Reduction of selenite by Neurospora.
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When measured simultaneously, selenium-75 selenomethionine accumulated identically with sulfur-35 methionine across everted hamster intestinal sacs in the presence of carrier methionine. The apparent K(m) for L-methionine transport was 0.8 x 10(-3) M, as calculated from the beta emissions of S(35)-methionine or the gamma emissions of Se(75)-selenomethionine. Absorption of Se(75)-selenomethionine from the gastrointestinal tract of man also occurred, with peak blood levels being reached in about 3 hours. Because of the 122-day half-life of selenium-75 and its multiple gamma emissions, Se(75)-selenomethionine may serve as a tool in evaluating amino-acid absorption.
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