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At least 19 recordsLinked to original sources
PubMed2004

Neoplasm staging and organ-confined renal cell carcinoma: a systematic review.

OBJECTIVES: Several TNM staging system editions were published over the years for renal cell carcinoma (RCC). Using a search strategy similar to the one used by the TNM process Subcommittee for "literature watch", we searched MEDLINE with the intent to critically analyze literature concerning the different TNM editions and the data regarding the optimal breakpoints to substratify localized RCC. MATERIAL AND METHODS: The electronic search was conducted as follows: "Neoplasm staging" [MeSH] AND "Carcinoma, Renal Cell" [MeSH]. At the end of a process of abstract analysis performed separately by three of the authors, 34 papers were included in the systematic review. RESULTS: All the 34 selected papers were retrospective studies. According to the 1987 version of TNM classification, no paper showed statistically significant cancer-specific survival probability differences between stage I and stage II RCC. According to the 1997 TNM version, the results were controversial. While a few papers found significantly different cancer-specific survival rates between stage I and stage II RCC, several others failed to do so. With the aim to stratify patients with localized RCC, most of the papers proposed an ideal breakpoint ranging from 4.5 to 5.5 cm. CONCLUSION: This literature review highlighted that a correct definition of the staging of organ-confined RCC was far from being achieved and provided an appropriate synopsis of the available data for further update of the TNM staging system.

Carcinoma, Renal Cell↗
PubMedDate not supplied

[State of the hemostasis system in patients with malignant III-stage neoplasms of the maxilla and larynx].

Hemostasis of patients with III stage malignant neoplasms of the maxilla and larynx was investigated. We examined 40 patients, 8 of which had maxillary tumor and 32 had laryngeal tumor. The age of the patients varied from 44 to 68 years. It was found that the patients with malignant neoplasms of the maxilla and larynx had hemostatic disorders which formed the thrombohemorrhagic syndrome. During the surgical intervention they displayed the hypocoagulation phase of the syndrome, which indicated the most dangerous prethrombotic state of the blood system.

Adult↗
PubMed1987

[Transurethral bladder echography in staging neoplasms: histopathological correlation (T/pT). Methodological proposal and preliminary results].

By real-time ultrasounds through an intra-vesical probe, bladder mucosal features, wall thickness and external profile, as well as their pathological changes, are beautifully imaged; therefore, the role of this echographic technique in the clinical pre-treatment assessment of tumor local staging is expected to be accurate and reliable, accordingly to the first results by Holms and co-w. We have intended to verify the value of the method, by comparing the pre-treatment staging by the more traditional non-invasive clinical procedures plus intra-vesical sonography to the pathological staging (pT) from the removed tumor samples. Our preliminary results are herein presented, from which the overall accuracy of this staging approach seems to be confirmed and a wider experimentation to be justified.

Evaluation Studies as Topic↗
PubMed1997

[Unexpected computerized tomography findings in neoplasm staging of a patient with plasmacytoma].

A case of a 69-year-old male patient is described. Staging CT brought unexpected findings with therapeutic consequences. Pneumoperitoneum was the most important sign. A pneumoretroperitoneum and a dilatation of the colon sigmoldeum were also found. Intraoperatively a perforated sigmadiverticulitis was detected. Therefore, one should pay attention to extraskeletal changes during the staging of multiple myeloma.

Aged↗
PubMed1994

[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].

Multidrug resistance represents one of the most important factors that may lead to a therapeutic failure in some patients affected by malignancies. One of the best known mechanisms is linked to the genic amplification or the overproduction of a membrane glycoprotein, GP170, that is the product of the gene MDR1. The existence of drugs (calcium blockers, cyclosporine, tamoxifen, reserpine, quinidine) able to bind themselves to gp170 and to paralyze its activity in vitro is well known. We studied 20 pediatric patients (median age 9 years) affected by acute lymphoblastic leukemia (ALL), osteosarcoma, neuroblastoma and medulloblastoma, in advanced stage of disease. We employed in all cases the association of cytostatics with verapamil (50-70 mg/m2 i.v.) and cyclosporine (5-8 mg/kg i.v.) with different infusion schedules. In leukemias we administered vincristine (1.5 mg/m2), and daunomycin (40 mg/m2), in solid tumors VP16 (150 mg/m2) and adriamycin (60 mg/m2). Seventy-two therapeutic courses were performed: 39 in ALL, 16 in osteosarcoma, 16 in neuroblastoma and 1 in medulloblastoma. On the whole 5 complete remissions were achieved in ALL patients and 1 in an osteosarcoma patient. We did not observe a significant myelosuppression during treatment, therefore few infectious complications occurred; furthermore electrocardiographic changes have been mild and promptly resolved after temporary discontinuation of verapamil infusion. Our data suggest a synergy of verapamil and cyclosporine in the inhibition of multidrug resistance induced by gp170, without the occurrence of heavy toxicity. The results obtained in ALL patients are encouraging., especially in view of a possible subsequent bone marrow transplantation, while in solid tumors they are not as satisfying.

Adolescent↗