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Results for “Periapical Periodontitis”

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At least 19 recordsLinked to original sources
PubMed2004

[Study on endotoxin levels of acute and chronic periapical periodontitis].

OBJECTIVE: To compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms. METHODS: 10 cases of acute periapical priodontitis(Group 1), 10 cases of chronic periapical periodontitis (group 2, the diameter of apical radiolucency area was less than 2 mm), 10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level. RESULTS: Endotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P < 0.01). CONCLUSION: Endotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.

Acute Disease↗
PubMed2003

[The observation of the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis].

OBJECTIVE: To observe the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis. METHODS: 202 teeth suffering from chronic periapical periodontitis were selected and divided into two groups. One group including 102 teeth were treated with metronidazole-chlorhexidine solution. Another group including 100 teeth were treated with formocresol. The acute symptoms during root canal therapy were observed. 164 teeth suffering from acute periapical periodontitis were also selected and divided into two groups. One group including 80 teeth were treated with metronidazole-chlorhexidine solution. Another group including 84 teeth were treated as the above except the pulp chamber keeping open. The other 44 teeth, in which purulence also presented in the root canal after treated with formocresol and iodoform for three times or more, were treated with metronidazole-chlorhexidine solution. The presence of purulence was evaluated. RESULTS: There are significant differences between the two groups of chronic and acute periapical periodontitis(P<0.05). The effective rate was 97.6% after changed to metronidazole-chlorhexidine solution treatment. CONCLUSION: Good treatment effect could be achieved by using metronidazole-chlorhexidine solution as the root canal cleaning and disinfection agent.

Adolescent↗
PubMed1996

Relationship between prostaglandin E2 concentrations in periapical exudates from root canals and clinical findings of periapical periodontitis.

In this study the relationship of prostaglandin E2 (PGE2) concentrations in periapical exudates with clinical findings of teeth with periapical periodontitis is discussed. Periapical exudate samples were obtained from root canals of 77 endodontically involved teeth during routine root canal treatment by the quantitative sampling method using paper points. PGE2 concentrations in periapical exudates (PE-PGE2) were determined by radioimmunoassay. Significantly higher levels of PGE2 were found in periapical exudates from teeth with radiolucent areas than from teeth without radiolucent areas (236.8 +/- 521.3 pg/microliter vs. 14.9 +/- 23.1 pg/microliter, respectively). The elevated PE-PGE2 levels were associated with the presence of clinical symptoms that reflected an acute inflammation in the periapical lesion. In contrast, a significantly negative association of decreased PE-PGE2 levels with increasing size of radiolucent areas was demonstrated. These results suggested that PGE2 was produced locally in periapical lesions and that the PGE2 concentration in periapical exudate could reflect the state of the disease activity in periapical periodontitis.

Chi-Square Distribution↗
PubMed1993

[The application of frozen homogenic brephobone in surgical treatment of chronic periapical periodontitis]

Clinical effectiveness of frozen homogenic brephobone as a filling material in the treatment in the treatment of chronic periapical periodontitis was evaluated.42 patents with chronic periapical periodontitis,periapical,cyst and periapical granuloma were observed.After apical curettage was performed,22 cases were filled with frozen homogenic brephobone and other cases were close bone cavity with traditional treatment.All these cases were then covered with periodontal packing agent.Radiograph and clinical observation were made respectively at 2 week,1 month,3 month,6 month and 12 month recall visit following the surgery.It was found that the way of filling with frozen homogenic brephobone is more advantageous than the traditional way.

Journal Article↗
PubMed1998

[Study on the relationship between the bond absorption of chronic periapical periodontitis and PGE2 and TXB2].

OBJECTIVE: To further study the mechanisms of damages and resorption of bone in chronic periapical periodontitis. METHODS: The quantities and distribution of PGE2 and TXB2 in apical granuloma of chronic periapical periodontitis were analyzed using radio immunization analysis. RESULTS: The quantities of PGE2 and TXB2 in apical granuloma of chronic periapical periodontitis were significantly (P < 0.05) higher than those in controls. CONCLUSION: The PGE2 has the close relation with the bone resorption of chronic periapical periodontitis during the whole process. Meanwhile, TXB2 also has certain relation with the bond absorption. The quantities of PGE2 and TXB2 are imbalanced.

Adolescent↗
PubMed2002

[The clinical evaluation of tinidazole-iodoform-phenocamphor paste as an intra-canal sterilization medication for acute periapical periodontitis].

OBJECTIVE: To compare the clinical effect of tinidazole-iodoform-phenocamphor paste on acute periapical periodontitis with of formocresol. METHODS: 80 permanent teeth of acute periapical periodontitis were selected and divided randomly into tinidazole-iodoform-phenocamphor paste group (T group) and formocresol group (C group). The periapical signs and symptoms were recorded. Radiographs were taken and periapical radiolucent areas were calculated. After root canal preparation,the tinidazole-iodoform-phenocamphor paste was used as an intra-canal dressing medication for 7 days in T group and the formocresol paper point was used in C group. During the course of root canal treatment,the standard paper-point sampling method was used to collect and quantify the periapical exudates and the clinical findings were assessed with clinical periapical index(CPI). All statistical analyses were finished with Sigmastat software. RESULTS: At the first visit, there was no significant difference between two groups of CPI indexes and exudates volumes (P>0.05). The stepwise regression results suggested that exudates volumes had a significant correlation to periapical percussion(P=0.0031). There was a close relationship between radiolucent areas and periapical percussion or swelling degree (P=0.1148, P<0.0001). After the root canal sterilization, there was a statistically significant decrease in exudates volumes and CPI indexes (P<0.01), but the difference of exudates volumes and CPI indexes between two groups was not statistically significant (P>0.05). CONCLUSION: It indicated that tinidazole-iodoform-phenocamphor paste had the same effect on controlling acute periapical periodontitis as that of formocresol.

Clinical Trial↗
PubMed1999

Focal malakoplakia in chronic periapical periodontitis.

AIMS: Three cases of chronic periapical periodontitis including focal areas with malakoplakia changes are reported. METHODS AND RESULTS: These areas included both von Hansemann-type macrophages and periodic acid-Schiff-positive, iron- and calcium-containing concretions. Some concretions corresponded to spherules with a targetoid configuration, thus fitting the morphological criteria for classical Michaelis-Gutmann bodies. CONCLUSION: The vast majority of the cases of malakoplakia that have been reported in the literature corresponded to a characteristic, fairly homogeneous lesion, but a few instances of focal malakoplakia have been described in various chronic conditions. These considerations support the opinion that the local conditions for the production of Michaelis-Gutmann bodies may occur focally in diseases characterized by macrophage accumulation.

Adult↗
PubMed2001

[Effects of different disinfectants on levels of endotoxin in canals of chronic periapical periodontitis].

OBJECTIVE: The objective of this study is to compare effects of formocresol, camphorated phenol and Ya Kan (metronedazole) on endotoxin levels in canals of chronic periapical periodontitis. METHODS: A total of 30 patients with chronic periapical periodontitis were selected from outpatients, and 10 cases each were randomly picked out to treat by sealing with formocresol, camphorated phenol and Ya Kan respectively. All patients were both sampled before and after sealing of these disinfectants, and chromogenic substrate method of limulus amebocyte lysate (LAL) test was used to measure levels of endotoxin. RESULTS: The effects of Ya Kan, formocresol and camphorated phenol on levels of endotoxin did not showed significant difference. CONCLUSION: Some anti-anaerobic bacterial drugs can be used to treat chronic periapical periodontitis.

Anti-Infective Agents, Local↗
PubMed2002

Participation of bacterial biofilms in refractory and chronic periapical periodontitis.

The aim of this study was to examine morphologically the participation of extraradicular biofilm in refractory periapical periodontitis. Six teeth and five extruded root filling gutta-percha points associated with refractory periapical periodontitis were investigated by scanning electron microscope. In nine of 11 samples examined, bacterial biofilms were seen at the extraradicular area. The gutta-percha surface was covered with glycocalyx-like structures, and filaments, long rods, and spirochete-shaped bacteria were predominant in the extraradicular sites. Planktonic cells, which were filaments and spirochete-shaped bacteria, emigrated from the glycocalyx structures in some spots. In the extracted teeth, biofilm consisting of both bacteria and glycocalyx-like structures were observed on the periapical root surfaces. Next to the residual periodontal ligament, a few filaments, rods, and fusiforms were attached on the healthy cementum surface. The present findings suggested that bacterial biofilms formed in the extraradicular areas were related to refractory periapical periodontitis.

Adolescent↗
PubMed2006

[Clinical evaluation of two canal obturation materials in treatment of periapical periodontitis in deciduous teeth].

PURPOSE: To analyze the clinical effects of 283 deciduous teeth which suffered from periapical periodontitis and sinus in 179 children from the year of 2001 to 2004. METHODS: In all the 283 teeth, the root canal of 196 teeth were obturated with paste zinc oxide-eugenal; the other 87 teeth were obturated with Vitapex. The signs,symptoms and radiographs of these teeth were evaluated at 3 and 12 months after treatment. RESULTS: The successful rate was over 96.0% in both treatment groups. CONCLUSIONS: Most of deciduous teeth which suffered from periapical periodontitis and sinus could be preserved if adequate indications were taken and treated in time.

Calcium Hydroxide↗
PubMed2004

[Garlicin and formocresol in the treatment of chronic periapical periodontitis].

OBJECTIVE: To evaluate the short period clinical responses after sealed garlicin and formocresol small cotton ball in the root canal entrance to treat chronic periapical periodontitis. METHODS: Treatment records of 185 teeth with chronic periapical periodontitis were compared. Of them, 94 teeth were treated by sealed small garlicin cotton ball in the root canal entrance, 78 were treated by sealed small formocresol cotton ball in the root canal entrance, and the other 13 were treated by sealed small normal saline cotton ball. The curative effects were evaluated through clinical observation. RESULTS: The ratios of acute reaction in 3 days following sealed garlicin, formocresol and normal saline small cotton ball were 5.1%, 10.7%, and 50% in the anterior teeth, and 5.5%, 8.0%, and 60%, in the posterior teeth, respectively. CONCLUSION: The clinical curative effects were similar between garlicin and formocresol in the short period. Formocresol can be substituted by garlicin.

Adolescent↗
PubMed1998

Inflammatory cytokine production and specific antibody responses against possible causative bacteria in patients with multilesional periapical periodontitis.

We examined the induction of inflammatory cytokines (including interleukin-1, interleukin-6, interleukin-8, and tumor necrosis factor-alpha) by several species of possible causative bacteria in periapical periodontitis. Assays were done on human whole blood cultures from patients with differing numbers of periapical lesions; those having radiographically clear periapical lesions in 10 or more teeth (high lesion group), in one or two teeth (low lesion group), and healthy volunteers having no periapical lesions (no lesion group). Prevotella melaninogenica ATCC 25845 induced interleukin-6 more strongly in subjects from the high lesion group than in the other groups. To ascertain the degree of sensitization by test bacteria, we examined the reactivities of antibodies in serum and saliva from the six subjects to different bacterial species. Porphylomonas gingivalis cells reacted strongly with sera from the high lesion group. Thus, Prevotella melaninogenica and Porphylomonas gingivalis may be involved in multilesional periapical periodontitis by inducing specific cytokines and/or humoral immune responses.

Aggregatibacter actinomycetemcomitans↗
PubMed1999

Inflammatory cytokine production and specific antibody responses to lipopolysaccharide from endodontopathic black-pigmented bacteria in patients with multilesional periapical periodontitis.

We examined the induction of the cytokines interleukin (IL)-1 beta, IL-6, and IL-8 by lipopolysaccharides (LPSs) from several species of possible endodontopathic black-pigmented bacteria. Studies were conducted in human whole blood cultures from six patients (two from each group) with differing numbers of periapical periodontitis lesions (i.e. patients with radiographically clear periapical lesions in 10 or more teeth (high-lesion group, n = 4), in one or two teeth (low-lesion group, n = 6), and six healthy volunteers with no periapical lesions (no lesion group)). LPS from Prevotella intermedia ATCC 25611, Porphyromonas gingivalis 381, and Prophyromonas endodontalis ATCC 27067 induced a higher IL-8 response in the subjects of the high-lesion group, compared with the subjects of the other two groups. To ascertain the degree of sensitization by test bacteria, we examined the reactivities of antibodies in serum and saliva from the subjects to different bacterial species. LPS from P. gingivalis reacted strongly with sera from the high-lesion group. Thus, LPS from black-pigmented bacteria may be involved in multilesional periapical periodontitis by inducing particular cytokines and/or humoral immune responses.

Adult↗
PubMed2001

The outcome of teeth with periapical periodontitis treated with nonsurgical endodontic treatment: a computerized morphometric study.

OBJECTIVES: This study investigated the prognosis for successful endodontic treatment and the correlation between the size of the periapical lesion, the quality of the root canal treatment, and the type of coronal restoration. METHOD AND MATERIALS: Periapical radiographs of 319 teeth with periapical periodontitis were studied. The area of each lesion was measured before treatment and 1 to 12 years after completion of the endodontic treatment. The measurements were performed using computerized morphometry. RESULTS: In 65.2% of the teeth, the size of the lesion decreased, while in 34.8% of teeth, there was an increase. Lesions larger than 10 mm2 had a greater tendency for healing. CONCLUSION: No significant correlation was found between the quality of root canal treatment, the type of the coronal restoration, and the success rate of the endodontic treatment.

Adolescent↗
PubMed1996

Long-term changes in marginal and periapical periodontal conditions in patients with fixed prostheses: a radiographic study.

Patients treated at a prosthodontic department during the years 1968-73 with fixed restorations (at least five units) were followed up in 1991-92. The aim of the present study was to compare marginal and periapical periodontal conditions on radiographs from 1968-73 and 1991-92 and relate the changes to the results of the prosthodontic treatment. In the group in which the restorations remained unchanged, 90% of the abutments that were not root filled and showed no periapical radiolucency when the restorations were placed, were still not root filled and showed no periapical radiolucency at the follow-up examination. The corresponding figure for the group in which the restorations had been replaced was only 69%. The changes in marginal bone levels also differed between the groups. In the group with remaining restorations, 66% of the surfaces were given the same score on a five-point scale both in 1968-73 and in 1991-92. In the other group, only 54% were scored the same on both occasions. Thus, unfavourable changes in both periapical and marginal periodontal conditions were associated with poorer results for the fixed restorations.

Adult↗
PubMed2003

Microbiological analysis of infected root canals from symptomatic and asymptomatic teeth with periapical periodontitis and the antimicrobial susceptibility of some isolated anaerobic bacteria.

The purpose of the present study was to investigate the correlation between the composition of the bacterial flora isolated from infected root canals of teeth with apical periodontitis with the presence of clinical signs and symptoms, and to test the antibiotic susceptibility of five anaerobic bacteria mostly commonly found in the root canals of symptomatic teeth against various substances using the E-test. Microbial samples were taken from 48 root canals, 29 symptomatic and 19 asymptomatic, using adequate techniques. A total of 218 cultivable isolates were recovered from 48 different microbial species and 19 different genera. Root canals from symptomatic teeth harbored more obligate anaerobes and a bigger number of bacterial species than the asymptomatic teeth. More than 70% of the bacterial isolates were strict anaerobes. Statistical analysis used a Pearson Chi-squared test or a one-sided Fisher's Exact test as appropriate. Suggested relationships were found between specific microorganisms, especially gram-negative anaerobes, and the presence of spontaneous or previous pain, tenderness to percussion, pain on palpation and swelling amoxicillin, amoxicillin + clavulanate and cephaclor were effective against all the strains tested. The lowest susceptibility rate was presented by Prevotella intermedia/nigrescens against Penicillin G. Our results suggested that specific bacteria are associated with endodontic symptoms of infected teeth with periapical periodontitis and the majority of the anaerobic bacterial species tested were susceptible to all antibiotics studied.

Adolescent↗