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At least 19 recordsLinked to original sources
PubMed2003

Arthroscopic removal of a loose body osteophyte fragment after superior patellar dislocation with locked osteophytes.

The authors report the case of a loose body from a fractured osteophyte after a superiorly dislocated patella with locked osteophytes. Few cases of superiorly dislocated patellae have been reported in the literature and no cases of osteophyte fracture fragments after locked osteophytes with subsequent arthroscopic loose body removal have been reported. The loose body was removed and the distal pole of the patella was debrided arthroscopically. This patient and the majority of previously reported cases, herein reviewed, had patella alta with pre-existing patellofemoral arthrosis. Patella alta in the face of patellofemoral arthrosis should be considered a risk factor for loose body formation. Therefore, recurrent superior patellar dislocation and locking osteophytes may be a relative indication for pre-emptive arthroscopic debridement of locked osteophytes.

Arthroscopy↗
PubMed1993

Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation?

Osteoarthritis is characterized by focal cartilage destruction and marked formation of osteophytes. We have investigated the possible relationship between site specific occurrence of cartilage damage and osteophytes in the collagenase induced murine osteoarthritis model. The degree of instability of the joint correlated with the amount of cartilage loss. Moreover, cartilage damage in the medial tibial plateau correlated only strongly with the osteophyte at the medial plateau, whereas a similar, site directed trend was noted for lateral damage and lateral osteophytes. A separate study with intraarticular injection of TGF beta 1 in normal murine knee joints revealed that this factor can induce osteophytes at characteristic sites, suggesting a role of endogenous TGF beta in this phenomenon.

Animals↗
PubMed2001

Central osteophytes in the knee: prevalence and association with cartilage defects on MR imaging.

OBJECTIVE: The objective of this study was to determine the prevalence and location of central osteophytes in patients referred for MR imaging of the knee and the relationship of central osteophytes to articular cartilage defects, marginal osteophytes, meniscal tears, and anterior cruciate ligament tears as seen on MR imaging. MATERIALS AND METHODS: Two hundred consecutive patients referred for MR imaging of the knee were evaluated for central osteophytes, articular cartilage defects, marginal osteophytes, meniscal tears, and anterior cruciate ligament tears. A 1.5-T scanner was used, and assessments were made by consensus of two experienced musculoskeletal radiologists. Seven patients were excluded, leaving 193 patients in the study population. RESULTS: The prevalence of central osteophytes in the knee was 15% (35 central osteophytes in 29 patients). Patients with central osteophytes were older (mean age, 52 years versus 38 years), weighed more (mean weight, 204 lb [92 kg] versus 174 lb [78 kg]), had more articular cartilage defects (mean, 4.3 versus 1.3), and had more marginal osteophytes (mean, 3.9 versus 1.1) than patients without central osteophytes (p < 0.0001, Student's t test). Patients with central osteophytes were more likely to have a meniscal tear (p = 0.004, chi-square test), but they were not more likely to have an anterior cruciate ligament tear. All central osteophytes were associated with articular cartilage defects at the same location, which were full or near-full thickness on MR imaging for 32 of 35 central osteophytes. CONCLUSION: Central osteophytes are common in patients referred for MR imaging of the knee. When central osteophytes are seen in the knee there is a high likelihood of an associated full thickness or near-full thickness articular cartilage defect.

Adult↗
PubMed2003

Topographical and histological examination of osteophytes taken from arthrotic femoral heads.

Until now it is not known whether osteophytes of the femoral head develop because of pathological joint alterations or arise from normal remodeling processes secondary to osteoarthrosis. Firstly, we analysed the topographical localization of osteophytes. We then compared the extracellular matrix components of macroscopically normal cartilage from the margin of osteophytes with osteophytic cartilage from weight bearing and non-weight bearing zones by histochemical staining of low and heavily sulfated glycosaminoglycans. For examination 65 femoral heads were taken during endoprosthetic hip surgery. Osteophytes from different locations and macroscopically normal cartilage from the margin of osteophytes were excised, decalcified and embedded in paraplast. A lateral or medial localization of osteophytes (47 cases) was more common than a ventral or dorsal position (18 cases). Histochemical staining for low and heavily sulfated glycosaminoglycans from normal cartilage at the rim of osteophytes was stronger in the unmineralized cartilaginous zones compared to the mineralized cartilaginous zone. Weight bearing zones of osteophytic cartilage, on the other hand, showed an even distribution of the two differently sulfated glycosaminoglycans. Surprisingly, non-weight bearing zones of osteophytic cartilage showed a weaker staining for low and especially for heavily sulfated glycosaminoglycans in the superficial cartilage layer than in the deep cartilage layer. Altogether, osteophytic cartilage can be regarded as a reparative phenomenon for two reasons: Firstly, osteophytes arise very often at the weight bearing lateral and medial femoral head. Secondly, despite local differences in osteophytic cartilage, the same types of glycosaminoglycans are synthesized as in normal cartilage at the margin of osteophytes.

Aged↗
PubMed2002

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study.

OBJECTIVES: To examine the size and direction of osteophyte in knee osteoarthritis (OA) and to determine associations between osteophyte size and other radiographic features. METHODS: Knee radiographs (standing extended anteroposterior and 30 degrees flexion skyline views) were examined from 204 patients referred to hospital with symptomatic knee OA (155 women, 49 men; mean age 70, range 34-91 years). A single observer assessed films for osteophyte size and direction at eight sites; narrowing in each compartment; varus/valgus angulation; patellofemoral subluxation; attrition; and chondrocalcinosis using a standard atlas, direct measurement, or visual assessment. For analysis, one OA knee was selected at random from each subject. RESULTS: Osteophyte direction at the eight sites was divisible into five categories. At all sites, except for the lateral tibial plateau and the medial patella, osteophyte direction varied according to (a) the size of osteophyte and (b) the degree of local narrowing. At the medial femur, medial tibia, and lateral femur osteophyte direction changed from being predominantly horizontal to predominantly vertical with increasing size. The size of osteophyte correlated positively with the severity of local narrowing, except for the medial patellofemoral compartment where osteophyte size correlated positively with the severity of narrowing in the medial tibiofemoral compartment. Logistic regression analysis showed that osteophyte size was associated not only with local narrowing but also with local malalignment and bone attrition, and that chondrocalcinosis was positively associated with osteophyte size at multiple sites. CONCLUSION: In patients referred to hospital with knee OA different patterns of osteophyte direction are discernible. Osteophyte size is associated with local compartmental narrowing but also local alignment and attrition. Chondrocalcinosis is associated with osteophytosis throughout the joint. These data suggest that both local biomechanical and constitutional factors influence the size and direction of osteophyte formation in knee OA.

Adult↗
PubMed2003

Lack of association between lumbar disc degeneration and osteophyte formation in elderly japanese women with back pain.

Our study was designed to assess the contributions of the physical and constitutional factors to osteophyte formation, disc degeneration, and bone mineral density (BMD) in lumbar vertebrae of elderly postmenopausal women. A total of 126 Japanese women with back pain, aged over 60 years, were invited to participate in the study. Then 80 subjects with a full set of data for physical examinations, radiographs, MRI, and DXA were examined. TaqI polymorphism of vitamin D receptor (VDR) gene was examined in 60 subjects. Prevalence rates of osteophytes (on radiographs) and disc degeneration (on MRI) were 61 and 68%, respectively. Body weight and BMI correlated significantly with anteroposterior (AP) and lateral (LAT) BMD (r = 0.354 for weight, r = 0.347 for BMI) and mean osteophyte area (r = 0.557 for weight, r = 0.486 for BMI), and body weight also correlated with number of discs with osteophytes. However, these did not correlate with the disc area or the number of degenerated discs. Stepwise regression analysis revealed that body weight and LAT-BMD values independently related to the osteophyte area. Disc area (r = 0.386 for AP view) and osteophyte area (r = 0.384 for AP view) significantly correlated with BMD. However, disc area and osteophyte area did not correlate with each other (r = 0.056). The proportion of degenerated discs was higher in the lower lumbar discs, but not the proportion of discs with osteophytes. Frequencies of T and t alleles of VDR did not correlate with disc degeneration, osteophyte formation, or osteoporosis. Our data showed that increases in osteophyte formation and BMD in the lumbar vertebrae are influenced by body weight and BMI, but did not correlate with disc area, which correlated inversely with BMD. Disc degeneration and osteophyte formation seem to represent two different factors that affect lumbar spine in elderly women.

Aged↗
PubMed1994

[Osteophyte formation in the knee joint: a radiological study].

Reported here are the results of a study on the significance of osteophyte formation in the osteoarthritic knee joint. The osteophyte formation was examined in a total of 795 cases involving 1040 joints. Of these, 415 cases (660 joints) had no symptoms of osteoarthritis of the knee joint (Group A); while the other 380 (380 joints) had primary osteoarthritis of the knee joint (Group B). The osteophyte location and osteophyte length were determined in all cases of Group A and Group B. The rate of annual increase in osteophyte length was determined in 224 cases (369 joints) of Group A (average study period: 7.1 years) and in 122 cases (122 joints) of Group B (average study period: 7.5 years). A special measuring unit called the "spur index" was devised for the present study to determine a corrected measurement of the osteophyte length; 1 spur index unit corresponded to 1/100 of the width of the proximal tibial articular surface. By using this spur index, measurements could be corrected for the magnifying effect of X-ray photography and for variations in the size of knee joints. On the assumption that age, obesity, arteriolosclerosis and femorotibial angle were factors that promoted the progression of osteoarthritis in the knee joint, the correlation between the osteophyte length and each of these factors was investigated. A significant difference in osteophyte length, and in the annual increase in osteophyte length, was found between Group A and Group B, but no difference between them with regard to osteophyte location. A significant correlation was found between the osteophyte formation and each of the above-mentioned factors. The correlation was strongest with the femorotibial angle followed by age, arteriolosclerosis and obesity, in that order.

Adult↗
PubMed1996

The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee.

The aim of this study was to investigate the relationship between location and size of osteophytes and cartilage loss in an instability-induced experimental model for osteoarthritis. Osteoarthritis was induced in murine knee joints by injection of highly purified bacterial collagenase, causing joint instability. The size of the osteophytes and the cartilage loss were measured at different locations in the joint using image analysis on histological sections of total kees. Cartilage damage did not occur without osteophytes. Osteophytes were located on both medial and lateral sides, independent of the location of cartilage damage, but the size of the osteophytes was related to the amount of cartilage damage on the corresponding side. Cartilage loss on the lateral tibial plateau correlated well with the size of lateral osteophytes, in particular with the osteophyte at the margin of the lateral tibial plateau. Cartilage loss on the medial tibial plateau appeared to have a good correlation with the size of medial osteophytes, which was most pronounced for the osteophyte on the medial margin of the tibial plateau. This side-specific correlation between cartilage damage and osteophyte formation suggests compartmentalization of the osteoarthritic process.

Animals↗
PubMed2000

Growth factor expression in the osteophytes of the human femoral head in osteoarthritis.

Osteoarthritis is characterized by marked osteophyte formation consisting of new cartilage and bone. Because several growth factors are known to be involved in chondrogenesis and osteogenesis, the expression of transforming growth factor-beta 1 and basic fibroblast growth factor in the osteophytes of the human femoral heads in osteoarthritis were examined. Transforming growth factor-beta 1 messenger ribonucleic acid was detected in the osteophytes by reverse transcription-polymerase chain reaction. All of the nine examined osteophytes expressed transforming growth factor-beta 1 messenger ribonucleic acid, whereas one of four osteoarthritic femoral heads and none of four osteonecrotic femoral heads expressed transforming growth factor-beta 1 messenger ribonucleic acid. The extent of transforming growth factor-beta 1 messenger ribonucleic acid expression varied among the osteophytes. Transforming growth factor-beta 1 or basic fibroblast growth factor was analyzed in osteophytes immunohistochemically. Transforming growth factor-beta 1 was localized in the superficial cells in the osteophyte cartilage, but it was scarcely detected in the superficial cells in the degenerative articular cartilage. Basic fibroblast growth factor was detected in the cells in the whole layer of osteophyte cartilage and in the articular cartilage. There was a difference in the localization, which suggests the different roles of transforming growth factor-beta 1 and basic fibroblast growth factor in bone and cartilage metabolism in osteophyte formation.

Fibroblast Growth Factor 2↗
PubMed1998

Morphologic study of lumbar vertebral osteophytes.

BACKGROUND: Vertebral osteophytes are one of the principal radiographic diagnostic criteria for degenerative change in the lumbar spine. These osteophytes have been previously classified by morphologic features into two groups, the "traction spur" and the "claw spur." It has been stated that the traction spur is a sign of spinal instability. METHODS: Lumbar spines from 20 cadavers provided 120 vertebrae from T-11 to L-5 and 240 vertebral rims for study. The presence of osteophytes was determined by measurement with digital calipers. The type of osteophyte was then determined visually, using the Macnab classification. RESULTS: Sixty vertebral rims were found to have significant osteophytes. Twenty-four vertebral rims had osteophytes of the claw type only, and 11 had osteophytes of the traction type only. Of the eight vertebrae with traction osteophytes alone and with the adjacent vertebra available for study, none had such a corresponding osteophyte. CONCLUSION: Traction spurs and claw spurs frequently coexist on the same vertebral rim. This suggests that they may result from the same degenerative process and do not necessarily reflect the results of two distinct pathologic processes.

Humans↗
PubMed2001

The effect of anterior osteophytes and flexural position on thoracic trabecular strain.

STUDY DESIGN: Compressive and shear trabecular strains were evaluated using six cadaveric thoracic spines that included anterior osteophytes. The treatments were divided into three groups: 1) osteophytes intact and the specimen in the neutral position, 2) osteophytes removed and the specimen in the neutral position, and 3) osteophytes removed and the specimen with 5 degrees of additional flexion. OBJECTIVES: To investigate the influence of osteophytes and flexural position on vertebral trabecular strain during axial compression. SUMMARY OF BACKGROUND DATA: In the thoracic spine, the incidence of anterior wedge fractures increases with the severity of kyphosis. It is unclear whether the role of anterior osteophytes in the thoracic spine is to restrict progressive kyphosis, conduct axial load anteriorly, or both. METHODS: Thoracic motion segments, T10-T12, were axially loaded in compression, and the minimum principal and maximum shear strains were measured using texture correlation. RESULTS: No dramatic changes were found in the spatial distribution of the strains following removal of the anterior osteophytes. Conversely, after removal of the osteophytes and orienting the specimen in 5 degrees of additional flexion, the strain distribution shifted anteriorly and the magnitude increased. CONCLUSIONS: This study demonstrated that osteophytes seem to restrict progressive kyphosis rather than conduct axial load anteriorly.

Aged↗
PubMed2002

Extraforaminal entrapment of the fifth lumbar spinal nerve by osteophytes of the lumbosacral spine: anatomic study and a report of four cases.

STUDY DESIGN: An anatomic study of the associations between the fifth lumbar spinal nerve (L5 spinal nerve) and a lumbosacral tunnel, consisting of the fifth lumbar vertebral body (L5 vertebral body), the lumbosacral ligament, and sacral ala, and clinical case reports of four patients with lumbar radiculopathy secondary to entrapment of the L5 spinal nerve in the lumbosacral tunnel. OBJECTIVES: To delineate the anatomic, clinical, and radiologic features and surgical outcome of patients with entrapment of the L5 spinal nerve in the lumbosacral tunnel. SUMMARY OF BACKGROUND DATA: Although several cadaveric studies on a lumbosacral tunnel as a possible cause of L5 radiculopathy have been reported, few studies had focused on osteophytes of the L5-S1 vertebral bodies as the major component of this compressive lesion, and clinical reports on patients with this disease have been rare. METHODS: Lumbosacral spines from 29 geriatric cadavers were examined with special attention to the associations between osteophytes of the L5-S1 vertebral bodies and the L5 spinal nerve. Four patients with a diagnosis of the entrapment of the L5 spinal nerve by osteophytes at the lumbosacral tunnel were treated surgically, and their clinical manifestations and surgical results were reviewed retrospectively. RESULTS: The anatomic study demonstrated osteophytes of the L5-S1 vertebral bodies in seven of the 29 cadavers. Entrapment of the L5 spinal nerve in the lumbosacral tunnel was observed in six of the seven cadavers with L5-S1 osteophytes but in only one of the 22 cadavers without such osteophytes (P < 0.05, chi2 test). All four patients had neurologic deficits in the L5 nerve root distribution. MRI and myelography showed no abnormal findings in the spinal canal, but CAT scans demonstrated prominent osteophytes on the lateral margins of L5-S1 vertebral bodies in all four. Selective L5 nerve block completely relieved all patients of pain but only temporarily. Three patients were treated via a posterior approach by resecting the sacral ala along the L5 spinal nerve, and the other patient was treated by laparoscopic anterior resection of the osteophytes. Pain relief was obtained in the four patients immediately after surgery, but one patient experienced recurrence of pain 1 year after the first surgery and was successfully treated by additional posterior decompression and fusion. CONCLUSIONS: Extraforaminal entrapment of L5 spinal nerve in the lumbosacral tunnel can cause L5 radiculopathy, and osteophytes of L5-S1 vertebral bodies are a major cause of the entrapment.

Aged↗
PubMed2000

Cervical osteophytes impinging on the pharynx: importance of size and concurrent disorders for development of aspiration.

OBJECTIVE: This study evaluated the clinical significance of cervical osteophytes impinging on the pharynx in patients with dysphagia and the importance of concurrent disorders that may affect swallowing function. MATERIALS AND METHODS: On videofluoroscopy, anterior cervical osteophytes were found in 55 (32 men, 23 women; mean age, 69 years) of 3318 patients with dysphagia (1.7%). Coexisting diseases that affected swallowing function were found in 28 patients (stroke, n = 7; thyroidectomy, n = 7; tongue base or laryngeal cancer surgery, n = 5; other diseases, n = 9). Swallowing function was assessed with videofluoroscopy evaluating epiglottic tilting, laryngeal closure, impression of the hypopharynx, pharyngeal residue, and aspiration. RESULTS: With advancing age, the probability of aspiration (odds ratio, 1.07; p < 0.05) and of enlarging osteophytes (odds ratio, 1.26; p < 0.01) increased; the probability was higher for osteophytes at more than one vertebrae (odds ratio, 8.00; p < 0.01) and for concurrent diseases (odds ratio, 8.02; p < 0.01). Aspiration was found in 75% of patients with osteophytes larger than 10 mm and in 34% with osteophytes smaller than or equal to 10 mm. In 88% of patients with small osteophytes who aspirated, other diseases affected swallowing function. CONCLUSION: Aspiration is common in patients with dysphagia and cervical osteophytes larger than 10 mm. Aspiration is rare in patients with osteophytes smaller than or equal to 10 mm unless these patients suffer from other disorders that may affect swallowing.

Cervical Vertebrae↗
PubMedDate not supplied

Management of respiratory compromise caused by cervical osteophytes: a case report and review of the literature.

BACKGROUND CONTEXT: Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition in the aging spine. DISH is associated with large anterior osteophytes of the cervical spine, which can cause complications by compressing adjoining structures. Dysphagia is reported in up to 28% of patients, but respiratory compromise is rare. There have been no published recommendations for treatment. PURPOSE: To report that resection of cervical osteophytes, without cervical fusion, can be successful in the treatment of severe respiratory distress. STUDY DESIGN: This report describes the management of a patient with DISH and severe respiratory distress resulting from large anterior cervical osteophytes. METHODS: A team approach was used with collaboration between the orthopedic spine surgeons and the otolaryngologists. RESULTS: This patient was found to have compression of her posterior pharyngeal wall by the osteophytes. Tracheostomy was required for the management of the airway. The patient was dependent on the tracheostomy until the osteophytes were resected. The patient was then able to breathe normally. Treatment recommendations were developed based on this case of osteophyte-induced respiratory compromise as well as the previously published accounts of osteophyte-induced dysphagia. CONCLUSIONS: Airway obstruction resulting from DISH can be treated according to the same principles as dysphagia resulting from DISH: surgical excision of osteophytes if conservative support fails.

Airway Obstruction↗
PubMed1998

Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the patellofemoral joint.

OBJECTIVE: To assess the correlation between radiographically diagnosed osteophytes in the axial and lateral view of the patellofemoral joint (PFJ) and (1) magnetic resonance (MR) detected cartilage defects in the same joint and (2) knee pain. METHODS: Fifty-seven people with chronic knee pain, (aged 41-58 years, mean 50 years) were examined with axial and lateral radiograms when standing of the right and the left PFJ. The presence and grade of osteophytes was assessed. On the same day, a MR examination was performed of the signal knee with proton density and T2 weighted turbo spin-echo sequences in the sagittal and axial view on a 1.0 T imager. Cartilage defects in the PFJ were noted. The subjects were questioned for current knee pain for each knee. RESULTS: Osteophytes at the PFJ had a specificity varying between 59 and 100% and a positive predictive value between 74 and 100% for MR detected cartilage defects. The corresponding values for osteophytes at the lateral aspect of the femoral trochlea were both 100%. In PFJ with narrowing (< 5 mm) osteophytes had a sensitivity and a positive predictive value of 90 and 95% respectively for MR detected cartilage defects, while in PFJ with non-narrowing (> or = 5 mm) the corresponding values were 75 and 65% and the specificity was 50%. A correlation (p < 0.05) between osteophytes at the inferior pole of the patella and knee pain was found. CONCLUSIONS: Osteophytes at the PFJ are associated with MR detected cartilage defects in the same joint. The relation was strong for osteophytes at the lateral femoral trochlea and in the PFJ with narrowing (< 5 mm), but weak in the PFJ with non-narrowing (> or = 5 mm).

Adult↗
PubMed1990

The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men.

To evaluate the influence of extravertebral calcification on spinal bone density determinations, we measured lumbar vertebral density in 71 hospitalized and 58 normal men using dual photon absorptiometry. The extent of vascular and osteophytic calcification was graded from lateral lumbar radiographs. Fifty-five (43%) of the subjects had identifiable osteophytes, and 86 (67%) had vascular calcifications. Despite similar ages and weights in subjects with and without ostephytes, those with osteophytes had greater spinal density (1.34 vs. 1.17 g/cm2; P less than 0.001), and there was a strong correlation between osteophyte severity and spinal density (r = 0.41; P less than 0.00001). Proximal femoral density was not different in those with and without osteophytes. The distribution of osteophytes in this population was not random, and as a result, the presence of osteophytes obscured the the relationship of bone density to age as well as the comparison of hospitalized to normal men. Vascular calcification had a minimal effect on vertebral density. In summary, osteophytic calcification exerted an important influence on the measurement of spinal bone density in men. This effect should be considered in both clinical and research applications of integral vertebral density measures.

Absorptiometry, Photon↗
PubMed1989

Bone remodeling and osteophyte formation after remission of rheumatoid arthritis.

Bone remodeling and osteophyte formation rarely take place in active rheumatoid arthritis (RA). To determine if disease inactivation leads to their occurrence, we studied 38 patients with RA whose disease had gone into drug induced remission. We looked for osteophytes at the metacarpophalangeal (MCP) joints in roentgenograms taken before and after remission, and correlated their presence to that of osteoarthritis of the distal interphalangeal (DIP) joints. There were 21 patients with RA who had a median of 3 (range 1-8) osteophytes in their "remission" films which were rarely present in their "activity" films (p less than 0.0001). The osteophytes were frequently symmetrical and most often located (41%) at the third MCP joint. In addition, we observed a peculiar remodeling of the styloid process in 13 patients, 9 of whom had developed MCP joint osteophytes. There were no other detectable differences between patients who had MCP joint osteophytes and those who did not. Presence of osteoarthritis at the DIP joints did not correlate with development of osteophytes. We were able to classify the MCP osteophytes into 3 types on the basis of their shape: hook-like that were most frequently bilateral and situated on the radial aspect of the metacarpal side of the joint, beak-like that were most often found at the ulnar aspect of the phalangeal side, and nipple-like which occurred equally on either sites. These differences in distribution indicate that they are not stages of the same process. Our findings indicate that paraarticular bone remodeling occurs upon remission of RA, even in joints where osteoarthritis is unusual. Its shape and location may depend on both their site and the mechanism of joint damage.

Adult↗
PubMed1980

[Aging process of the acetabulum with special reference to the osteophyte formation (author's transl)].

Osteophyte formation at the acetabulum was investigated in connection with aging and osteoarthritis. The materials consisted of 39 specimens of the acetabula obtained from fresh cadavers ranging from 14 to 89 years of age. Of those two of the specimens were in the second decade, two in the third, and others were over 40. Osteophyte appeared at three parts of the acetabula; the peripheral part, the foveal area and the lower portion at the ligamentous attachment. Two types of the peripheral osteophytes were distinguished from their growth direction, and in some sections both types were observed together. Foveal osteophytes were recognized at the rim of the semilunar cartilage in the advanced age group and a double acetabular floor was formed by both the osteophytic projection and the existing foveal trabeculae. In some cases there were small osteophytes formed in the ligamentous tissue at the lower ends of the acetabula. As distribution and growth of the osteophytes in the aging process were in accord with those in osteoarthritis, it would be reasonable to assume that the osteophyte formation in aging might be one of the initial changes of the development of osteoarthritis.

Acetabulum↗