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At least 19 recordsLinked to original sources
PubMed1981

[Silicosis with a rapid and pseudo-tumoral course occurring in a case of pre-existant progressive and treated pulmonary sarcoidosis in a miner little exposed to silicosis risk : sarcoido-silicosis (author's transl)].

The authors report the case of a miner suffering from pulmonary and nodal sarcoidosis treated with corticosteroids where during a multivisceral exacerbation with iritis and erythema nodosum there developed rapidly progressive pseudo-tumoral silicosis. Pulmonary and nodal biopsies by thoracotomy revealed silicotic masses in the upper lobe, penetrated and bordered by sarcoid granulomas. In the middle lobe and hilar nodes, only sarcoid process was present. This new entity, sarcoido-silicosis, follows its own course, insensitive to corticosteroids. By virtue of its immune status, sarcoidosis favourised the rapid development of silicosis, the latter being unexpected since exposure had been moderate. Deficiency in the elimination of silica particles from the lungs is discussed. A trial of treatment using aluminium hydroxy-allantoinate did not lead to any conclusion.

Adrenal Cortex Hormones↗
PubMed2002

[Studies on blood viscosity and external thrombus in patients with silicosis and silicosis complicated with tuberculosis].

OBJECTIVE: To explore the changes of blood viscosity and external thrombus in patients with silicosis and silicosis complicated with tuberculosis (TB). METHOD: Blood viscosity and external thrombus were measured in 288 patients with silicosis, 178 patients with silicosis complicated by TB and 150 healthy subjects. RESULTS: Blood viscosity and external thrombus value were significantly higher in the patients of silicosis and silicosis complicated with TB than in the healthy controls, except for patients of phase I of silicosis. Blood viscosity in the silicotics increased significantly with the advance of the disease, but no significant difference in external thrombus between patients in different phases. Apparent viscosity of whole blood significantly increased in the high-shear rate (200 s(-1)) and middle-shear rate (30 s(-1)) in patients of silicosis complicated with TB than in those without complication of TB at the same phases, but not seen in the low-shear rate (5 s(-1)) and in plasma viscosity, and the length and dried weight of external thrombus increased significantly too. There was no significant difference in blood viscosity and external thrombus between patients of silicosis at phase III and those of silicosis complicated with TB at the same phase. CONCLUSION: Blood in patients with silicosis appeared highly viscous and highly coagulant status. Blood viscosity and external thrombus value significantly increased with the advance of the disease, especially in the patients complicated with TB.

Adult↗
PubMed1986

Silicosis in the iron-ore mine in Kiruna, Sweden, and the future need for silicosis control.

From 1931 to 1977 a total of 144 cases of silicosis have been diagnosed in the iron-ore mine in Kiruna, Sweden. Drilling, loading and tapping caused all cases of silicosis. In 24% of the cases, the disease had progressed after the diagnosis. The progression of the disease after diagnosis showed no significant correlation to the length of the exposure but a dose-response relationship was present between the cumulative quartz exposure and the stage of silicosis 20 years after the diagnosis. Signs of tuberculous infection were found in 17%. There was a significant relationship between tuberculosis and progression of the silicosis. Mortality was increased in association with silicosis stage II-III and in stages with concomitant tuberculosis infection. Half of the cases of silicosis had been diagnosed before 1942, and after 1960 no more cases in stages II or III were diagnosed. The mean concentration of respiratory quartz was approximately 0.8 mg/m3 in the 1950s and early 1960s and decreased progressively to below 0.05 mg/m3 in the late 1970s. The cumulative incidence rate, with respect to the decade in which the exposure began, was 0.021% in 1951-1960. With an unaltered dose-response, less than one case of silicosis per 500 workers may be expected among those who start working underground in the 1980s. Evidently silicosis is no longer a major health risk among those who start working underground in this mine today, and it is recommended that the 40-year-old regulations for the medical prevention of silicosis be revised.

Adult↗
PubMed1986

[Coincidence of silicosis and sarcoidosis. 2. Relations between silicosis and sarcoidosis as well as forensic consequences].

The observation of a coincidence of silicosis and sarcoidosis (see the 1st Communication) raises many problems on the pathogenesis of both diseases, their possible causal connections and not last the medical judgement. The mutual influence of both diseases is not discernible in the particular case. Pathogenetic connections derived from mentioned examples of coincidence of silicosis and sarcoidosis stay hypothetical, because its experimental confirmation cannot be realized. Within the medical judgement of the coincidence of silicosis and sarcoidosis the differentiation of injury caused only by silicosis must be tried. If that is not possible, the whole bodily injury must be imposed to silicosis to protect the patient from a disadvantageous expert opinion. The professional activity of patients with sarcoidosis in an atmosphere of quartz dust is not permissible, because the momentary injury of tissues of lung and lymph nodes as well as the prognosis of sarcoidosis are not definable with the actual available methods, but it is safe to say, that silicosis is an additional danger to the patient.

Dust↗
PubMed2001

Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients.

Eighty-one Japanese silicosis patients and 66 healthy volunteers were analyzed for autoantibodies by ELISA, and HLA-genotyping using the PCR-RFLP method was performed. Anti-topoisomerase I (anti-topo I) autoantibodies were detected in seven patients without any clinical features of autoimmune diseases such as progressive systemic sclerosis (PSS), although anti-topo I have been mostly reported in PSS patients. Antibodies directed to RNP, ssDNA, dsDNA and cent-B were not detected among the anti-topo I positive patients. The indirect immunofluorescent staining pattern of Hep-2 cells with the sera of anti-topo I positive silicosis patients demonstrated the typical mode of anti-topo I autoantibodies observed in the patients with PSS. The allelic frequency of HLA-DQB1*0402 was significantly higher in anti-topo I positive patients (28.6%) than in anti-topo I negative patients (1.5%, P < 0.001) or healthy controls (0.8%, P<0.001). HLA-DQB1*0301, DQB1*0601 and DPB1*1801 alleles were more frequently detected in anti-topo I positive patients than in the patients without anti-topo I or in healthy volunteers, but no significant difference was observed. DQB1 allele is associated with the induction of anti-topo I autoantibodies in Japanese silicosis patients, but the allele is not the same as in Caucasian PSS patients. Another allele (DQB1*0402) plays an important role in Japanese silicosis patients. The most important factor to induce anti-topo I autoantibodies seems not to be the type of alleles themselves, but the position of some specific amino acid residues in the DQ beta first domain. These findings will be useful for preventing occupational autoimmune diseases.

Aged↗
PubMed1994

Effects of dietary supplementation on the function of alveolar macrophages of silicosis rats, on the blastogenic response of lymphocytes and on the peroxidase activity in blood of silicosis patients.

We studied the effects of a nutrient supplemented diet on the function of alveolar macrophages of silicosis rats and on the blastogenic response of lymphocytes, glutathione peroxidase (GSH-PX) activity, and lipid peroxidase (LPO) activity in the blood of silicosis patients. The results showed that a nutrient supplemented diet increased the phagocytosis rate (p < 0.01) and index (p < 0.05) of alveolar macrophages of silicosis rats. A nutrient supplemented diet also enhanced significantly the GSH-PX activity (p < 0.001) and the blastogenic response of lymphocytes (p < 0.01), and decreased substantially the LPO content (p < 0.05) in the blood of silicosis patients. We conclude that a nutrient supplemented diet may play an important role in antilipid peroxidation, decreased free radical reaction, stabilizing cell membrane, delaying lung fibrosis, and enhancing immune functions of the body.

Animals↗
PubMedDate not supplied

Silicosis and tuberculosis: Part 2--a radiographic presentation of nodular tuberculosis and silicosis.

Indolent nodular pulmonary tuberculosis (TB) in workers exposed to silica dust may go undetected clinically and radiographically, especially in the absence of identification of tubercle bacilli in sputum. Illustrative cases demonstrating the radiographic manifestations of coexistent pulmonary silicosis and the indolent form of nodular TB are presented. Alterations in the usual chronologic progress, a rapid advance in nodular profusion or size outside the expected time frame, and distinct pattern alterations are features indicating the presence of TB associated with silicosis.

Environmental Exposure↗
PubMed1987

[Experimental silicosis. Analysis of collagen levels in the heart, spleen and liver of rats in experimental silicosis].

Possibilities of increasing the content of collagen in heart, spleen and liver have been tested in rats affected by silicosis induced by intratracheal administration of 50 mg of siliceous earth dust suspension. An increased level of collagen has been found in rats' hearts after 9 months, whereas in spleens after 6 and 9 months of experiment. In the liver of rats suffering from experimental silicosis, no changes which would clearly indicate the fibrosis of this organ were found. In addition, the animals administered with dust exhibited inhibited physiological growth of the body weight and liver weight.

Animals↗