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Results for “SODIUM HYDROXIDE”

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At least 19 recordsLinked to original sources
PubMed1988

Alkalinization of peritoneal dialysis solutions with sodium hydroxide or sodium bicarbonate.

Peritoneal dialysis solution containing 1.5% dextrose was titrated with either sodium hydroxide or sodium bicarbonate. The titratable acidity was approximately 1.5 mmol/L as determined by sodium hydroxide titration. Generation of carbon dioxide on addition of sodium bicarbonate resulted in a titration curve that was shifted downward and to the right compared with the curve for sodium hydroxide addition. The information presented can be used to guide the amount of base to be added when partial or complete neutralization of peritoneal dialysis solution is desired.

Bicarbonates↗
PubMedDate not supplied

A comparison of sodium hydroxide and sodium sulfide digestion of mouse hair in the recovery of radioactivity following systemic administration of [3H]-nicotine and [3H]-flunitrazepam.

Pigmented (C57BI) and nonpigmented (balb/c) mice, 25 days of age, were treated intraperitoneally with [3H]-nicotine (4 mg/kg, 555 dpm/ng) or [3H]-flunitrazepam (1 mg/kg, 2200 dpm/ng) daily for three days. After 21 days, shaved back hair was digested at 37 degrees C for 24 h with either 1 M sodium hydroxide or 1 M sodium sulfide. With both drugs, sodium sulfide extraction removed the same amount of radioactivity as sodium hydroxide from nonpigmented hair. However, sodium sulfide removed significantly more radioactivity from pigmented hair than did sodium hydroxide. In pigmented hair, sodium sulfide solubilized 35% and 74% of the flunitrazepam- and nicotine-associated radioactivity, respectively. Of this, 12% and 43%, respectively, could be partitioned into ethyl acetate. Microscopic examination of residual pellets after digestion demonstrated a more thorough dissolution of the hair shaft with sodium sulfide with only melanosomes remaining. The results demonstrate the significant interaction of flunitrazepam and nicotine with melanins and the utility of sodium sulfide in increasing drug recovery.

Acetates↗
PubMed1990

Simultaneous determination of ampicillin and sulbactam by liquid chromatography: post-column reaction with sodium hydroxide and sodium hypochlorite using an active hollow-fibre membrane reactor.

A high-performance liquid chromatographic method has been developed for the simultaneous determination of ampicillin (ABPC) and sulbactam (SBT) in serum and urine. The method involves separation of ABPC and SBT from the background components of serum and urine on a C18 column, post-column reaction with sodium hydroxide and sodium hypochlorite using an active hollow-fibre membrane reactor, and detection at 270 nm. At ABPC and SBT concentrations of 10 and 5 micrograms/ml in urine and serum samples, the precisions (relative standard deviations) were 0.9-2.5% (n = 8). The detection limits were 20 and 5 ng for ABPC and SBT, respectively, at a signal-to-noise ratio of 3.

Ampicillin↗
PubMed1992

Obstructive airway disease associated with occupational sodium hydroxide inhalation.

Sodium hydroxide (NaOH) is well known for its corrosive properties and its ability to generate heat on contact with water. The respiratory effects of industrial exposure to NaOH have, however, never been reported. A 63 year old man worked daily for 20 years cleaning large industrial jam containers by boiling lye (NaOH) solution without using respiratory protective equipment. Physical examination, chest x ray film, pulmonary function tests, and arterial blood gases were all compatible with severe obstructive airway disease with significant air trapping. It is probable that this massive and prolonged occupational exposure to the corrosive effect of NaOH mists induced irritation and burns to the respiratory system, eventually leading to severe obstructive airway disease.

Humans↗
PubMed2004

Chemical injury to the tongue following contact with sodium hydroxide drain cleaner.

Solid sodium hydroxide compounds are used to unclog drains. In Turkey, these agents are easily available and commonly used by housewives. They are sold in weak bags and usually stored within these bags. We present the case of an elderly woman with dementia who developed severe alkaline tongue burn and edema after unintentional short contact with solid sodium hydroxide drain cleaner. Official legislation for safety packing in Turkey will lead to reduction in the incidence of accidental caustic injuries.

Aged↗
PubMed1984

Intrapericardial instillation of sodium hydroxide: failure to produce pericardial symphysis.

Previously reported clinical studies have suggested sodium hydroxide as an effective agent in causing pleural symphysis. To explore the sclerosing potential of this agent, we instilled 0.5% sodium hydroxide into the pericardium of four dogs. Normal saline was instilled into the pericardium of one control dog. Echocardiograms, 24 hour EKG monitoring and intracardiac pressures were recorded. One dog was sacrificed at the end of 24 hours, another at the end of seven days and three other dogs were sacrificed at the end of 28 days. ST elevations and prolonged episodes of supra-ventricular and ventricular tachycardia were noted during and within 24 hours after the intrapericardial instillation of sodium hydroxide in all the dogs. No arrhythmias were noted in the control dog. None of the dogs showed pericardial symphysis. These results suggest that sodium hydroxide causes serious cardiac arrhythmias when instilled intrapericardially and is of limited value in causing pericardial symphysis.

Animals↗