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PubMed2002

Anomia for common names and geographical names with preserved retrieval of names of people: a semantic memory disorder.

This paper describes the case of an anomic patient (FH) who is impaired at naming pictures of objects but has no difficulties in recalling the names of familiar people. Even though his performance on McKenna's (1997) Category Specific Naming Test was at the first percentile, he consistently recalled the names of familiar people as successfully as controls. It is argued that the pattern of performance displayed by FH represents a much clearer double dissociation with proper name anomia than any case previously reported (Cipolotti et al., 1993; Semenza and Sgaramella, 1993). FH is unable to provide detailed semantic information about many of the objects that he cannot name, even though he can recall semantic information about familiar people. Consequently his case appears to represent the mirror image of the proper name anomic patient (APA) described by Miceli et al. (2000) who was unable to recall detailed semantic information about many of the people she was unable to name. Further investigation of FH's anomia revealed impairments in retrieving both common nouns and verbs, and difficulties in retrieving and comprehending geographical names. It is argued that FH's preserved ability to name and recall biographical information about people supports the view that knowledge about familiar people may be subserved by its own dedicated neural subsystem (Kay and Hanley, 1999; Miceli et al., 2000; Gentileschi et al., 2001).

Aged↗

PubMed1993

Naming faces and naming names: exploring an interactive activation model of person recognition.

In this paper we present an interactive activation and competition (IAC) model of name recognition. This is an extension of a previous account of name retrieval (Burton & Bruce, 1992) and is based on a functional model due to Valentine, Bredart, Lawson, and Ward (1991). Several empirical effects of name recognition are simulated: (1) names that are known are read faster than names that are unknown; (2) common names are read faster than rare names; and (3) rare names are recognised as familiar faster than common names. The simulations demonstrate that these complex effects can arise as a natural consequence of the architecture of the IAC model. Finally, we explore a modification of the Valentine et al. functional model, and conclude that the model as originally proposed is best able to account for the available data.

Association↗

PubMed1996

What's in a name? Electrophysiological differences between spoken nouns, proper names and one's own name.

To investigate the neural processing of different word categories, we recorded event-related potentials (ERPs) from 32 individuals listening to sentences, beginning either with a proper name (first name), the subject's own name, or a common noun. Names and nouns both elicited ERP waveforms with the same early componentry, but the N1 and P2 components were larger for proper names than common nouns. The ERPs to the subject's own name also had a large N1/P2 plus a prominent negativity at parieto-central site peaking around 400 ms and a late positivity between 500-800 ms over left lateral-frontal sites. These findings are consistent with differential processing of people's first names within the category of nouns.

Acoustic Stimulation↗

PubMed1993

Repetition priming and proper name processing. Do common names and proper names prime each other?

Three experiments are reported in which a repetition priming technique was used to investigate whether recognition of a person's surname which is also a known word (e.g. Baker) activates the lexical representation that mediates word recognition. Experiment 1 showed that a familiarity decision to familiar full names produced an effect of repetition priming on subsequent lexical decision to words that were presented in the initial task as surnames. Experiment 2 demonstrated that, conversely, a lexical decision primed subsequent familiarity decision to full names involving the same word. Experiment 3 showed that repeating the same decision during the initial and test phases did not produce a larger repetition priming effect than that obtained when the task at test differed from the prime task (name familiarity decision vs lexical decision or vice versa). The results are interpreted as support for the view that repetition priming is due to repeated activation of representations that are accessed by both common names and proper names.

Adult↗

PubMed2003

[Anatomical names of Sulcus in skeleton--analysis of Latin names and comparison with Japanese names].

For better understanding of the structures of the human body and for possible revision in the future Latin anatomical names of Sulcus in skeleton were analyzed and compared with Japanese anatomical names. The words that follow after Sulcus indicated: 1) the structure that exists in Sulcus, 2) the structure that contains Sulcus, 3) the location of Sulcus, or 4) the structure of which Sulcus enters into the formation. By the comparison between Latin and Japanese anatomical names, some characteristics of each name were made clear and some problems in Japanese names were pointed out.

Anatomy↗

PubMed2004

[Anatomical names of skeletal processes--analysis and classification of Latin names, and comparison with corresponding Japanese names].

For better understanding of the structures comprising the human body and in view of possible need for future revision, Latin anatomical names (Nomina Anatomica, 3rd edition) of the skeletal processes were analyzed and classified, and compared with the corresponding Japanese anatomical names. The words following Processus indicated: 1) morphological resemblance of the process; 2) the structure to which the process belongs; 3) location of the process; 4) direction of the process; 5) an articulation of the process; 6) the bone or one of the bones with which the process is connected; 7) the structure of which the process is a component; 8) the structure attached to the process; 9) the structure contained in the process; 10) homology of the process; 11) participation in another process; or 12) other uncertain information. Comparison between Latin and Japanese anatomical names clarified some characteristics of each name and revealed some problems in Japanese names.

Bone and Bones↗

PubMed2006

[Anatomical names of skeletal notches--analysis and classification of Latin names, and comparison with corresponding Japanese names--].

For better understanding of the structures comprising the human body and in view of possible need for future revision, Latin anatomical names (Nomina Anatomica, 3rd edition) of the skeletal notches were analyzed and classified, and compared with the corresponding Japanese anatomical names. The words following Incisura indicated: 1) the structure to which the notch belongs; 2) location of the notch; 3) the structure of which the notch is a component; 4) the bone or osseous structure with which the notch is connected; or 5) non-osseous structure attached to the notch. Analysis of Latin names and comparison with Japanese names clarified some characteristics of both names and revealed some problems in them.

Bone and Bones↗

PubMed2001

Recommended conservation of the names Streptococcus sanguis, Streptococcus rattus, Streptococcus cricetus, and seven other names included in the Approved Lists of Bacterial Names. Request for an opinion.

With reference to the first Principle of the International Code of Nomenclature of Bacteria, which emphasizes stability of names, it is proposed that the original names Streptococcus sanguis, Streptococcus rattus, Streptococcus cricetus, Erwinia ananas, Eubacterium tarantellus, Lactobacillus sake, Nitrosococcus oceanus, Pseudomonas betle, Rickettsia canada and Streptomyces rangoon, all included in the Approved Lists of Bacterial Names, be conserved. Request for an Opinion.

Streptococcus↗

PubMed2003

Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

BACKGROUND: This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone acetate (DOCA). METHODS: The control, DOCA, L-NAME, L-NAME + DOCA, L-NAME + OMA, and L-NAME + DOCA + OMA groups were used. Tail systolic BP was measured twice a week. After 4 weeks of treatment, mean arterial pressure (MAP), and metabolic, morphologic, and renal variables were measured. RESULTS: The final values of MAP were 109 +/- 5.1 mm Hg for the control group, 113 +/- 3.0 mm Hg for DOCA, 175 +/- 3.7 mm Hg for L-NAME, 193 +/- 3.8 mm Hg for L-NAME + DOCA, 117 +/- 3.9 mm Hg for L-NAME + OMA, and 158 +/- 3.0 mm Hg for L-NAME + DOCA + OMA. The rats treated with L-NAME showed mild and scarce renal lesions, which were prevented by OMA treatment and the L-NAME + DOCA group showed proteinuria and hyaline arteriopathy, which were markedly attenuated in the L-NAME + DOCA + OMA group. Plasma urea and creatinine were significantly increased in the L-NAME + DOCA group, whereas these variables were not significantly greater in the L-NAME + DOCA + OMA group versus controls. The L-NAME + DOCA group showed relative renal and cardiac hypertrophy that was not observed in the L-NAME + DOCA + OMA group. CONCLUSIONS: The simultaneous blockade of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) completely prevents L-NAME hypertension. Our results also show that OMA attenuates the increased BP and the renal injury in L-NAME hypertensive rats treated with DOCA. Assuming that this is a low-renin model of hypertension, the protective effect of OMA may be due to an increase in vasodilator peptides produced by both ACE and NEP inhibition.

Animals↗

PubMed2002

Chronic alpha1-adrenergic blockade improves hypertension and renal injury in L-NAME and low-renin L-NAME-DOCA hypertensive rats.

BACKGROUND: The present study investigated the contribution of alpha1-adrenergic blockade to hypertension induced by long-term blockade of nitric oxide and chronic treatment with deoxycorticosterone acetate (DOCA), which produced a low renin model of hypertension. We studied the effects of chronic administration of prazosin, an alpha1-receptor antagonist, on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) and L-NAME+DOCA hypertensive rats. MATERIAL/METHODS: The rats were divided into 6 groups: Control, DOCA, L-NAME, L-NAME+DOCA, L-NAME+ prazosin, and L-NAME+DOCA+prazosin. Tail systolic BP was measured twice a week. After a 6-week evolution, mean arterial pressure (MAP) was measured, along with selected metabolic, morphological and renal variables. RESULTS: The final MAP values were 105+/-1 for Control, 107+/-0.6 for DOCA, 153+/-3 for L-NAME, 175+/-2 for L-NAME+DOCA, 126+/-2 for L-NAME+prazosin and 127+/-5 for L-NAME+DOCA+prazosin. Proteinuria and hyaline arteriopathy were prevented in L-NAME+prazosin rats and markedly attenuated in the L-NAME+DOCA+prazosin group. Plasma urea and creatinine were significantly increased in the L-NAME+DOCA group, but not in the L-NAME+ DOCA+prazosin group as against controls. The DOCA and DOCA+L-NAME groups showed relative renal and cardiac hypertrophy, which was not observed in the DOCA+L-NAME+prazosin group. CONCLUSIONS: Alpha1-adrenergic tone plays an important role in the increased BP and renal injury of L-NAME hypertension. Our results also indicate that when PRA is suppressed by DOCA in L-NAME hypertension, the increased BP and renal injury are largely dependent on the alpha1-adrenergic tone.

Adrenergic alpha-1 Receptor Antagonists↗

PubMedDate not supplied

Differences in functional MR imaging activation patterns associated with confrontation naming and responsive naming.

BACKGROUND AND PURPOSE: Direct cortical stimulation studies suggest that responsive naming is more widely distributed within the temporal lobe than confrontation naming and involves anterior temporal regions typically resected in a standard temporal lobectomy. The aim of the current study was to further demonstrate the anatomic dissociation between confrontation and responsive naming by using functional MR imaging (fMRI). METHODS: Twenty participants underwent fMRI while performing either a confrontation or responsive naming task. Regions of interest were identified within the anterior and posterior temporal lobe. RESULTS: Responsive naming produced more activation than confrontation naming within the dominant temporal lobe, with activation extending into the temporal pole. Activation in the dominant temporal lobe associated with responsive naming was observed in the superior, middle, and inferior temporal gyri but was limited to the middle temporal gyrus for confrontation naming. Although both naming tasks produced activation within the posterior temporal region of interest in all participants, responsive and confrontation naming produced activation within the anterior temporal region of interest in 90% versus 60% of the sample, respectively. Areas of the dominant hemisphere activated by both tasks included parts of the middle occipital and middle temporal gyri, inferior frontal lobe, and hippocampus, among others. CONCLUSION: Findings are consistent with cortical stimulation studies and suggest that responsive naming produces more widespread activation within the temporal lobe compared with confrontation naming. The activation more often included anterior temporal regions during responsive naming as compared with confrontation naming. In clinical cases where the functional assessment of the temporal lobe-particularly the anterior regions-is important, the current results suggest responsive naming should be a useful fMRI paradigm and may ultimately help predict the risk of postsurgical language changes.

Adult↗

PubMed2004

What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration.

Confrontation naming is impaired in neurodegenerative conditions like Alzheimer's disease (AD), frontotemporal dementia (FTD) and corticobasal degeneration (CBD). Some behavioural observations suggest a common source of impaired naming across these patient groups, while others find partially unique patterns of naming difficulty. We hypothesized that a large-scale neural network underlies naming, and that patterns of impaired naming in AD, FTD and CBD reflect cortical atrophy that interrupts this network in a manner that is partially shared and partially unique across these patient groups. We tested this hypothesis by correlating naming impairments with voxel-based morphometric (VBM) analyses of cortical atrophy in structural MRIs of 50 patients. We found significant naming deficits in all patient groups. Naming also correlated with lexical retrieval in all patient groups, including subgroups of patients with FTD. VBM analyses showed significant cortical atrophy, which was shared across AD, FTD and CBD patients in the left lateral temporal cortex; this area correlated with naming accuracy in all groups. Left lateral temporal atrophy thus appears to interfere with a lexical retrieval component of naming in AD, FTD and CBD. Impaired naming also correlated with semantic memory and visual perceptual-spatial functioning in specific groups of patients and, correspondingly, naming correlated with cortical atrophy in partially distinct neuroanatomical distributions in AD, FTD, CBD and subgroups of patients with FTD. These partially unique correlation profiles appear to reflect selective interruption of other components of the naming process, including semantic and visual perceptual-spatial functioning. These findings are consistent with the hypothesis that a large-scale neural network supports naming, and that this network is interrupted in several distinct ways in patients with neurodegenerative diseases.

Aged↗

PubMedDate not supplied

Does your patient know your name? An approach to enhancing patients' awareness of their caretaker's name.

This brief report determines whether patients admitted to a large teaching hospital knew the name of their caretaker (physician or nurse) and whether emphasis on patients' awareness of this name improved their recall. A survey of 100 patients on the internal medicine and neurology services at a large teaching hospital in BrookLyn, NY, was conducted. A derivative survey was also conducted on 30 different patients to see whether caretaker name recall was enhanced after the patients were advised of the importance of remembering this name. Of patients initially tested, 14.7% correctly stated their physician's name, and 21.3% correctly stated their nurse's name (p < 0.3). After being given the name of their physician in writing and being asked to remember it, 76.2% of a different group of patients correctly stated their physician's name. Less than a quarter of the patients initiaLLy surveyed were able to state either their physician's or nurse's name. However, after a specific effort to have a smaller group of patients remember their physician's name, more than 75% did so. Therefore, it was concluded that simple interventions such as providing the patients with their physician's name in writing and emphasizing the importance of knowing it result in a significantly greater percentage of physician-name recall.

Aged↗

PubMed2001

Proper-name processing: are proper names pure referencing expressions?

Theoretical models of proper-name processing have been primarily derived from studies of people's names; however, they are thought to generalize to all classes of proper name. Five experiments are reported that use repetition priming to compare different classes of proper names. It was found that for people's names and landmark names, (a) production of a name in response to seeing a picture primed a subsequent familiarity decision to the same item's written name and (b) similarly, making a familiarity decision to an auditory presentation of a name primed a familiarity decision to the same item's written name. No comparable facilitation was found for the country-name stimuli. The presence of this specific facilitation was attributed to the nature of connectivity between conceptual and lexical representations. Theoretical views that proper names are unique, meaningless labels and that they are pure referencing expressions are evaluated.

Adult↗

PubMed1995

[No one is disgraced by the name. About the drug manufacturers' choice of name of their products].

Choosing the "right" trade name for a drug is important for the manufacturer, both because the name identifies the product and because it can create an image which helps the marketing and thus increases the sale of the drug. A name registered as a trade mark is the company's property and cannot be used by others. Choosing a good name from scratch is not easy, but several ground rules exist: Get as close as possible to the non-proprietary (generic) name, the name of the company, the properties of the drug, or a combination of these. Try to have the first letter of the name near the beginning (or the end) of the alphabet. Keep the name short and avoid names that could be difficult to pronounce or may have a bizarre meaning in other languages. In this article, examples of "good" and "bad" drug names are presented. Various aspects of the non-proprietary and chemical names of drugs are also discussed, as well as the risk of confusing different drugs that have names that look alike or sound alike.

Drug Industry↗

PubMed2003

Time-dependent neural activations related to recognition of people's names in emotional and neutral face-name associative learning: an fMRI study.

Previous data have indicated that the left anterior temporal lobe contributes to the retrieval of familiar people's names, and that the extended network including the bilateral anterior temporal lobe plays an important role in the retrieval of newly learned people's names. However, there has been no direct evidence for time-dependent change in brain activation in face-name associations. In addition, previous studies have demonstrated that emotional information such as emotional faces may contribute to the organization of long-lasting episodic memory. In the present study, we investigated the activations related to the recognition of people's names in the context of emotional and neutral face-name associative learning. Before fMRI scanning, subjects learned face-name associations that included emotionally positive and neutral facial expressions. In immediate (5 min later) and delayed (2 weeks later) recognition with fMRI scanning, subjects were presented with studied faces with two names, and were asked to choose the correct associative name learned previously. Recognition-related activations were identified in the anterior part of bilateral temporal lobe for immediate recognition and only in the left temporal lobe for delayed recognition. Further analysis confirmed the time-dependent change in activation of the right anterior temporal lobe. Activation related to the processing of faces with positive expressions were observed in the left periamygdaloid area and temporal pole, although emotional information did not have an influence on task performance in this study. These findings suggest that the neural network involving the bilateral temporal lobe contributes to the retrieval of newly learned people's names, and that the left temporal lobe has a crucial and stable role in retrieval of people's names from faces, whereas the role of the right temporal lobe in retrieval of people's names may decrease with the time course.

Adult↗

PubMed2006

Retrieval of names in face and object naming in an interference study.

Two experiments using the interference paradigm are reported. In the first experiment, the participants spoke aloud the names of celebrities and the names of objects when presented with pictures while hearing distractors. In the case of proper names, we replicated the data obtained by Izaute and Bonin (2001) using the interference paradigm with a proper name written naming task. In the case of common names, the results replicated those obtained by Shriefers, Meyer, and Levelt (1990). In the second experiment, the participants produced the names of celebrities when presented with their faces while hearing distractors that were either proper names associated with the celebrities (associate condition), that belonged to a different professional category (different condition), or that corresponded to the proper names of the celebrities (identical condition). For negative SOAs, "associate" distractors were found to increase latencies compared to the "different category" condition. The implications of the findings for proper name retrieval are briefly discussed.

Analysis of Variance↗

PubMed2001

What's in a name? A comparison of men's and women's judgements about food names and their nutrient contents.

The current study had two goals: first, to examine the stereotypes people have of particular foods by having them rate foods' names and nutrient descriptions; second, to determine if men and women rated food names and descriptions differently, and to examine the characteristics used to gauge salubrity. Of 33 foods presented, 16 had names rated better than their descriptions (a positive stereotype). In 11 cases, foods' descriptions were rated more positively than their names (a negative stereotype). Therefore, people have expectations about food names that do not match descriptions of foods' nutritional contents. Also, names of particular types of foods (e.g. fruits) were often perceived to be healthier than their corresponding descriptions. Women rated certain low-fat food names as more healthy compared to men. In addition, women tended to have bigger discrepancies between food names and their corresponding descriptions than did men, indicating that women were more likely to have biases about food names that did not match their ratings of the same foods' descriptions. Regression analyses indicated that women used fat content when judging healthfulness of food names, while men used fat content and vitamins and minerals. Men and women used similar characteristics when judging healthfulness of food descriptions.

Adult↗