SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
This notice sets forth actions taken by the Director, National Institute of Allergy and infectious Diseases (NIAID), by authority of the Director. NIH, under the June 1983 NIH Guidelines for Research Involving Recombinant DNA Molecules (48 FR 24556).
This notice sets forth actions taken by the Director, National Institute of Allergy and Infectious Diseases, by authority of the Director, NIH, under the April 1982 Guidelines for Research Involving Recombinant DNA Molecules (47 FR 17180).
This notice sets forth an action to be taken by the Director, National Institutes of Health (NIH), under the NIH Guidelines for Research Involving Recombinant DNA Molecules (59 FR 34496, amended 59 FR 40170, 60 FR 20762, 61 FR 1482, 61 FR 10004, 62 FR 4782, 62 FR 53335, 62 FR 56196, 62 FR 59032, 63 FR 8052, 63 FR 26018).
New NIH Guidelines for research involving recombinant DNA (R-DNA) molecules were issued on December 15, 1978. These are composed of four main parts, the first defining R-DNA and specifying prohibitions and exemptions, the second describing physical and biological containment, the third assigning the containment levels for many R-DNA experiments, and the fourth detailing the roles and responsibilities of the investigator, research institutions and NIH. Although the new Guidelines reduce restrictions, principally on those R-DNA experiments that use Escherichia coli K-12 host-vector systems, and exempt from the Guidelines several classes of experiments on prokaryotes that naturally exchange their DNA, most of their provisions are unjustified by the present assessment of the absence of any practical risks; many totally innocuous experiments are unnecessarily restricted and even virtually prohibited mainly because no host-vector systems were officially certified. The term Guidelines is a misnomer since they are mandatory regulations, even without any statutory basis. They impose large but unnecessary bureaucratic burdens on scientists, research institutions, research committees and NIH, and represent unwarranted censorship of basic research, which is antithetical to the creativity of human thought, thus posing serious dangers to the traditional freedom of inquiry.
BACKGROUND: Asthma is the most common chronic disease of childhood. In 1991 the National Institutes of Health (NIH) published guidelines for the diagnosis and management of asthma, yet little is known about their impact on clinical practice. OBJECTIVE: To examine the impact of the NIH guidelines on the emergency management of asthmatic children in the United States. METHODS: A short anonymous survey concerning the emergency management of childhood asthma was mailed to 234 Directors of Pediatric Emergency Medicine in all Pediatric Residency Training Programs in the United States. The survey consisted of questions originally used in a similar study conducted in 1988 and an additional question relating to the impact of the NIH guidelines. RESULTS: One hundred and thirty-seven (59%) completed surveys were returned. Compared with the results of the 1988 survey, more physicians routinely use pulmonary function testing (73% versus 47% in 1988, P < .001), inhaled beta-agonists as the initial drug of choice (98% versus 17%, P < .001), and early corticosteroid administration (82% vs 21%, P < .001) in their emergency management of asthmatic children. Fifty percent of survey participants believe that NIH guidelines changed their emergency management of childhood asthma. CONCLUSIONS: Significant changes in the emergency management of asthmatic children have occurred since the publication of the NIH guidelines.
The NIH (National Institutes of Health) Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research requires investigators applying for NIH research funds to develop and, if funded, implement plans for the inclusion of women and minority populations in their research, when that research involves human participants. It is the purpose of this article to help investigators understand (a) the scientific context and rationale behind the NIH Guidelines; (b) the NIH-defined concepts and the specific content of the NIH Guidelines; and (c) how the intent of the NIH Guidelines is related to mental health services research, the most applied area of mental health research. The article also discusses where investigators can find additional information as they work to implement the NIH Guidelines.
The National Institutes of Health (NIH) issued final guidelines last week allowing NIH-funded researchers to derive human pluripotent stem cells from fetal tissue, but not from embryos. Scientists may also work with embryonic stem cells, but may obtain them only from private sources and must ensure that derivation meets certain ethical conditions. The NIH spent nearly a year finalizing the guidelines, which researchers hope will allow work leading to the improved treatment of diabetes, Parkinson's, and other diseases.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.