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At least 19 recordsLinked to original sources
PubMed1976

A minicomputer-automated array spectrometer for liquid-chromatographic detection of metabolites.

A third-generation multiwavelength array spectrometer was developed as a detector for the high-resolution liquid-chromatographic characterization of metabolites. Components include a PDP-8/e minicomputer, matched pair of linear photodiode arrays, holographically-ruled gratings, fiber optics, flow cells, and high intensity xenon light source. The wavelength range is 256 nm differential with 1-nm resolution and can be adjusted from 200 to 800 nm. The system is capable of storing 20 spectra per second (200-456 nm) in a dual-beam mode. Special features include minicomputer-driven signal enhancement via integration as a function of signal strength. The display output includes presentation of the total absorption chromatogram vs. elution time in both real and post-run time as well as selectable single absorption band vs. elution time (post-run time). Application of this dedicated system is illustrated by the separation and charcterization of the metabolites of a carcinogen, 4-ethylsulfonyl-1 napthalenesulfonamide.

Animals↗
PubMed1979

Automated nerve fiber counting using an array processor in a multi-minicomputer system.

It has been suggested that recovery of motor and sensory function in the site distal to a peripheral nerve lesion should be improved if the nerve bundles (fasciculi) are matched and individually sutured. Three parameters are proposed to provide quantitative data: the count of the nerve fibers that regenerate, the number of functional regenerated nerve fibers, and a measurement of end organ reinnervation. A thin cross section of a transected and repaired sciatic nerve of a mongrel cat is fixed, stained, photographed, and digitized through a microscope 6 months following nerve repair. The data arrays are then subjected to four basic processing routines: edge enhancing, thresholding, template matching, and peak detection. Finally, the peaks are counted and provide an estimate of the number of nerve fibers in the nerve under study. Comparing counts of nerve fibers proximal and distal to the transection site of the nerve provide data on the proportion of regeneration present at various times. The content of this paper is, to a large extent, describing the implementation of the needed image-processing algorithms for automated counting on the Multi-MiniComputer System (MMCS). Optimal use of the AP-120B array processor and the pipeline processing provided by using the Eclipse 200s and the Nova 3 make a marked improvement in overall throughput.

Animals↗
PubMed1979

[Quantitative echocardiography using a minicomputer (author's transl)].

Echocardiography should not remain merely qualitative but every effort should be made to make it quantitative, providing the clinician with numerical values. Three items are necessary: a graphic table, a minicomputer and an electronic reprograph, all small in size. The tracings obtained in TM technique are digitalised using the graph table, and the computer provides the results in the form of listings and graphs. The latter are of two types: --some are used for the analysis of the respective chronology of the various phenomena: left ventricular diameter and its normalised derivative, apexocardiogram or carotid pulse, movement of the greater cusp of the mitral valve, thickness of the myocardium, heart sounds; --the others are used for study, with the aid of an X-Y representation in the form of loops, of variations in one phenomenon in relation to the other. Deformation of such loops makes it possible to detect poor synchronisation between 2 phenomena.

Computers↗
PubMed1975

Operant conditioning and behavioral analyses using a minicomputer.

An operant conditioning and data analysis software system was developed for use on a PDP-12A minicomputer. The operant software functions in quasi time-sharing fashion to control and acquire data from any peripheral device that operates in the binary mode. In addition to independently running different experiments in near simultaneous fashion, the program also provides information on the current status of each experiment using a cathode ray-tube display. Response data from each experimental subject is stored on magnetic tape and analyzed, off-line, by the data analysis portion of the software system. A discussion of the operation of this system is given for one possible application: visual discrimination training.

Animals↗
PubMed1978

A minicomputer system for display and rate analysis in vectorcardiography.

A system has been constructed for recording vectorcardiographic signal with a FM taperecorder. Off-line AD-conversion and analysis of rates and magnitudes of partial vectors are made with a minicomputer. The reason for studying particularly initial vectorrates is that according to our hypothesis these contain valuable information for classification of certain cardiac arrythmias according to supraventricular or ventricular impulse focus. Preliminary results confirm the hypothesis. In vectorcardiography one difficulty is to give an easily comprehensible presentation of the vectorloop. In this study a method for '3-dimensional' display has been developed, using a graphic display processor and varying intensities of the beam. The system is to a high degree man-machine interactive.

Arrhythmias, Cardiac↗
PubMed1978

An approach for physiological signal processing by laboratory minicomputer.

Physiological signal-processing instrumentation including the digital oscilloscope is becoming more dependent upon the microprocessor. Minicomputer software has been developed which demonstrates data-processing approaches that should be considered for incorporation into the firmware of digital oscilloscopes. This core-resident software called DATAC operates in an interpretive mode and provides such features as digital signal editing, filtering, and basic processing including differentiation and integration.

Computers↗
PubMed1979

[Results of employing single crystal gammacamera and minicomputer in the first tracer passage to determine left-ventricular ejection fraction and wall motion (author's transl)].

Single crystal gammacamera and minicomputer were employed in 71 patients to determine left-ventricular ejection fraction (EF) (17 mCi 99mTc-HSA; 30 degrees RAO projection) by means of the first tracer passage. In 30 out of these patients, ventricular wall motion could be analyzed additionally because later on the gammacamera was equipped with a converging collimator. Comparison with cineventriculographically determined EF values revealed a good correlation (r = 0.91), not depending on left-ventricular wall motion pattern. Hereby, with first transit, high EFs were computed somewhat lower and low EFs were found somewhat higher. This non-limiting discrepancy is closely related to the influence of paracardiac "background"-radioactivity. Comparative analysis of segmental wall motion demonstrated agreement in 83% of the 90 segments examined. Therefore, it can be confirmed that performance of the first tracer passage for a evaluating segmental wall motion must not mandatorily be done with a multicrystal camera.

Adult↗
PubMed1975

Optimization of dose distributions in moving-strip therapy using a minicomputer.

Optimized 60-Co dose distributions for the moving-strip technique were calculated for 3 patients using a PC-12 minicomputer program which corrects for field obliquity and changes in patient thickness. Beam profiles were measured using an ionization chamber in a water phantom. A Masonite phantom was constructed to simulate a patient and used to measure optimized and unoptimized midplane dose distributions by thermoluminescent dosimetry. Measured midplane doses agreed with computer-calculated doses within experimental error. The computer optimization technique improved dose uniformity, reducing the midplane dose variation from plus or minus 12-13% to plus or minus 3-4%.

Cobalt Radioisotopes↗
PubMed1979

A study of the multiple pinhole coded aperture and the application of the minicomputer in image decoding.

Research has been done on optically reconstructed imaging employing the Multiple Pinhole Coded Aperture (hereafter abreviated as MPCA) in radioisotope tomographic imaging. However, problems remain in the optically reconstructed image method. Therefore, we employed a minicomputer (hereafter abbreviated as CPU) and developed the software for decoding and managing the radioisotope tomographic image. Combining the MPCA and the CPU system, we were able to decode and manage the radioisotope tomographic image. 1) In comparison to the optically decoded MPCA image, various input commands are possibly in the CPU method according to the dialogue between the CPU and the on line typewriter. In addition to this, decoded tomographic images of unrestricted depth are readily attainable. 2) In the CPU method noise elimination and other aspects of image management can be easily performed.

Computers↗
PubMed1975

Automated weighing procedure for toxicological studies on small animals, using a minicomputer.

A compact system was designed for weighing procedures in toxicological studies on small animals that integrated 4 basic functions: data acquistion, record keeping, statistical analysis, and report preparation. An electric balance, a minicomputer, and a typewriter were incorporated into the system. Elimination of clerical work and accelerated flow of information between planning, operation, and evaluation of experiments were found to be the main advantages.

Animal Feed↗
PubMed1977

[Applications of a minicomputer in an electrocadiography department].

The wide potential of minicomputers and their versatility have modified the traditional image of the computer, allowing it to gain a real foothold in a cardiological service. Examples of some original programmes are: the automatic assessment of a pacemaker on the test bench, the formation of programmed impulses for electrocardiographic investigation, the analysis of arrhythmias by a histogram of the RR interval of frequency analysis, the recording of isochrones in pericardial cartography.

Computers↗
PubMed1978

[Clinical use of a minicomputer in heart surgery intensive care units].

The Authors present three respiratory parameters useful to estimate the respiratory and hemodynamic conditions of a cardiac patients before these turn into obvious pathological clinical pictures. The parameters are: alveolar-arterial oxygen difference, respiratory index and arterial-venous pulmonary shunts. The sophisticated mathematic calculations necessary to calculate and to elaborate such data are made, in few seconds, by a minicomputer which is very easy to work with. A clinical example in which the above-mentioned data have been employed helps to demonstrate their extreme usefulness.

Blood Gas Analysis↗
PubMed1976

Minicomputer enhancement of scintillation camera images using fast Fourier transform techniques.

Minicomputer methods were developed to enhance lesions in scintillation camera images. This study was directed towards improving the diagnostic quality of liver images. A PDP-12 digital computer was interfaced to a Pho/Gamma HP III scintillation camera and programmed to carry out two-dimensional frequency-domain analysis and processing as an on-line operation. A two-dimensional frequency spectrum is produced. An interactive program allows the operator to construct graphically a frequency-domain filter and apply it to the data matrix. The filter is optimized using the image of a known phantom and then applied unchanged to the clincial liver image. An inverse Fourier transform produces an enhances image in the spatial domain. Significant enhancement of both phantom and liver images has been obtained.

Diagnosis, Computer-Assisted↗
PubMed1979

[Research method using discriminant subsets on minicomputers].

Given a set of elements (illnesses, medicines,...) characterised by criteria or attributes (symptoms, characteristics, colour,...), each able to assume a certain number of states (for colour, more than nine), the problem is to find a minimal discriminant chain, or in other words, the smallest sequence of criteria enabling one to distinguish the elements of the initial set, unless of course they are identical. This problem is very general, but when tackled together it often involves excessive calculations. Based on the research principles proposed by Begon and Tremolieres, the authors propose a method well adapted to criteria in several states, which can be used on a small computer, when searching for pseudo-minimal chains by sampling. An application of this method (in liaison with the 'Centre Anti-Poisons', Nancy Pr Larcan) has enabled us to carry out a search for discriminant chains for more than 2800 medical tablets by their external characteristics, among which 3 quantitative criteria were known with a certain margin of error, and 21 qualitative criteria, making a total of more than 60 different states.

Computers↗