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At least 19 recordsLinked to original sources

Transcriptomic signatures of mind-body transformations therapy in breast cancer: Downregulation of the interferon signaling pathway.

BACKGROUND: Growing evidence has shown that Mind-Body Transformations-Therapies (MBT-T) are able to modulate chronic inflammation, a well-known driver of cancer progression and drug resistance. In our previous work, we showed that a specific MBT-T protocol was able to reduce the release of various pro-inflammatory cytokines and chemokines in the sera of patients with breast cancer that completed adjuvant chemotherapy. Despite these clinical observations, the underlying molecular pathways through which this therapy exerts its effects remain unclear. This study aims to address this gap by characterizing genome-wide transcriptional profiles in patients undergoing a novel MBT-T protocol. METHODS: In this proof-of-concept study, patients with breast cancer were randomized into two groups: Group 1 (CTL), receiving standard follow-up care, and Group 2 (MBT-T), receiving standard follow-up plus biweekly MBT-T for 4 months. Blood samples were collected at different timepoints during the treatment. After RNA extraction from whole blood, gene expression was analyzed on twenty-one patients (CTL, n = 7; MBT-T, n = 14) using the nCounter® Human Inflammation Panel (249 genes). RESULTS: Patients undergoing MBT-T showed a significant global downregulation of inflammatory gene expression compared to the control group. The analysis revealed that the Interferon (IFN) signaling pathway was the most significantly suppressed, by downregulation of key genes such as IFIT1, IFIT3, IFI44, MX1 and OASL in the MBT-T group. CONCLUSIONS: MBT-T acts as a biological modulator capable of downregulating key inflammatory pathways at the transcriptional level. These findings provide a genomic basis for the clinical benefits of mind-body interventions in oncology.

Breast cancer↗

Mind-body problems in family therapy: contrasting first- and second-order cybernetics approaches.

Using detailed case examples, we contrast first- and second-order cybernetics approaches to family problems involving somatic symptoms in a family member. A second-order cybernetics approach views the reality of the problem as linguistically shaped by those interacting around it, including the therapist and observing team members. This co-constructed reality, the story of the problem, inadvertently contributes to the problem's endurance by narrowing the choice of more effective solutions. In our approach, the therapist elicits from each person his or her story about the illness in the family. The therapist then facilitates a therapeutic conversation that provides a context for new linguistic distinctions to be drawn, including the way mind and body may interact to generate the symptoms. Shifts in beliefs and behaviors follow, and more innovative solutions to the problem can then emerge. Unlike the approach in our previously published work based upon ecosystemic patterns as "system diagnoses," this approach uses only descriptions and explanations of the problem as are collaboratively constructed within this therapeutic conversation.

Adult↗

Mind-body patterns of symptom generation.

Effective ways for joining family therapy with other treatment modalities are becoming increasingly important as the efficacy of family therapy gains acceptance in the medical and mental health community. When one interfaces family therapy with medical and psychopharmacological treatments, which find the sources of symptoms within individuals, rather than interpersonal systems, careful attention must be paid to the mind and body relationships that guide interactions between family behavior and the somatic physiology of each family member. We present six mind-body patterns of symptom generation found to be particularly useful for designing multimodality treatments and for communicating the treatment rationale to medical and psychiatric clinicians or to family members. Case examples illustrate their clinical use.

Combined Modality Therapy↗

Psychosomatic disease and acupuncture.

The medical philosophy implied by a "mind-body unity" hypothesis is outlined and the type of therapy appropriate to the stage of development of disease is discussed; special reference is made to the place of acupuncture within a modern medical program. Starting from the premise that mind is the primary causal force determining neural states, it is concluded that the highest level medical art would be "psychosomatic psychoanalysis." The next highest form of therapy would deal directly with nerve impulses (acupuncture, etc.), followed by drug therapies directed at intra- and extracellular fluid composition, hormone macromolecule manipulation, and finally minor and major surgery.

Acupuncture Therapy↗

Mental imagery and its potential for physical therapy.

The purposes of this article are 1) to review the sports and motor-learning literature regarding the effects of mental imagery and mental practice on physical skills and 2) to explore the feasibility of using them as adjunctive techniques in physical therapy. In the area of sports, evidence exists that mental practice can improve motor skills. Research that supports a mind-body relationship is cited, in addition to research using mental imagery from the areas of medicine, biofeedback, psychoneuroimmunology, and physical therapy. Variables that influence the outcome of mental practice such as vividness, kinesthetic imagery, and combining physical and mental practice are examined, and two major variables associated with ineffective results are identified. The advantages and disadvantages of using mental imagery for physical therapy patients are discussed with the conclusion that mental imagery has the potential to be a viable technique for physical therapists.

Biofeedback, Psychology↗

[A case of vocal cord dysfunction diagnosed as bronchial asthma, that was improved by psychosomatic therapy].

A 19-year-old psychologically disturbed female was admitted to our hospital because of intractable dyspnea and wheezing for twenty two months. She had been diagnosed as having asthma and had received several medications including steroids before admission to our hospital. According to our clinical observations, she was considered not to have asthma because neither FEV1.0 nor PaO2 was decreased during the periods of wheezing and FEV1.0 was not changed by inhalation of bronchodilators, although she had a family history of allergy and false bronchial hyperreactivity by asthograph. On physical examination, diffuse wheezing was heard mainly over the larynx during inspiration at the times of dyspnea. There was flattening of the inspiratory flow-volume loop during wheezing. Bronchoscopy performed during an attack confirmed that wheezing was due to adduction of the vocal cords throughout the respiratory cycle. Therefore, this case was diagnosed as vocal cord dysfunction. Her symptom was considered to be a form of conversion reaction derived from her unhappy past history. Following psychosomatic therapy, all of her medications became unnecessary. She understood the mind-body relationship of her condition, and learned to achieve self-control.

Adult↗

Evaluation and treatment of headache. Practical approach to a common symptom.

Chronic headache pain has many causes but is generally attributed to one of three mechanisms: muscular contraction, vascular inflammation, or traction or inflammation of pain-sensitive structures. Because of the wide variety of headache types and the often-confusing terminology and classification systems in use, evaluation of headache can be difficult. A step-by-step approach to patient workup, including patient history, physical examination, and appropriate tests, can help the physician pinpoint the underlying problem and determine appropriate therapy. Long-term drug therapy is effective for most patients with vascular headaches. For headaches of psychogenic origin, therapy includes psychotropic drugs, biofeedback training, counseling, and behavior modification. More research in the area of mind-body interactions will lead to improved management of chronic headache of nonorganic origin.

Antidepressive Agents, Tricyclic↗

Identifying and treating the sexual repercussions of incest: a couples therapy approach.

Given the significant number of adults who were sexually victimized as children and the serious negative effects that sexual abuse can have on sexual functioning, clinicians need to be prepared to recognize and treat the intimacy concerns of adult incest survivors. Broadening the definition of incest to include nontouch sexual abuse, this paper describes types of sexual problems commonly expressed by survivors, such as sexual dysfunction, fear of sex, conditioned negative reactions to sex, flashbacks to the abuse, and mind-body dissociation. The intimate partner of the survivor is viewed as a secondary victim of the incest, who often displays a unique set of sexual and emotional concerns as well. A four-stage couples therapy approach is presented which includes identifying the problem, working together on incest resolution, changing old sexual intimacy patterns, and creating positive sexual experiences. This model is a dynamic combination of incest resolution therapy, sex therapy, and couples therapy. Therapeutic dilemmas and considerations are discussed and recommendations given for increasing the effectiveness of therapy. An argument is made as to why a couples therapy approach is the preferred method of treatment.

Female↗

Comments about cognitive therapy and behavior therapy.

This article identifies, describes and discusses two major sources of controversy between cognitive therapists and behavior therapists. One class of conflict has been generated by specific misinterpretations of opposing viewpoints. Appropriate quotations are used in an attempt to clarify the views of the major protagonists. The other source of conflict is the metaphysical issue of mind-body dualism and differing definitions of psychology. After discussing justifications for renewed research on cognitive interactions and the major behaviorist objections to such an effort, the author recommends intensified applications of behavioral technology in the socio-economic and political arena.

Behavior Therapy↗

Psychosomatic disease and the problem of causation.

Despite its impressive rate of growth in the past decades, an increasing amount if dissatisfaction with the area of psychosomatic medicine is reflected in recent literature. The discipline's failures relate to concepts of pathogenesis and therapeutic application of research findings. These failures are explained as a necessary consequence of the philosophical tenet of mind-body dualism which underlies medical theory. It is urged that advocates of psychosomatic medicine give the concept of "holism" meaning at the most fundamental level by establishing a rational basis for theory, or else forsake this line of research for others which yield causal relationships conductive to effective therapy.

Forecasting↗

The mind-body connection: the psychophysiology of many traditional nursing interventions.

The bidirectional relationship between mind and body and the concept that psychological processes can produce attendant physiologic changes are explored in this article. The mind-body connection provides a framework for exploring a psychophysiologic explanation for the therapeutic properties of some traditional nursing interventions to potentiate health and healing. This model allows nurses to move from tradition-based practice to knowledge-based practice. CNSs provide direct patient care, consult with staff nurses, influence systems of care, and engage in outcome research. This mind-body paradigm provides a model for practice and a framework for quantifying outcomes.

Holistic Health↗

Tai Chi Chuan.

Tai Chi Chuan, a mind-body relaxation exercise, was devised by Chang San Feng for meditation and self-defense in the thirteenth century A.D. The 108 forms are performed in a slow relaxed manner, taking 30 minutes altogether. Practitioners of Tai Chi claim that it promotes health and cures certain illnesses but this has not been substantiated and therefore further research into its health benefits is warranted.

China↗

Mind and brain in psychiatric treatment.

Psychological and biological components of psychiatric illness must be integrated to avoid the perils of reductionism in diagnosis and treatment. With the decline of dualism, a number of creative thinkers have conceptualized the mind-body problem in a manner that values perspectives derived from psychoanalytic thinking as well as from the neurosciences. Similarly, modern studies of the etiology and pathogenesis of major psychiatric disorders suggest that only through a sophisticated synthesis of psychosocial and genetic/biochemical points of view can causation be comprehensively understood. In light of this accumulating knowledge, the author concludes that treatment must be informed by psychotherapeutic approaches as well as by pharmacotherapy.

Adult↗

A case of hysteria, with a note on biology.

Psychoanalysis recently has shown interest in the data of neurobiology. This interest has been fostered by the realization that a model of Cartesian mind-body dualism is inadequate to current observation and knowledge. Despite the theoretical appeal of integrating knowledge from the two fields, there have been few attempts at correlation in specific clinical situations. This paper presents a case of hysteria in which the physical manifestations of hyperprolactinemia, galactorrhea, amenorrhea, and infertility are considered in relation to both the brain regulation of prolactin and to unconscious fantasy, motivation, and conflict. Some of the intriguing possibilities and limitations of research at the frontier of psychoanalysis and neurophysiology are discussed.

Adult↗

Why patients seek unproven cancer remedies: a psychological perspective.

When it is discovered that cancer has recurred, patients experience a period of acute emotional distress, with increased anxiety, fear, helplessness, and depression. Well-meaning colleagues, friends, and relatives feel compelled to tell them about unorthodox cancer "cures." These unproven remedies tend to fit holistic health concepts purporting to enhance the body's own defenses; most involve the use of chemicals or drugs, nutritional supports, vitamins, vaccines, and mind-body techniques. In the past decade, laetrile has been the most popular unorthodox remedy. The distraught patient and family are deluged with information and have trouble evaluating what is valid. Physicians who treat patients with cancer should make sure that they themselves understand the emotional basis for a patient's need to pursue unorthodox remedies. The risk is heightened when the patient senses the doctor has "given up" and has "nothing more to offer." Patients should feel able to ask questions about unproven remedies without fear that the physician will be judgmental or punitive. Participation in a clinical trial of a new and promising treatment under investigation, within the full protection of ethical guidelines, should be suggested as an alternative to unproven treatments outside the medical system that are not subject to the same constraints.

Anxiety↗

Optimal dose and exercise modality to improve HbA1c in older adults with type 2 diabetes mellitus: a systematic review with pairwise, network, and dose-response meta-analyses.

We aimed to compare exercise modalities and evaluate dose-response relationships with glycemic control including continuous aerobic exercise (CAE), resistance training (RT), combined exercise (CE), mind-body exercise (MBE), and high-intensity interval training (HIIT) in older adults with type 2 diabetes mellitus (T2DM). Three databases were searched for randomized controlled trials of exercise interventions in older adults with T2DM reporting glycated hemoglobin (HbA1c). Pairwise, Bayesian network, and dose-response meta-analyses were conducted. Compared with control, HIIT demonstrated the largest estimated reduction (MD = -0.95%; 95% CrI -1.45, -0.49), followed by CE (MD = -0.59%; 95% CrI -0.93, -0.25), CAE (MD = -0.46%; 95% CrI -0.69, -0.24), MBE (MD = -0.42%; 95% CrI -0.76, -0.10), and RT (MD = -0.29%; 95% CrI -0.51, -0.08). Dose-response network meta-analyses suggested a non-linear association between overall exercise dose and HbA1c reduction, with maximal estimated benefits at approximately 704 METs-min/week with the 95% CrI excluding zero between 241 and 920 METs-min/week. HIIT demonstrated the steepest estimated dose-response relationship, but with wider credible intervals. Other exercise modalities showed more gradual dose-response patterns across their estimated effective ranges. Our findings suggest that exercise prescription for older adults with T2DM should be individualized according to exercise modality, dose, and health status.

Humans↗

Self-regulation of the immune system through biobehavioral strategies.

Increasing scientific study and attention is being directed to mind-body interactions, particularly to the interrelationships between the brain and the immune system. This effort has created a new interdisciplinary field, psychoneuroimmunology. An overview of this new field is provided, followed by a comprehensive survey of the growing evidence suggesting that measurable immune system parameters can be influenced by biobehavioral strategies involving self-regulation. Modalities included are relaxation and imagery techniques, biofeedback-assisted strategies, the use of humor, and affiliation to influence emotional states, hypnosis, and conditioning paradigms. The majority of studies have reported significant immune parameter changes. Additional well-designed research is needed to clarify and confirm these initial findings. Future research would benefit from investigating the clinical implications of these immune parameter changes. Knowledge of effects of the mind on the body is rapidly expanding and may be important for achieving improved immune system functioning and health.

Behavior Therapy↗