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Results for “Lutheran Blood-Group System”

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At least 19 recordsLinked to original sources
PubMed1977

[Problematic blood transfusion (author's transl)].

Two patients were admitted with signs of haemolysis due to severe transfusion reactions. Serological investigations showed the presence of the antibodies anti-IKb and anti-Fya. After a short period of haemodialysis the patient with Kidd antibodies died. A further patient with triple antibodies (anti-c, -K, -Lub) was so pre-immunised that with an antigen frequency of over 99.9% no compatible blood could be found in Europe. By means of information from the European Central Index in Amsterdam compatible blood for the operation could be obtained from Australia. In the fourth case the antibody anti-Cob was found which had not previously been described in Germany and with which the phenotype could be determined in 1405 unselected persons in the German population. The frequency of Cob is 7.2%.

Adult↗
PubMed1979

Autologous blood transfusions and pregnancy.

The application of autologous and frozen red blood cell (RBC) programs is described for 3 pregnant women with antibodies to high-incidence blood group antigens (anti-Lutheranb, anti-Cellano, anti-Vel). The cases illustrate how readily available supplies or rare blood types can be maintained throughout pregnancy using autologous and frozen RBC techniques, including selective predeposit, "family-sharing," and intensive phlebotomy with fluid replacement. The RBC phenotypes described in this paper are exceedingly rare since they occur in only 0.1-0.001% of random donors. However, the principles of autologous blood transfusions are universal and they can be applied to the general problems of blood group incompatibility in pregnancy.

Adult↗
PubMedDate not supplied

Eluate analysis of anti-Bg a associated renal allograft rejection.

Renal allograft rejection, following development of a positive indirect antiglobulin reaction, occurred in a multiply transfused recipient. Panel techniques confirmed both anti-Bga and anti-Kell antibodies. Recognition of the concordant antigenic specificity of the Bga and HL-A7 antigens led to an investigation of the potential role of this antibody in the rejection phenomenon. In the absence of serological cytotoxicity, a modified elution technique was used to directly obtain immunoglobulin from the rejected allograft. The eluate obtained displayed specificity for the Bga red blood cell antigen. The described technique affords an additional approach to the documentation of immunologically mediated graft rejection and obviates the limitations imposed by the absence of serological cytotoxicity. Emphasis is placed on the need for recognition of the relationship between red blood cell and HL-A antigens.

Adolescent↗
PubMed1976

Significance of HLA and blood-group incompatibility in spontaneous abortion.

The frequencies of antigen-incompatible matings within the HLA, Rhesus, Lutheran, MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1,197 (HLA) and 12,123 (the remaining eight systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matins in which the mother was Lu (a+) and had a karyotypically abnormal abortus. It is concluded that antigen incompatibility between the parents within the nine systems studied is not important in the aetiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the foetus.

Abortion, Spontaneous↗
PubMed1976

Null types of the human erythrocyte blood groups. Philip Levine award lecture.

Null types of 12 human erythrocyte blood groups are reviewed. They have helped in identifying new antigens and defining the various genetically-distinct systems. They are very valuable in identifying the antibodies in alloimmunized people and in transfusion therapy of some of these people. Fy(a-b-) erythrocytes resist invasion by malarial parasites. At least two (Rh null and the McLeod type) are responsible for congenital hemolytic disorders. Testing for K15(Kx) on neutrophils appears to be diagnostic for chronic granulomatous disease of the sex-linked recessive type.

ABO Blood-Group System↗
PubMed1976

Irregular antibodies causing hemolytic disease of the newborn.

The known antigens associated with hemolytic disease of the newborn along with the degree of severity of the disease caused by each antigen are presented in Table 13. The genotype frequencies for the major blood groups have been presented in the text. It is hoped that this information will help the clinician in managing sensitization to irregular antibodies and in predicting the likelihood of future affected siblings. Proper periodic screening of the antenatal patient for irregular antibodies can alert the physician to a potential problem with hemolytic disease and alert the laboratory so that time is available to find acceptable donors. One should always remember that autologous blood transfusion can be used if time is available to obtain the blood. When the antenatal patient with an irregular antibody presents, the husband should be tested for the presence of the antigen. If present, the physician should determine the severity of the disease that can be caused by this antibody and manage the patient appropriately. It is hoped that with good antenatal care, the morbidity and mortality of hemolytic disease of the newborn can be diminished.

Blood Group Antigens↗
PubMed1976

Sero-genetic studies on the Dama of South West Africa.

The Dama of South West Africa are a Negroid people living as a reproductive isolate in the desert and semi-desert areas of the north-west of the country. Until recent times a large proportion of them were held in bondage by the Khoikhoi (Hottentot) Nama, while the rest lived as hunter-gatherers in the mountains. This study and the work of Knussmann and Knussmann indicate that they are a Negro people, which probably has been cut off over a period from contact with other Negroes. They have received very little genetic contribution from the Khoikhoi or the San (Bushmen). The results of this investigation of 24 blood genetic marker systems in a carefully selected random sample of Dama support these conclusions.

ABO Blood-Group System↗
PubMed1977

Anti-Lu14: a Lutheran antibody defining the product of an allele at the Lu8 blood group locus.

A 'new' Lutheran-related antibody, named anti-Lu14, reacts with approximately 2.4% of random bloods. Red cells of the rare Lu:-8 phenotype are Lu:14. The data indicate, with a high probability, that the Lu 14 antigen is a product of an allele of Lu8 and that Lu14 and Lu8 comprise a third pair of alleles at the Lutheran locus. Red cells of the original Sw (a+) propositus are Lu:14. By coincidence, he has inherited two low-incidence genes. This observation may explain the discrepancy in different families concerning a possible relationship between Swa and Lutheran. Pedigree information now suggests that Swa is not a Lutheran gene.

Alleles↗
PubMed1977

The Lutheran and secretor loci: genetic linkage analysis.

Linkage analysis of Lu and Se and 31 other loci indicate that Lu:Se are not closely linked to ABO, ACP1, Co, Do, Est.D,Fy, GC, Gm, GLO:HLA, GPT, Inv, Jk,K,MN,P,PGD,PGM1, Rh,Sc, UMPK OR Yt. Lod scores for 18 families informative for Lu:Se gave no evidence for sex differentiation in recombination fraction: theta for males was 0.07, and for females, .08.

Adolescent↗
PubMed1978

[Determination of biological individuality by blood group studies].

Author deals with the possibility of determination of the biological individuality by serological methods. Determination of HL-A tissue-compatibility antigens and system of MN/Ss and Rh seen to be the most suitable tools. Alloantigens, serum proteins and group of enzymes characterize the biological individual i. e. serological methods can be used as a tool of the identification of a person. Author deals with the possiblity of determination of various razes. For this purpose investigation of the following systems are necessary: ABO-, Rh-, MN/Ss-, Kell-, Duffy-, Lutheran, Kidd, Lewis and Diego. Nevertheless, this problem is not yet solved.

ABO Blood-Group System↗
PubMed1978

[Genetic analysis of a population with abnormalities of gene frequencies].

Nineteen out of the 53 blood donors of french village with 241 inhabitants (Cezay Loire) are Rh negative (D--). This discrepancy in the distribution is analysed. 1.--The study of the genetic erythrocyte markers (ABO and Rh system for 158 inhabitants, Kell, Rautenberg, Duffy, Kidd, MNSs, P1 Lutheran, PGM1, PGM2, 6 PGD, AK, ADA, Acid phosphatase systems for 104 inhabitants) show significant abnormal gene frequencies (No. 10%) compared with a control population from Saint-Etienne, for A1, Ms, r, P1 alleles; conversely rare alleles do not seem to exist. HLA system was not tested. 2.--The genetic study led to: a) a demographic study which implied 7840 registrar's certificates and the building up of 1364 families to which the 5096 subjects belonged identified and having lived in Cezay since 1607 (this date corresponds to the earliest registrar's certificate). b) it also led to the analysis of the origin and evolution of the genetic inheritance throughout the 13 generations of known inhabitants. The calculation of the chances of each generation having passed on its genetic material to following generations shows that: Cezay has an integrated population; 30% of the genes are renewed for each generation the average value of each founder can vary according to the various generations but there seems to exist a "founder effect" of the Rh--(D--) having been and lived in the village before 1860. Although they represent 68% of the total population, the tested samples can be contested for certain systems, in its constitution (formation, choice) which prevents from ascertaining the foundation effect observed. The authors underligne the contribution of immunogenetics to the genetics of populations, and show the incidence of the choice of samples in the method used.

Alleles↗