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At least 19 recordsLinked to original sources

Significance of mucosal vs salivary gland changes in lip biopsies in the diagnosis of chronic graft-vs-host disease.

Lip biopsy is frequently utilized to diagnose and stage chronic graft-vs-host disease (cGVHD). However, the significance of mucosal (MU) vs salivary gland (SG) involvement as well as the minimal histologic changes necessary for diagnosis remain unclear. We evaluated 68 lip and oral mucosa biopsy specimens using published diagnostic criteria. Thirty-four specimens contained both MU and SG tissue. Both MU and SG were definitely involved in 13 patients while apparent false-negatives for MU of 20% (2/10) and SG of 11% (1/9) were observed. No clinical differences were noted among the patients with both MU-alone-, or SG-alone-positive biopsy specimens. Patients with no evidence of cGVHD in either MU or SG showed significantly less other organ involvement than patients with positive evidence. Patients with minimal MU changes (rare dyskeratotic cells) were clinically indistinguishable from negative patients in terms of other organ involvement. However, 50% of the biopsy specimens with minimal MU involvement in which SG were present had definite GVHD in the SG. These data indicate that lip biopsy specimens must include both MU and SG tissue to rule out oral GVHD. Minimal MU changes are insufficient to diagnose oral cGVHD, although they do warrant close follow-up and a second biopsy if SG tissue is not present in the specimen.

Adolescent↗

[Stigmas, symptoms and diseases of the skin in musicians].

There are numerous characteristic skin symptoms that are common in musicians and are usually harmless marks of their profession. There are, however, many less frequent and more serious skin diseases that are due either to mechanical irritation and other physical noxae or to allergic and non-allergic contact reactions. Professional musicians can be affected by other skin diseases that cause serious problems and ultimately put an end to their career. This applies especially to lip diseases in woodwind and brass players.

Callosities↗

Extensive Riga-Fede disease of the lip and tongue.

Riga-Fede disease presents in early infancy and is characterized by firm, verrucous plaques arising on the oral mucosal surfaces. These histologically benign lesions occur as a result of repetitive trauma of the oral mucosal surfaces by the teeth. Early recognition of this entity is important, because it may be the presenting sign of an underlying neurologic disorder. We report the case of a 10-month-old boy with extensive Riga-Fede disease involving the lip and tongue that prompted a diagnosis of congenital autonomic dysfunction with universal pain loss.

Autonomic Nervous System Diseases↗

Diseases of the lips and oral cavity of domestic animals.

Oral and lip lesions in domestic animals, as in man, may be due to a vast number of diseases. While some of these diseases are unique to each species, the majority of them are similar to human afflictions. These represent an untapped resource in comparative medicine, and research in this area can only benefit both man and the domestic animals he is dependent upon.

Animals↗

Paying more than lip service to lip lesions.

OBJECTIVE: To review the epidemiology, etiology, diagnosis, management, and prognosis of the most common, potentially lethal, lip lesions: leukoplakia, actinic cheilitis, and squamous cell carcinoma (SCC). QUALITY OF EVIDENCE MEDLINE: was searched from 1966 to 2002 for English-language articles on prevalence of lip lesions. No articles for a family physician audience were found. MEDLINE was searched again using the terms "leukoplakia," "actinic cheilitis," and "squamous cell carcinoma." Randomized, controlled trials were selected; non-blinded trials, population-based studies, and systematic reviews were also used. MAIN MESSAGE: Leukoplakia, actinic cheilitis, and SCC of the lips are relatively common presentations that can cause substantial morbidity and, more rarely, mortality. Any abnormality of the lips can be an embarrassment. Because of the seriousness and frequency of lip disease, it is important to look for, diagnose, and treat lip lesions to prevent morbidity and mortality and also to maintain social acceptance and self-esteem. CONCLUSION: Knowledge of leukoplakia, actinic cheilitis, and SCC of the lips will aid family physicians in diagnosing and managing these lesions and in preventing associated morbidity and mortality.

Carcinoma, Squamous Cell↗

[Lymphocytic interstitial pneumonia in primary Sjögren syndrome].

Ljmphocytic interstitial pneumonia (LIP) is a rare form of interstitial pneumonia. It can occur as a idiopathic disease however most frequently associated with other diseases, particularly Sjogren syndrome. We present a 58 years old woman, with primary Sjögren syndrome who developed after 7 years interstitial lung disease. LIP was diagnosed on the basis of histological examinations of specimens obtained by open lung biopsy. Diffuse infiltrations composed of small polyclonal lymphocytes, plasma cells with reactive follicules were found. Infiltrates observed in bronchial and bronchiolar walls expanded into interlobular and alveolar septae. Prednisone in a dose of 40 mg per day was introduced and clinical, radiological, spirometric and gasometric improvement was observed. The dose of prednisone was gradually reduced but is still continued.

Collagen Diseases↗

Common lesions of the oral mucosa. A guide to diseases of the lips, cheeks, tongue, and gingivae.

Canker sores and cold sores are common, relatively banal diseases of the oral mucosa and lips, occurring most often in young persons. Some otherwise healthy patients may have a more severe variant, such as major aphthous ulcers, recurring lesions of aphthous stomatitis, or acute herpetic gingivostomatitis. Other patients may present with severe recurrent herpes simplex labialis or chronic oral candidiasis, and in these patients an immunodeficiency state must be considered.

Cheek↗