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Results for “SPLENOMEGALY”

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At least 19 recordsLinked to original sources
PubMed1980

Massive splenomegaly in Northern Zambia. II. Schistosomal splenomegaly and elevated IgG.

Twenty-three patients from Northern Zambia with massive splenomegaly due to chronic schistosomiasis were studied. The mean serum IgG levels were found to be extremely high compared with local blood donors and local patients with Tropical Splenomegaly Syndrome (TSS). Mean serum IgG levels also appear to be higher in Zambians with schistosomal splenomegaly than in those reported in patients from most other areas. Mean IgM levels of patients with schistosomal splenomegaly were higher than those of local blood donors, but not as high as in the TSS. IgG and IgM estimations are sometimes of value in the differential diagnosis of splenomegaly in the tropics.

Adolescent↗
PubMed1975

Splenomegaly, macrothombocytopenia and stomatocytosis in healthy Mediterranean subjects (splenomegaly in Mediterranean macrothrombocytopenia).

Spleen size, stomatocytosis, macrothrombocytopenia, haemoglobin level, white cell count, and abdominal pain episodes were assessed in a coded study of healthy Mediterranean immigrants to Australia. Spleen size was estimated from a length measurement, L, on a standardized plain abdominal radiograph and expressed both as spleen weight and as a spleen length index, L/square root BSA; the platelet count and size parameters were determined electronically and the presence of stomatocytes was evaluated in stained blood films. In relation to 16 Northern European control women 12 of 25 Mediterranean women had radiographic splenomegaly, 10 had macrothrombocytopenia, 9 had stomatocytosis, but none had episodes of abdominal pain. The median spleen weights of the two groups were estimated as 157 and 247 g with ranges from percentile 2.3 to 97.7 of 75 to 328 and 112 to 669 g. Within the Mediterranean group splenomegaly correlated with macrothrombocytopenia (P less than 0.001) but not with stomatocytosis, haemoglobin values or white cell counts. Thus, mild splenomegaly may be expected in Mediterranean macrothrombocytopenia, Mediterranean stomatocytosis appears unrelated, and all of these apparently benign anomalies may be incidental findings in patients from the Italian and Balkan peninsulas.

Adult↗
PubMed1986

Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome).

Hyperreactive malarious splenomegaly (HMS), formerly known as tropical splenomegaly syndrome (TSS), was recognized some 20 years ago as an entity distinct from the splenic enlargement resulting directly from malarial parasitaemia. Its basis appears to be a disturbance in the T-lymphocyte control of the humoral response to recurrent malaria, possibly linked to particular HLA Class II antigens. Gross overproduction of IgM antibodies leads to the formation of high molecular weight immune complexes, persistent gross splenomegaly recurrent episodes of profound anaemia and increased susceptibility to infections. Those with gross disease experience a high mortality, which constitutes a major public health problem in communities where the syndrome affects a majority of adults.

Journal Article↗