Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Satiation”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

Gastric satiation is volumetric, intestinal satiation is nutritive.

Gerry Smith's thoughtful survey in his book Satiation (1998) outlined the established principles of gastric and intestinal satiation and delineated several questions still requiring clarification. Experiments since the time of the review have addressed some of these questions. A synthesis of the principles outlined in the Gerry Smith survey and the subsequent experimental results indicates that the direct controls, or neural feedback signals from the GI tract, that limit meal size consist of gastric volumetric signals and intestinal nutritive signals. The two types of negative feedback synergize in the control of feeding, and both are carried by vagal afferents.

Animals↗

"De-satiation" produced by liquid diet in rats satiated for glucose solution.

Previous work has shown that after rats have drunk a glucose solution to "satiety," and during the time when solution intake would remain inhibited, intake can be reinstated by offering powdered glucose. This "de-satiation" phenomenon shows that solution intake comes to an end before any limit on caloric or solute intake has been reached. Here we show that a milk-based liquid diet can also reinstate ingestion in the solution-sated rat. And such a rat increases its intake further when the diet is diluted with water. Therefore, the original "satiety" for glucose solution does not reflect a refusal of fluid per se, or of water; nor does it reflect an inhibition on the lapping response.

Animals↗

"De-satiation": the reinstatement of feeding in glucose-satiated rats.

In rats "satiated" for glucose in solution, feeding can be reinstated by presentation of the same commodity (glucose) in powdered form. The effect is not reciprocal, so it is not a response to change or variety per se; and it does not reflect a greater palatability of the powder, which is rejected in favor of the solution in choice tests. Sucrose powder leads to an even larger "second meal" than glucose powder, showing that intake in the solution-sated rat remains sensitive to the stimulus properties of the diet. We conclude that the postingestive conditions necessary for satiety must be set by the stimulus properties of the diet--including, but not limited to, the properties that specify a diet's nutrient composition.

Animals↗

A food satiation and oral hygiene punishment program to suppress chronic rumination by retarded persons.

Food satiation and oral hygiene punishment were used to treat the non-life-threatening rumination of two institutionalized profoundly retarded persons. Satiation consisted of allowing the clients to eat until a satiation criterion of food refusal was achieved or until two full meal portions were consumed. The oral hygiene procedure consisted of cleansing the clients' teeth and gums with Listerine for 2 minutes following each instance of rumination. In the formal study, three conditions--baseline, satiation, and satiation plus oral hygiene--were used following the lunch meal in a multiple-baseline across-subjects design. One client's rumination decreased from an average of 89.5% during baseline to 48.8% during the satiation condition and to 3% during satiation plus oral hygiene. The second client's rumination decreased from a baseline average of 49.9% to 7.9% during satiation and to 1.4% during satiation plus oral hygiene. Generalization probes taken following the breakfast and dinner meals showed a systematic decline in rumination as the various conditions were implemented following the lung meal. In the 16-week follow-up, rumination was treated following all meals with oral hygiene, and satiation was used at one of the daily meals for 1 week on a rotating basis. Rumination remained at a near-zero level following all meals throughout the follow-up. Thereafter, a maintenance program was conducted by the ward staff. The satiation plus oral hygiene punishment treatment program appears to be an immediate, effective, enduring, and humane method of treating the non-life-threatening rumination of retarded individuals.

Adult↗

Mechanisms underlying satiation of feeding behavior of the mollusc Aplysia.

Animals filled almost to satiation by nonnutritive bulk do not satiate when they ingest a small amount of seaweed. This suggests that satiation is not triggered by chemostimulation of an anteriorly located "hot spot." Inflation of a balloon placed in the gut of the animal results in satiation as reflected in a number of different parameters of feeding behavior. The suppressive effect of a relatively brief inflation is rapidly and fully reversible, although repeated inflation and deflation appeared to produce slowly reversible or irreversible effects. The parameters of the changes in feeding during gut inflation are comparable to those of normal animals that are slowly fed individual pieces of food. The inflation volume needed to satiate the animal is a function of the rate of inflation--more rapid inflations requiring larger volumes. Cutting of the esophageal nerves results in a significant increase in the volume needed to satiate the animals, but nevertheless they eventually cease feeding and generally do not show a burst gut. The evidence indicates that the satiation that eventually occurs in nerve-sectioned animals, at least in part, is due to depression of feeding following very prolonged sensory stimulation. The data suggest that for a rapidly consumed meal, satiation results primarily due to distension-related gut signals conveyed by the esophageal nerves, whereas for very slowly consumed meals, the former factor interacts with a process associated with sensory stimulation, such as receptor adaptation. The current results indicate that balloon distension can serve as a reasonable stimulus in experiments in simplified preparations in which the nervous system can be studied.

Animals↗

Semantic satiation in healthy young and older adults.

In four experiments, semantic satiation was investigated in young and old adults. In the first two experiments, subjects were repeatedly presented a word (e.g., DOG) and then were presented a pair of words (e.g., DOG-CAT or DOG-CHAIR) for a relatedness decision. The results of both experiments indicated that for the young adults, the relatedness effect (the difference between response latency on related and unrelated trials) decreased as a function of the number of times the satiated word was repeated, whereas for the older adults, there was no evidence of a decrease in the relatedness effect across repetitions of the satiated word. In the third experiment, we investigated whether phonological codes are also susceptible to satiation. This experiment was similar to the first two experiments with the exception that subjects made rhyme decisions (SAME-CLAIM VS. SAME-DIME) instead of semantic relatedness decisions. The results of this experiment did not yield any evidence of satiation for either the young adults or the older adults. The final experiment eliminated a simple decrease in attentional alertness or fatigue account of the semantic satiation effects found in the first two experiments. In this experiment, the repeated word was always unrelated to the pair of words presented for the relatedness decision. The results of this experiment did not yield any evidence of semantic satiation for either the young or the older adults. The discussion focuses on the mechanisms underlying semantic satiation and the implications of age-related changes in these mechanisms.

Adolescent↗

The satiating efficiency of foods.

Experiments were undertaken to test the general hypothesis that some foods are more satiating than others, to find a mechanism for their differential satiating efficiencies, and to determine whether certain soups had a high enough satiating efficiency to recommend their addition to a meal as a way of reducing total caloric intake of that meal. In the first experiment it was found that intake of a test meal was lower after a large preload of tomato soup than after a small preload in women, but not in men. However, the total energy intake (soup plus test meal) was no less with meals which included the large soup preload than it was with meals that did not include a preload. Therefore adding a normal portion of tomato soup to a meal would not reduce its total energy intake. We noted the interesting incidental finding that total energy intake (i.e., preload plus test meal) of the meals which contained the larger amount of soup was less than the total energy intake of the meals which contained a combination of crackers , jelly, and juice. In the second experiment we confirmed this finding by showing that when equal weights of tomato soup preloads and a preload of crackers , cheese, and apple juice, which contains more energy, were given, total energy intake was less in meals which included soup. Therefore, substituting tomato soup for a more calorically dense first course could reduce total energy intake of that meal. In the third experiment, the hypothesis suggested by the second was confirmed. Two soups were more satiating than crackers , cheese, and juice. When two calorie levels were used for each preload, it was shown that calorie for calorie, these soups decreased intake of the test meal more than crackers , cheese, and juice. In the fourth experiment we showed that the mechanism for this differential satiating efficiency is not readily attributable to either bulk related factors or fat content. We suggest that the differential satiating efficiencies are related to differences in nutrient dispersion, orosensory cues, or temperature. Finally, reductions in intake were accompanied by reductions in the initial rate of eating and not by increases in the rate of deceleration. This reduction was small but consistent and suggests that foods which are more satiating reduce intake by decreasing desire to eat (i.e., hunger), not by accelerating the onset of meal termination (i.e., satiety). In fact the duration of meals was unaffected by the preloads.

Adolescent↗

Satiating efficiency and a strategy for conducting food loading experiments.

The general hypothesis is proposed that foods vary along a small number of dimensions, such as nutrient composition, energy content, or weight, each of which makes a potentially measurable, but presently unknown, contribution to the satiation process. Because of the differential contributions of each of these dimensions (or factors), foods will vary in the effectiveness with which they induce satiety. Predictions of this hypothesis can best be tested by using the preloading strategy, in which preloads, varied along one dimension at a time, are given on different occasions in amounts which vary along the dimension being studied, and the experimental subject is permitted to eat the test meal following the preload until satiated. The contribution of that dimension is then assessed by the equation relating intake of the test meal to the magnitude of preload along the chosen dimension. The negative of the slope of the intake-preload equation is an index we call "satiating efficiency" of the magnitude of the satiating effect per unit of the chosen dimension. The satiating efficiency therefore provides a method of comparing the ability of different foods to induce satiety, along any dimension. This strategy can be used theoretically to measure the contribution of various dimensions of food to satiety. Practically it could be used to improve the satiating efficiency of foods designed for appetite control, by incorporating into the food, components which are high in satiating efficiency per unit of energy.(ABSTRACT TRUNCATED AT 250 WORDS)

Eating↗

Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors.

Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the role of CCK-A receptors in satiation by intestinal nutrient infusion, we examined intake of solid (pelleted rat chow) or liquid (12.5% glucose) food intake, following intestinal infusions of fats (oleic acid or fat emulsion), sugars (maltotriose or glucose), or peptone in OLETF rats and Long Evans Tokushima Otsuka control rats (LETO). Intestinal infusion of glucose or maltotriose reduced solid food intake more in LETO than in OLETF rats from 30 min through 4 h post infusion. Reduction of solid food intake by intestinal infusions of fat or peptone did not differ between OLETF and LETO rats during the first 30 min post infusion, but reduction of intake by these infusates was attenuated in OLETF rats over the ensuing 4h post infusion. Intestinal infusion of glucose, oleate, fat emulsion and peptone reduced 30-min intake of 12.5% glucose more in LETO than OLETF rats. Furthermore, pretreatment with the CCK-A receptor antagonist, devazepide, attenuated intestinal nutrient-induced reduction of food intake only in LETO, but not OLETF rats. Our results confirm pharmacological results, indicating that CCK-A receptors participate in satiation by nutrients that elevate plasma CCK concentrations, as well as by nutrients that do not stimulate secretion of endocrine CCK. In addition, our results indicate: 1) that OLETF rats have deficits in the satiation response to a variety of intestinal nutrient infusions; 2) that the temporal pattern for CCK-A receptor participation in satiation by intestinal nutrients is different during ingestion of liquid and solid foods and 3) that intestinal nutrients provide some satiation signals that are CCK-A receptor mediated and some that are not.

Animals↗

Multiple factors in the satiation of salt appetite.

There is evidence in the literature that has been taken to show that, unlike hunger and thirst, salt appetite cannot be satiated in the absence of salt taste stimulation. The present study showed that repletion of body sodium in the absence of taste stimulation, that is, by gavage, can diminish subsequent saline intake. The satiating effects of gavage versus drinking of saline were studied at various intervals after repletion. For the first few hours, gastric loading was constantly less satiating than was drinking. But as the interval between gavage and testing was lengthened beyond 4-8 hr, the satiating effect began to increase until by 16 hr it was equal to that of drinking. The specificity of the satiating effect of saline gavage as a function of time between treatment and testing was also studied. There appeared to be a transient nonspecific blocking effect of solutes on solute intake which had a duration of less than 30 min. The satiating effect of saline gavage became specific after that time. The experiment suggests that there are multiple factors involved in the satiation of salt appetite--a taste factor, a short-latency post ingestional factor, and a long-latency postingestional factor.

Animals↗

Effects of asimadoline, a kappa-opioid agonist, on satiation and postprandial symptoms in health.

AIM: To evaluate the effect of single administrations of asimadoline, a kappa-opioid agonist, on satiation volume, postprandial symptoms and gastric volumes. METHODS: Healthy subjects received oral placebo, or 0.5 or 1.5 mg asimadoline in a randomized, double-blind fashion 1 h prior to testing. We assessed effects on the volume of Ensure to achieve full satiation and postprandial symptoms 30 min after meal, and on gastric volume (fasting and postprandial) measured by 99mTc-single photon emission tomography (SPECT) imaging. RESULTS: Thirteen healthy subjects were studied in each treatment arm. Compared to placebo, asimadoline 0.5 mg decreased postprandial fullness (P = 0.027) without affecting the volume ingested at full satiation (P = 0.6). Asimadoline 1.5 mg decreased satiation during meal, allowing increased satiation volumes (P = 0.008) and tended to decrease postprandial fullness (P = 0.067), despite higher volumes ingested. There was a significant treatment-gender interaction in the effect of asimadoline on gastric volumes (P < 0.05). Asimadoline 0.5 mg (not 1.5 mg) increased fasting (P = 0.047) and postprandial (P = 0.009) gastric volumes in females but decreased fasting volumes in males (P = 0.008). The effect of asimadoline on gastric volume did not explain the effect observed on satiation volume (P = 0.371) or postprandial fullness (P = 0.399). CONCLUSION: A single oral administration of asimadoline decreases satiation and postprandial fullness in humans independently of its effects on gastric volume.

Acetamides↗

Independent influences of body mass and gastric volumes on satiation in humans.

BACKGROUND & AIMS: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. METHODS: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. RESULTS: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m(2) (range, 17-48 kg/m(2)). Increased body mass index, but not height, was associated with delayed satiation (P < 0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 +/- 57 more kilocalories (945 +/- 239 kJ) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 +/- 32 kcal (479 +/- 134 kJ) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of postprandial bloating and pain were higher with increased body mass index (both P < 0.05, adjusted for sex and volume of Ensure ingested). CONCLUSIONS: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.

Adolescent↗

The effect of meal composition on the degree of satiation following a test meal and possible mechanisms involved.

1. Possible links between metabolism and satiation were investigated using volunteer subjects given test meals based on milk solids. Satisfaction was rated by the subjects on a six-point scale and the course of metabolism was followed by measurement of the respiratory quotient (RQ). 2. The time-course of satiation was the same for a high-carbohydrate, a high-fat and a high-protein meal, in spite of the very different time-course of metabolism. The degree of satiation was reduced by added sodium chloride, without affecting the RQ rise. On the other hand, calcium chloride produced a suppression of the RQ rise without altering the satiation. 3. It is proposed that the results indicate that the primary receptors responsible for post-prandial satiation lie within the gut wall and that there is probably a number of receptor types. Likely candidates for these receptors are the gut hormone-secreting cells. 4. Although very-low-protein meals produce less satiation than meals containing 220 g protein/kg dry weight, there is no additional satiation obtained by increasing the protein level further. This is not inconsistent with the possibility of a protein hunger separate from an energy hunger.

Adult↗

[Semantic satiation and language disorders in schizophrenia].

The term semantic satiation refers to the subjective experience of loss of meaning of a word as a result of prolonged repetition of that word. Satiation is a general property of neural activity: it reflects a spreading of activation in semantic networks and some type of inhibitory process. The aim of this paper is to present the hypothesis about the influence of the semantic satiation upon the language disorders in schizophrenia. This article contains a review of semantic satiation experiments in healthy participants, it also deals with the semantic priming paradigm, which was usually used to investigate this effect. The author presents a theoretical hypothesis about the connection between semantic satiation and language disorders. This hypothesis is based on a review of semantic priming experiments in schizophrenia, which provides the evidence that for schizophrenic patients the priming effect is larger than for healthy individuals. This hyperpriming effect suggests that schizophrenic patients are more susceptible to semantic satiation than healthy individuals, which may be a likely cause of a few of schizophrenia--related language disorders. Satiation may prove to be a useful tool for exploring the thought and language disorders in schizophrenia. Some empirical investigations should be made to verify the hypothesis which is described in this paper.

Humans↗

Further studies of bulk and orosensory decrement in producing satiation of feeding in Aplysia.

Prior evidence has suggested that meal satiation in the marine mollusk Aplysia is associated with stretch of the crop. The current data, however, suggest that under some conditions, bulk in the crop can be dissociated from the propensity to feed. The crop was hyper-distended 6 h after a satiating meal of rehydrated seaweed; that is, the crop took in water and therefore contained a greater volume than it had contained immediately after satiation. Animals presented with food 6 h after an initial satiating meal consumed a new meal despite the fact that their crop was distended beyond the level at which they had previously terminated feeding. This unexpected result led to additional experiments designed to study possible orosensory decrement during presentation of food. Orosensory input was assessed by recording from the metacerebral cell (MCC) in free-moving animals. The MCC receives excitatory input in response to chemosensory stimulation of the lips, and exhibited a slow decrement during the course of a meal or during repeated lip stimulation without ingestion. Lesions of the cerebro-buccal connectives abolished the long-term MCC response decrement to lip stimulation. This result suggests that the MCC long-term response decrement to lip stimulation is a product of buccal-ganglion feedback and may not reflect sensory decrement of chemosensory pathways. Therefore, satiation may not produce a change in lip sensitivity to chemosensory input. Our data suggest that one important factor that determines satiation is a stretch stimulus of the posterior esophagus/anterior crop. This stretch stimulus may subside over several hours as the crop contents are redistributed or as receptors slowly adapt.

Action Potentials↗

Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency.

To examine leptin's role in human appetite regulation, we studied recombinant methionyl human leptin's effects on satiation and satiety in a model of leptin insufficiency, lipodystrophy. Eight females with hypoleptinemia and lipodystrophy were given sc injections of A-100 (maximal dose, 200% of that predicted to normalize serum leptin) for 4 months. Satiation and satiety were determined before and again during leptin treatment. Satiation was measured as the time to voluntary cessation of eating from a standardized food array after a 12-h fast. Satiety was determined as the time to hunger sufficient to consume a full meal after consumption of a standardized preload. During leptin treatment, satiation time decreased (41.2 +/- 18.2 to 19.5 +/- 10.6 min; P = 0.01), satiety time increased (62.9 +/- 64.8 to 137.8 +/- 91.6 min; P = 0.04), energy consumed to produce satiation decreased (2034 +/- 405 to 1135 +/- 432 kcal or 8.5 +/- 1.7 to 4.7 +/- 1.8 MJ; P < 0.01), and the amount of food desired in the postabsorptive state decreased (P < 0.02). Ghrelin concentrations also decreased during leptin administration (284.3 +/- 127.9 to 140.6 +/- 104.5 pmol/liter; P < 0.002). We conclude that increased leptin in patients with lipodystrophy results in less caloric, shorter, more satiating meals and longer-lived satiety. These data support the hypothesis that leptin plays an important, permissive role in human appetite regulation.

Adolescent↗

Food satiation in the pigeon.

The experiment was designed to find the shape of food satiation curves of the pigeon as a function of hours of deprivation or percentage of free-feeding weight, and to study the fluctuation in free-feeding weight as a function of deprivation and satiation. At a systematically and progressively increased number of hours' deprivation, eight birds were allowed to satiate on grain presented contingent upon the emission of a pecking response. In the second part of the experiment, in which two birds were used, a similar procedure was followed except that the independent variable was percentage of free-feeding weight. These were the conclusions.1. Approximately 64% of the satiation curves were classified as straight with an abrupt stop. The next highest percentage of curves was 18% for curves classified as straight with a curvilinear stop. No "classic" satiation curves, curvilinear with curvilinear stop, were found.2. The pigeons responded at fairly constant rate during the early part of each satiation session, or they did not respond at all. The critical weight, above which they did not respond, was 85% of free feeding.

Animals↗