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At least 19 recordsLinked to original sources
PubMedDate not supplied

[Effect of D,L-malic acid dibenzylhydrazide on changes in the antioxidizing activity of lipids and monoamine oxidase activity in mouse organs].

Administration of dibenzylhydracide of D,L-malic acid (inhibitor of monoamine oxidase) into animals caused not only inhibition but also transformation of the mitochondrial monoamine oxidase activity, which acquired the property to deaminate histamine. Effect of the monoamine oxidase inhibitor on the antioxidative activity of lipids from mouse liver and brain tissues was studied. Effect of the dose administered and of the period of its action after administration were characterized. Influence of the inhibitor on oxidation of methyloleate was also studied in a model system. The data obtained suggest that the transformation-producing effect of the substance was not related to its immudiate action on the enzyme molecule but was apparently due to its influence on the intensity of lipid peroxidation in membranes.

Animals↗
PubMed1975

[Age differences in the reactivity of the organism after administration of isoprenaline in rats (author's transl)].

To three age groups of animals 2, 6 and 12 months old isoprenaline was administered in amounts of 8 mg/kg body weight. In these rats changes in the weight of some organs after administration of isoprenaline were followed-up. In the oldest group of rats were the myocardial lesions were most severe, the authors found the slightest oedematous response of the myocardium. The oedema of their aorta, on the other hand, was most marked. The weight of the adrenals, contrary to younger groups, did not change in the course of the experiment.

Adaptation, Physiological↗
PubMed1976

Organization and administration of the United States Air Force Dental Service.

The United States Air Force was established as an independent department in 1947 and in 1949 became responsible for its own medical support. In 1951 the dental division was renamed the USAF Dental Service and 432 dental officers were transferred to it from the Army. The dental service now provides a world-wide oral health service from 286 fixed dental centers having a total of over 2200 treatment rooms. The backbone of the service is the general dental practitioner and great stress is laid on the preventive aspects of the service. Eight specialty areas are recognized and in-service training, supplemented by specialist training in civilian institutions provide the trained professional resources required. The facilities for the provision of dental services comprise clinics with multiple treatment rooms for each dentist and adequate space for oral hygienists and support and administrative services. Equipment follows the modern trend towards 4-handed seated practice by the dental team.

Aerospace Medicine↗
PubMed1992

Distribution of tritiated cocaine in selected genital and nongenital organs following administration to male mice.

STUDY OBJECTIVE: To determine the distribution of cocaine administered to male mice in selected extragenital and genital organs and to investigate its possible binding to sperm. DESIGN: Twenty-seven sexually mature virus-free albino male mice were used in various experiments whereby following intravenous injection of tritiated cocaine hydrochloride, radioactivity was determined in several extragenital and genital organs, as well as sperm. RESULTS: Radioactivity was detected in all of the organs that were tested, and the highest concentrations per milligram of tissue were found in the kidney and epididymis. Removal of the sperm from the epididymis significantly reduced the radioactivity of the organ. The spermatozoa that were isolated on glass filters showed a linear correlation vs radioactivity (r = .93). CONCLUSIONS: Radioactivity is distributed to several organs, including the genital tract, and is found in association with sperm after in vivo administration of tritiated cocaine. These results may explain the mechanism underlying a male-mediated teratogenesis, which has been observed in animals that were exposed to cocaine, and they raise a possibility that the spermatozoa may carry cocaine into the oocyte during fertilization.

Animals↗
PubMedDate not supplied

[Functional-morphological state of the digestive organs after administration of dianabol].

In tests set up on rats the effect of methandrostenolone on the external secretion of the liver, fermentative activity of the pancreatic tissue and histological and hisochemical findings subsequent to an investigation of internal organs were studied. Introduction of methandrostenolone led to changes in bilification and to a reduced concentration basic components of the bile, to a distinctly pronounced rise in the level of the trypsin inhibitor and to a depressed activity of trypsin in the pancreatic tissue. It also resulted in a change of histochemical and fermentative indices in the tissue of the liver, spleen and other organs.

Acid Phosphatase↗