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Results for “Mikulicz' Disease”

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At least 19 recordsLinked to original sources
PubMed1971

Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion).

Benign lymphoepithelial lesion (Mikulicz disease) is generally regarded as an inflammatory disorder of unknown aetiology, characterized by epimyoepithelial islands, and unrelated to malignant lymphoma. Five cases have been collected which show evidence at the same site of both Mikulicz disease and a malignant lymphoma. The latter took the form of reticulum-cell sarcoma or Hodgkin's disease. The two diseases were discovered simultaneously or the malignant lymphoma was detected at a subsequent date. The probable sequence of events is discussed. These cases are regarded as one of the best illustrations in man of an autoimmune disorder being followed by the development of malignant lymphoma. It is concluded that so-called benign lymphoepithelial lesion is not always innocuous and an attempt is made to establish histological criteria which might be regarded with suspicion in a particular case.

Adult↗
PubMed2004

Elevated IgG4 concentrations in serum of patients with Mikulicz's disease.

Mikulicz's disease has recently been included within primary Sjögren's syndrome. It is a unique condition involving enlargement of the lacrimal and salivary glands, characterized by few autoimmune reactions. It is responsive to glucocorticoid treatment. Analysis of IgG fractions was performed in patients with Mikulicz's disease in order to determine the differences between Mikulicz's disease and Sjögren's syndrome. The study showed that serum IgG4 concentrations are elevated in patients with Mikulicz's disease, but not in those with Sjögren's syndrome.

Aged↗
PubMedDate not supplied

[Mikulicz disease].

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Humans↗
PubMed1978

Mikulicz disease of a minor salivary gland.

The third recorded instance of Mikulicz disease of a minor salivary gland is described; this is the first case in which a surgical specimen, in addition to the biopsy specimen, was obtained for microscopic examination. A brief description of the disease and its treatment is also presented.

Aged↗
PubMed2006

A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease.

Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but it represents a unique condition involving persistent enlargement of the lacrimal and salivary glands characterized by few autoimmune reactions and good responsiveness to glucocorticoids, leading to the recovery of gland function. Mikulicz's disease was recently reported to be associated with elevated immunoglobulin G4 (IgG4) concentrations in the serum and prominent infiltration of plasmacytes expressing IgG4 into the lacrimal and salivary glands. The following features were used for diagnosis: (1) visual confirmation of symmetrical and persistent swelling in more than two lacrimal and major salivary glands; (2) prominent mononuclear cell infiltration of lacrimal and salivary glands; and (3) exclusion of other diseases that present with glandular swelling, such as sarcoidosis and lymphoproliferative disease. These features are not observed in most SS cases. The complications of MD include autoimmune pancreatitis, retroperitoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, and Riedel's thyroiditis, all of which show IgG4 involvement in their pathogenesis. Mikulicz's disease thus differs from SS and may be a systemic IgG4-related plasmacytic disease.

Adult↗
PubMed2005

Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma.

OBJECTIVE: To remove the confusion surrounding the terms "Mikulicz's disease" and "Mikulicz's syndrome" by discovering the nature of the disease that Mikulicz described. STUDY DESIGN: Investigation of the original 1892 publication by Mikulicz in the light of current knowledge. RESULTS: Mikulicz described bilateral painless swellings of the lacrymal, major salivary, and minor salivary glands that were present for 14 months without a reduction in salivary flow before the patient, a man of 42 years, died. A print of a microscopical field of one of the submandibular glands contains a uniform lymphocytic infiltrate of centrocyte-like cells typical of MALT lymphoma, which is strongly supported by the reported clinical features. CONCLUSION: Mikulicz published the first case report of a MALT lymphoma of salivary glands, and the terms "Mikulicz's disease" and "Mikulicz's syndrome" should no longer be used.

Adult↗
PubMed1976

Mikulicz's disease and Mikulicz's syndrome.

The pathogenesis, clinical manifestations, and historical development of Mikulicz's disease and Mikulicz's syndrome are given. It is recommended that the term "Mikulicz's syndrome" be dropped to avoid confusion with the rare and well defined entity "Mikulicz's disease."

Diagnosis, Differential↗
PubMed1977

Mikulicz disease and subsequent lupus erythematosus development.

In a 12-year-old boy with clinical and histologic features of Mikulicz disease, systemic lupus erythematosus (SLE) developed two years later. Atrophic plaques and nodules in the skin along with substantial increase in salivary gland enlargement characterized the onset of SLE. There was lack of renal and joint manifestations, and no evidence of keratoconjunctivitis sicca or xerostomia was seen. Histopathologic changes in the skin lesions included mucinous infiltrates, chronic vasculitis, and dermal-epidermal junction findings typical of SLE. Direct immunofluorescene studies of skin lesions and normal-appearing skin showed granular deposition of immunoglobulins and complement at the dermal-epidermal junction zone. Level of anti-DNA antibodies was noticeably elevated, and the serum C3 value was depressed. The patient's response to systemic corticosteroid therapy was dramatic.

Age Factors↗
PubMed2006

[The significance of disease-independence in Mikulicz's disease--revival interests in Mikulicz's disease].

Mikulicz's disease represents a unique condition involving enlargement of the lacrimal and salivary glands. Mikulicz's disease has been considered part of primary Sjögren's syndrome because both diseases were histologically similar. However, the gland swellings in Mikulicz's disease are persistent, and its decreased secretional function is good responsiveness to glucocorticoid. Serologically, Mikulicz's disease is characterized by few autoantibody including anti-SS-A and anti-SS-B antibodies. Recently, it is revealed elevated IgG4 concentrations in the serum and prominent infiltration by plasmacytes expressing IgG4 in the lacrimal and salivary glands in Mikulicz's disease. Prominent IgG4-positive plasma cells are also detected in systemic lymph tissues. We cannot detect the phenomenon in Sjögren's syndrome. In complications with Mikulicz's disease, there are autoimmune pancreatitis, retroperitoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, Riedel's thyroiditis, which are related to IgG4 in its pathogenesis. Mikulicz's disease is different from Sjögren's syndrome, and may be a systemic IgG4-related plasmacytic disease.

Autoantibodies↗
PubMedDate not supplied

[Mikulicz' disease].

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Dentistry↗