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Results for “Oxyclozanide”

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At least 19 recordsLinked to original sources
PubMed1976

[Effectiveness of oxyclozanide in cattle naturally invaded by Liorchis scotiae trematoda].

The paper reports on the results of the clinical tests for the effectiveness of oxyclozanide pure substance (produced by ICI, U.K.) in cattle naturally invaded by the paramphistomata Liorchis scotiae. Helminthological dissection, performed 21 days after a single application of 15 mg oxyclozanide per 1 kg 1. w., revealed 87.5% intenseffectiveness on sexually mature paramphistomata on 85% intenseffectiveness on juvenile paramphistomata. The extenseffectiveness of the chemical was equal to zero. The coprological examinations performed for the three weeks in one-week intervals after therapy showed a decline in the number of produced eggs. The animals were given the medicated feed containing oxyclozanide only after preceding starvation. The chemical did not produce any unfavourable side effects or signs.

Animals↗
PubMed1985

Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide.

The effects of liver fluke infection (Fasciola hepatica) on hepatic microsomal UDP-glucuronosyl-transferase activity have been studied in microsomes from experimentally infected rats and naturally infected cattle to see if they explain the toxic episodes observed in parasite-infected animals subjected to intensive chemotherapy with the flukicidal drug oxyclozanide. Dramatic decreases in the activity of this enzyme system with the typical substrate p-nitrophenol were observed in both animal species, even when little or no degenerative lesions could be seen in the liver parenchyma. In vitro there was a similar loss of glucuronic acid conjugation of oxyclozanide by hepatic microsomes from infected cattle. In vivo this would result in slower elimination of the drug and in drug accumulation.

Animals↗
PubMed2000

LC assay method for oxfendazole and oxyclozanide in pharmaceutical preparation.

A method has been developed for the simultaneous determination of oxfendazole and oxyclozanide in a pharmaceutical preparation. The method involves reversed phase chromatography with isocratic elution of the mobile phase and detection at 300 nm. The range of quantification for oxfendazole and oxyclozanide was found to be 2-7 microg ml(-1) and 3-10 microg ml(-1), respectively. The validity of the method was evaluated in terms of linear regression analysis, precision, specificity and accuracy.

Antiplatyhelmintic Agents↗
PubMed1979

[Effectiveness of levamisole and oxyclozanide in paramphistomiasis in sheep and cattle].

The antiparasitic effectiveness of Levamizole and Oxyclozamide in the control of paramphistomatosis in sheep and cattle was studied. Experiments were performed in the 1975--1978 period with 1880 sheep and 132 cattle naturally invaded by P. microbothrium. The two drugs were administered orally in the following doses: Levamizole -- 7.5 mg/kg, Oxyclozanide -- 15 mg/kg for sheep and 10 mg/kg for cattle. A part of the experimental animals were treated by the combined drug Nilzan and received the above mentioned doses of both chemico-therapeutic means. Results were scored by ovoscopic investigation on the 10th and 15th day post treatment and by helminthological investigation on a part of the animals. Egg deposition was followed on 1415 sheep in the course of 4 months. A comparatively low effectiveness of Levamizole was established, namely U = 15--50%, IU = 81.56--99.40% and a good effectiveness of Oxyclozanide application, namely -- U = 30--80%, IU = 73.94-- 99.40% for sheep, and U = 0--50%, IU = 74.84--89.97% for cattle. Highest effectiveness was observed following the application of the combined drug Nilzan -- U = 47.7--92.0%, IU = 89.07--99.98% for sheep, and U = 20--73.20%, IU = 99.32--99.96% for cattle. The enhanced effectiveness of Nilzan application is considered by the authors as a result of synergism of the two chemico-therapeutic means.

Animals↗
PubMed1974

Uncoupling activity of the anthelmintic oxyclozanide in rodents.

The uncoupling activity of oxyclozanide in warm blooded animals has been studied in whole animals, isolated tissue in vitro and on mitochondrial preparations. The onset of post mortem rigidity in mice and rats is accelerated and a contracture of striated muscle is produced. Oxyclozanide (1 muM) stimulated rat liver mitochondrial respiration and stimulated an ATP-ase activity.

Adenosine Triphosphatases↗
PubMed1981

Studies of the effect of diamphenethide and oxyclozanide on the metabolism of Fasciola hepatica.

Studies were made of the effects of diamphenethide-amine on glucose transport, glycogen breakdown, adenine nucleotides, metabolites and excretory products in both parenchymal and bile duct flukes in vitro and in bile duct flukes in vivo. The most consistent and pronounced effect observed was an elevation of malate levels. There appeared to be no differences between responses of parenchymal and of bile duct flukes to diamphenethide-amine. For comparative purposes the effect of oxydozanide was assessed on most of these parameters in bile duct flukes in vitro. Not all the changes caused by oxyclozanide were characteristic of an uncoupler; however, the pattern of changes in the metabolites was markedly different from that caused by diamphenethide-amine.

Acetanilides↗
PubMed2002

Spectrophotometric multicomponent resolution of a veterinary formulation containing oxfendazole and oxyclozanide by multivariate calibration-prediction techniques.

Four multivariate calibration-prediction techniques, classical least-squares, inverse least-squares, principal component regression and partial least-squares regression were applied to the spectrophotometric multicomponent analysis of a veterinary formulation containing oxfendazole (OXF) and oxyclozanide (OXC) without any separation step. The multivariate calibrations were constructed by measuring the absorbance values at 14 points in the 285-350 nm wavelength range and by using the training set of standard mixtures containing OXF and OXC in the different compositions. The validity of building multivariate calibrations was checked by using the synthetic mixtures of both drugs. The multivariate calibration models were successfully applied to the spectrophotometric determination of OXF and OXC in laboratory prepared mixtures and a veterinary formulation. The results obtained were statistically compared with each other.

Algorithms↗
PubMed2006

[Concentration in plasma and excretion in milk of lactating cows after oral administration of tribromsalan, oxyclozanide and bromofenofos].

The fasciolicides tribromsalan (TBS), oxyclozanide (OCZ) and bromofenofos (BFF) were orally administered to three lactating cows. The concentrations of TBS, OCZ and the BFF metabolite dephosphate bromofenofos (DBFF) in plasma, and the excretion of these compounds in milk were determined by high-performance liquid chromatography. In plasma, the concentrations of TBS, OCZ and DBFF reached maximum at about 1.0 day and the compounds remained detectable until 5.7, 7.4 and 15.1 days after administration, respectively. The detection limits of these compounds in plasma were 10, 2 and 2 ppb, respectively. In milk, the concentrations of TBS, OCZ and DBFF reached maximum at about 24 hours and the compounds remained detectable until 30-47, 30-47 and 78-119 hours after administration, respectively. The detection limits of these compounds in milk were 5.1 and 1 ppb, respectively. The residence times of TBS and BFF were very close to the withdrawal times of the fasciolicides.

Administration, Oral↗