[Isolated polypi of the colon in adults: benign and degenerative polypi].
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UNLABELLED: Single cases of genuine colon rectum polypi, histologically adenomatous, adeno-villous and villous tumours have been treated with cryosurgery. INDICATION: Relapses after polyectomy showing malignant degeneration; malignantly degenerated polypi, treatment of the basis of sessile lesions; sessile polypi up to 1 cm in diameter; extensive polyposis--polyposis of the rectum. After an initial regression of the polypous changes growth can be stated and quickly developing degenration leading to the formation of a carcinoma of the rectum and to stenoses of the lumen. It was only partially possible to clarify the cause of the growth in animal experiments. Primary application of low temperatures in polyposis recti and in primarily malignant degenerated polypi have to be avoided.
Aural polypi associated with chronic suppurative otitis media have been studied histopathologically and histochemically in 20 patients. The polypi consist of an edematous connective tissue stroma infiltrated by chronic inflammatory cells and numerous blood vessels. The surface is covered by intact stratified squamous epithelium. The histochemical study revealed altered permeability of the blood vessels which seem to be the main pathological background for polyp formation. An enhanced phagocytic activity and increased metabolic activity were found in the epithelium in the chronic inflammatory cells. No glandular activity was found in the polypi.
OBJECTIVE: A trial to determine a simple way to predict recurrence of nasal polypi to determine the need for long term medical therapy. METHODS: Retrospective clinical analysis of the records of 100 patients with nasal polypi and studying various parameters including radiological, intra-operative and bacteriological data. RESULTS: Among the various parameters studied, maxillary antral involvement, and positive bacterial cultures seemed the most predictive criteria of recurrence. Patients without polypoid involvement of the maxillary sinus and/or with negative cultures were less likely to have early recurrence of their disease. CONCLUSION: Using simple clinical criteria, two patient populations could be defined. One in which recurrence is inevitable requiring continuous local steroid therapy after surgery and another group requiring occasional local treatment after an initial short course of local steroid spray.
A report is presented on 11 patients with histologically confirmed nasal sarcoidosis, including one case with very large nasal polypi. The most frequent symptom was obstruction of the nose followed by dryness and crusting. Thickening of the nasal mucosa was the most frequent finding. Yellowish dots were observed in four patients, and polypi in two. In one patient, a granulomatous maxillary sinusitis was diagnosed. Cutaneous sarcoidosis was found in only one patient. Nine of the patients had noted their nasal symptoms during the early phase of the disease. The response to treatment with corticosteroids is discussed. It seems that an enquiry about nasal symptoms and examination of the nasal cavity are valuable even in patients with early sarcoidosis.
A case of benign polypi at the site of uretero-rectal anastomosis is herein reported. Nine other similar cases are reviewed. Possible aetiology and diagnosis are discussed.
The results of a clinical, histopathological and biochemical study on twenty patients with schistosomal polyposis of the large bowel and ten patients with normal colon as a control are reported. The biopsy showed clearly the absence of any malignant or premalignant changes in all the twenty bilharzial patients. Results of the biochemical study showed that there is a statistically significant increase in beta-glucuronidase activity in schistosomal polypi compared to normal mucosa. This enzymatic activity is absent in schistosoma ova. The causes of the increase in the enzyme activity have been attributed to leucocytic infiltration present in schistosomal granulomata and possible to some degree of liver disfunction. The protein content of the excess mucus present in the colon could also activate the enzyme. Our results also show that the increased enzyme activity does not necessarily have carcinogenic properties. We did not come across a single case of malignancy even in a patient with very high level of enzyme activity (11615 units) or in those patients with a prolonged history of the disease.
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