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At least 19 recordsLinked to original sources
PubMed1975

Malarial infections in Aotus trivirgatus with special reference to renal pathology. II. P. falciparum and mixed malaria infections.

This paper describe the renal pathology in Aotus trivirgatus (owl monkeys) following P. falciparum infections and also when the initial P. falciparum was followed by infection with P. malariae or P. brrasilianum. Acute P. falciparum infections were associted with high parasitaemia but relatively mild changes in the glomeruli. This was also the case when a second infection with P. falciparum was given after the first infection had been terminated with chloroquine. Four monkeys with multiple infections involving P. Malariae or P. brasilianum after P. falciparum showed a glomerulonephritis. Two of these also showed a necrotizing arteriolitis. The findings suggest that P. falciparum alone does not give progressive renal disease and that this is more likely to occur with mixed infections.

Animals↗
PubMed1979

Effect of sequential infection with Plasmodium vivax and P. falciparum in the Aotus trivirgatus monkey.

Aotus trivirgatus monkeys with prior experience with Plasmodium vivax were inoculated with P. falciparum via the bites of infected mosquitoes. The animals with prior malaria had higher parasitemias and significantly higher levels of mosquito infectivity than monkeys with no prior P. vivax experience. Monkeys with a history of P. falciparum that were inoculated with P. vivax had essentially the same parasitemias as those with no prior malaria. However, levels of mosquito infectivity were markedly increased in those monkeys with a history of P. falciparum. The results imply that the introduction of another malaria species into a malarious area may result in higher levels of mosquito infection and more rapid establishment and distribution of that species.

Animals↗
PubMed1975

A focus of hyperendemic Plasmodium malariae-P. vivax with no P. falciparum in a primitive population in the Peruvian Amazon jungle.

Findings in a sample population in southeastern Peru with a very high rate of malaria infection, due to Plasmodium malariae and P. vivax with apparently no P. falciparum, are described. The proportion of persons with P. malariae in this sample population, as determined by slide examination, appears to be the greatest ever reported for any area before the introduction of control measures. Although very few P. vivax were found on stained slides, results of the indirect immunofluorescence test indicated that this species was probably as prevalent as P. malariae; the absence of P. falciparum was supported by results of serologic tests. Possible reasons for this focus of malaria with no P. falciparum are discussed.

Fluorescent Antibody Technique↗
PubMed1979

[Serodiagnosis of malaria. Plasmodium berghei and P. falciparum as antigen for the indirect immune of fluorescence test (author's transl)].

Serum samples of malaria patients were investigated by the IIFT with P. berghei antigen (from mice) and P. falciparum antigen (from in vitro cultures). Both antigens were useful principally and produced approximately identical results. P. falciparum antigen produced mostly higher titres than P. berghei antigen. In cases of lack of homologous malaria antigen it can be suitable to use an antibody-free P. berghei antigen for the IIFT, especially in cases of epidemiological studies. For the individual clinical diagnosis titres of 1:64 are significant.

Animals↗
PubMed1977

Morphologic variants of Anopheles albimanus and susceptibility to Plasmodium vivax and P. falciparum.

Three morphologically different, true-breeding phenotypes have been isolated from a strain of Anopheles albimanus from Lake Apastepeque, El Salvador. Studies with coindigenous strains of Plasmodium vivax and P. falciparum show that these phenotypes differ significantly in their susceptibility to malaria parasites. This difference is apparent both in the number of mosquitoes that become infected and the level of infection obtained. Variations in malaria susceptibility are markedly greater with P. vivax than with P. falciparum. The significance of genetic variants within a local vector population with respect to the epidemiology of malaria is discussed.

Animals↗
PubMedDate not supplied

[The reaction of hyperbasophilic mononucleated cells during P. falciparum malaria; its role in the immune response].

In 34 patients with a primary attack of P. falciparum malaria, hyperbasophilic mononucleated cells (atypical lymphocytes) were found 22 times. These cells appeared around the 3rd or 4th day of fever and represented 4 to 10% of all white blood cells in 14 cases, 10 to 15% in 6 cases, and 15 to 21% in 2 cases. Their transitory appearance seems to reflect the involvement of cell-mediated immunity, and more specifically of K cell-related cytotoxicity.

Cell Count↗
PubMed1975

Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment.

Chloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine. During this time the monthly attack rate for P. falciparum rose four-fold to an average of nearly 18% per month, while that of P. vivax remained relatively constant at about 8%. Eight in vivo chloroquine resistance studies, which allowed both detection of late recrudescing R-I resistance and estimation of the risk of reinfection, showed an apparent rise in the drug resistance rate, from 12% to 20% prior to the study to the range of 40-50%. Virtually all resistance encountered was R-I in nature. There was no convincing evidence of chloroquine resistance among 148 tested P. vivax infections.

Blood↗