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Results for “Organomercury Compounds”

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At least 19 recordsLinked to original sources
PubMed1989

Hepatobiliary transport of the anionic organomercury compound (mersalyl) is carrier mediated.

The hepatobiliary excretion of the anionic organic mercury compound (mersalyl) was studied in the isolated perfused rat liver and in isolated rat liver plasma membrane vesicles. In the isolated perfused liver, mersalyl is immediately taken up from the perfusion medium and concentratively excreted into bile. Uptake is characterized by saturation kinetics (S)0.5 = 20 microM, Vmax = 117 nmoles/min/g liver, cooperatively of mersalyl binding sites, stimulation by extracellular sodium and temperature dependence. Uptake of mersalyl into basolateral membrane vesicles also exhibits characteristics of a carrier mediated transport: saturation kinetics (S)0.5 = 28 microM, Vmax = 1.6 nmoles/min/mg protein, dependence on extravesicular sodium, cooperativity of mersalyl binding sites, temperature dependence and transstimulation by intravesicular non-radioactive mersalyl. Uptake was inhibited by alpha-naphthylacetic acid and mercapto group reagents, indicating involvement of mercapto groups on the carrier and a binding site for carboxylic anions. Data from the isolated perfused liver and from isolated basolateral vesicles indicate that mersalyl uptake into the liver is carrier mediated. Uptake mechanism and driving forces appear analogous to those for the uptake of chemically related compounds such as taurocholic acid. Therefore it is speculated that mersalyl may be transported by carrier molecules which apparently accept numerous chemically unrelated compounds.

Animals↗
PubMed1975

Solvent extraction of organomercury compounds with quaternary amines.

Methylmercuric chloride and phenylmercuric acetate extract very efficiently with quaternary amines dissolved in diethylbenzene or other simple solvents. The extraction is effective from either alkaline or acidic solution. The technique considerably extends the scope of conventional solvent extraction practice to permit the extraction and concentration of total mercury in environmental and biological matrices.

Amines↗
PubMed1986

Radiolabeling with organomercury compounds: Part 2. High specific activity synthesis of iodine-125 and iodine-131-6-iodocholest-5-en-3 beta-ol and its tissue distribution in rats.

Iodine-125 (125I) and iodine-131- (131I) 6-iodocholest-5-en-3 beta-ol has been prepared directly from 6-chloromercuricholest-5-en-3 beta-ol and [125I] or [131I]sodium iodide. This method produces material of "no-carrier-added" specific activity and excellent radiochemical purity. The entire procedure is complete in 10 min and can be carried out in 95% ethanol. The biodistribution of this new high specific activity form of [131I]-6-iodocholest-5-en-3 beta-ol has been measured in rats and found to be very similar to that found for low specific activity [131I]-6-iodocholest-5-en-3 beta-ol produced by exchange labeling. The whole-body elimination curve over a 4-day period was measured and a dependence between the rate of elimination and specific activity was detected. Products of three different specific activities in addition to "no-carrier-added" material were studied.

Animals↗