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At least 19 recordsLinked to original sources
PubMed2004

The prairie vole (Microtus ochrogaster): an animal model for behavioral neuroendocrine research on pair bonding.

Pair bond formation has been investigated much less than many other social behaviors, perhaps in part because traditional laboratory mice and rats do not exhibit this behavior. However, pair bonding is common among monogamous animals such as the prairie vole (Microtus ochrogaster). In this review, we discuss how the prairie vole has been used as a model system to investigate the neurobiology of pair bonding. Descriptions include neuroanatomical differences between monogamous and non-monogamous voles, as well as how manipulations of vasopressin, oxytocin, dopamine, and corticosterone systems affect pair bond formation. Also summarized are potential interactions among these systems that regulate pair bonding, and the extent of sexual dimorphism in underlying mechanisms. Pair bonding in prairie voles is an excellent model system for studying central processing of social information. Understanding the mechanisms underlying this behavior may provide important insights into human disorders associated with impaired social functioning.

Animals↗
PubMed2007

Electron pairing and chemical bonds: pair localization in ELF domains from the analysis of domain averaged Fermi holes.

This article reports the application of a recently proposed formalism of domain averaged Fermi holes to the problem of the localization of electron pairs in electron localization function (ELF) domains and its possible implications for the electron pair model of chemical bond. The main focus was on the systems, such as H2O or N2, in which the "unphysical" population of ELF domains makes the parallel between these domains and chemical bond questionable. On the basis of the results of the Fermi-hole analysis, we propose that the above problems could be due to the fact that in some cases the boundaries of the ELF domains need not be determined precisely enough.

Journal Article↗
PubMed2004

Neurochemical regulation of pair bonding in male prairie voles.

Pair bonding represents social attachment between mates and is common among monogamous animals. The prairie vole (Microtus ochrogaster) is a monogamous rodent in which mating facilitates pair bond formation. In this review, we first discuss how prairie voles have been used as an excellent model for neurobiological studies of pair bonding. We then primarily focus on male prairie voles to summarize recent findings from neuroanatomical, neurochemical, cellular, molecular, and behavioral studies implicating vasopressin (AVP), oxytocin (OT), and dopamine (DA) in the regulation of pair bonding. Possible interactions among these neurochemicals in the regulation of pair bonding, the brain areas important for pair bond formation, and potential sexually dimorphic mechanisms underlying pair bonding are also discussed. As analogous social bonds are formed by humans, investigation of the neurochemical regulation of pair bond formation in prairie voles may be beneficial for our understanding of the mechanisms associated with normal and abnormal social behaviors in humans.

Animals↗
PubMed2005

Charge-shift bonding--a class of electron-pair bonds that emerges from valence bond theory and is supported by the electron localization function approach.

This paper deals with a central paradigm of chemistry, the electron-pair bond. Valence bond (VB) theory and electron-localization function (ELF) calculations of 21 single bonds demonstrate that along the two classical bond families of covalent and ionic bonds, there exists a class of charge-shift bonds (CS bonds) in which the fluctuation of the electron pair density plays a dominant role. In VB theory, CS bonding manifests by way of a large covalent-ionic resonance energy, RE(CS), and in ELF by a depleted basin population with large variances (fluctuations). CS bonding is shown to be a fundamental mechanism that is necessary to satisfy the equilibrium condition, namely the virial ratio of the kinetic and potential energy contributions to the bond energy. The paper defines the atomic propensity and territory for CS bonding: Atoms (fragments) that are prone to CS bonding are compact electronegative and/or lone-pair-rich species. As such, the territory of CS bonding transcends considerations of static charge distribution, and involves: a) homopolar bonds of heteroatoms with zero static ionicity, b) heteropolar sigma and pi bonds of the electronegative and/or electron-pair-rich elements among themselves and to other atoms (e.g., the higher metalloids, Si, Ge, Sn, etc), c) all hypercoordinate molecules. Several experimental manifestations of charge-shift bonding are discussed, such as depleted bonding density, the rarity of ionic chemistry of silicon in condensed phases, and the high barriers of halogen-transfer reactions as compared to hydrogen-transfers.

Journal Article↗
PubMed2004

The neurobiology of pair bonding.

A neurobiological model for pair-bond formation has emerged from studies in monogamous rodents. The neuropeptides oxytocin and vasopressin contribute to the processing of social cues necessary for individual recognition. Mesolimbic dopamine is involved in reinforcement and reward learning. Concurrent activation of neuropeptide and dopamine receptors in the reward centers of the brain during mating results in a conditioned partner preference, observed as a pair bond. Differential regulation of neuropeptide receptor expression may explain species differences in the ability to form pair bonds. These and other studies discussed here have intriguing implications for the neurobiology of social attachment in our own species.

Animals↗
PubMed2000

Hylobatid communities: Changing views on pair bonding and social organization in hominoids.

Social organization involving pair bonding and two-adult groups is rare in mammals. Current sociobiological theory suggests that this grouping and behavior pattern is somewhat anomalous. The gibbons (genus Hylobates) are the only hominoids to exhibit pair bonds and two-adult groups. In this article I present an overview of the current issues in monogamy and pair-bond theory, and review traditional conceptualizations and the accumulated data relevant to gibbon social organization. The significance of hominoid behavioral phylogeny and population-wide studies is also considered. Recent findings indicate that pair-bonding and two-adult groups are not ubiquitous among the hylobatids. Many aspects of gibbon behavior and ecology do not conform to expectations of the conditions under which two-adult groups and/or pair-bonding patterns should evolve. A review of the information available from long-term and short-term studies of gibbons suggests an alternative way of viewing their socioecology. I propose that gibbons currently exist in variable communities that have arisen via ecological pressures and specific behavioral patterns from an ancestral multimale/multi-female grouping pattern. This social organization is not best characterized as "monogamous." This review also suggests that hominoid grouping patterns can be viewed as occurring along a continuum rather than as being discretely different units.

Animals↗
PubMed1998

Pair-bond disruption in Mongolian gerbils: effects on subsequent social behaviour.

Gerbils are social rodents which form stable male-female pairs. These pair bonds appear to be based on prolonged association rather than an exclusive mating relationship. However, both sexes contribute to territorial defense and pup rearing. Therefore, pair-bond disruption may be expected to have consequences for subsequent behaviour. This hypothesis was examined in a series of laboratory studies. Behavioural consequences of pair-bond disruption were seen in both sexes and the optimum housing parameters were found to be to pair males and females for 5 weeks and to examine their behaviour 1 week after pair-bond disruption. Two further studies using these parameters were conducted to examine the combined influence of pair-bond disruption and the sex of the animal being interacted with. Results across all studies revealed a consistent pattern. Females showed increased immobility in contact, that is, freezing upon another animal's approach, and altered cage-orientated behaviour, regardless of the sex of the animal they were interacting with. In contrast, males showed decreased social investigation and offense and initiated fewer social interactions. However, these effects were only seen in interactions with other males. No changes in social behaviour were evident in interactions between pair-bond-disrupted males and females. The behavioural strategies of pair-bond-disrupted males and females in a social situation therefore differ. From these studies, it may be concluded that pair-bond disruption has consistent and reproducible effects on subsequent social behaviour in gerbils and that there are important sex differences in the behavioural expression of this.

Agonistic Behavior↗
PubMed2005

Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds.

The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance-namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1-like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed2001

Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral septum blocked mating-induced pair bonding, whereas administration of AVP induced this behavior in the absence of mating. In addition, administration of an oxytocin (OT) receptor antagonist in the lateral septum also blocked pair bond formation induced by either mating or AVP administration, suggesting that the OT receptor blockade may have interfered with the AVP regulation of behavior. Together, these data provide evidence suggesting that AVP in the lateral septum regulates pair bond formation in male prairie voles and that this process requires access to both AVP and OT receptors.

Animals↗
PubMed2000

The relationship between duet songs and pair bonds in siamangs, Hylobates syndactylus.

One of the most commonly cited functional explanations for animal duet songs is strengthening of the pair bond. However, the evidence to support this view is, at best, limited. This study provides support by documenting a relationship between pair bonds and duet singing in siamangs. As a working hypothesis, we assume that if duetting were related to pair bonding, we might expect to see a relationship between duetting intensity and indicators of pair bond strength. Like most gibbon species, siamang pairs produce loud, long and well-coordinated duet songs. We recorded daily frequency and duration of duetting and three generally accepted indicators of pair bond strength (mutual grooming, behavioural synchronization and distance between mates) in 10 siamang groups in zoos. Duetting activity was positively correlated with grooming activity and behavioural synchronization, and negatively correlated with distance between mates. These results suggest that the production of coordinated duets by siamang pairs is related to pair bonding. Copyright 2000 The Association for the Study of Animal Behaviour.

Journal Article↗
PubMed2001

Lesions of the vomeronasal organ disrupt mating-induced pair bonding in female prairie voles (Microtus ochrogaster).

The prairie vole (Microtus ochrogaster) is a highly social, monogamous species and displays pair bonding that can be assessed by the presence of selective affiliation with the familiar partner versus a conspecific stranger. In female prairie voles, exposure to a male or to male sensory cues is essential for estrus induction, and the subsequent mating facilitates pair bond formation. In the present study, we examined the role of the vomeronasal organ (VNO) in estrus induction and pair bonding in female prairie voles. VNO lesions did not alter olfaction mediated by the main olfactory system, but did prevent male-induced estrus induction. We by-passed the necessity of the VNO for estrus induction by estrogen priming the females. Despite the fact that all subjects displayed similar levels of mating, social contact and locomotor activities, VNO lesioned females failed to show mating-induced pair bonding whereas intact and sham-lesioned females displayed a robust preference for the familiar partner. Our data not only support previous findings that the VNO is important for estrus induction but also indicate that this structure is crucial for mating-induced pair bonding, suggesting an important role for the VNO in reproductive success in prairie voles.

Animals↗
PubMed2003

Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles.

Although oxytocin (OT) and dopamine (DA) have been implicated in pair bond formation in monogamous prairie voles (Microtus ochrogaster), the nature of potential interactions between these two neurochemical systems and the brain circuits important for such interactions in the regulation of pair bonding have not been explored. Here, we demonstrated that access to both OT and DA D2-type receptors is necessary for pair bond formation, as blockade of either type of receptor prevented partner preferences induced by OT or a D2-type agonist. We also demonstrated that the nucleus accumbens (NAcc) is a brain area important for such OT-DA interactions. In NAcc, blockade of OT receptors prevented partner preferences induced by a D2-type agonist whereas blockade of D2-type, but not D1-type, DA receptors blocked OT-induced partner preferences. Together, our data suggest that concurrent activation of OT and DA D2-type receptors in NAcc is essential for pair bond formation in female prairie voles.

Animals↗
PubMed2003

Forebrain c-fos expression under conditions conducive to pair bonding in female prairie voles (Microtus ochrogaster).

Repeated mating over a period of 6 h facilitates pair-bond formation in monogamous prairie voles. Using this paradigm, we examined fos expression in brain areas implicated in social behavior in voles. We hypothesized that the presence of the fos protein after a period of time sufficient for pair bonding to occur may indicate brain areas that are especially important in pair bond formation. We found elevated levels of fos immunoreactivity in the medial and cortical amygdala, medial preoptic area (MPOA), and bed nucleus of the stria terminalis (BNST) in females that mated several times over a 6-h period as compared to a variety of unmated controls. No treatment effects were found in the central amygdala, nucleus accumbens (NAcc), or lateral septum (LS). We suggest that areas that show evidence of fos expression after sufficient time for pair bonding to occur may be important in the formation of associations between the partner and mating stimuli.

Amygdala↗
PubMed2004

Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole.

Arginine vasopressin and its V1a receptor subtype (V1aR) are critical for pair bond formation between adult prairie voles. However, it is unclear which brain circuits are involved in this vasopressin-mediated facilitation of pair bond formation. Here, we examined mating-induced Fos expression in several brain regions involved in sociosexual and reward circuitry in male prairie voles. Consistent with studies in other species, Fos expression was induced in several regions known to be involved in sociosexual behavior, namely, the medial amygdala, bed nucleus of the stria terminalis, and medial preoptic area. Fos induction also occurred in limbic and reward regions, including the ventral pallidum, nucleus accumbens, and mediodorsal thalamus (MDthal). Next, we infused a selective V1aR antagonist into three candidate brain regions that seemed most likely involved in vasopressin-mediated pair bond formation: the ventral pallidum, medial amygdala, and MDthal. Blockade of V1aR in the ventral pallidum, but not in the medial amygdala or MDthal, prevented partner preference formation. Lastly, we demonstrated that the mating-induced Fos activation in the ventral pallidum was vasopressin-dependent, since over-expression of V1aR using viral vector gene transfer resulted in a proportionate increase in mating-induced Fos in the same region. This is the first study to show that vasopressin neurotransmission occurs in the ventral pallidum during mating, and that V1aR activation in this region is necessary for pair bond formation in male prairie voles. The results from this study have profound implications for the neural circuitry underlying social attachment and generate novel hypotheses regarding the neural control of social behavior.

Animals↗
PubMed2002

Development of sexual partner preference in the zebra finch: a socially monogamous, pair-bonding animal.

Zebra finches are group living socially monogamous birds that pair for life. Partner preference is strongly sexually differentiated: males prefer to pair with females and females prefer to pair with males. Where do these preferences come from? What occurs during development that produces adult birds that pair with the opposite sex? There is surprisingly little animal research that addresses such questions, especially in species that form pair-bonds. Our research program focuses on two processes that may be involved in the development of adult sexual-partner preference: (1) early (possibly organizational) hormone actions and (2) social experience. Females treated with estradiol or fadrozole (an estrogen synthesis inhibitor) as nestlings or embryos showed masculinized sexual-partner preference as adults, preferring to pair with other females even when potential male partners were available. Removal of adult males from breeding cages, so that young birds were not exposed to males or to male-female pairs during development, eliminated sex-typical partner preferences; these birds were equally interested in both sexes and were more likely than controls to pair with a same-sex partner. These experiments provide insights into the development of sexual-partner preference that may be applicable to other group living pair-bonding animals with biparental care. They also contribute to the foundation of animal research that is necessary for a biological approach to understanding the pair-bonding component of human sexual orientation.

Animals↗
PubMed1995

Determination of the disulfide bond pairings in human tissue factor pathway inhibitor purified from Escherichia coli.

The disulfide bond assignments of human alanyl tissue factor pathway inhibitor purified from Escherichia coli have been determined. This inhibitor of the extrinsic blood coagulation pathway possesses three Kunitz-type inhibitor domains, each containing three disulfide bonds. The disulfide bond pairings in domains 1 and 3 were determined by amino acid sequencing and mass spectrometry of peptides derived from a thermolysin digest. However, thermolysin digestion did not cleave any peptide bonds within domain 2. The disulfide bond pairings in domain 2 were determined by isolating it from the thermolysin treatment and subsequently cleaving it with pepsin and trypsin into peptides which yielded the three disulfide bond pairings in this domain. These results demonstrate that the disulfide pairings in each of the three domains of human tissue factor pathway inhibitor purified from Escherichia coli are homologous to each other and also to those in bovine pancreatic trypsin inhibitor.

Amino Acid Sequence↗
PubMed2005

Anatomy and neurochemistry of the pair bond.

Studies in monogamous rodents have begun to elucidate the neural circuitry underlying the formation and maintenance of selective pair bonds between mates. This research suggests that at least three distinct, yet interconnected, neural pathways interact in the establishment of the pair bond. These include circuits involved in conveying somatosensory information from the genitalia to the brain during sexual activity, the mesolimbic dopamine circuits of reward and reinforcement, and neuropeptidergic circuits involved specifically in the processing of socially salient cues. Here we present an integrated description of the interaction of these circuits in a model of pair bond formation in rodents with a discussion of the implications of these findings for evolution, individual variation, and human bonding.

Animals↗