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Results for “Renal Plasma Flow, Effective”

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At least 19 recordsLinked to original sources
PubMed1983

Relationship of creatinine clearance to orthoiodohippurate measured effective renal plasma flow.

Effective renal plasma flow (ERPF) was measured utilizing 1-131 orthoiodohippurate (OIH). The OIH ERPF was correlated in 50 patients with routine 24-hour urine creatinine clearance measurements and with a formula predicting creatinine clearance based on age, weight, and serum creatinine (formula creatinine clearance). The filtration fraction (routine creatinine clearance/OIH ERPF) in 38 patients with hypertensive nephrosclerosis, tubulointerstitial renal disease, or normal renal function were compared. Filtration fractions in the three groups tested were not statistically different. ERPF had a correlation coefficient of 0.62 with routine creatinine clearance and 0.72 with formula creatinine clearance. Thus, OIH ERPF correlates with creatinine clearance measurements but cannot be used to replace creatinine clearance as a method of evaluating renal function. The reasons for the lack of a stronger positive correlation between ERPF and glomerular filtration rate (GFR) remain to be elucidated.

Adult↗
PubMed1991

Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses.

The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (ERPF) and effective renal blood flow (ERBF) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean ERPF and ERBF was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although ERPF and ERBF decreased after flunixin meglumine administration, the difference was not statistically significant.

Animals↗
PubMed1985

Serial measurement of renal plasma flow.

Effective renal plasma flow was measured two or three times in 1 h in 12 healthy volunteers. Radiohippuran (ortho-iodohippurate) was injected intravenously, and blood samples were obtained 8, 13 and 18 min post-administration. The problem of interference in succeeding measurements by activity from preceding injections was overcome by the use of three different radiolabels. These were, in order of use, 125I, 123I and 131I. The principal energies of gamma- and/or X-ray emission were 30, 160 and 365 KeV, respectively, allowing completely independent assay. A close correlation was observed between the results obtained for the three radionuclides over a wide range of renal plasma flow. The technique is relatively non-invasive and is presented as a suitable method for the important task of measuring renal plasma flow under the influence of drugs, especially of anaesthetics.

Adult↗
PubMed1990

Effects of halothane, enflurane and isoflurane anaesthesia on renal plasma flow.

Effective renal plasma flow (ERPF) and linear cardiac output (aortic blood velocity) were measured in 15 patients who received halothane, enflurane or isoflurane in oxygen. All three agents caused a significant reduction in ERPF (P less than 0.05) and the effect was greater at 1.25 MAC than at 0.75 MAC. No significant difference was demonstrated between the agents. Linear cardiac output did not change significantly during the study, suggesting that the observed reduction in ERPF was not caused by cardiovascular depression.

Adult↗
PubMed1990

Renal function immediately after piezoelectric extracorporeal lithotripsy.

We evaluated changes in renal function in 14 patients treated for renal calculi with the Richard Wolf 2300 piezoelectric lithotriptor. Each patient received, 3,000 to 4,000 shocks at the maximal recommended voltage. Each patient was evaluated with 131iodine-orthoiodohippurate renal scans performed within 24 hours before and after treatment. Changes in total effective renal plasma flow, effective renal plasma flow of the treated kidney and differential renal function were compared by paired t testing. No significant changes were associated with lithotripsy. On the basis of the renal scans we conclude that piezoelectric lithotripsy causes no significant changes in renal function, even in the early post-treatment period based on renal scan studies.

Humans↗
PubMed1982

New formulas for the calculation of effective renal plasma flow.

Estimation of effective renal plasma flow (ERPF) can be made easily, inexpensively, and accurately by means of a single plasma concentration determination, sampled 44 min after injection of 131I-orthoiodohippurate (OIH). We originally established predictive regression equations based on a series of patients with a wide variety of diseases and a few normal potential kidney donors. The equation best fitting that data was parabolic in form and assumed a negative slope when high ERPF rates were encountered. This problem has been corrected by deriving new equations (parabolic and exponential) based on an expanded series which includes a large number of subjects with high ERPF. Errors of estimation are lower than those of the more classic para-aminohippuric acid (PAH) clearances and well within the exigencies of clinical practice.

Adolescent↗
PubMed1994

Evaluation of the single-injection plasma disappearance of technetium-99m mercaptoacetyltriglycine method for determination of effective renal plasma flow in dogs with normal or abnormal renal function.

Effective renal plasma flow (ERPF) was evaluated, using continuous-infusion p-aminohippurate clearance (CLPAH) and single-injection plasma clearance of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3; CLMAG3) methods. Simultaneous clearance determinations were made in 6 dogs: 2 determinations for each dog before, and 1 determination after renal failure was induced by administration of amphotericin B. Linear regression analysis was used to derive an equation to estimate ERPF from CLMAG3 after the single IV injection. A Student's t-test was used to compare pharmacokinetics between the dogs when they were healthy and when they were in renal failure. An F-test was used to determine the appropriate Student's t-test. Results indicated that CLMAG3 correlated reasonably well (r = 0.83, P < 0.0001) with ERPF obtained from the CLPAH value. The volume of distribution and elimination of 99mTc-MAG3 decreased during renal failure. Although there was minimal binding of 99mTc-MAG3 to erythrocytes, it was significantly (P = 0.0008) lower during renal failure. Protein binding was not significantly different during renal failure. All dogs had signs of nausea and emesis at variable times after injection of 99mTc-MAG3. Determination of CLMAG3 after a single injection provides an adequate means to rapidly assess ERPF in dogs. The technique could easily be performed in dogs with renal disease, thus providing valuable information regarding progression of naturally acquired renal failure.

Animals↗
PubMed1985

Effective renal plasma flow: clinical significance after spinal cord injury.

We conducted a study to determine if effective renal plasma flow routinely measured by hippurate clearance during a comprehensive renal scintillation procedure is a relevant measure for assessing renal function in spinal cord injury patients. All subjects had spinal cord injury and had had contemporaneous comprehensive renal scintillation procedures and excretory urograms on 2 occasions 24 months or less apart. Each of the 469 kidneys was placed into 1 of 5 quintiles on the basis of its effective renal plasma flow at the first examination. The percentage of the kidneys that had clinically significant pyelocaliectasis or in which the pyelocaliectasis significantly worsened was 20.4 per cent in the lowest (first) quintile and 9.3, 2.2, 5.4 and 3.2 per cent in the second, third, fourth and fifth quintiles, respectively. Analogous data for ureterectasis were 16.1, 8.2, 2.2, 3.3 and 3.2 per cent. There was a significant (p less than 0.01) correlation between effective renal plasma flow and renal parenchymal thickness. Kidneys with renal calculi averaged effective renal plasma flows about 25 per cent lower than those of kidneys free of calculi. We conclude that effective renal plasma flow is a relevant measure for assessing renal function in spinal cord injury patients.

Acute Disease↗
PubMed1980

Evaluation of effective renal plasma flow during renography.

A method to determine effective renal plasma flow that requires only a single injection of 131-iodine hippuran and eliminates the necessity of obtaining blood samples is described. Good correlation was obtained between this procedure and a method requiring a blood sample. The technique should prove useful in determining effective renal plasma flow when difficulty is encountered in obtaining blood. However, before it is used as a method in its own right it must be compared to an independent method of measuring effective renal plasma flow.

Humans↗
PubMed1994

Quantitative renal scintigraphic determination of effective renal plasma flow in dogs with normal and abnormal renal function, using 99mTc-mercaptoacetyltriglycine.

Effective renal plasma flow (ERPF) was evaluated, using the measurement of p-aminohippurate clearance (CLPAH) and quantitative renal scintigraphy (QRS) with 99mTc-mercaptoacetyltriglycine (99mTc-MAG3). The CLPAH and QRS determinations were made in 6 dogs: 2 determinations for each dog before, and 1 determination after induction of renal failure by administration of amphotericin B. Least-squares regression analysis was used to derive an equation to estimate ERPF from QRS data. The results indicated that QRS, using 99mTc-MAG3, correlated reasonably well (r = 0.82, P < 0.001) with ERPF determined from the CLPAH value. The right kidney contributed 53.3% of global ERPF (P = 0.002). Hepatobiliary excretion of 99mTc-MAG3 was variable within each dog. There was not a consistent pattern with respect to time or renal function. All dogs had nausea or emesis, or both, after IV administration of 99mTc-MAG3. The QRS method with 99mTc-MAG3 provides an adequate means to estimate ERPF in healthy dogs and dogs with renal failure.

Animals↗
PubMedDate not supplied

Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep.

1. The effect on renal function in sheep of inhibiting converting enzyme with captopril was examined before and after 5 days ACTH administration. 2. Glomerular filtration rate, effective renal plasma flow, effective renal blood flow, mean arterial pressure and plasma sodium were all significantly increased by ACTH treatment and plasma potassium was decreased. Captopril (20 mg i.v.) had no effect on renal function or blood pressure before or after ACTH treatment, although urinary potassium excretion decreased following captopril on day 6 of ACTH treatment. 3. The increase in glomerular filtration rate and effective renal plasma flow seen with ACTH treatment in sheep does not appear to be mediated by the reninangiotensin system.

Adrenocorticotropic Hormone↗
PubMed2001

Effective renal plasma flow calculated from a single blood sample following Technetium-99m mercaptoacetyltriglycine renal scan can predict delayed graft function in renal transplantation.

PURPOSE: Effective renal plasma flow (ERPF) can be calculated by obtaining a single blood sample at a fixed time after injection in a patient undergoing a technetium-99m mercaptoacetyltriglycine (99mTc MAG3) renal scan. The purpose of this study was to determine whether the calculated ERPF following cadaveric renal transplantation could accurately predict the need fordialysis within the first 10 postoperative days or the serum creatinine at postoperative day 10. MATERIALS AND METHODS: Between February 1994 and September 1998, 41 patients underwent 45 99mTc MAG3 renal scans within the first 10 days following a cadaveric renal transplantation at Harbor-UCLA Medical Center. A blood sample was drawn 44 minutes after injection of 99mTc and was used to calculate ERPF. This calculated ERPF was compared to measures of early function, such as the need for dialysis and serum creatinine. RESULTS: Decreased ERPF strongly correlated with the need for dialysis within the first 10 postoperative days (p < .0001). No patient with ERPF >210 mL/min/1.7 M2 required dialysis, whereas 35% (6/17) of patients with ERPF < or =210 mL/min/1.7 M2 required dialysis within the first 10 postoperative days. For those patients who did not undergo dialysis, the calculated ERPF was significantly related to the serum creatinine on postoperative day 10 (p<.0001 ). CONCLUSIONS: ERPF can be calculated from a single blood sample when performing a 99mTc MAG3 renal scan following cadaveric renal transplantation. This calculated ERPF provides a useful clinical tool to identify patients at high risk for development of delayed graft function.

Cadaver↗
PubMed1980

Effect of droperidol on dopamine-induced increase in effective renal plasma flow in dogs.

The interaction between small doses of dopamine and droperidol on effective renal plasma flow was studied in dogs. Small doses of dopamine are known to produce renal vasodilatation by a dopaminergic mechanism and droperidol, a selective dopamine antagonist used in neuroleptanaesthesia, may attenuate this response. Effective renal plasma flow was measured non-invasively using 125I-hippuran. A 20-min infusion of dopamine 2 microgram kg-1 min-1 significantly enhanced effective renal plasma flow (mean increase of 16%; P < 0.05) in anaesthetized dogs. This effect was abolished (mean decrease 6.6%) by droperidol 0.2 mg kg-1 administered at the commencement of anaesthesia. It is concluded that droperidol reduces the renal vasodilatation induced by dopamine in anaesthetized dogs.

Animals↗
PubMed1986

A simplified method for the routine determination of effective renal plasma flow.

Quantitative renal data (i.e., glomerular filtration rate or effective renal plasma flow) often would be useful ancillary information when radionuclide renography is carried out. The added time, and therefore cost, of obtaining quantitative information might be the main reason a department does not routinely perform a quantitative study, although there is no added radiation or risk to the patient. To simplify the procedure for determining effective renal plasma flow with I-123 orthoiodohippurate (OIH), the published methodology was modified to eliminate the repetitive preparation of a standard solution. This allows the routine incision of effective renal plasma flow (ERPF) determination in I-123 OIH renography with minimal impact on departmental operations.

Humans↗
PubMed1999

Tc-99m MAG3 renal studies: renogram and effective renal plasma flow in spinal cord injury patients.

To determine whether years since injury, level of injury, degree of injury, gender, or age influence renal function in 66 spinal cord injuries (SCI) patients without urological complications, individual kidney effective renal plasma flow (ERPF) and radionuclide renogram (RR) were measured using technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3). The 176 individual kidneys included 84 kidneys with normal ERPF and RR, 48 kidneys with normal ERPF but abnormal RR, and 44 kidneys with abnormal ERPF and RR. The incidence of abnormal Tc-99m renal study results was higher in the kidneys of female patients (37/54, 68%) than of male patients (55/122, 45%) (p < 0.05). We found that Tc-99m MAG3 renal studies including ERPF and RR are safe and noninvasive urological screening tests for SCI patients.

Adult↗
PubMed1996

Captopril-induced changes in effective renal plasma flow in hypertensive renal transplant recipients.

The role of converting enzyme inhibitor enhanced radionuclide investigations in post-transplant hypertension is not clearly defined. Presence of renal failure, chronic rejection and use of cyclosporin A complicates the results. Captopril-induced changes in effective renal plasma flow (ERPF) were studied in 10 patients with severe post-transplant hypertension and no evidence of rejection. Angiographic correlation was available in all. Six patients had a significant increase in ERPF after captopril, and all had a negative angiogram. One patient on CsA with a negative angiogram had no change in ERPF. Three patients had a fall in ERPF, and all 3 had transplant renal artery stenosis. Captopril-induced changes in ERPF can differentiate patients with native-kidney-induced hypertension from those with hypertension secondary to transplant renal artery stenosis in patients without evidence of rejection.

Angiography↗
PubMed1996

99Tcm-MAG3 renal studies: effective renal plasma flow in patients with spinal cord injuries.

To assess whether number of years since time of injury, level or degree of injury, gender or age influence renal function in patients with spinal cord injury (SCI), single and total kidney effective renal plasma flow (ERPF) was measured in 66 patients using 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In approximately 50% of the SCI patients, the single kidney ERPF was less than 250 ml min-1 and total ERPF was less than 500 ml min-1. The single kidney ERPF was worse in female and older SCI patients than in male and younger patients. For total ERPF, age only was a significant factor. Total ERPF was worse in female than in male SCI patients, though this did not reach significance. We conclude that the non-invasive measurement of renal function using 99Tcm-MAG3 is safe and applied easily to SCI patients.

Adult↗