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At least 19 recordsLinked to original sources
PubMed2002

Caiman periodontium as an intermediate between basal vertebrate ankylosis-type attachment and mammalian "true" periodontium.

The teeth of many fish, amphibia, and reptiles are attached to the alveolar bone via ankylosis. In contrast, mammalian periodontia are characterized by a gomphosis, an attachment of the tooth root in the alveolar bone socket via periodontal ligament fibers. Among the reptiles, the crocodilians are the only group featuring a gomphosis-type connection between tooth root and alveolar bone, while in other reptiles tooth-root and jawbone are connected via ankylosis. The purpose of the present study was to compare several key features of the crocodilian periodontium with those of the mammalian and noncrocodilian reptile periodontium. As experimental models for our study we chose the periodontium of newborn geckos (Hemidacylus turcicus), juvenile caimans (Caiman crocodilus crocodilus), and 10-day-postnatal Swiss-Webster mice (Mus musculus) as representative models for noncrocodilian reptiles, crocodilian reptiles, and mammals. The caiman periodontium emerged as an intermediary between the mineral-free mouse ligament and the mineralized gecko ankylosis-type attachment. Caiman ligament fibers were less organized than mouse ligament fibers but featured distinct fasciae surrounding ligament fiber bundles. Caiman Hertwig's epithelial root sheath (HERS) was similarly perforated as mouse HERS and distinctly different from the continuous gecko HERS. Both caiman and mouse HERS covered the entire tooth root length, while in the gecko HERS was limited to the coronal portion of the root, allowing for cementoid-mediated ankylosis at the apical tip of the root. We interpret our data to indicate distinct differences in mineral distribution, periodontal ligament fiber organization, and HERS distribution between noncrocodilian reptiles, crocodilian reptiles, and mammals. Mineral deposits in the caiman ligament may reflect an evolutionary position of the caiman periodontium between ankylosis and gomphosis.

Alligators and Crocodiles↗
PubMed1996

Histopathologic alterations of periodontium in cyclosporin-treated rats. Is the periodontium a target tissue for the drug?

Gingival dimensions and histopathologic alterations in periodontium were examined in rats continuously exposed to cyclosporin-A (CSA). 60 male Sprague-Dawley rats were divided into 2 groups. Rats in the test group daily received CSA in mineral oil by gastric feeding at a dosage of 30 mg/kg body weight for 6 weeks. Rats in the control group received mineral oil only. 10 rats from each group were sacrificed at 2-week intervals. Gingival dimensions were assessed from stone models obtained from the maxillary and mandibular incisal regions. Horizontal, sagittal and frontal tissue sections were obtained from these regions as well. Gingival dimensions in the mandibular and maxillary incisal regions were significantly increased in rats exposed to CSA. Light-microscopic observations revealed a granulation tissue formation at tooth-gingiva interface and an irregular bony surface on dental alveoli in experimental animals. Because both soft and hard tissue of periodontium in experimental rats being significantly effected by CSA compared to control animals, we hypothesized that the periodontium is a target tissue for CSA.

Alveolar Process↗
PubMed2006

Protective and destructive immunity in the periodontium: Part 1--innate and humoral immunity and the periodontium.

Based on the results of recent research in the field, the present paper will discuss the protective and destructive aspects of the innate vs. adaptive (humoral and cell-mediated) immunity associated with the bacterial virulent factors or antigenic determinants during periodontal pathogenesis. Attention will be focused on: (i) the Toll-like receptors (TLR), the innate immune repertoire for recognizing the unique molecular patterns of microbial components that trigger innate and adaptive immunity for effective host defenses, in some general non-oral vs. periodontal microbial infections; (ii) T-cell-mediated immunity, Th-cytokines, and osteoclastogenesis in periodontal disease progression; and (iii) some molecular techniques developed and used to identify critical microbial virulence factors or antigens associated with host immunity (using Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis as the model species). Therefore, further understanding of the molecular interactions and mechanisms associated with the host's innate and adaptive immune responses will facilitate the development of new and innovative therapeutics for future periodontal treatments.

Adaptor Proteins, Signal Transducing↗
PubMed2006

Protective and destructive immunity in the periodontium: Part 2--T-cell-mediated immunity in the periodontium.

Based on the results of recent research in the field and Part 1 of this article (in this issue), the present paper will discuss the protective and destructive aspects of the T-cell-mediated adaptive immunity associated with the bacterial virulent factors or antigenic determinants during periodontal pathogenesis. Attention will be focused on: (i) osteoimmunology and periodontal disease; (ii) some molecular techniques developed and applied to identify critical microbial virulence factors or antigens associated with host immunity (with Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis as the model species); and (iii) summarizing the identified virulence factors/antigens associated with periodontal immunity. Thus, further understanding of the molecular mechanisms of the host's T-cell-mediated immune responses and the critical microbial antigens related to disease pathogenesis will facilitate the development of novel therapeutics or protocols for future periodontal treatments.

Aggregatibacter actinomycetemcomitans↗
PubMedDate not supplied

[Rheographic and photoplethysmographic research on the periodontium in adults with an orthognathic bite, healthy periodontium and an intact dental arch].

The periodontal hemodynamics was investigated in 27 individuals aged 18 to 23. Qualitative evaluation of the curves recorded from marginal gingival sites revealed the identity of the data to those obtained using rheographic and photoplethysmographic techniques. Quantitative parameters of photoplethysmography were somewhat different from rheographic ones, though their course was similar. Pronounced reduction of variability characteristics in the plethysmography substantially increased the informative value of the technique.

Adolescent↗
PubMed1992

Morphology of central terminations of intra-axonally stained, low-threshold mechanoreceptive primary afferent fibers from oral mucosa and periodontium in the rat.

Horseradish peroxidase (HRP) was injected intra-axonally into functionally identified primary afferent fibers within the rat spinal trigeminal tract in order to study the morphology of their central terminations. They were physiologically determined to be large, myelinated afferent fibers from periodontium or oral mucosa by means of electrical and mechanical stimulation of their receptive fields. Twenty-eight axons that innervated the periodontium of incisors and 21 axons that innervated the oral mucosa were stained for distances of 2-5 mm from the injection sites at the levels of the main sensory nucleus (Vms), spinal trigeminal nucleus and rostral cervical spinal cord. The collaterals of these primary afferent fibers formed terminal arbors in the medial or dorsomedial part of the Vms, and the oral and interpolar spinal trigeminal nuclei (Vo and Vi). In the caudal spinal trigeminal nucleus (Vc), the collaterals of one half of the periodontium afferent fibers terminated mainly in lamina V at the rostral and middle levels of Vc. On the other hand, the collaterals of the other half of the periodontium afferent fibers terminated mainly in lamina IV at the rostral level of Vc, and rostrally these terminal areas shifted to the most medial part of Vi. The collaterals of mucosa afferent fibers terminated in lamina V at the rostral level of Vc, and these terminal areas shifted gradually to laminae III and IV as the parent axons traveled more caudally. These shifts were staggered rostrocaudally according to the rostrocaudal locations of the receptive fields. The density of collaterals of periodontium afferent fibers in Vi was significantly larger than that of mucosa afferent fibers. The average size of the varicosities of periodontium afferent fibers was significantly larger than those of mucosa afferent fibers in Vo, Vi and Vc. The average number of varicosities belonging to single collaterals of slowly-adapting periodontium afferent fibers in Vi were significantly larger than those in Vo. In Vi, the average number of varicosities of single collaterals of slowly-adapting periodontium afferent fibers were significantly larger than those of rapidly-adapting periodontium afferent fibers.

Afferent Pathways↗
PubMed1997

Dynamic biologic transformation of the periodontium: a clinical report.

The technology of dynamic biologic transformation of the periodontium differs from orthodontic therapy in that the primary goal of dynamic biologic transformation of the periodontium is to reshape an abnormal periodontium. The goal of orthodontic treatment usually is the straightening of teeth in the orofacial complex. The new term dynamic biologic transformation of the periodontium has been coined to differentiate between a change in the periodontium that is secondary to straightening teeth through usual orthodontic methods to one that the primary goal is the rearrangement of the periodontium in which the tooth is merely used as a handle to pull the periodontium into the desired shape and location. The tooth or teeth that are moved in this process are often reshaped or put into abnormal positions to accomplish this goal. A review of the literature revealed that these changes in the periodontium can be used in various manners that will lessen surgical morbidity and maximize esthetics in conjunction with restorative and periodontal care. Combinations of dynamic biologic transformation of the periodontium and surgery were shown through clinical reports to illustrate this principle.

Adult↗
PubMed1981

Innervation of the periodontium in the monkey.

The distribution and structure of the sensory nerves and various neural endings in the periodontium were examined in adult monkeys, Macaca irus, by means of the silver nitrate technique. 1. The nerve fibers enter the periodontium passing through the bottom and the lateral wall of the bony socket. They are accompanied by blood vessels after entering the periodontium. 2. In the whole height of the periodontium, the area of richest nerve supply is the apical one third of the tooth root, while fewer nerves occur in the upper and middle third. In the apical third periodontium, nerve bundles with blood vessels are located near the alveolar bone, whereas single nerve fibers tend to occur adjacent to the cementum and surround the root of the tooth. 3. The nerve endings in the periodontium can be classified into three types by their structure. (1) Free endings or knob-like endings which, though found in the whole area of the periodontium, are concentrated near the alveolar bone. (2) Tree- or bush-like terminations located in the central part of the periodontium and near the cementum. They occasionally send out numerous branches to the cementum. (3) Specialized endings closely resembling Meissner's corpuscles. They are fairly rare. (4) Tree- or bush-like terminations localized at regular intervals as if each takes its own share of innervation territory. This type of terminals is presumed to represent periodontal mechanoreceptors.

Animals↗
PubMed1984

Effect of age on the periodontium.

It is generally known that the degree of periodontal breakdown increases with increasing age. The extent to which aging of periodontal tissues plays a part in this respect poses a question which is yet to be answered. Aging proves to be accompanied by a variety of periodontal changes. The periodontal tissues themselves show evidence of aging, there are indications that the composition of the plaque changes, and the reaction of the periodontium to the presence of plaque probably changes as well. There is as yet no sufficient evidence of a physiological apical migration of the epithelial attachment in human subjects. It seems plausible that periodontal breakdown can occur only in the presence of plaque with consequent inflammation of the periodontium, or as a result of trauma. Whether changes in plaque composition with age exert any influence on the course of periodontal breakdown is uncertain: the data available are not yet sufficient to warrant definite conclusions. The same applies to the influence which a changing reaction of the periodontium to the presence of plaque may have on the course of periodontal breakdown. Research findings do suggest that the degree of periodontal breakdown increases with age, that with increasing age inflammation of the periodontium tends to develop more rapidly and that in the process of aging the periodontium shows a slower rate of wound healing. However, these phenomena are overshadowed by the patients' susceptibility to periodontal disease. This implies that (1) the susceptibility to periodontal disease is more significant for the rate of periodontal destruction than the length of time plaque is present (the age effect) and (2) the greater the susceptibility to periodontal disease, the slower the rate of wound healing and the more rapidly inflammation of the periodontium tends to develop.

Adult↗
PubMed2000

Morphogenetic behavior of periodontium on inorganic implant materials: an experimental study of canines.

Periodontal ligament derived cells have the potential to regenerate all the components of the periodontium on the surface of inorganic implants, as well as on dentin. This suggests the hypothesis that the nature of the material affects the migration, proliferation, and differentiation of the progenitor cells for periodontium formation. To clarify this hypothesis, we evaluated the material-specific morphogenetic potential of periodontium-derived cells using an animal model for inducing cell migration from the functioning periodontium onto bioactive (hydroxyapatite, HA) and bioinert (titanium alloy, TA) material. Histologically, total periodontium including calcified cementum-like tissue only formed on HA and not on TA. Morphometrically, however, the length of fibrous connective tissue formed on HA was the same as on TA. This suggests that the bioactivity of the material does not affect the migration of periodontium-derived cells but strongly influences cell differentiation.

Animals↗
PubMed2003

Root resorption related to hypofunctional periodontium in experimental tooth movement.

Orthodontic movement of non-occluding teeth may result in undesirable apical root resorption. These teeth present with a histologically altered periodontium and are considered to be hypofunctional. The purpose of this study was to compare the amount of root resorption associated with a normal and a hypofunctional periodontium in rats during experimental tooth movement caused by heavy continuous force. The mandibular first molar was induced into a non-occluding condition in the hypofunctional periodontium group. Mesial orthodontic force was applied by means of 50-gram-force closed-coil springs for 15 days in both groups. The active root-resorption lacunae from histological sections, identified by tartrate-resistant acid phosphatase, were measured in terms of length, depth, and area. The results showed that the amount of root resorption was significantly greater in teeth with a hypofunctional periodontium than in those with a normal periodontium (p < 0.05). These results suggest that orthodontic movement of non-occluding teeth should be performed with caution.

Acid Phosphatase↗