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Results for “STAPHYLOCOCCUS/chemistry”

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At least 19 recordsLinked to original sources
PubMed1962

Studies on the chemistry and immunochemistry of cell walls of Staphylococcus aureus.

The cell walls of an 80/81 strain of Staphylococcus aureus (NYH-6) contain alanine, glycine, glutamic acid, lysine, muramic acid, glucosamine, and ribitol phosphate. 94 per cent of the phosphorus and 41 per cent of the glucosamine are removed by extraction of the cell walls with hot 5 per cent TCA, but significant amounts of the other constituents are not extracted by this procedure. The residue after hot TCA extraction (mucopeptide) is susceptible to lysozyme whereas the intact cell walls are resistant. Staphylococcus aureus cell walls are agglutinated by S. aureus antisera. Agglutination of the cell walls of one S. aureus strain is inhibited by absorption of antisera with cell walls of other S. aureus strains but not by absorption with S. albus cell walls. The ribitol teichoic acid can be isolated from cold TCA extracts of the cell walls. This compound consists almost entirely of ribitol phosphate and glucosamine. The isolated teichoic acid of strain NYH-6 is readily fixed to tanned sheep erythrocytes and these sensitized cells are agglutinated by S. aureus antisera. Cold TCA extracts of cell walls of other strains of S. aureus inhibit hemagglutination whereas extracts of S. albus walls do not. Studies on the inhibition of both hemagglutination and precipitation indicate that the antigenic determinant of S. aureus NYH-6 teichoic acid is beta-N-acetylglucosamine.

Animals↗
PubMed1961

Toxohormone-like factor from microorganisms with impaired respiration.

A substance that significantly depresses liver catalase values when injected into mice has been isolated from biochemical mutants of yeasts and staphylococci with impaired respiration. This is considered as an important argument in support of the Warburg hypothesis on the origin of cancer cells.

Animals↗
PubMed1962

Isolation and partial characterization of a capsular material from Staphylococcus aureus.

Wiley, Bill B. (University of Saskatchewan, Saskatoon, Sask., Canada) and Jane C. Wonnacott. Isolation and partial characterization of a capsular material from Staphylococcus aureus. J. Bacteriol. 83:1169-1176. 1962.-An encapsulated strain of Staphylococcus aureus, which underwent a specific capsular reaction with homologous antiserum, was grown in a semisynthetic Casamino acids-glycerol broth. A fraction containing the capsular material was isolated from the culture supernatants. The preparation was antigenic in rabbits and absorbed the antibody responsible for both the passive protection of chick embryos and the specific capsular reaction in rabbit antiserum against the homologous organism. Chemically, the material was free of nucleic acids, contained 8% nitrogen, 4.25% total phosphorus, 26% hexosamine, and 26% reducing sugar. Acid hydrolysis yielded the amino acids glycine, alanine, glutamic acid, and lysine. Glucosamine and organic phosphate compounds were also present. Organic phosphate compounds were accounted for as glycerophosphate.

Acids↗