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Results for “Nevus, Intradermal”

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At least 19 recordsLinked to original sources
PubMed1990

Lymphatic invasion of nevus cells observed in intradermal nevus.

A pigmented nevus was observed on the medial aspect of the left scapula of a 30-year-old woman. Histologically, the lesion showed the pattern of a typical intradermal nevus, consisting of type A, B and C cells. However, the most characteristic feature of this intradermal nevus was the projection of polypoid masses of nevus cells containing melanin into the lumen of a lymphatic vessel in the upper dermis. To our knowledge, lymphatic invasion in pigmented nevi is rare; this finding is interesting, if we consider the relationship between nevus cells and lymph nodes.

Adult↗
PubMed1987

Giant cerebriform intradermal nevus.

Giant cerebriform intradermal nevus (GCIN) is a form of cutis verticis gyrata and may be associated with a number of systemic diseases. Clinically it manifests itself as a scalp deformity resembling the surface of the brain with cerebriform morphologic characteristics. Degeneration into malignant melanoma has been reported. We herein report 3 cases of GCIN successfully treated by surgical extirpation and scalp flap reconstruction.

Adult↗
PubMed1985

Nevus cells within lymph nodes. Possible metastases from a benign intradermal nevus.

Two axillary lymph nodes from a patient who underwent modified radical mastectomy for carcinoma of the breast showed benign nevus cells in the fibrous capsule and within afferent lymphatics. Subsequently, an intradermal nevus from the area of drainage of the axillary lymph nodes was excised, which showed groups of nevus cells lying within small lymphatic channels. It is postulated that the nevus cells in the lymph node capsule could represent benign metastases from the intradermal nevus.

Adult↗
PubMed2004

Elevated serum antimelanocyte antibody level in cerebriform intradermal nevus with vitiligo.

We describe a rare, but typical case of cerebriform intradermal nevus associated with vitiligo. A 45-year-old man had a patch of alopecia over his vertex scalp for 15 years. The microscopic findings of the biopsy revealed a typical deep-seated intradermal nevus and neuroid differentiation with a few pigments. Three hypopigmented patches developed on the forehead, cheek and index finger five years after the scalp lesion, with loss of both melanocytes and melanins. In addition, no dopa reactions were present. Compared to normal controls, the serum anti-melanocyte antibody level in the patient was elevated as determined by cellular enzyme-linked immunosorbent assay (cellular ELISA). This is the first reported case with elevation of serum antimelanocyte antibody level of cerebriform intradermal nevus with vitiligo. This antibody's presence may be related to the occurrence of the vitiligo in patient with cerebriform intradermal nevus.

Autoantibodies↗
PubMed1994

Malignant melanoma within an intradermal nevus.

We describe a case of malignant "dermal" melanoma that arose within a preexisting intradermal nevus. Clinically, the lesion had recently enlarged. Histologically, two patterns were noted. One was an intradermal nevus in the upper portion of the dermis; the other was a deeper nodule composed of malignant neoplastic cells that extended into the reticular dermis. No melanocytic epidermal junctional activity was noted. Despite careful clinical investigation, no alternative primary source was found. Neoplastic transformation of the intradermal nevus without junctional activity is our proposed interpretation of the lesion's histology. Immunohistochemical stains demonstrated that the deeper dermal neoplastic cells were positive for both HMB-45 and PCNA, whereas the superficial nevoid-appearing cells were negative; these findings support our postulate that this melanoma arose within an intradermal nevus. It is important to distinguish this neoplasm from other diagnostic possibilities, including a metastatic lesion originating from another site.

Aged↗
PubMed2005

An intradermal nevus of the external auditory meatus.

We herein describe a rare case of an intradermal nevus arising in the external auditory meatus. A 36-year-old woman presented with progressive hearing loss on the right ear, and otomicroscopic examination revealed the presence of a large, violaceous, dome-shaped, papillomatous lesion originating from the posterior wall of the external canal of the right ear. Upon excisional biopsy, the tumor was diagnosed as an intradermal nevus. Thus, this is a unique case of intradermal nevus obstructing the external ear canal with the patient presenting with progressive hearing loss. The possibility of a benign nevomelanocytic nevus should not be underestimated when evaluating a lesion obstructing the ear canal, and all melanocytic nevi should be excised instead of biopsied to rule out melanoma.

Adult↗
PubMed1998

Malignant melanoma developing from an intradermal nevus.

A 58-year-old man presented a black nodule with satellites located in the left upper region of the umbilicus. Clinical history and microscopic findings led us to diagnose it as a malignant melanoma developing from an intradermal nevus. Histopathologically, melanoma cells developed upward from the nest of the intradermal nevus and no junctional activity was shown. Cases of malignant melanoma arising from an intradermal nevus have rarely been reported. Moreover, previously reported cases showed melanoma cells beneath the intradermal nevus.

Humans↗
PubMed1994

Paramyxovirus-like inclusions in an intradermal nevus from a healthy woman.

A healthy 52-year-old woman had an intradermal nevus removed from the right preauricular region. Histopathologic examination disclosed intranuclear and intracytoplasmic inclusions in many of the nevus cells. A basal-cell carcinoma, an additional intradermal nevus, and a fibrous papule of the nose were also excised, however, none of these lesions showed histologically similar inclusions within the lesions. Electron microscopic studies showed inclusions that were similar to those observed in cases of subacute sclerosing panencephalitis. Immunoperoxidase and polymerase chain reaction studies for the measles virus were performed, with negative results. The patient remains in good health 2 years after excision of the skin lesions.

Basal Cell Carcinoma↗
PubMed1983

Cerebriform intradermal nevus.

Tumors make up almost 25% of the causes of cutis verticis gyrata. An underlying dermal nevus or neurofibroma is the tumor most often found. Two new cases of cutis verticis gyrata caused by an intradermal nevus cell nevus (cerebriform intradermal nevus) are presented. The importance of early diagnosis and aggressive surgical excision and plastic reconstruction in an attempt to minimize the emotional trauma of the required surgery is stressed. Cerebriform intradermal nevi are a type of large congenital nevi and should be evaluated with this in mind.

Adult↗
PubMed1983

Simultaneous occurrence of intradermal nevus and syringoma.

A 59-year-old white woman presented with two lesions on her face. A clinical diagnosis of intradermal nevus was made and the lesions were excised. In each lesion, histopathologic examination showed an intradermal nevus associated with syringoma. The unusual association of syringoma and intradermal nevus in two lesions forms the basis of this report.

Adenoma↗
PubMed2004

Cutis verticis gyrata secondary to a cerebriform intradermal nevus.

We report the case of a 30-year-old black man with a large mass consisting of longitudinal parallel ridges and furrows on the left parietal region. A small, single, hyperpigmented macule was present at birth and gradually grew and extended over the years. Cutis verticis gyrata was suspected, and an investigation was performed to discharge the possibility of pachydermoperiostosis. However, results of biopsies obtained from 3 different lesional areas showed the same histopathologic features--deep-seated hair follicles and clusters of nevus cells concentrated in the dermis. Cerebriform intradermal nevus is a rare cause of cutis verticis gyrata. Early diagnosis is extremely important to prevent the development of malignant melanoma.

Adult↗
PubMed2004

Intradermal nevus of the external auditory canal: a case report.

The external auditory canal is an uncommon location for the nevi that are common benign tumors of the skin. A papillomatous lesion was detected in the external auditory canal of the patient who was on follow-up for acute otitis externa. The lesion which resembled a nevus was excised and was diagnosed as an intradermal nevus in pathological examination. The clinical and pathological picture of the intradermal nevus of the external auditory canal was discussed.

Diagnosis, Differential↗
PubMed1987

Desmoplastic trichoepithelioma and intradermal nevus: a combined malformation.

We studied 13 desmoplastic trichoepitheliomas associated with intradermal nevi. Ten intradermal nevi were found among 76 new cases of desmoplastic trichoepithelioma (13%); three additional examples of the combined malformation were seen in consultation. Clinically, desmoplastic trichoepithelioma associated with an intradermal nevus was typically a small, firm or hard, sometimes annular, nodule on the face, particularly the cheek, of a relatively young woman. Microscopically, the combined malformation contained narrow strands of basaloid cells and keratinous cysts in a desmoplastic stroma, intimately mixed with intradermal nests of nevocytes. Melanocytic nevi have been associated with epidermal hyperplasia resembling seborrheic keratoses, follicular cysts, trichostasis spinulosa, syringomas, basal cell carcinomas, and hair follicle formation on the soles. The frequency of the occurrence of intradermal nevus with desmoplastic trichoepithelioma and the close anatomic association of the two elements may indicate that this combined malformation is another example of epithelial induction by melanocytic nevi.

Biopsy↗