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[Tholozan and Persia].

Tholozan arrived in Persia in 1858 and remained there until his death in 1897. Personal physician of Nasreddin Shah with the title of hakim bachi, he was also appointed director of the Medical School of Teheran founded in 1850. He trained many Persian physicians and wrote medical treatises printed in persian. In 1866 he married in Teheran a widow of greco-italian origin from whom he had a daughter, Elise, who will have many descendants. Besides his important monographs on epidemic diseases (plague, cholera, etc.) Tholozan wrote in 1869 a "Rapport a S.M. le Shah sur l'etat de l'hygiene en Perse". He accompanied the Shah during his three voyages in Europe (1873, 1878, 1889) and stayed for his health three years in France after the last one, being replaced by Dr. Feuvrier as physician of the Shah. The friendly relations between Tholozan and the French archeologists Marcel and Jane Dieulafoy for whom he obtained from the Shah the permission to undertake diggings at Susa are recalled with the help of unpublished documents.

Famous Persons↗

[Tholozan and plague in Persia].

In Persia since 1858, Tholozan studied between 1870 and 1882 the plague foci of the iranian Kurdistan which shall be dealt a century later (1947-1963) with Dr. M. Baltazard and his co-workers from the Pasteur Institute of Teheran. Tholozan had already pointed out the localization of the disease in some well defined villages and gave a good clinical description mentioning the traces of flea bites on the patients skin. One knows nowadays that wild rodents (Meriones) are the storing places of the plague bacilli in the Kurdistan. Tholozan's observations confirmed by modern ones allow to consider him a great loïmologist of modern times.

Epidemiology↗

History of headache in medieval Persian medicine.

Despite the many studies into the history of headache, the ways in which the disorder was treated in medieval Persia are not well known in the west. Several documents still exist from which the definitions and treatments of headache in medieval Persia can be ascertained. These documents give detailed and precise clinical information on different types of headache. The medieval doctors listed various signs and symptoms, apparent causes, and hygienic and dietary rules for prevention of headaches. The medieval writings are both accurate and vivid, and they provide long lists of substances used in the treatment of headaches. Many of the approaches of physicians in medieval Persia are accepted today; however, still more of them could be of use to modern medicine. The main objective of this paper is to review the clinical approaches to headache used by practitioners in medieval Persia.

Analgesics↗

[A great Franco-Mauritian epidemiologist: Joseph Désiré Tholozan (1820-18970].

Born in 1820 from French parents in Diego Garcia, an islet then linked to Mauritius where he started in Port-Louis his school years, Joseph Désiré Tholozan was an original personality. He undertook medical studies in France (M. D. thesis, Paris, 1843) after having joined the military Health Service (1841) as a surgeon serving in various garrisons in the country and later at the Hospital of the Valde-Grâce in Paris (1849). Successful at the "agrégation" of Medicine in 1853, he later participated to the Crimean War (1854-1855) where he performed-interesting medical observations. In 1858, he was appointed personal physician to Nasreddin Shah and remained in Persia until his death in Teheran (1897) where he is buried. Tholozan published between 1847 and 1892 over fifty articles and books dealing chiefly with infectious pathology and epidemiology, written at a time when microbial etiology and specificity of such diseases were wholly unknown. He considered chiefly bubonic plague, studying as soon as 1871 the focus of the Iranian Kurdistan, a research which will be resumed by M. Baltazard and his collaborators between 1947 and 1971, i.e. a century later. He was also deeply interested by the "oriental" cholera of which he recalled masterly the history and geography in the Near and Middle East. He also performed, while in Crimea and Persia, personal observations on tuberculosis, diptheria, remittent fever, acrodynia and had studied in France in his early years various other diseases such as cutaneous staphylococcic infections, glanders, pulmonary haemorrhagies, etc. In Persia, he reorganized Public Health and medical teaching and educated many local physicians and surgeons. Being assured of the unlimited confidence of the Shah, he played an important cultural role, promoting French influence in Persia. Holder of many French and foreign decorations, Tholozan was Fellow of the French Academies of Sciences and Medicine. His name was given by Laboulbène to Ornithodoros tholozani, a tick vector of a recurrent fever (spirochetosis due to Borrelia persica), of which he had described both the symptoms and the vector in 1882.

Epidemiology↗

[Observational medicine in 19th century Iran].

The ravages wrought by epidemics in Iran as of 1821 acted as a stimulus to medical thought while the awakening of political consciousness mobilized efforts to fight contagious diseases. The combination "epidemics-politics-medicine" made nineteenth-century Persia turn to European science for help. Thus western medicine was introduced into Persia. If this introduction has been perceived by political means and epidemiological justification, the theoretical and epistemological process involved has been almost completely overlooked or misinterpreted. It is generally considered that the imported medicine swept away the local one, but this is not altogether true. It was the internal evolution of traditional medicine which paved the way for anatomoclinical medicine. This evolution comes accross clearly in the works of Shirâzi and Sâveji between 1831 and 1862, years in which epidemics struck frequently and violently. While Europeans in Iran such as Dr. Polak qualified heyzeh (a kind of severe diarrhea) a "sporadic cholera" or "autumn cholera", Shirâzi wrote three treatises to show that heyzeh was not cholera but an ordinary kind of diarrhea caused by generalized malnourishment. Shirâzi was also an innovator in the theoretical and terminological fields, doing away with the notion of vabâ which meant a putrid atmosphere. Vabâ became a physiological anomaly which took on epidemic proportions in an impure atmosphere. The modern definition of vabâ meaning cholera was therefore elaborated thanks to Shirâzi.

Communicable Disease Control↗

In the kingdom of the Shah: Treacher Collins' Persian adventure.

Early in his career, the British ophthalmologist Edward Treacher Collins (1862-1932) was asked to travel to Persia to evaluate the ocular problems of the Shah's eldest son. On the evening of his wedding, Collins and his bride left England to go on this great adventure. Collins was able to provide expert care to the Persian royal family and to many commoners. The success of this Persian tour helped Collins reach the highest level of British ophthalmology.

History, 19th Century↗

Avicenna's contribution to the development and progress of medical sciences.

Avicenna was born in the village of Belkh near Bukhara in Persia. He was a very famous philosopher, wiseman and an efficient physician. He wrote more than one hundred books on all aspects and sciences known in his time i.e. philosophy, wisdom, religion, mathematics, sophism, literature, poetry and medicine. In medicine, the most celebrated of them is "Al-Qanun fil Tibb", which surpassed other similar books on medicine and considered the biggest medical encyclopaedia of his time. Those orientalists who believe in Greek medicine consider this book as the only textbook on the art of curing and recovery.

Arab World↗

[Tholozan: military physician].

Born in 1820 Joseph-Desire Tholozan joined in 1841 as "chirurgien sous-aide auxiliaire" the French military Health Service, being still a medical student in Marseille where the School of Medicine was directed by his uncle F. Cauviere. He was later appointed at the hospital of Bastia, obtained his M.D. (Paris 1843), went back to Marseille and later to Metz (1845) and Paris, at the Val-de-Grace (1846-47). He returned there as assistant physician (1851) and later as professor "agrege" of Medicine (1852), his agregation thesis devoted to hematology being presided by Andral. Tholozan later participated to the Crimean war (1854-55) during which he performed important observations on infectious diseases (cholera, dysentery, typhus, typhoid fever) or deficiency ones (scurvy, acrodynia). An unpublished report given here deals with a probable epidemic of murine typhus occurring in soldiers returning from Crimea on an American ship which had been used to transport horses. Promoted first class major physician (1857) Tholozan was chosen in 1858 by the French ministry of Foreign Affairs to become the physician of the Shah of Persia, Nasreddin Shah. In this country where he remained until his death (1897) he will have a threefold activity as organizer of the medical teaching, epidemiologist (of plague and cholera) and as a surgeon. Principal first class physician (the equivalent of Physician-Colonel) in 1868, he was definitely dismissed from the Army in 1880.

France↗

[Joseph Désiré Tholozan and the Persian relapsing fever].

In the year 1879, Tholozan seems to have been convinced of the danger caused by the bites of ornithodores in Persia, as a result of very careful observations of sick persons suffering from iranian relapsing fever due to Borrelia persica. Among the ticks collected by him and sent to entomologists in France was the true vector, named Argas (presently Ornithodoros) tholozani by Laboulbene and Megnin. Tholozan's contribution to our knowledge on persian relapsing fever is really important. He was one of the first to provide a good clinical description of the disease and to involve an argasid tick in its transmission. He discovered the real vector species which is now called after him.

Animals↗