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Results for “Maxillofacial Development”

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[Tasks of pedodontics from the viewpoint of maxillofacial development].

Out of every 100 children, only two to four develop a set of teeth which is free of disturbances. Eugnathia is common, but the condition does not require orthodontic treatment. The beginning stages of maldevelopment may be overlooked if the parents do not take their children to the dentist regularly. The consequences of premature teeth loss for the first and particularly the second dentition may be considerable; the sensitive development of dentition may be disturbed. Maldevelopment in the mixed dentition period however may be the cause of early space loss. If lack of space is severe, the neighboring deciduous teeth are also forced out by the cause of early space loss. If lack of space is severe, the neighboring deciduous teeth are also forced out by the erupting teeth. On the one hand, this loss tends to increase the lack of space and therefore all the detrimental consequences. Dental care of children requires the knowledge necessary to directly establish and immediately correct incipient disturbances in development in addition to the recognition and treatment of diseases of the teeth and the periodontium.

Child

Influences of different surgical procedures on growth of dentomaxillary complex in dogs with artificially created cleft palate.

Possible detrimental effects of palate repair on dentomaxillary growth have been reported before. In our study, two principally different surgical techniques were compared. Dogs with artificially created clefts of the palate were subjected to either a periosteal flap (Langenbeck) or to a bone flap (Dieffenbach) closure. Skull roentgenograms and upper jaw impressions were used to study the possible effects on growth. Definite abnormalities were found following both procedures; there are strong indications that the bone flap is the more detrimental one.

Animals

Whole exome sequencing and cluster analysis reveal that EPB41L4A mutation may trigger tooth agenesis.

OBJECTIVE: To detect and analyze the correlation between commonly mutated genes and known genes associated with tooth agenesis in patients with non-syndromic tooth agenesis. The aim is to explore new genes that may be associated with tooth agenesis, to provide a genetic reference for its prevention as well as for the clinical diagnosis and treatment of tooth agenesis. METHODS: Genomic DNA was extracted from the peripheral blood of 18 congenitally edentulous subjects, and related gene mutations were identified by whole-exome sequencing. The genes related to maxillofacial development and the known pathogenic gene sequences of congenital tooth agenesis were selected for local alignment analysis of pairwise sequences, and the metric relationship of related sequences was determined. Hierarchical and fuzzy clustering methods were used for cluster analysis. RESULTS: Hierarchical clustering and fuzzy clusterings yielded consistent results. The EPB41L4A gene clustered with a large number of well-known and well-defined genes associated with tooth agenesis. From the perspective of cluster analysis, it can be inferred that the genes clustered together generally have similar functions. CONCLUSION: EPB41L4A, which is involved in the Wnt pathway, may be a candidate gene warranting further investigation.

Humans

[Surgical correction of facial asymmetry].

It is not possible to group the facial asymmetries in one single nosological entity. However, whatever the origin of these malformations, their surgical treatment is governed by the same principles. In this article, the author attempts to define certain aetiologies:genetic, congenital and developmental, of the minor assymmetries of the face. He then reviews the different techniques in current use, in plastic and reconstructive surgery:autogenic or homogenic tissue grafts (bone, cartilage, derm, fascia, etc.), implants of plastic material, osteotomies. He stresses the use of simple techniques which cause little mutilation, as well as the simultaneous correction of the profile which greatly enhances the aesthetic appearance and the psychological well-being of these patients.

Adolescent

The initial evaluation in maxillofacial trauma.

Evaluation in maxillofacial trauma is primarily an extension of the art of the physical examination, with inspection, palpation, and evaluation of loss of normal function as the primary requisites. X-ray evaluation is critical, and best results are usually obtained by taking films as soon following the injury as possible, before opacification of the sinus with blood, swelling, or hematoma obscures critical bone landmarks. Primary reduction and surgical management of these fractures can usually be delayed for a reasonable period; however, the most accurate findings on both physical examination and x-ray studies are those obtained as soon as possible after the injury.

Child

Morphology of growing bone surfaces.

The relation between bone surface patterns and the rate of bone formation and destruction was studied by observing surface sections and ground sections. The material used consisted of the dried skulls of three pigs. Observations on surface sections revealed two prinicipal types of bone surface patterns, i.e. a type characterized by smoothness and regularity and a type characterized by roughness and irregularity. Observations on corresponding ground sections revealed that these patterns represent appositional surfaces and resorptive surfaces, respectively. Within each type of surface pattern, variations occurred. As judged from the corresponding ground section, these variations might express variations in growth rates.

Animals

Growth potential of cranial suture bone autografts. I. An experimental macrosopic investigation in young rabbits.

On 25 rabbit sucklings a coronal suture-bone graft was transplanted into an experimental unilateral premaxillo-maxillary bone and stuture defect. 21 animals survived the experimental period and were sacrificed fullgrown (6 months). The graft was found to be well incorporated into the recipient site in all cases, its structure being remodelled to a striking similarity with the unoperated side and the suture was still visible. Photographic measurement of the snout deviation revealed that the longitudinal growth of the grafted suture approximately followed the general growth of the facial skeleton. This indicates an up to 3-fold increase of the growth in comparison to its original cranial growth site.

Animals