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Results for “PROTEIN-BOUND IODINE TEST”

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At least 19 recordsLinked to original sources
PubMed1975

[Value of separation on ion exchange resins of plasma iodine fractions. Comparison with Werner's suppression test].

This was a study of 71 patients suspected of hyperthyroidism who had undergone a tri-iodothyronine suppression test. A study of circulating protein-bound iodine after separation on ion-exchange resins had been carried out before triiodothyronine administration, on the same patients. The results showed that the radioactive hormonal fraction has a better diagnostic value than radioactive serum protein-bound iodine. In 60% of cases, a study of the radioactive hormonal fraction could have permitted to avoid the use of the suppression test.

Evaluation Studies as Topic↗
PubMed1975

Thyroid function during erythrosine ingestion in doses encountered in therapy with conventional antibiotics.

Six euthyroid patients without clinical or biochemical evidence of any renal or thyroid disorder received a diet of fixed composition. They were given no drugs. Urine was collected quantitatively throughout the whole investigation for determination of iodine and creatinine. After 5 days on diet they received 1.91 mumol of erythrosine, corresponding to approximately 7.88 mumol of iodine daily for 10 days. Thyroidal radioiodine studies were performed, levels of plasma inorganic iodine were calculated, and thyroxine, protein-bound iodine, and total iodine in serum were determined before and during erythrosine ingestion. A statistically significant increase in plasma inorganic iodine or in urinary iodine excretion was not found. The other test results of thyroid function remained virtually unchanged. Based on clinical aspects of thyroidal iodine metabolism we conclude that at most 7.8 per cent of the iodine content of the ingested erythrosine could have supplemented the iodine space.

Adult↗
PubMed1975

Mustard meal in dairy rations.

Consumption of 0% mustard meal and 15% soybean meal, 7.5% mustard meal and 7.5% soybean meal, or 15% mustard meal and 0% soybean meal rations did not differ in palatability studies with 10 group-fed lactating cows when the mustard meal was treated with 3% caustic soda. Order of preference was for 0, 7.5, and 15% mustard meal rations when mustard meal was untreated. Twelve lactating cows were in each of two lactation trials to compare the three rations of untreated mustard meal. Milk, milk fat, and solids-not-fat, and milk protein did not differ for either trial. Protein-bound iodine of plasma for all cows were within the normal range. Three cows were placed on each of the three rations and received a minimum of 9 kg per day for 6 mo preparturition to determine goitrogenic effects. All cows gave birth to normal, vigorous calves. Limited organoleptic evaluations of milk indicated that untreated mustard meal may impart a detrimental flavor to milk, but a taste panel could not differentiate between milk from cows on the three rations of treated mustard meal. Twenty-one male and 43 female Holstein claves received either 0, 10, or 20% mustard meal starter rations from birth to 3 mo of age. Growth, feed consumption, or plasma protein-bound iodine did not differ.

Animal Feed↗
PubMedDate not supplied

[The effect of emotional stressors on thyroid gland function].

Response of the normal and goiterous thyroid gland to the information on the forthcoming operation was studied in 12 patients with varicose veins of the lower limbs and in 67 patients with thyrotoxicosis; this was done by determination of protein-bound iodine (PBI). PBI proved to increase before the operation in both groups of the patients. Due to undesirable hyperfunction of the thyroid gland prior to the operation in thyrotoxicosis, the psychodepressive premedication component should be increased.

Goiter, Endemic↗
PubMed1975

Metabolic parameters in women with metastatic breast cancer.

The metabolic mechanism for increased circulating free fatty acids in post-menopausal women with metastatic breast cancer was investigated. Hormone and metabolic response to glucose and growth hormone were compared to cancer patients and control subjects; thyroid, adrenal and pituitary function were evaluated. The results of these studies indicated that breast cancer patients had glucose intolerance and delayed and prolonged insulin secretion, increased basal growth hormone levels and insensitivity of adipose tissue to growth hormone. Cortisol and protein-bound iodine levels were normal and there was no lipolytic factor in the sera of breast cancer patients. The changes observed in breast cancer patients were not attributable to age, obesity, inanition or stress. These metabolic abnormalities may characterize host susceptibility to breast cancer or be effects of tumor.

Adipose Tissue↗
PubMedDate not supplied

[The character of functional connections in the endocrine system of female white rats and their transformation with age].

The authors studied the functional interrelations between the adrenal glands and the thyroid gland of female albino rats of various age groups. Blood content of 11-oxycorticosteroids and protein-bound iodine was determined. Analogous determinations were carried out in partial exclusion of the adrenal gland function (metapyron block) and of the thyroid gland function (6-methyluracil block). It is supposed that in the young sexually-mature female albino rats the functions of the adrenal glands and the thyroid gland were in direct relationship irrespective of the cyclic variations in the sex steroid secretion; with the advance of age this association became deranged.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[State of the renin-angiotensin system in thyrotoxicosis].

A study was made of the blood plasma renin activity in 63 patients suffering from thyrotoxicosis before the treatment and in 42 healthy individuals. In comparison with the healthy, renin activity was increased in patients with thyrotoxicosis and displayed a positive correlation with the severity of the disease the level of protein-bound iodine, tachycardia and the degree of loss of weight. Stimulation of the renin-angiotensin system by the salt-free diet, hydrochlorthiazide and by placing the body into orthostatic position caused a relatively weaker increase in the renin activity in comparison with such in healthy individuals. Following successful treatment and the occurrence of an euthyroidal state renin activity proved to fall to the normal level. An increased renin activity was combined with increased urinary aldosterone excretion with a normal serum electrolyte level. Such combination pointed to the secondary character of aldosteronism. Block of the alpha- and beta-adrenergic receptors led to reduction in the level of renin activity. Despite the frequent affection of hepatic function there was revealed no correlation between the increase in the renin activity and the pathological results of hepatic tests. Plasma renin activity was reduced in 8 patients with myxedema. It is supposed that the principal factors causing activation of the renin-angiotensin system in thyrotoxicosis were the loss of water and electrolytes by the organism and the appearance of oversensitivity to adrenergic receptors.

Adrenergic alpha-Antagonists↗
PubMed1976

Lithium as an adjunct to radioiodine therapy for thyrotoxicosis.

16 patients with diffuse thyroid hyperplasia were given lithium carbonate (400 mg daily) for 1 week before and 1 week after a standardised 5 mCi therapy dose of 131I. A comparable control group of 16 patients were treated with 5 mCi of 131I without lithium therapy. The % retention of the therapy dose was measured in all patients at 7 days (168-hour 131I uptake). In the lithium-treated group the 24-hour 131I uptake showed no significant change after the first week of lithium therapy. The mean 48-hour protein-bound 131I, however, fell considerably from 1-21 to 0.55%/dose/1. The mean 24-168 hour % thyroidal 131I uptake drop was significantly less in the lithium group. These results show that low-dosage lithium therapy increases the retention of a standard-therapy dose of 131I. Lithium promises to be a useful adjunct to 131I therapy in patients with a rapid thyroidal iodine turnover and particularly in young patients where the total body-radiation dose must be kept to a minimum.

Adolescent↗
PubMed1975

[Experimental study of the correlation between function and morphology of rat thyroid after the application of methylthiouracil and thyroid stimulating hormone].

In an experimental study with 359 male Wistar rats the thyroid function was altered with MTU and TSH. The morphological changes developing due to this treatment were compared with the hormone blood level measured as labelled protein-bound iodine (PBI-127). Furthermore, the content of PBI-131 was determined and the I-131 uptake of the thyroid after application of TSH was measured. It was shown that with a dosis which had no influence on the PBI-127 and radioiodine values, the height of the thyroid epithelium already revealed a significant reaction. By a morphological examination together with the histometrical determination of the height of the thyroid epithelium the hormone-dependent increase in activity may be determined quantitatively.

Animals↗
PubMed1975

The functional state of the thyroid gland of the mother and fetus in the prenatal development of rabbits.

The functional state of the thyroid gland of the mother and fetus was studied in different periods of intrauterine development of rabbits, as well as in newborn rabbits according to the level of protein-bound iodine (PBI) in the blood plasma and thyroid gland tissue. Similar studies were conducted after a thyroidectomy of females on the 10th-12th day of pregnancy in order to demonstrate the possibility of mutual compensation of the hormonal function under pathological conditions. The level of PBI in the blood plasma of the mother clearly increases in the second half of pregnancy and decreases sharply after birth. The content of PBI in the fetal blood plasma increases continuously beginning with the 22nd day of intrauterine development. The level of PBI in the thyroid gland tissue both of the mother and the fetus increases sharply at the end of pregnancy. In fetuses of thyroidectomized females the amount of PBI in the blood plasma and thyroid gland tissue on the 22nd day of pregnancy considerably exceeded that in normal fetuses.

Animals↗
PubMed1975

Changes with age in protein-bound iodine (PBI) and body temperature in the mouse.

Protein-bound iodine (PBI), body temperature, and the response of the thyroid gland to different doses of thyrotropin (TSH) were examined in males of two inbred strains of mice at different ages. Results indicate persistent decline in PBI with advancing age that is significantly greater in DBA/2J than C57BL/6J mice. The magnitude of the PBI response to TSH diminishes in both strains with advancing age but is significantly greater in strain DBA/2J than C57BL/6J. Body temperature was found to decline with advancing age and was highly correlated with thyroid function. Although additional research is needed, a tentative conclusion is that advancing age imparts a diminished response of the thyroid gland to endogenous thyrotropin. This is the first report of age-related changes and particularly correlation between PBI and body temperature in genetically controlled mouse strains. The indications are that such thyroid-temperature relationships are genotype dependent.

Aging↗
PubMedDate not supplied

[Activity of the hypophyseal-thyroid gland system in relation to the funcitonal state of the sex glands. Report I].

Experiments were conducted on intact female rats; it was revealed that the content of protein-bound iodine (PBI) in the blood depended on the stage of the estral cycle. It was decreased at the metestrus and diestrus stages. Castration produced an even greater reduction in the blood PBI content. The blood PBI content proved to elevate in administration of estradiol dipropionate (EDP) to castrated rats. The TSH content in the hypophysis increased at the metestrus and diestrus stages and decreased at the proestrus and estrus stages. The relationship was reverse in the case with the blood TTH content. Castration was followed by a marked increase in the TSH content in the hypophysis accompanied by a reduction in the blood hormone level. The TSH concentration in the hypophysis decreased and in the blood increased under the effect of EDP in castrated animals. The data obtained indicated that the interrelationship between the thyroid gland and the sex glands was realized at the level of the hypophysis, and possibly, of the hypothalamus.

Animals↗
PubMed1975

[Diurnal rhythms of thyroid hormones in rooster chicks (Gallus domesticus). 2. Studies on the protein-bound radioiodine and the "free" hormone portion].

In four week old cockerels the plasma was investigated for cyclic changes in total radioactivity, PB131I, PI131I, and "free" thyroid hormones 24 hours after injection of Na131I. Maxima in total radioactivity were observed at 3.00 am and 9.00 pm. They were significant different from the minima at noon (2P less than 0.005). At the same points of the day maxima, resp. minima were found in the PB131I and the "free" hormones. The "free" hormones expressed in per cent of total hormones showed low values at 6.00 am, 3.00 pm, and 9.00 pm. The diurnal changes in haematocrit and albumin concentration were not responsible for the variation of PB131I. In order to eleminate effects of isotope dilution by ingested iodine the PB131I was expressed in per cent of total radioactivity of plasma (= conversion rate) or resp. in per cent of thyroidal radioiodine uptake. The obtained values showed maxima at 6.00 am and 9.00 pm. From that we conclude again on a stimulation of the thyroid at these times.

Animals↗
PubMed1976

Thyrotoxicosis with painless thyroiditis.

Four women and one man with painless subacute thyroiditis presented with hypermetabolic signs and symptoms. Thyroxine (T4) and triiodothyronine (T3) resin uptakes (T3R) were increased but the 24 hour radioactive iodine (RAI) uptakes were less than 1 per cent. Surreptitious use of thyroid hormone was excluded. The thyroid was enlarged in one patient and nontender in all. Exophthalmos was absent. The protein-bound iodine level was 1.1 to 9.5 mug/dl greater than the T4 level. The sedimentation rate was normal or minimally increased, and antithyroglobulin and antimicrosomal antibodies were undetectable. In one hospitalized patient 84 per cent of the administered dose of 131I was recovered in the urine within 48 hours (normal 64 per cent) excluding extrathyroidal uptake. In all subjects the T4 and T3R levels fell to normal or slightly below normal within one to four months. An increase in the 2 and 24 hour RAI uptake to minimally increased or high normal values and return of the T4 and T3R levels to normal occurred in four of five patients within six months. In one of these, the administration of thyroid-stimulating hormone (TSH) resulted in an appropriate increase in 24 hour RAI uptake from 14.9 to 37.1 per cent. One woman remained clinically hypothyroid for six months with a low T4 concentration (3.2 mug/dl), an elevated TSH level (48 muU/ml) and evidence of a persistent organification defect -- two hour RAI uptake decreasing from 33 to 23 per cent after the administration of perchlorate and the 24 hour RAI uptake increasing from 32 to 76 per cent following the administration of TSH. At 21 months after the initial onset of her illness, she is euthyroid but increased RAI uptake persists. The clinical course in four of the five patients is similar to that in an additional eight patients treated during the same time period who presented with typical subacute thyroiditis. Thus, these patients have a form of painless subacute thyroiditis which presents as thyrotoxicosis but is differentiated from it by a low RAI uptake and in whom recovery of thyroidal iodine trapping is the first indicator of recovery. The hyperthyroidism is self-limiting and should be treated conservatively.

Adult↗