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At least 19 recordsLinked to original sources

Pupillary measurement and release from proactive inhibition.

One of the explanations of release from proactive inhibition in short-term memory is that the subjects re-attend to the items on the release trial because the items are different from the previous ones. It is further assumed that this increase in attention causes the relase items to be learned better than the preceding items. This experiment measured the pupils of the subjects' eyes while they were participating in a proactive-inhibition release-type task. The results showed no increase in attention, as indexed by pupil size, on the release trial. This did not support the attentional explanation of the proactive-inhibition release phenomenon.

Attention

Accumulation of and release from proactive inhibition in short-term memory by retarded and nonretarded persons.

One group of EMR adolescents and adults and three groups of nonretarded children and adolescents were compared during accumulation of and release from proactive inhibition. All groups demonstrated the effects of and release from proactive inhibition. Analyses of intralist intrusions indicated that these errors did not differentially affect performance by any group during the accumulation of proactive inhibition and did not occur during its release. These results were discussed in terms of the groups' discrimination abilities within and between taxonomies, short-term memory limitations, and the utilization of categorical information on this task by the mentally retarded subjects.

Adolescent

Effect of typicality level on proactive inhibition in adults with mental retardation.

Adults with mental retardation heard four triads of highly typical, atypical, or unrelated words (Experiment 1, proactive inhibition buildup) and three triads of typical, atypical, or unrelated words, shifting to either typical or atypical words (Experiment 2, inhibition release). Our purpose was to examine the structure of their semantic system and determine whether they encode information in semantic memory on the dimensions of item prototypicality and list organization. No list differences occurred in Experiment 1. Apparently, interference effects inhibited encoding by organization and typicality. Amount of release varied as a function of item typicality and list organization (Experiment 2), demonstrating multidimensional encoding in semantic memory.

Adult

Buildup of proactive inhibition as a function of temporal spacing and adult age.

Glenberg's theory of temporal distinctiveness (Glenberg, 1987; Glenberg & Swanson, 1986) was used to examine whether the buildup of proactive inhibition (PI) may be interpreted as an overloading of temporal retrieval cues. The Brown-Peterson task was selected on the basis of the assumption that successful performance on such a task requires the use of a recency rule where the subject must use temporal cues to retrieve the contents of the most recent study list. Two variables were manipulated that were presumed to affect the utilization of temporal cues: length of intertrial interval (ITI) (0 or 90 s) and adult age (young or elderly). Glenberg's theory suggests that temporal spacing improves memory by enhancing the distinctiveness of temporal retrieval cues. Thus, it was predicted that PI buildup should be less in the 90-s condition than in the 0-s condition. Assuming that older adults are more sensitive to the overloading of temporal cues, it was anticipated that older adults would experience a greater buildup of PI than younger adults at the 0-s condition. Results showed that although PI buildup varied with length of ITI, it did not vary with adult age. Analysis of delayed measures of recall, recognition, and temporal memory suggested that a retrieval interpretation based on Glenberg's theory is insufficient as an explanation of the current results; encoding difficulties also appear to contribute to the buildup of PI.

Adolescent

Encoding of colors in short-term memory.

A theory is proposed to explain results from prior experiments on release from proactive inhibition and the recall of colors or color names in short-term memory. It is assumed that colors are encoded in two ways, verbally and perceptually, while color names are encoded only verbally. Assuming that the release occurs when a new and different encoding is performed on changed material, it follows that release from proactive inhibition should occur with shifts from color names to colors but not with shifts in the opposite direction. These results were obtained in prior experiments. In the present experiment ambiguous colors were used to minimize the verbal encoding. As predicted, release from proactive inhibition was found with shifts from ambiguous colors to names as well as with shifts from names to the ambiguous colors.

Adult

Anna Thompson and the American liner New York: some normative data.

Increased proactive inhibition is claimed to be common in brain-damaged subjects and the Wechsler Memory Scale is often used in the clinical examination of such subjects. Normative data are presented on the two paragraphs of the Logical Memory sub-test of the WMS, Form 1, which allow evaluation of the frequency of occurrence of a discrepancy of a given size between performances on the two paragraphs, based on the performances of 500 subjects without any known neuropsychiatric involvement.

Adult

Categorical encoding in short-term memory by retarded and nonretarded children.

The use of consonants and digits as encoding categories in short-term memory by 32 EMR children and 32 nonretarded children of the same CA was investigated. The task employed was a modification of the release from proactive inhibition technique similar to that used by Wickens, Born, and Allen (1963). Results indicated that digits and consonants are significant categories used for encoding in short-term memory by 10- to 12-year-old EMR and nonretarded children but that nonretarded children more effectively utilize consonant material as an encoding dimension than do CA-matched EMR children.

Child

Spoken words and manual signs as encoding categories in short-term memory for mentally retarded children.

The release from proactive inhibition paradigm was used to test differential encoding of manual signs and spoken words by six severely retarded children. Scores for shift conditions were significantly different from scores for nonshift conditions on the last trial, indicating that manual signs were encoded differently from spoken words for short-term memory storage. Implications of separate encoding categories for the investigation of language processes were discussed.

Adolescent

Lack of memory for nonattended items in dichotic listening.

Three experiments were conducted to investigate whether semantic information presented to the unattended ear in a dichotic listening experiment has a memory effect after 30 sec. In all three experiments the Brown-Peterson paradigm was employed. Experiment 1 used the release from proactive inhibition technique and found no evidence that semantic material presented to the unattended ear produced proactive inhibitory effects on attended ear material. Experiment 2 suggests that this result was not due to a memory deficiency resulting from a lack of intent to learn. Experiment 3 indicates that repetition of the same information for three trials to the unattended ear did not enhance memory performance when the material was later presented to the attended ear. Assuming that some semantic processing does occur at the time of input, an interpretation based upon the levels-of-processing approach was suggested as a possibility for explaining the negative results.

Attention

The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers.

The effects of chronic treatment (5 mg b.i.d. for 2 days followed by 10 mg b.i.d. for 5 days) with R 58 735 on human memory functions were studied in healthy elderly (age greater than or equal to 50 years) volunteers in a double-blind placebo-controlled study. Serial learning of nonsense syllables was better under R 58 735, and relearning 1 week after termination of the treatment was superior to relearning of similar material initially learned under placebo. Free recall of nonsense syllables was significantly better when these were learned under active compound. Proactive inhibition induced by consecutive presentation of word lists was attenuated by R 58 735. Short-term memory functions, retrieval accuracy from semantic memory and unprepared reaction times were unchanged. R 58 735 ameliorated both learning and recall in conditions of age-related mild hypofunction in healthy volunteers. The compound seems to have had positive effects on encoding and consolidation of new material.

Cognition

Titrating matching-to-sample performance: effects of drugs of abuse and intertrial interval.

Previous reports have shown that increasing the length of the intertrial interval (ITI) in a matching-to-sample schedule of reinforcement results in increased matching accuracy. This has traditionally been interpreted in the context of proactive inhibition, the disruption of memory for a stimulus as a consequence of events that occurred prior to the presentation of the stimulus. In an effort to more fully characterize a titrating matching-to-sample baseline, the effect of ITI ranging from 0-30 s was determined in pigeons trained to respond under the titrating matching-to-sample procedure. In addition, the effect of ITI length on the dose-response curve for pentobarbital, phencyclidine, D-amphetamine, and cocaine were determined. Surprisingly, performance under the titrating matching-to-sample was not altered as a function of ITI length, nor did the effects of the four drugs of abuse change as a function of ITI length. These results suggest that performance under the titrating matching-to-sample is under a different control than matching-to-sample using fixed delays.

Amphetamine

Conceptual encoding following severe closed head injury.

This investigation examined whether survivors of severe closed head injury encode semantic properties of to-be-remembered words and the relationship of such processing to frontal lobe functioning. Fourteen patients enrolled in rehabilitation and 12 controls were administered the Release from Proactive Inhibition paradigm involving trials of recalling words from the same category followed by a shift to a new category or continued presentation of identical material. Similar to the controls, patients demonstrated a facilitation in recall when the category shifted. An association between the amount of release and frontal lobe functioning (as evaluated by neuropsychological tests and magnetic resonance imaging) was not compelling and depended upon the particular measure of release that was utilized. Pending replication in a larger, more representative sample, we suggest that conceptual encoding is relatively preserved in long-term survivors. The failure to find a robust relationship between frontal lobe pathology and semantic encoding is discussed in light of other investigations suggesting an association.

Craniocerebral Trauma

Memory functioning following a left medial thalamic hematoma.

A patient with a discrete, left medial thalamic hematoma developed a severe anterograde amnesia. The memory deficit was most consistent for verbal materials, but was also observed on several tests of figural memory. The patient appeared to have a normal short-term memory (STM) capacity, performed normally on a STM distractor task and was not abnormally sensitive to proactive inhibition. This case is evidence that unilateral damage to the medial thalamus alone can produce a severe memory deficit.

Aged

Effects of the lateral septum and latent inhibition on successive discrimination learning.

Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was demonstrated in sham operated animals. Rats in which the lateral septum was damaged demonstrated a paradoxically smaller learning deficit in the presence of a conditioned stimulus that was previously presented without reinforcement, when compared to the performance of both septal lesioned rats no receiving nonreinforced preexposure and sham operates receiving preexposure. The interaction of nonreinforced preexposure and lateral septal lesions can be explained using a proposed sensitization hypothesis.

Animals