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At least 19 recordsLinked to original sources
PubMed2005

[Pathological and ultrastructural observation on the epithelia of nasal cavity and nasal sinuses in chronic sinusitis and nasal polyps after endoscopic sinus surgery].

OBJECTIVE: To research the restoration characteristics of epithelia in nasal cavity and nasal sinuses with chronic sinusitis and nasal polyps after endoscopic sinus surgery,and to provide basis for improving the treatment after operation. METHOD: Twenty patients with chronic sinusitis and nasal polyps after endoscopic sinus surgery were observed. The "Vesicle tissues" situated ostiomeatal complex (OMC) were observed with light and transmission electron microscopy after operation of 7-14 days. RESULT: (1) The "Vesicle tissues" were off white or buff, some contained liquid, and some were parenchyma under the endoscopy. (2) The epithelia of "Vesicle tissues" were pseudostratified ciliated columnar epithelium (16/20), and some were stratified squamous epithelium (2/20), some were squamous metaplasia in pseudostratified ciliated columnar epithelium (2/20). Lamina propria were edema. Inflammation cells infiltrated epithelial lining and subepithelial lining. We found mucous gland, mixed gland and glandular duct under subepithelial lining,and small vascular ectasia under light microscopy. (3) Transmission electron microscope: epithelia were pseudostratified ciliated columnar epithelium, cilia were in good order, microvilli located between cilia. The cross section of majority cilia were 9 + 2 form microtubule, but in some cilia we could not find microtubule and could only find one central microtubule. Golgi complex were up growth, and endoplasmic reticulum expand, and multi-mitochondrion were coagulation degeneration in epithelial cells. Some mitochondrion were 1-2 degree swelling and the lysosome increased. Inflammation cells infiltrated epithelial lining. Majority were neutrophil and lymphocyte, but we also found eosinophil and plasmacyte. CONCLUSION: "Vesicle tissues" is the manifestation of active epithelia regeneration in nasal cavity and nasal sinuses after endoscopic sinus surgery, it's the earlier period of imbalance regeneration of the epithelization in postoperative cavity. "Vesicle tissues" is similar to the nasal polyp histopathology, and it is phenomena of limited pathological rebuilding in earlier period. Cleaning "Vesicle tissues" can effectively control the nasal polyps relapse and impel the postoperative cavity to epithelization.

Adult↗
PubMed2000

[Radiofrequency treatment of hemangioma of nasal cavity under nasal endoscopy].

OBJECTIVE: To further understand the advantage of radiofrequency treatment of hemangioma of nasal cavity under nasal endoscopy. METHOD: Fifteen cases with hemangioma of nasal cavity were treated with radiofrequency under nasal endoscopy. RESULT: The hemangioma of fifteen cases could be removed completely. The complication was absent. None of them recurred in six months to four years following up. CONCLUSION: This method has many advantages such as clear operation visual field, less hemorrhage and postoperative pain, no facial scar. The radiofrequency under endoscopy is valuable in treatment for hemangioma of nasal cavity.

Adolescent↗
PubMed2003

[Remarks concerning up to date TNM staging of cancer localized in lip and oral cavity, pharynx, nasal cavity and paranasal sinuses, and major salivary glands].

The general principles and historical background of TNM classification was briefly discussed, with advantages as well as weakness and limitations of the system. The current TNM staging of lip and oral cavity, pharynx. The currant TNM staging of carcinoma in lip and oral cavity, pharynx, larynx, nasal cavity and paranasal sinuses and major salivary glands was presented, pointing out the last changes in the classification.

Head and Neck Neoplasms↗
PubMed2005

[Rotated pedicle flap of the floor of nasal cavity to repair nasal septal perforation].

OBJECTIVE: To report a new procedure with rotated pedicle flap of the floor of nasal cavity to repair nasal septal perforation. METHOD: Dissecting mucoperichondrium and mucoperiosteum around the perforation and taking downward to the floor of nasal cavity to make a posterior end pedicle flap. Then rotating the flap backward and upward to overlap the more large perforation and suturing it with the margin of the pocket of mucoperichondrium and mucoperiosteum of the perforation. RESULT: Repair of the perforation in 11 cases were all successful with primary healing. CONCLUSION: Autogenous rotated pedicle flap of the floor of nasal cavity for repairing nasal septal perforation has a lot of advantage. The graft is easy to take, no rejection, having good blood supply, highly survival rate and wide and long enough to be available to the implant for repairing the larger perforation according to its size and shape.

Adolescent↗
PubMed1999

Nitric oxide accumulation in the nonventilated nasal cavity.

BACKGROUND: Nasal nitric oxide is present in high concentrations in the upper airway relative to the lower respiratory tract. OBJECTIVE: To explore the rate of nitric oxide accumulation in the nonventilated nasal cavity. METHODS: In 9 healthy subjects previously trained to close the soft palate, steady-state plateau nitric oxide levels were recorded while air was aspirated through the nasal airway in series at a constant flow rate. Nitric oxide was then allowed to accumulate in the nasal cavity by occluding both nares and keeping the velum closed. After varying occlusion times, peak nitric oxide levels and a second plateau were ascertained. RESULTS: While the subjects aspirated air at a constant flow, there was a slow rise to a first nitric oxide plateau. On opening to the analyzer after the accumulation period, the peak nitric oxide level was several times higher than the initial plateau (range, 2810-19008 ppb) and then slowly returned to previous plateau levels. There was no significant difference between initial and second plateau nitric oxide levels for any period. The accumulated nitric oxide peak increased in direct proportion to the accumulation time (P<.001). CONCLUSIONS: Nitric oxide concentrations accumulate in the nonventilated nasal cavity in proportion to the time of nonventilation. Peak nasal nitric oxide values after accumulation are similar to published sinus nitric oxide measurements obtained by direct puncture. These results suggest an important alternative source of nitric oxide in humans.

Adult↗
PubMed2006

[Results of combined therapy for malignant tumors of the nasal cavity and accessory nasal sinus depending on the fractionation of preoperative radiotherapy].

Data on the treatment of 215 patients with locally advanced malignancies of the nasal cavity and accessory nasal sinus are presented. All patients received preoperative radiotherapy using different fractionation schemes under a total target dose (TTD) of 32-40 Gy. Surgery was carried out two weeks later. Whenever radicality of surgery was in doubt, postoperative gamma therapy included exposure to 2 Gy 5 times a week (TTD--30-40 Gy) (n=121). Group I (n-57) received radiation at standard fractionated dosage. In group II (n=66), fractionation, tentatively considered "dynamic" was used while, in group III, fractionation was dynamic in actual fact. In group IV (n=10), superfractionation (1+1 Gy) was employed in group V (n=6),--gamma-neutron therapy. Patients in group VI (n=51) were operated on as scheduled and received 5 Gy, twice a week (TTD--20 Gy). According to 5-year follow-up, the best results were obtained with the use of larger doses of preoperative radiation (groups II, III, VI). Postoperative radiotherapy proved ineffective and it would be useless unless ablative procedures were definitely faulty during surgery.

Adult↗
PubMed1997

Endoscopic excision of a giant pyogenic granuloma of the nasal cavity caused by nasal packing.

A case of a giant pyogenic granuloma of the inferior turbinate secondary to nasal packing is presented and its removal via an endoscopic approach is detailed. The sinus endoscope provides excellent visualization and operative control during excision, obviating the need for a lateral rhinotomy. Pyogenic granulomas of the posterior nasal cavity are rare, and should be considered when a nasal mass is detected after packing for epistaxis.

Adult↗
PubMedDate not supplied

Three-dimensional mapping of the lesions induced by beta-beta'-iminodiproprionitrile, methyl iodide and methyl methacrylate in the rat nasal cavity.

The nasal cavity is an important target organ for toxicity, and many chemicals induce site-specific lesions in this region. The factors responsible for this site-selectivity have not been unequivocally identified, but probably include regional dosimetry and bioactivation. The purpose of this study was to map, in 3 dimensions, the lesions induced by beta-beta'-iminodipropionitrile (IDPN), methyl iodide (MeI) and methyl methacrylate (MMA) in the rat nasal cavity. Animals were administered IDPN (150 mg/kg, IP) or exposed via inhalation to MeI (100 ppm, 2 hours) or MMA (400 ppm, 4 hours) and sacrificed after 24 hours. Heads were decalcified, step-sections (1 every 400 microm) cut and stained, and the severity of the epithelial lesion graded as mild (vacuolation and pyknosis), moderate (undulation and mild stripping), or marked (complete stripping). These grades were mapped onto a 3D-model of a rat nasal cavity using the KS400 imaging system (Imaging Associates, Thame, UK). Despite the different routes of exposure the lesions induced by the 3 compounds had very similar distributions, predominantly affecting the dorsal-medial aspects of the ethmoturbinates and, in the case of MMA, the organ of Rodolfo Masera. These results suggest that, with these chemicals, local bioactivation plays a more important role than dosimetry in determining lesion distribution.

Animals↗