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At least 19 recordsLinked to original sources
PubMed1992

[Introduction neurodermatitis and urea].

Neurodermatitis is a multiphasic disease, yet despite intensive research, its etiopathogenesis still remains unclear. A large number of immunological and nonimmunological dysfunctions as well as their diverse interplay lead to very different types of manifestation. Consequently, treatment must also be varied and is mainly determined by the clinical picture. External therapy without glucocorticoids is no longer conceivable in acute and subacute dermatological conditions, although attenuated glucocorticoids which have the least amount of side effects should always be used. Improvement in the therapeutic efficacy of hydrocortisone can be achieved by combining it with urea which, depending on the vehicle used, represents one of the most effective penetration promoters for this glucocorticoid. Fighting the symptoms of dry skin and itching are of central importance in the follow-up treatment and prophylaxis of neurodermatitis. Here, urea preparations have been applied with great success. Urea's efficacy in the skin is largely based on its ability to elevate the water-binding capacity of the corneal layer, on its keratoplastic properties, its antipruriginous effect and its proliferation-suppressant action. However, the intensity and the duration of this therapeutic efficacy are dependent on several factors which must be taken into consideration in the galenics of urea preparations. As a whole, there is a multitude of possibilities for the use of urea in the therapy, follow-up and prophylaxis of neurodermatitis which we have only just begun to exploit in full.

Administration, Topical↗
PubMed1975

Epidermal nicotinamide adenine dinucleotides in psoriasis and neurodermatitis (lichen simplex hypertrophicus).

Epidermal nicotinamide adenine dinucleotides were measured in subcorneal and basal epidermal layers in patients with psoriasis and neurodermatitis and in healthy controls. Lowry's microtechniques utilizing enzymatic cycling were used. The total NAD content in these groups was except for the involved psoriatic skin about 1.1 mmoles/kg dry weight. Between 40 and 50% of this content consisted of the reduced form. In the involved psoriatic skin the total NAD content was increased to 1.5 mmoles/kg, this increase being mainly due to a rise in NAD+. There was no difference in NAD content between epidermal layers in the various groups studied. The total NADP content was near 0.15 mmoles/kg in healthy controls and in patients with neurodermatitis. The subcorneal layers contained 10% more of the dinucleotide than the basal layers, but in the two layers the reduced form amounted to about 80% of the total. In both non-involved and involved skin of the psoriatic patients the total NADP content was significantly increased above the control level, by up to 20% in the former and up to 65% in the latter. In the two layers studied the NADP+ content was increased by about 75% in both non-involved and involved areas. In contrast, the NADPH content rose only in the basal layers of the lesion, by 55%. The increased levels of NADP+ and NADPH found in psoriasis might suggest an accelerated or differently conducted NADPH dependent biosynthesis in this disease.

Adolescent↗
PubMed1992

[Long-term study "Neurodermatitis therapy using urea-containing Externa". Experience report of a pediatrician].

The experience gained in the pediatric sector within the framework of a neurodermatitis study on the use of urea and urea/hydrocortisone combinations will be reported. Particularly in young children, these preparations yield very good results, even after short-term use. The compliance of the patients is increased because, using alternating therapy, these preparations quickly make it possible for the patients to responsibly help determine their own therapy. The active participation of the parents in therapy makes it easier for the therapist to improve access to the psychosomatic environment of the disease. The consistent use of urea/hydrocortisone and urea preparations is a valuable enhancement of an all-encompassing neurodermatic therapy.

Administration, Topical↗
PubMed1992

[Moisture retaining effect and tolerance of urea-containing Externa in neurodermatitis patients].

Urea ointments and emulsions are excellently suited for the care and supportive therapy of neurodermatitis patients. In treating children and in the case of acutely irritated skin conditions, we have arrived at a concentration of 5% urea. All other dermatological conditions can be easily and effectively treated with a 10% urea preparation. It goes without saying that galenics also play an important role. An unbalanced composition can lead to poor results. In a short-term test (180 minutes) and in a long-term test (7 days), we tested the moisture level of the corneal layer with the corneometer in a climate-controlled room. We were able to show that urea in hydrous topical agents ensures acceleration of corneal hydration and helps retain water in the corneal layer. Thus, urea preparations can also be especially recommended for use in patients with neurodermatitis.

Dermatitis, Atopic↗
PubMed1992

[Epidemiology of constitutional atopic neurodermatitis].

There are more and more reports of an increase in atopic diseases, and particularly atopic constitutional neurodermatitis. In this context, evidence is accumulating that atopic constitutional neurodermatitis exhibits a dominant prevalence, particularly in children. In addition to verified genetic disposition with impairment of IgE regulation, realization factors of greatly variant quality and quantity appear to be characteristically responsible for the phenotypic expression and determination of the course of the disease. In order to definitively assess the global situation, subtle longitudinal studies on representative numbers of the population are needed, with the primary objective of obtaining parameters for real preventative measures.

Adult↗
PubMed1978

Neurodermatitis and intralesional steroids.

The present work describes the results of treatment of 30 cases of neurodermatitis circumscripta by intralesional injections which were given by Dermo-Jet. 15 cases were treated with triamcinolone acetonide (0.25 mg/cm2 of the skin) and the rest with aqua distillata every week for 8 weeks and were followed for another 4 weeks. The results of treatment were excellent in 66% of triamcinolone treated cases and 46% of aqua distillata treated cases. The difference in the response was statistically insignificant. So we conclude that aqua distillata might have worked as suggestion therapy in emotionally labile individuals.

Female↗
PubMedDate not supplied

[Atopic neurodermatitis, basic concepts in pediatrics].

Atopic neurodermatitis (AND) is the first or second most frequent skin diseases in childhood. It represented 15% of all skin diseases seen at the Hospital del Nino, IMAN. The clinical and epidemiologic aspects of AND, the different hypothesis of its pathogenesis, management and treatment are discussed. The importance of emotional factors in AND have been over stressed, resulting in therapeutic abuses of psychyatric drugs and psychotherapy.

Adolescent↗
PubMed1977

Neurodermatitis: a skin condition that affects surgical wound healing.

Neurodermatitis, or lichen simplex chronicus, generally found in females between the ages of 25 and 55 years, is highly inflammatory and may become generalized. The patients are hypersensitive and are not good candidates for surgery as a Köbner-like phenomenon may occur at the site of the incision with consequent breakdown of the incision, wound dehiscence, and infection. If these patients are to respond normally to treatment, it is sometimes necessary for the surgeon to treat their tensions.

Humans↗
PubMed1992

[Long-term study "Neurodermatitis therapy using urea-containing Externa"].

A long-term study on the therapy of atopic dermatitis with topical urea agents was conducted by over 400 practising dermatologists and pediatricians in Western Germany from March 1989 to March 1991. 1905 patients of all ages who had a baseline diagnosis of acute exacerbation of their neurodermatic skin condition were entered into this open, uncontrolled, multicenter study. Acute attacks were treated with a combination of hydrocortisone and urea. Once the acute symptoms had subsided, therapy was continued with a 10% urea ointment. Over the 12-month observational period, a total of 84% of the patients were exclusively treated with the two trial preparations and only 16% additionally required other corticosteroids.

Administration, Topical↗
PubMed1992

[Long-term study "Neurodermatitis therapy using urea-containing Externa". Experience report of a dermatologist].

This is a report on the therapeutic experience gained in 10 patients treated with a urea ointment combination alternatively with and without 1% hydrocortisone. Four of the ten patients successfully completed the therapy as planned after 12 months. The reasons for therapy drop-outs will be discussed. Based on our observations, the above-mentioned therapeutic regimen can be recommended in conjunction with all treatment measures for longer term therapy of neurodermatitis if the patients are well instructed.

Administration, Topical↗