Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “RADIATION INJURY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1999

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

Radiation injury to the central nervous system (CNS) results in glial activation accompanied by expression of pro-inflammatory cytokines and adhesion molecules. In this study we demonstrate intercellular adhesion molecule-1 (ICAM-1) induction in the irradiated mouse brain at the mRNA and protein levels. Immunocytochemical analysis revealed that ICAM-1 protein was primarily expressed in endothelial cells and microglia. In vitro, ionizing radiation significantly induces TNF alpha, IL-1beta and ICAM-1 mRNA in primary microglia cultures. Interestingly, although ionizing radiation activated primary astrocyte cultures, it did not induce ICAM-1 expression. However, exposure of astrocytes to conditioned medium collected from irradiated microglia resulted in ICAM-1 induction, which was abrogated when the conditioned medium was pre-incubated with neutralizing antibodies raised against murine TNF alpha and IL-1beta. These results indicate that pro-inflammatory cytokines may be necessary for ICAM-1 expression in astrocytes in CNS radiation injury.

Animals↗
PubMed1981

Considerations in the diagnosis of radiation injury.

Radiation injury develops in a small proportion of patients after therapeutic radiation. The key factors that influence the likelihood and character of these radiation sequelae are discussed in this article. Proper consideration of these points will lead to more accurate diagnosis and, hence, more effective patient management.

Adult↗
PubMedDate not supplied

[The equivalent dose as a dosimetric criterion for acute radiation injury by radiations of various quality. The generalized equivalent dose].

Using different quality coefficients as functions of LET, generalized equivalent doses were calculated, and the survival of dogs after gamma/neutron irradiation was determined using the concept of an equivalent dose. LET functions of the generalized quality coefficients providing a good agreement between theoretical and experimental results were chosen. Various functions of the generalized quality coefficients for different ingredients of bone-marrow haemopoiesis activity should be used to estimate the severity of radiation injury to red bone marrow.

Animals↗
PubMed2000

Natural history and prevention of radiation injury.

Radiation therapy for cancers of the head and neck can irreversibly damage the salivary glands. Xerostomia (subjective oral dryness) develops within the first week of therapy and is progressive, with devastating effects on the quality of life of the individual. The xerostomia does not correlate with the degree of salivary gland hypofunction. The mechanism of tissue injury in humans is still unclear, but much progress has been made with animal models. This paper reviews the natural history of radiation damage to human salivary glands and highlights the inter-individual variations in the responses to and recovery from therapeutic radiation. The degree of salivary gland damage is correlated to the dose of radiation delivered and the volume of gland included in the field of radiation. The molecular mechanism of acute radiation damage is not fully understood; however, long-term salivary gland dysfunction is associated with both loss of gland weight and loss of acinar cells. Various strategies have been used to prevent or alleviate the problem of salivary gland hypofunction following therapeutic radiation. This paper reviews the progress made to date and the possibilities for future interventions to prevent radiation damage.

Animals↗
PubMedDate not supplied

[The equivalent dose as a dosimetric criterion of acute radiation injury by radiations of various quality. Energy dependence of generalized coefficients of the quality of neutrons].

The notion of "a generalized equivalent dose" was introduced in order to use an equivalent dose as a dosimetric criterion for the estimation of acute exposure to densely ionizing radiation. The generalized quality coefficients that were used to quantify a generalized equivalent dose depended on LET, and with gamma/neutron radiation, on neutron energy. Several possible LET functions of the generalized quality coefficients were chosen and mean quality coefficients were transformed, depending on neutron energy, and estimated for actual neutron energy distributions, used in radiobiological experiments, with due regard for the alteration in the neutron spectrum with the body depth.

Animals↗