Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Liver Circulation”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1979

Liver circulation and oxygen metabolism during short time ligation and the hepatic artery in the dog.

The changes of liver circulation and liver oxygen metabolism during and after one hour hepatic artery ligation (HAL) were studied in eight mongrel dogs. At the end of the HAL period total hepatic blood flow (THBF) was reduced from 115.6 +/- 5.5 ml/min . 100 g liver tissue to 68.0 +/- 3.7 ml/min . 100 g or 59% of the initial value. The portal venous blood flow was reduced from 83.1 +/- 3.4 to 58.8 +/- 3.7 ml/min . 100 or 82% of the initial value and the liver oxygen consumption was reduced from 4.1 +/- 0.2 ml/min . 100 g to 3.1 +/- 0.3 ml/min . 100 g or 76% of the initial value. The changes in portal venous blood flow and liver oxygen consumption were reversible following reopening of the hepatic artery. The clinical importance of a reduced portal venous blood flow and liver oxygen consumption following HAL and the possibilities to increase the portal venous blood flow are discussed.

Animals↗
PubMed1979

[New aspects of liver circulation: effects and consequences for the portocaval shunt therapy in liver cirrhosis].

Hepatic circulation, which is of essential importance in supplying the liver cells with oxygen and substrates needed for securing metabolic homeostasis of the organism, is characterized by well-regulated mechanisms of intrahepatic arterial, portal and hepatovenous interaction. Furthermore, the hepatic circulation is integrated in the systemic and splanchnic hemodynamic as interposed in a high, or respectively low, pressure system. Beside these hemodynamic mechanisms there are also specific morphologic features in the hepatic vascular bed responsible for regulating liver blood flow. For hepatic nutritions and trophics, and for the metabolic homeostasis of the organism, portal blood is of greater importance than arterial. In porto-caval shunt surgery it is recommended that any remaining portal flow to the liver be preserved to the greatest extent possible.

Homeostasis↗
PubMedDate not supplied

[Changes in the liver circulation and kidney function during pulsatile and non-pulsatile perfusion].

Pulsatile flow perfusion (PFP) requires smaller volume of additional infusion. Extravascular hyperhydration is more marked after nonpulsatile flow perfusion (NPFP). In NPFP there is an increase in free water clearance, lower urinary osmolality and diuresis rate. PFP prevents urinary hypoosmolality and retains baseline values of free water clearance. No significant differences in Na+ urinary excretion have been revealed. Bilirubinemia level following NPFP was significantly higher than the baseline level, while following PFP the level of total and bound bilirubin remained unchanged. No differences in the total hepatic flow have been observed during pulsatile and nonpulsatile flow perfusion.

Cardiac Surgical Procedures↗
PubMed1989

Assessment of liver circulation by quantitative scintiangiography: evaluation of the relative contribution of the hepatic arterial and portal venous blood flows to liver perfusion.

Quantitative hepatic scintiangiography was previously used for evaluating the relative contribution of hepatic arterial and portal venous blood flows to the hepatic circulation. The present study compares 3 different procedures (automatic and manual integration, and slope fitting methods) for analyzing the hepatic time activity curves obtained after bolus i.v. injection of 370 MBq 99mTc-diethylentriaminopentacetic acid. Twenty five subjects were studied: five controls, ten cirrhotics, and ten portal hypertensive patients previously submitted to side to side portacaval anastomosis. The correspondence between results given by the different methods was satisfactory only in shunted patients, and the reproducibility of computed parameters was quite poor for all procedures. Accordingly, none of the methods can be considered as supporting reliable quantitative pathophysiological evaluations. However, the hepatic arterial/portal venous flow ratio was found to be increased in liver cirrhosis and in shunted patients and therefore, in spite of the limitations underlined before and of the absence of data on the reproducibility of consecutive injections, hepatic scintiangiography may be of some clinical utility.

Adult↗
PubMedDate not supplied

[Liver circulation under the effect in intestinal hormones in patients with diabetes mellitus].

The following significant disturbances of the blood flow were revealed in the liver of 104 patients suffering from diabetes mellitus as a result of rheographic studies: a reduction of the amplitude-frequency index, of the sphygmometric velocity and of its components--the rate of rapid and slow blood filling. The intestinal hormones--secretion and cholecystokinin-pancreosimin improved these indices. The duration of their effect (1.5 U/kg, intravenously) was not less than 20, and not less than 10 min, respectively.

Adult↗
PubMedDate not supplied

[Liver circulation during acute cardiac insufficiency and the use of intra-aortic balloon counterpulsation].

Liver hemodynamics was experimentally studied in a model of acute heart failure caused by successive ligation of coronary artery branches and the following cardiogenic shock and during assisted circulation using intraaortic balloon contrapulsation. It has been established that intraaortic balloon contrapulsation promotes to the elimination of hemodynamic liver disturbances, however no final recovery of the organ hemodynamics was observed after 2 hours of contrapulsation. The method of intraaortic balloon contrapulsation is recommended at early stages of acute heart failure prior to the onset of profound ischemic changes in the liver.

Acute Disease↗
PubMed1977

[Hemodynamic studies on liver circulation with special reference to the hepatic artery].

Hepatic and systemic hemodynamics were studied in the rat under different experimental conditions. It could be demonstrated that the hepatic arterial blood flow in normal as well as in sick liver of animals is well regulated: for example by means of the venovasomotorical reaction (portoarterial interaction) and systemically by autoregulation. There exists an inverse correlation between arterial and portalvenous liver blood flow: As portal liver blood flow decreases hepatic arterial flow increases. Especially a marked increase of hepatic artery flow was found after portocaval end-to-side anastomosis. Yet, the hepatic artery flow improvement after portocaval shunt could not compensate the diverted portalvenous blood supply at all. In states of portal hypertension with a relevant portocaval collateral circulation, also after surgical portocaval shunt, the systemic circulation becomes more hyperdynamic. There also exists a remarkable relation between the extent of portocaval shunt flow to circulating blood volume, cardiac output and circulation time. Some correlates of the experimental findings with the altered hemodynamics in human liver cirrhosis were found and discussed from the viewpoint of portocaval shunt surgery in man.

Animals↗
PubMed1992

[Effect of the volatile anesthetics halothane, enflurane and isoflurane on liver circulation in the human].

In 40 patients with normal liver function total hepatic blood flow (HBF) was determined by the indocyanine-green clearance method simultaneously with haemodynamic parameters, including cardiac output by means of the noninvasive thoracic electrical bioimpedance method. Furthermore, the influence of halothane, enflurane or isoflurane on HBF and the interaction with haemodynamic parameters was studied. HBF and the cardiocirculatory parameters were determined under normal conditions (waking state) and the 40 patients were then divided into 4 groups (each n = 10). After standardised induction of anaesthesia (0.3 mg/kg etomidate and 2 micrograms/kg fentanyl) and tracheal intubation (1.5 mg/kg suxamethonium chloride) an inhalation anaesthesia in O2/air under control of normal end tidal carbon dioxide concentration was performed by intermittent positive pressure ventilation. Anaesthesia was maintained in the 4 groups either with 1 MAC halothane, 1 MAC enflurane, 1 MAC isoflurane or 1.3 MAC isoflurane. The measurements were repeated at a steady of the desired end expiratory concentration of the respective volatile anaesthetic. All three anaesthetics produced a significant and comparable decrease of cardiac output and arterial blood pressure. Differences between halothane, enflurane and isoflurane in respect of haemodynamic parameters were only minimal. Contrariwise, marked differences could be seen in the effects of the anaesthetics on HBF. In the presence of halothane and enflurane HBF dropped to 58% and 56% resp. of the control value, whereas during isoflurane anaesthesia HBF remained unchanged. Furthermore, only during halothane anaesthesia a significant correlation between arterial blood pressure and HBF could be observed indicating a loss of autoregulation of the hepatic blood flow.

Adolescent↗