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At least 19 recordsLinked to original sources
PubMed1983

[Painful sciatic rubbing caused by benign synovioma of the spinal joints. Apropos of 4 cases].

Synovioma, a benign neoplasm arising from pigmented villonodular synovium or synovitis, is uncommon. It involves the tendons and joints of the finger, ankle and foot. In this study four cases of villonodular synovioma of spinal joints are reported. The authors studied 555 cases of patients operated for sciatica due to herniated disk. Histopathology showed that in four out of 555 cases sciatica was found to be due to synoviomas of the spinal joints. The patients, three women and one man, were between 54 and 70 years of age and each had had a long history of low back pain with episodes of sciatica. Clinical evaluation at the time of surgery showed moderate severity of signs and symptoms. Roentgenographic studies of all four cases revealed osteoarthritic changes of vertebral apophyses, with two cases of spondylolisthesis. The pathogenesis of synovioma remains controversial and its histopathological characterization -hyperplasia VS/true tumours- has not yet been determined. It is possible that the number of recorded cases of sciatica due to synoviomas is small because surgical and pathological studies in patients with sciatica associated with osteoarthritic changes have not been adequately performed. Surgery consists of a large resection of the capsule and ligament including resection of intraspinal extension. Because this study involves only four cases, the first of which occurred in 1977, the possibility of recurrence cannot be evaluated.

Aged↗
PubMed1995

DNA content and morphological parameters in synovial sarcoma and synovioma.

By using image analysis technique with 6 normal synovial tissue specimens as controls, nuclear DNA content and morphological parameters in specimens from 51 synovial sarcomas and 15 synovioma were examined quantitatively. The DNA content in synovial sarcoma and synovioma was significantly different (P < 0.01), and that of synovioma and normal synovial tissue was also different (P < 0.05). Morphological parameters including nuclear areas and perimeters differed significantly among the above three groups (P < 0.01). There was no correlation between the DNA content of synovial sarcoma and its histologic type (P > 0.05), but the DNA content greatly differed between its higher and lower differentiated grade in each type (P < 0.01). The DNA content in synovial sarcoma IIA stage, according to Enneking's staging system was lower than that in IIB, IIIA and IIIB (P < 0.05). The 5-year survival rate of synovial sarcoma with diploid/nearly diploid (D/ND) pattern was higher than that of aneuploid (AN) pattern (P = 0.028). The study suggests that analysis of the DNA content and morphological parameters of tumor cells is helpful in the diagnosis and pathologic grading of synovial sarcoma. It also provides a guide to clinical operation and estimation of the prognosis. Although synovioma is usually a well-differentiated and benign lesion, this investigation also suggested that increased DNA content may be an indication of poor prognosis for this neoplasm.

Adolescent↗
PubMed1979

The potential histogenic relationship of the peripheral nerve to synovioma.

The belief that synoviomas differentiate from the synovial membrane has been widely accepted. Absolute proof is lacking, mainly because precancerous synovial atypia has not been documented in human tissue. During the last 50 years, pain has emerged as one of the significant features of synovioma, occurring very early in the course of the disease in some patients. Gross relationship to nerve, cumulative histological data, and theoretical relationships with three other cancers of neural origin suggest the nerve sheath as an alternate parent tissue for synovioma. Three cases illustrating nerve involvement are included.

Adult↗
PubMed1978

Malignant synovioma: electron microscopical findings in three patients and review of the literature.

Ultrastructural findings in three malignant synoviomas are described. Two typical "biphasic" tumours contained "epithelial" cells possessing filopodia or microvilli, specialised cell attachment and a basal lamina, and smaller "stromal" cells showing transitions to fibroblasts. In one case, the microvilli included fibrils resembling those in epithelial cells of the intestine and renal tubules. The third tumour was mainly spindle-celled with little epithelial differentiation and no clear division into cell types, but intracytoplasmic microfibrils were conspicuous, forming ovoid masses. The tumour cells differ a good deal from normal human synovial cells but some of the features of the neoplasm are found in inflamed human synovium and in normal synovial membranes of other species. The cytoplasmic fibrils in the third case are similar to those reported by others in epithelioid sarcoma, a tumour that may be of related origin to synovioma; however, the phenomenon may be merely degenerative.

Adolescent↗
PubMedDate not supplied

[The spine as an unusual location for a malignant synovioma].

The authors report on a case of malignant synovioma of the spine, a rare condition. A general review of the literature on the pathogenesis and localization, and the histologic and immunohistochemical investigation possibilities for differential diagnosis is given. The surgical and radiotherapeutic treatment possibilities are pointed out.

Female↗
PubMed1990

Benign synovioma causing internal derangement of the knee. A report of nine cases.

Nine pedunculated benign synoviomata causing mechanical symptoms similar to those of a torn meniscus are described. The average age of the patients was 34.4 years. During the period of study, 2254 meniscal lesions causing mechanical symptoms were identified, giving an incidence of one benign synovioma for every 250 meniscal lesions. All the lesions were removed arthroscopically with relief of symptoms.

Adult↗
PubMed1978

Cutaneous pain without tumor: a manifestation of occult synovioma.

A thirty-four year old male presented with severe spot tenderness for eighteen months, situated in the right upper anterior thigh. The skin was normal. No tumor, swelling, or inflammation was found. On the basis of a clinical diagnosis of glomus tumor, the area was biopsied and a microscopic synovioma was documented in the fascia just deep to the subcutis. From the literature, it is apparent that approximately 20 percent of the patients with this cancer go through a pretumor phase characterized by only sustained pain or tenderness. By detecting the lesion in this phase, the dermatologist can contribute substantially to an increased cure rate, which has lingered at about 50 percent for at least ten years.

Adult↗
PubMed1978

[Morphometric analysis of ultrastructure of human synovioma cells].

Under examination were two gigantic-cell benign synoviomas and seven synovial sarcomas, including two metastatic tumors. The most specific ultrastructural criterion allowing a judgement of the degree of malignancy of the neoplasm under study is a parameter characterizing the predominance of ergastoplasmic protein synthesis over polyribosomal one.

Endoplasmic Reticulum↗
PubMed1994

[Evaluation of prognostic factors in malignant synovioma].

Prognostic factors in 78 patients (36 males and 42 females) aged 9 to 68 treated for malignant synovioma in Warsaw Institute of Oncology between 1950 and 1988 have been assessed. Case history ranged from 1 month to 18 years. The neoplasm was found primarily within lower limb- 45 cases (58%), upper limb- 23 (29%), head, neck and trunk were the sites in 10 patients (13%). In 37 cases tumor diameter was less then 5 cm (T1) and in 37 more (T2 and T3). The diameter remained unknown in 4 patients. Monophase structure was found in 50 cases, biphase structure in 28. Five years survival constituted 48%, 10 years- 28%. The best prognostic value had size of the tumor and the duration of the symptoms. The size below 5 cm gave 58% years survival, above 5 cm only 34%. The history longer then 12 months offered 70% of 5 years survival and shorter one only 27%. Patients with longer history and smaller size of the tumor had significantly better prognosis then those with short history and tumor exceeding 5 cm in size. Females with tumor larger than 5 cm had much better changes then males. Remote metastases worsened the prognosis markedly. The age, localization and histological type of the neoplasm had no prognostic value.

Adolescent↗