and greater consumption than women, college educated individuals more than people with no college background, and employees of alcohol-related environments more than those of nonalcohol-related environments. The results confirmed the predictions for environment and sex. There were also significant interactions between sex and environment and for sex and education concerning consumption. The triple interaction was also significant for the consumption variable. Further investigation is needed to determine the ramifications for both employers and employees of alcohol-related areas.

Adult

Brief Report: Beyond Testing: Exploring the Psychosocial Impact of HIV Self-Testing Among Ugandan Gender-Diverse Sex Workers.

BACKGROUND: The psychosocial effect of HIV self-testing (HIVST) on sex workers' self-esteem, depression, alcohol misuse, perceived sex work stigma, and empowerment remains poorly characterized. We hypothesized that HIVST would reduce sex work stigma and improve these psychosocial outcomes by enabling private, autonomous testing and reducing exposure to stigmatizing healthcare encounters. SETTING: Kampala, Uganda. METHODS: We conducted a secondary analysis of the Empower study (NCT03426670), an open-label randomized trial in which 117 cisgender female, transgender female, and cisgender male sex workers were assigned 1:1 to monthly HIVST plus quarterly clinic-based testing, or to quarterly clinic-based testing alone, and followed for 12 months. Self-esteem (Rosenberg Self-Esteem Scale), depressive symptoms (PHQ-2), alcohol misuse (RAPS4), perceived sex work stigma (adapted Female Sex Worker Stigma Scale), and empowerment were assessed quarterly. Mixed-effects regression models, adjusted for baseline values, evaluated intervention effects. RESULTS: Data from 117 participants were analyzed, including 7 early disenrollments. Over 12 months, HIVST participants reported significantly lower perceived sex work stigma than standard of care participants (β = -0.38, P = 0.04; monthly reduction P = 0.003), although the rate of decline did not differ significantly between arms (interaction P = 0.08). Self-esteem and depressive symptoms improved in both arms, with no between-arm differences (interaction P = 0.41 and 0.32). Alcohol misuse and empowerment showed no significant arm differences. CONCLUSION: HIVST may reduce sex work stigma without adverse psychosocial effects, supporting its integration into combination HIV prevention for gender-diverse sex workers in sub-Saharan Africa.

Humans

Nicardipine as antihypertensive monotherapy: positive effects on quality of life.

The effects of nicardipine and propranolol on patients' quality of life were compared during a double-blind, multicentre, parallel, randomised study of hypertension therapy. After a placebo run-in period, the doses for each patient were successfully titrated to reduce supine diastolic blood pressure to less than 90 mmHg with either nicardipine 60 or 90 mg/day (123 patients) or with propranolol 90-240 mg/day (120 patients). Both drugs demonstrated similar efficacy in reducing systolic and diastolic blood pressure. Total duration of therapy ranged from 6-12 weeks. The Nottingham Health Profile questionnaire was used to assess the effect of each treatment on the patients' quality of life. The overall quality of life score for patients on nicardipine showed a tendency toward improvement, while for those on propranolol, the trend was toward overall worsening. The differences between the two treatment groups were statistically significant for males (P = 0.02). The analysis of the separate components of this evaluation demonstrated that physical mobility was reported to be decreased more for the propranolol-treated patients than for the nicardipine-treated patients (P = 0.02). In contrast to the propranolol-treated patients, the nicardipine-treated patients reported improvements for sleep, social life, work, sex life, and for activities related to hobbies and interests. A second questionnaire was used to assess the effects of the therapies on work productivity. Among those patients who worked for pay, more patients treated with propranolol than those treated with nicardipine rated themselves as less productive at work (P = 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

Work-health relationships in middle-aged and elderly residents of a Jerusalem community.

Work-health relationships were examined cross-sectionally in 1886 men and women aged greater than or equal to 50 years in Jerusalem in 1985-1987, in the third round of a multipurpose longitudinal community health study. The main occupational variables were employment status, reasons for not working, and satisfaction with work. Sex and age were controlled in all comparisons. Workers were clearly healthier than nonworkers with respect to general, physical and emotional health, and people who had given up work were less healthy than those still working, whether they had stopped for health reasons, only because of their age, or only for extrinsic reasons (retrenchment or dismissal). Workers who expressed satisfaction with their work were healthier than others, the odds ratio in favour of good general health being 2.4 at 50-64 and 2.5 at greater than or equal to 65 years of age. The associations between job satisfaction and health remained apparent when education and origin were controlled. Multivariate analyses suggested that the associations were not spurious ones attributable to proneness to report both dissatisfaction and ill-health. Job dissatisfaction was not significantly associated with angina pectoris, possible myocardial infarction, or hypertension. Taken at their face value, the findings support the impact of job satisfaction or its determinants on the health of middle-aged and elderly men and women. The associations will be re-appraised in the longitudinal analysis of the study data.

Aged

Multifactorial analysis of renal transplants reported to the United Network for Organ Sharing Registry.

1. From a multivariate log-linear analysis of 35,625 renal transplants between 1988 and 1991, center effects accounted for 28%, 45%, and 27% of all assignable variation in 3-month, 1-year, and 2-year outcomes, respectively. Although center variation dominated 22 other variables, most factors were relatively independent of transplant center (ie, a percent of factor variation due center less than 10%). Recipient race and health status were notable exceptions; both highly influenced by center affiliation. Centers also differed in the age mix of recipients and racial mix of donors in some epochs. Again, we found only extremely weak correlations among a center's 3-month, 1-year, and 2-year graft survival rates. 2. In order of 3-month accountability, the other important factors were PRA, donor age, recipient working status, year of transplant, HLA-A,B mismatching, previous transplant, donor's death, donor relationship, recipient race, body mass, recipient age, cold ischemia time, donor race, donor kidney mode (ie, left/right kidney), original disease, and HLA-DR mismatching. Regarding 1-year outcome, the important factors were recipient race, donor age, donor's death, donor relationship, HLA-A,B mismatching, previous transplant, and recipient sex. Finally at 2 years, the important factors were recipient race, donor age, year of transplant, donor relationship, recipient sex, working status, donor's death, recipient age, CMV status, body mass, and donor sex. 3. Body mass, donor kidney mode, and CMV status were novel factors in our own multifactorial analyses of the UNOS Registry file. An elevated body-mass index (> 30 kg/m2) had a negative impact on short- and long-term graft survival. Recipients receiving left kidneys had nominal improvement in 3-month graft survival, but no impact thereafter. Survival rates over the 4 combinations of donor/recipient CMV statuses, suggest that this covariate was principally long-term and donor related. 4. It is noteworthy that graft failures in the 2 most recent transplant years, 1990 and 1991, have shown both short- and long-term declines, breaking stationary patterns previously reported in this series on clinical transplants. 5. The transitory nature of most transplantation factors was confirmed in this study, implying that future multifactorial studies in renal transplantation must include some mechanism for varying risks.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent

[Clinico-statistical data on 1,478 cases of burns admitted to the Burn Center of the Plastic Surgery Institute of the University of Parma in the 10-year period of 1967-76].

After having shortly illustrated the work's purpose, the Authors start to examine the statistics obtained in a research developed on 1,478 burned patients admitted at the burn center of the Institute of Plastic Surgery of Parma's University from 1967 to 1976. By and by are taken into consideration the statistics concerning age, sex, work, the percentage of burned body surface, the burn's causes, the mortality due to burns and the time spent in hospital. The most important data are those that come out from the comparison of the data that the N.B.I.E. considers optimal for a burn center, and those of the Burn Center of Parma, that have resulted practically the same. At the end of the work are related some considerations concerning the necessity of a bigger prevention of the illness and of collaboration with the other italian Burn Centers.

Accidents, Occupational

[Alleviation of pain through posterolateral spondylodesis in patients with prolonged severe backache].

In order to study the effect of posterolateral spinal fusion on pain and returning to work of patients with chronic lower back pain, a retrospective study was carried out at the University Hospital, Maastricht. Fifty-nine patients with spondylolisthesis I or II, spondylolysis, hemisacralisation, disc degeneration and pseudoarthrosis after spinal fusion were treated by posterolateral spinal fusion. A questionnaire and visual analogue scale were used to assess the pain. The mean preoperative pain level was 8.6; the postoperative pain level was 4.5; 13 patients were without pain. Before operation 41 patients had a job; after operation 34 returned to work. Sex, age, period of complaints, indication or level of operation did not significantly affect the pain score. In particular cases, posterolateral spinal fusion diminishes pain in patients with spondylolisthesis I or II, spondylolysis or hemisacralisation in whom pain does not improve after non-operative therapy. After the operation most patients return to their work.

Adolescent

Leisure time habits and physical fitness in adults with epilepsy.

By means of a questionnaire, we analyzed leisure time habits of 44 adult in-patients with active epilepsy (i.e., at least one seizure a month for the last year). Twelve patients had a generalized epilepsy and 32 a partial epilepsy. All received antiepileptic drugs (AEDs), and none had additional handicaps. Despite good facilities in their surroundings for participation in social, cultural, and physical activities, most patients lived a sedentary life. Social contact was limited, and they were only half as active physically as the average Norwegian population of comparable age and sex. Work capacity was tested as maximum oxygen uptake, using the bicycle ergometer test. Maximum oxygen uptake was considerably lower (75-80%), and the decrease observed in aerobic capacity with increasing age was more pronounced than that of the average Norwegian population. In comprehensive care of patients with epilepsy, we believe that prescription of adapted physical activity is an important means of improving quality of life.

Adolescent

[Ergometric determination of cardiac output in 1500 Swiss children and adults of both sexes, aged 5 to 65 years. Relation to body constitution, sex, age and work capacity in the step test (Part 2)].

The stroke volume of the heart during exercise in upright position (steptest) was determined in 1500 Swiss children and adults of either sex, aged 5 to 65 years. The use of the simplified ergometric method (Strehler) allowed to carry out these determinations mainly in series and without any difficulty. Average absolute values are presented for each year during childhood and adolescence and for each decade in the period of adult life. The stroke volume is lower in the female than in the male group; this refers to absolute values as well as to values relative to body size. The absolute values are approximately proportional to body weight, to the cube of body height and to a standard volume calculated from body height and body weight. There is a typical age-depending course of the relationship between stroke volume and body size (standard volume), the development of the stroke volume showing a minimum before and a maximum during puberty. Provided work load in per cent of the maximal working capacity is the same the stroke volume of the heart during exercise in upright position remains unchanged until the age of about 55 to 60 years. The practical scope of the investigation was to collect data for the setting up of a new stroke volume standard.

Adolescent

[The psychosocial characteristics of the patient who has undergone amputation for vascular reasons. The work, family and sex life aspects].

Forty-one amputee patients because vascular disease, 20 of them diabetics and 21 non-diabetics, with a mean of 68 years, were studied--from psychosocial aspect--by interviewing them 3 or 4 years after their amputation. Different factors were evaluated, like prosthesis usage, personal cares that patient could do by him self, home activities made by the patients, sexual life quality and labor status. For this evaluation different variables were considered, like age, sex, scholar level, familial economic level, original pathology, amputation level, stump status and phantom [correction of fantasm] limb perception. The most important variables correlated with good psychosocial conditions of amputee patients are noted, and considerations and recommendations for a rehabilitation program are established.

Aged

Assessing Hardy-Weinberg equilibrium in T2T-aligned 1000 genomes project.

Quality control of markers in genome-wide association studies often includes testing for Hardy-Weinberg equilibrium (HWE). However, this is usually implemented in a homogeneous population without stratifying by sex. Previous work indicates sex-based selection at numerous autosomal loci in cohorts with active recruitment. Sex chromosome sequences can also interfere with autosomal SNPs. These motivate a re-examination of HWE in sex-aware analyses. Using the telomere-to-telomere (T2Tv2)-aligned high-coverage whole genome sequencing data from 2,490 individuals in the 1000 Genomes Project, we examined genome-wide sex-specific deviations from HWE across five super-populations. Our analyses were restricted to bi-allelic SNPs with non-missing genotypes and minor allele frequency (MAF) &#x2265;5% in both sexes of the five super-populations. We applied an allele-based framework to quantify both the magnitude and direction of Hardy-Weinberg disequilibrium (HWD), followed by a second-order omnibus meta-analysis that combined HWD results across populations and sexes. At a genome-wide significance threshold of p&#x2009;<&#x2009;5e-8, 0.9% of autosomal SNPs exhibited significant deviations from HWE. The majority of these deviations were associated with genomic features indicative of poor sequence quality. Restricting the analysis to reliable genomic regions substantially reduced the number of signals, yielding 255 autosomal SNPs and one non-pseudoautosomal chromosome X SNP. Among these, 140 autosomal SNPs displayed significant heterogeneity across populations but not across sexes. Notably, eight SNPs within a 15-bp region on chromosome 14q31.3 showed excess heterozygosity in both sexes of the African super-population (AFR). Finally, we developed a multivariate predictor of HWD based on sequence features, providing a practical tool that can be integrated into existing quality control pipelines for whole genome sequencing studies.

Journal Article

Sex-role orientation and work adaptation of male nurses.

Three competing hypotheses regarding the influence of sex-role orientation on work-stress (pressure and strain at work) and work-attraction (work centrality and satisfaction) adaptation of 154 male nurses were contrasted. The findings reveal that even in a female-dominated profession, masculine-type male nurses were, on the whole, the best adapted type while the feminine-type male nurses were the least. The androgynous-type nurses, though ranking high in pressure and strain stemming from their work, nevertheless ranked highest in work satisfaction. In contrast, the undifferentiated were not stressed nor pressured at work, but they did not enjoy their work. These analyses were repeated for 54 female nurses. Among the female nurses no significant differences were found between the four sex role orientations, indicating that the differences found among the male nurses stemmed from the special situation in which a male nurse finds himself. It is suggested that change in the nature of the nursing profession into more "masculine" tasks also may partially explain the results.

Adaptation, Psychological

Environmental, occupational, and personal factors related to the prevalence of sick building syndrome in the general population.

Possible relations between prevalence of sick building syndrome (SBS) and environmental, occupational, and personal factors were studied in a random sample (0.1%) of the general population aged 20-65 in a three county region in middle Sweden. Childhood exposure to environmental tobacco smoke from smoking mothers and a childhood in urban areas was related to SBS symptoms. Current urban residency, fresh paint, and preschool children in the dwelling were also related to symptoms. Other residential factors such as age of building, type of building, degree of crowding, mechanical ventilation, or signs of moisture or mould growth were not related to symptoms. Other factors related to symptoms were history of atopy, allergy to nickel, proneness to infection, hyperreactivity, static electricity, work with video display units (VDU), work satisfaction, and climate of cooperation at work. Age, sex, marital state, education level, work stress, obesity, current or earlier smoking, regular physical exercise, or occupational exposure to chemicals did not correlate with symptoms. Women had a higher proportion of symptoms than men but these differences were not significant when adjusting for differences in allergy to nickel, hyperreactivity, and proneness to infection. Maternal smoking was related to a twofold increase of both atopy and allergy to nickel in the adult offspring. Eye symptoms were most common in administrative, managerial, and service work. Airway symptoms were most common in transport and communication work. Dermal symptoms were most common in professional and technical and related work. General symptoms were most common in service, health, hospital, and social work. The lowest prevalence of symptoms was found in agricultural, forestry, and sales work. Women and subjects allergic to nickel worked more often in occupations without exposure to chemicals, but no evidence was found for selection mechanisms causing sensitive persons to move from exposed to unexposed occupations. It was concluded that symptoms included in SBS are common in the general population, and of multifactorial origin related to both personal, occupational, and residential factors, and certain environmental exposures such as maternal smoking, the urban environment, VDU work, and volatile organic hydrocarbons from newly painted dwellings.

Adult

Helicobacter pylori and gastritis in Peruvian patients: relationship to socioeconomic level, age, and sex. The Gastrointestinal Physiology Working Group.

Studies in 1,120 Peruvian adults suffering from upper gastrointestinal symptoms and stratified according to socioeconomic level, age, and sex have shown the following: Rates of Helicobacter pylori infection range from 3% in patients with normal gastric mucosa to 92% in cases of chronic active gastritis. Age-specific infection rates do not vary with the severity of active gastritis and are similar in men from low and high socioeconomic levels. Women from higher socioeconomic backgrounds show a significantly lower age-specific rate of infection than women from lower levels or from men from either level. In addition, a seroepidemiologic survey of children, predominantly from families from lower socioeconomic levels, demonstrates that infection begins for many of them in the first years of life.

Adolescent