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At least 19 recordsLinked to original sources
PubMed1988

Effects of iloprost, a prostacyclin analog derivative, on renal plasma flow, renal function, and renin-aldosterone system in humans.

The effects of iloprost, a stable analog derivative of prostacyclin, on heart rate, blood pressure, renal plasma flow (RPF), glomerular filtration rate, filtration fraction, urine flow, fractional excretion of sodium (FENa), proximal fractional sodium reabsorption (PFRNa), fractional sodium resorption at the ascending limb of Henle's loop (HFRNa), plasma renin activity (PRA), and plasma aldosterone concentration (PA) were evaluated in patients with peripheral vascular disease and normal renal function. In 10 patients the drug was administered intravenously for 6 hours daily for 6 days at a rate of 1 ng/kg/min. In 7 patients iloprost was also administered at a dose of 2 ng/kg/min for the same time. There was no significant change in heart rate and blood pressure at both iloprost doses. At the dose of 1 ng/kg/min the drug had no effect on renal hemodynamics and function, PRA, and PA. At the dose of 2 ng/kg/min iloprost significantly increased RPF (p less than 0.025) and FENa (p less than 0.025) and significantly decreased HFRNa (p less than 0.025) without affecting glomerular filtration rate, filtration fraction, urine flow, PFRNa, PRA, and PA. No correlation was found between the increase in RPF and FENa (r = 0.01). We conclude that at a dose of 2 ng/kg/min, but not 1 ng/kg/min, iloprost has a natriuretic effect secondary to inhibition of sodium reabsorption at the ascending limb of the Henle's loop and not related to the renal hemodynamic effect.

Aged↗
PubMed1985

Serial measurement of renal plasma flow.

Effective renal plasma flow was measured two or three times in 1 h in 12 healthy volunteers. Radiohippuran (ortho-iodohippurate) was injected intravenously, and blood samples were obtained 8, 13 and 18 min post-administration. The problem of interference in succeeding measurements by activity from preceding injections was overcome by the use of three different radiolabels. These were, in order of use, 125I, 123I and 131I. The principal energies of gamma- and/or X-ray emission were 30, 160 and 365 KeV, respectively, allowing completely independent assay. A close correlation was observed between the results obtained for the three radionuclides over a wide range of renal plasma flow. The technique is relatively non-invasive and is presented as a suitable method for the important task of measuring renal plasma flow under the influence of drugs, especially of anaesthetics.

Adult↗
PubMed1983

[Behavior of blood pressure, renal plasma flow and renal vein renin activity in renovascular hypertensive patients before and after PTA].

Percutaneous transluminal angioplasty (PTA) is more and more accepted for interventional management of renal artery stenosis in hypertensive patients. This study was carried out to assess the behaviour of arterial blood-pressure, renal plasma flow and renal venous renin activity in renovascular hypertension following catheter dilatation. Using the data the possibility is calculated to predict the effect of PTA on blood pressure preinterventionally. The results demonstrate that a successful employment of PTA depends on a normal contralateral renal plasma flow and a normalization of plasma flow of the post-stenotic kidney. Determination of plasma renin activity is only of restricted value.

Adult↗
PubMed1972

Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics.

Glomerular filtration rate and renal plasma flow were simultaneously determined in comparable groups of 43 diabetics less than 40 years of age and with a duration of diabetes less than 10 years and 32 control subjects. The average glomerular filtration rate in the diabetic group was significantly higher than that in the control group (P <0.01). The average renal plasma flow in the diabetic group was found to be significantly lower than that in the control group (P <0.05). The filtration fraction in both male and female diabetics was significantly higher than in the male and female control groups (P <0.001). These changes were found to be present even in recent juvenile diabetics with disease of a duration of less than one year. No correlation was apparent between the average levels of serum growth hormone and glomerular filtration rate.The urinary protein excretion was determined in 36 diabetic and 38 healthy subjects comparable with regard to glomerular filtration rate. In the diabetic group there was a greater frequency of cases with higher protein excretion rates (P <0.02). The average protein excretion rate was increased even in diabetics with less than one year's duration of the disease.The results of the changes in renal haemodynamics in subjects with recent and short-term diabetes are compatible with the presence of a constrictive state of the vas efferens leading to an increase in the filtration pressure. The increase in protein excretion rate may similarly be a consequence of this process or of an increase in the glomerular permeability with augmented molecular sieving of proteins or both.

Adolescent↗
PubMed1983

Relationship of creatinine clearance to orthoiodohippurate measured effective renal plasma flow.

Effective renal plasma flow (ERPF) was measured utilizing 1-131 orthoiodohippurate (OIH). The OIH ERPF was correlated in 50 patients with routine 24-hour urine creatinine clearance measurements and with a formula predicting creatinine clearance based on age, weight, and serum creatinine (formula creatinine clearance). The filtration fraction (routine creatinine clearance/OIH ERPF) in 38 patients with hypertensive nephrosclerosis, tubulointerstitial renal disease, or normal renal function were compared. Filtration fractions in the three groups tested were not statistically different. ERPF had a correlation coefficient of 0.62 with routine creatinine clearance and 0.72 with formula creatinine clearance. Thus, OIH ERPF correlates with creatinine clearance measurements but cannot be used to replace creatinine clearance as a method of evaluating renal function. The reasons for the lack of a stronger positive correlation between ERPF and glomerular filtration rate (GFR) remain to be elucidated.

Adult↗
PubMed1990

Effects of halothane, enflurane and isoflurane anaesthesia on renal plasma flow.

Effective renal plasma flow (ERPF) and linear cardiac output (aortic blood velocity) were measured in 15 patients who received halothane, enflurane or isoflurane in oxygen. All three agents caused a significant reduction in ERPF (P less than 0.05) and the effect was greater at 1.25 MAC than at 0.75 MAC. No significant difference was demonstrated between the agents. Linear cardiac output did not change significantly during the study, suggesting that the observed reduction in ERPF was not caused by cardiovascular depression.

Adult↗
PubMed1987

Predictive value of bedside effective renal plasma flow for renal recovery in severe acute renal failure.

Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recovery of renal function in hemodynamically stable patients. Over 18 months, ERPF was determined in 33 such patients with ARF in whom an etiologic diagnosis could be established. Eight patients died within 2 months of onset and while on dialysis, did not have an autopsy, and were not considered further. Six patients (Group A) either remained on dialysis after at least 6 months follow-up or had irreversible renal disease at autopsy. In Group B (19 patients, 13 of whom were dialyzed), serum creatinine returned to less than 2.0 mg/dL (n = 16) or was decreasing without dialysis. Peak serum creatinine (Group A 11.2 +/- 1.4; Group B 10.1 +/- 1.3 mg/dL) did not differ between groups. Oliguria was present in 75% of Group A patients and in 25% of Group B patients. Initial ERPFs differed (p less than 0.001) between Group A (90 +/- 11) and Group B (204 +/- 20 mL/min). Initial ERPF was greater than 125 mL/min in 15 Group B patients but in no Group A patients; the false-positive rate was 21% and the false-negative rate was 0%.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗
PubMed1996

The glomerular filtration rate, effective renal plasma flow, and renal blood flow in the adult male chacma baboon (Papio ursinus).

The radionuclide determination of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) has been validated in man, but not in the primate. GFR, ERPF, and renal blood flow (RBF) were measured in a group of 12 adult male chacma baboons using radiopharmaceuticals. GFR was determined using 99mtechnetium-labelled diethylenetriamine-pentacetic acid. ERPF was measured with 131iodine-labelled hippuran. RBF, body surface area, and kidney weights were calculated using standard formulae. GFR was 49 +/- 11 ml/min and ERPF was 237.9 +/- 54.2 ml/min. Calculated RBF was 430.7 +/- 111.9 ml/min and 507.4 +/- 138.4 ml/min/100 g of renal tissue. The results are in agreement with those obtained using more laborious nonradioisotopic techniques such as para-aminohippurate (PAH) and creatinine clearance and could serve as baseline normal values in the adult male chacma baboon.

Animals↗
PubMed1993

[Effective renal plasma flow in renal transplant rejection].

It is important to differentiate between cell-mediated (acute) and humoral (chronic) rejection in renal transplantation in order to initiate appropriate therapy. Since effective renal plasma flow (ERPF) provides a sensitive method of analyzing renal function, this test was undertaken to evaluate the possibility of differentiating acute and chronic rejections by ERPF. A total of 90 patients (no rejection: 33, acute rejection: 45, chronic rejection: 12) were retrospectively included in this study. ERPF was determined by performing comprehensive renal function test (Tauxe et al., 1980) and Student's unpaired t-test was used to evaluate the statistical difference (no rejection vs chronic rejection, no rejection vs acute rejection, acute rejection vs chronic rejection). The ERPF value of the no rejection group (228.9 +/- 119.2 ml/min) was significantly higher than the ERPF value of the acute rejection group (167.5 +/- 86.9 ml/min) and the chronic rejection group (137.2 +/- 60.2 ml/min) (P < 0.05). By in contrast, there was no significant difference between the acute rejection group and the chronic rejection group (P > 0.05). We concluded that ERPF value alone could not differentiate between acute rejection and chronic rejection in renal transplantation.

Adolescent↗
PubMed1986

A simplified method for the routine determination of effective renal plasma flow.

Quantitative renal data (i.e., glomerular filtration rate or effective renal plasma flow) often would be useful ancillary information when radionuclide renography is carried out. The added time, and therefore cost, of obtaining quantitative information might be the main reason a department does not routinely perform a quantitative study, although there is no added radiation or risk to the patient. To simplify the procedure for determining effective renal plasma flow with I-123 orthoiodohippurate (OIH), the published methodology was modified to eliminate the repetitive preparation of a standard solution. This allows the routine incision of effective renal plasma flow (ERPF) determination in I-123 OIH renography with minimal impact on departmental operations.

Humans↗
PubMed1991

Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses.

The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques. Effective renal plasma flow (ERPF) and effective renal blood flow (ERBF) were determined by plasma clearance of 131I-orthoiodohippuric acid before and after administration of flunixin meglumine. Mean ERPF and ERBF was 6.03 ml/min/kg and 10.7 ml/min/kg, respectively, before treatment and was 5.7 ml/min/kg and 9.7 ml/min/kg, respectively, after treatment. Although ERPF and ERBF decreased after flunixin meglumine administration, the difference was not statistically significant.

Animals↗
PubMed1985

The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow.

The effects of the acute and continued administration of the calcium antagonist nisoldipine on hepatic and renal blood flow and on renal function were studied in nine normotensive volunteers. There were no significant changes in supine blood pressure or heart rate but acute administration significantly increased both apparent liver blood flow and effective renal plasma flow. With continued administration these increases were attenuated and were not significantly different from placebo after 4 days treatment. Acute nisoldipine administration was also associated with significant increases in glomerular filtration rate and urinary sodium excretion.

Adult↗
PubMed1989

[Polyfructosan and para-aminohippuric acid clearance, comparison of 2 methods for determining glomerular filtration and plasma renal flow].

Glomerular Filtration Rate (GFR) and Renal Plasma Flow (RPF) were measured respectively, Polyfructosan and Para-aminohippuric acid clearances, in 13 patients with different degrees of renal insufficiency. Two different methods were used, the standard method and one without urine collection. The mean GFR (66.4 +/- 27.8 vs. 72.2 +/- 19.0 ml/m, r = 0.74) and RPF (431 +/- 204 vs 490 +/- 188 ml/m, r = 0.76) as well as Filtration Fraction (17.7 +/- 8.3 vs. 16.6 +/- 6.6%) were well correlated. These data show that within the normal range of GRF and RPF the method determining only plasma levels is as reliable as the standard method, giving the advantage to be less troublesome for patients and staff, requiring no bladder catheterization.

Adult↗
PubMed1996

Captopril-induced changes in effective renal plasma flow in hypertensive renal transplant recipients.

The role of converting enzyme inhibitor enhanced radionuclide investigations in post-transplant hypertension is not clearly defined. Presence of renal failure, chronic rejection and use of cyclosporin A complicates the results. Captopril-induced changes in effective renal plasma flow (ERPF) were studied in 10 patients with severe post-transplant hypertension and no evidence of rejection. Angiographic correlation was available in all. Six patients had a significant increase in ERPF after captopril, and all had a negative angiogram. One patient on CsA with a negative angiogram had no change in ERPF. Three patients had a fall in ERPF, and all 3 had transplant renal artery stenosis. Captopril-induced changes in ERPF can differentiate patients with native-kidney-induced hypertension from those with hypertension secondary to transplant renal artery stenosis in patients without evidence of rejection.

Angiography↗
PubMed1995

Differential effects of recombinant human growth hormone on glomerular filtration rate and renal plasma flow in chronic renal failure.

In normal subjects recombinant human growth hormone (rhGH) increases glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) through the action of insulin-like growth factor-I (IGF-I). We have measured clearance of inulin and para-aminohippuric acid in 18 children with chronic renal failure (CRF) during their 1st year of rhGH treatment to look at the immediate (first 3 h), short-term (1 week) and long-term (1 year) effects of treatment. On day 1 mean (range) age was 9.1 (4.9-13.9) years, GFR 19 (9-58) and ERPF 77 (34-271) ml/min per 1.73 m2. During treatment height velocity increased from 4.5 (1.7-6.5) to 9.5 (4.8-12.7) cm/year (P < 0.0001). Two children required dialysis after 0.75 years and 1 child was electively transplanted after 0.5 years. There were no other serious adverse events. GFR and ERPF were unchanged in the 3 h following rhGH. GFR remained constant on day 8, 22 (6-56) and after 1 year, 20 (9-59) ml/min per 1.73 m2. ERPF increased to 96 (33-276) ml/min per 1.73 m2 on day 8 (P = 0.005), and remained elevated, but not significantly so, at 99 (24-428) ml/min per 1.73 m2 at 1 year. Fasting IGF-I increased from 147 (46-315) ng/ml to 291 (61-673) by day 8 (P < 0.003), and to 341 (101-786) ng/ml at 1 year. There was no correlation between the change in IGF-I and renal function. Blood pressure, albumin excretion and dietary protein intake were unchanged by treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1980

Delayed scanning with DMSA: a simple index of relative renal plasma flow.

Relative renal uptake of 99mTc-dimercaptosuccinic acid (DMSA) was compared with the relative effective renal plasma flow (ERPF) to each kidney. In 25 patients with serum creatinine less than or equal to 2.0 mg/dl, there was excellent agreement when the regions of interest were assigned by a computer. In 10 patients with serum creatinine greater than 2.0 mg/dl, agreement was poor. A 24-hour image is sufficient to obtain such data. In patients with renal failure, this technique may give inaccurate results due to high tissue background activity; moreover, since it reflects the current functioning status of the kidney, it should not be used to predict recoverable function in patients with acute or unstable renal disease.

Acute Kidney Injury↗
PubMed1991

The simultaneous measurement of glomerular filtration rate (GFR) and renal plasma flow (RPF) following renal transplantation by use of functional imaging.

A new method for evaluating renal function using dynamic scintigraphy and deconvolution is described; functional images can be created from the data to quantitate kidney function. Our data are indicating that GFR measurements obtained by this method do not differ from those obtained by classical renal clearance methods. As was expected measurements of renal plasma flow exceed the values of PAH clearance. Additional studies to determine extraction ratios must be done along with direct flow meter measurements.

Animals↗