[Diagnosis of malignant pulmonary tumors by scintiscanning with mercury isotopes].
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Comparative tests of net mercury methylation potentials, with cultivated and macrophyte-associated periphyton and using stable ((200)HgCl(2) and CH(3)(199)HgCl) and labeled ((203)HgCl(2)) mercury, have been conducted in the Everglades nutrient removal area (Florida, USA) and in a tropical coastal Brazilian lake (RJ, Brazil). More methylmercury was formed by macrophyte-associated (up to 17% of added (203)Hg(II)) than cultivated (up to 1.6%) periphyton and methylmercury formation was lower in periphyton exposed to light (0.2%). High methylation was also observed for samples incubated with stable mercury isotopes (1.5-7.7% of added (200)Hg(II)), confirming the results obtained with labeled mercury. Simultaneous addition of (200)HgCl(2) and CH(3)(199)HgCl indicated that CH(3)(199)HgCl had no inhibitory effect on Hg methylation. The elevated methylation potentials observed in macrophytes, because of their root-associated periphyton, might contribute significantly to the high levels of methylmercury observed in Everglades biota. Comparative mercury methylation tests were also conducted in the water of a stratified temperate lake (Wisconsin, USA). Similar trends were observed for both stable and radioisotopes, with increasing mercury methylation along the depth profile. The highest levels (0.9% (203)Hg(II) and 0.8% (200)Hg(II)) were obtained below the oxic/anoxic boundary, where sulfide starts to increase, probably as a result of the intense activity of sulfate-reducing bacteria in the anoxic layer.
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A 61-year-old female patient accidentally aspirated liquid mercury during a medically ordered diagnostic procedure. To develop animal-based guidelines, liquid mercury was introduced into the lungs of four dogs. Based on the study of these animals, a method of predicting the kidney inorganic mercury burden was developed using radioactive isotope dilution techniques. It was further demonstrated in dogs that oral administration of dimercaptopropane sulfonate (DMPS) increased mercury excretion and reduced the kidney burden. A rat experiment was performed permitting a statistical evaluation of the assumptions basic to the use of the method. The method was applied to the patient with the result that the kidney inorganic mercury burden was predicted to be 28.1 mg, 8 months after the accident. Treatment with DMPS increased urinary excretion and the post-treatment kidney burden was estimated at 19.6 mg Hg. Inasmuch as the radioactive dose to the subject may be kept at a negligible level and because sensitive methods exist for measurement of radioactive and stable mercury concentrations, the technique may be applicable in special cases to the estimation of kidney inorganic mercury burdens incurred by industrial exposure.
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