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At least 19 recordsLinked to original sources
PubMedDate not supplied

Myositis ossificans.

Myositis ossificans is a fairly common disorder that typically involves progressive heterotropic bone formation. A typical case is discussed in this paper. The radiographic findings in myositis ossificans are relevant in differentiating it from a malignant bone tumor and a benign process. Myositis ossificans can cause impairment to a joint with poor rehabilitative results. Limitation of joint function and little reabsorption of the heterotopic bone formation is common. Most cases are posttraumatically related with the brachialis and the quadricep femoris muscles frequently involved. This is especially true for sport injuries.

Hematoma↗
PubMed2003

Usefulness of ultrasonography for early recurrent myositis ossificans.

Myositis ossificans is a benign heterotopic ossifying condition of soft tissues. The lesion may cause persistent functional impairment of adjacent joints. Surgical intervention is often needed to regain normal function, even though a high recurrence rate is reported. In the present case, we found that recurrent myositis ossificans could not be demonstrated by radiography during the early stage. However, ultrasonography proved to be an excellent tool for detecting early recurrence of myositis ossificans and for distinguishing the condition from extraosseous sarcomas.

Alkaline Phosphatase↗
PubMed1998

Differential expression of bone and cartilage related genes in fibrodysplasia ossificans progressiva, myositis ossificans traumatica, and osteogenic sarcoma.

Fibrodysplasia ossificans progressiva, myositis ossificans traumatica, and osteogenic sarcoma are representative genetic, traumatic, and neoplastic disorders of osteogenesis, respectively. However, the pathology, pathophysiology, and natural history of the disorders differ substantially. Gene expression related to bone induction was studied in these disorders. Primary cell lines established from lesional tissues derived from each of these disorders expressed different patterns of protooncogenes, bone morphogenetic protein genes, and bone phenotype specific genes. The osteogenic sarcoma cell line expressed the entire repertoire bone morphogenetic proteins 1 to 7, c-fos and c-jun messenger ribonucleic acids. Myositis ossificans traumatica cells expressed phenotype markers similar to those of the osteogenic sarcoma cells, and expressed bone morphogenetic proteins 1, 4, and 6 and c-fos messenger ribonucleic acids, but not c-jun messenger ribonucleic acid. Fibrodysplasia ossificans progressiva early lesional cells demonstrated specific over-expression of bone morphogenetic protein 4 messenger ribonucleic acid. Differential expression of genes related to osteogenesis have important implications for understanding the earliest molecular events in normal and dysregulated osteogenesis in humans.

Adolescent↗
PubMed1992

Unusual clinical presentation and scintigraphic pattern in myositis ossificans.

Myositis ossificans, or heterotopic bone formation, is a possible sequela of musculoskeletal trauma. Its radiographic and scintigraphic appearances have been well documented. Specifically, plain film radiographs usually show soft tissue calcification in the muscle groups adjacent to the trauma. The three-phase bone scan may demonstrate an area of nonspecific increased tracer uptake in all three phases. The authors present a case of radiographically demonstrated heterotopic bone formation in the leg of a retired football player.

Adult↗
PubMed1977

Histochemical and ultrastructural studies in fibrodysplasia ossificans progressiva (myositis ossificans progressiva).

By light microscopy the subdermal nodule of a patient with fibrodysplasia ossificans progressiva (FOP) had a fibromatoid histologic appearance. The cytoplasm of the cells stained strongly for mannose-rich glycoprotein with the concanavalin A-horseradish peroxidase (con A-HRP) method. The tumors also exhibited abundant hyaluronidase-digestible mucopolysaccharide in the interstitium with various basic staining reagents. This material appeared to consist principally of hyaluronic acid or chondroitin sulfate with few or mainly masked sulfate esters. At the ultrastructural level, cells interpreted as the tumor cells in the subdermal nodule from the patient displayed extremely hyperplastic granular reticulum and well-developed Golgi elements and appeared very active in synthesis and secretion of protein. The material in the dilated cisternae of the granular reticulum stained for glycoprotein with the con-A-HRP method. Macrophages which comprised the other main cell type in the nodules commonly contacted the tumor cells and occasionally evidenced engulfment of these cells. The intercellular matrix of the nonossified subdermal nodule exhibited greatly increased mucosubstance and, by electron microscopy, showed an unusual network of dialyzed iron-reactive acid muco-substance in the interstitium.

Alkaline Phosphatase↗
PubMed1995

Fracture of a supracondylar humeral myositis ossificans.

Although myositis ossificans is a well-known sequela of elbow trauma, reinjury to the affected region can also occur, resulting in acute symptoms from a fracture of the myositis ossificans. An 18-year-old man presented with localized pain, soft-tissue swelling, and a bony mass along the anterolateral distal humerus with restricted elbow range of motion after injury to his elbow during football. One year earlier he had sustained a similar crush injury to his elbow that resulted in a limited, although painless, arc of motion. Radiographs and tomograms established the diagnosis of a fractured supracondylar humeral myositis ossificans. Surgical excision of the large mature ossified fragment confirmed the diagnosis and restored a full range of motion of the elbow.

Adolescent↗
PubMed1995

[Circumscribed myositis ossificans: bone changes detected by MRI].

The authors report a case of ossificans myositis, in which MRI showed inflammatory changes of the adjacent bone. T1 weighted fat saturation sequence with gadolinium injection showed enhancement of medullary and cortical bone. This potentially mistaking pattern must be known, to avoid misdiagnosing with malignant osseous tumor, specially before achievement of the characteristic pattern of zonal maturation and its calcified rim.

Adult↗
PubMed1987

A viable pregnancy in a patient with myositis ossificans progressiva.

Myositis ossificans progressiva is a rare autosomal dominant disorder characterized by a progressive ectopic ossification of the connective tissue of the voluntary muscles and ligaments with associated debilitation and characteristic skeletal malformations. There have been less than 600 cases in the literature. This is the first reported case of a viable pregnancy in a patient with myositis ossificans progressiva.

Adult↗
PubMed1992

Myositis ossificans traumatica.

Myositis ossificans is a benign condition of heterotopic bone formation. It is a generalized term for four separate clinical entities. Although not a rare disease process, diagnosis often remains difficult. This article reviews the various forms of myositis ossificans, as well as the pathology, diagnostic tests, and treatment options.

Adolescent↗
PubMedDate not supplied

MRI of myositis ossificans circumscripta.

Myositis ossificans circumscripta (or pseudomalignant osseous tumor of soft tissue) may be confused with malignant neoplasms if there is no clear history of trauma. Two cases are presented in which magnetic resonance imaging (MRI) clearly demonstrates disproportionally extensive abnormal signal intensity along the course of muscle fibers. Although the specificity of this finding is uncertain, MRI enhances the level of confidence in diagnosing myositis ossificans.

Adolescent↗
PubMedDate not supplied

Anesthesia in 'stone man': myositis ossificans progressiva.

Myositis ossificans progressiva is a rare disease leading to complete ossification of the muscular system. Very little information about this rare disease and its anesthetic implications has appeared in anesthetic literature. This disease is felt to have an autosomal dominant pattern of inheritance and is usually associated with anomalies of the hands and feet. Afflicted patients are frequently misdiagnosed in childhood as having a rheumatologic disorder. Later in life (as true bone is formed in striated muscle, ligaments, and fascia), the correct diagnosis becomes obvious. Although muscles of the heart, diaphragm, larynx, and sphincters are spared, those of the chest wall are not, and pulmonary function progressively deteriorates. Death frequently occurs as a result of a pulmonary infection. Specific anesthetic considerations include positioning to avoid injury, potential need for fiberoptic intubation or tracheostomy, decreased thoracic compliance with the need for increased ventilating pressures, and the ultimate in disuse atrophy contraindicating the use of succinylcholine. Myositis ossificans progressiva can present the anesthesiologist with interesting challenges. Anesthetic management will need to be individualized according to the severity of the disease.

Adenocarcinoma↗
PubMed1991

Myositis ossificans progressiva.

Myositis ossificans progressiva is a rare, incurable disease causing progressive ossification of skeletal muscles leading to total immobility. We report one such case.

Adult↗
PubMed1989

The nuclear medicine bone image and myositis ossificans progressiva.

Myositis ossificans progressiva most commonly effects adolescents and young adults. It is characterized by progressive calcification of muscle and frequently follows trauma. Bone imaging may be helpful in determining the full extent of the disease process and may be more accurate than conventional radiographs. Bone imaging is able to detect lesions before they can be observed with radiographs. In addition, radiographs may tend to underestimate the severity of the disease.

Adult↗
PubMed1989

The management of athletes with myositis ossificans traumatica.

Myositis ossificans traumatica (MOT) is often encountered by young male athletes participating in contact sports. The purpose of this paper is to review this disorder, characterized by a localized bone formation within muscle and other connective tissues as a result of a single or repeated contusion. MOT merits close attention because it may cause protracted disability and absence from competitive and recreational activities. Moreover, it may be mistaken for serious pathologies such as sarcoma. Confusion regarding the optimal management of MOT may also arise because the literature proposes conservative, experimental and surgical treatment approaches.

Adolescent↗