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At least 19 recordsLinked to original sources
PubMed1977

Distribution of intravenously injected 201thallium in the legs duging walking. A new test for assessing arterial insufficiency in the legs.

There is a multitude of method for assessing the efficiency of the arterial circulation in the legs. Most of these methods can give conclusive information about the patency of the main arteries in the leg; the level of an arterial obstruction can also be estimated. However, none of these methods provides a direct estimate of the functional importance of arterial lesions of light to moderate severity. The present report describes preliminary findings of the distribution of intravenously injected 201Thallium, a potassium analogue, in the legs during exercise provoking symptoms of ischemia. From this pilot study the general impression is that the thallium uptake pattern corresponds well with the clinical, physiologic, and angiographic picture.

Arterial Occlusive Diseases↗
PubMed1978

The place of the cross-leg flap in reconstructive surgery of the lower leg and foot: a review of 165 cases.

In a series of 165 cross-leg flaps, 94 per cent were successful. Some degree of necrosis occurred in almost half of them. Major necrosis requiring split-skin grafting occurred in less than one-fifth. Thrombo-embolic complications were rare and mainly in the older age group. The retunr of sensation was good; better in the flap than in the donor site. The long-term results were good with a low complication rate. On weight-bearing surfaces the cross-leg flap skin stands up well to wear and tear.

Adolescent↗
PubMed1976

Repair of skin and soft tissue loss of the lower leg with cross-leg flaps.

Forty patients with severe leg injuries associated with skin or soft tissue loss were treated. Cross-leg flaps were used. The flaps healed well. Special attention was paid to the pre- and postoperative periods of disability of the patients. The former were very long (37.7 months) compared to the latter (10.5 months) which ceased when the patient became fit for work.

Child↗
PubMed1978

Contralateral influence on recruitment of curarized muscle fibres during maximal voluntary extension of the legs.

The force of maximal voluntary contraction (MVC) was compared during extension of one leg alone and during simultaneous extension of both legs. In 6 subjects MVC of two legs extension was 75 +/- 3.6 (S.E.)% of the sum of the single one leg MVC. This may indicate a reduced muscle fibre involvement during two leg extension as compared with one leg extension. We investigated the possibility that either red (type I) or white (type II) muscle fibre recruitment was restricted during two leg extension. The neuromuscular transmission in the two types of fibres was partially blocked with d-tubocurarine (dtc) or decamethonium (C10) for either type I or II, respectively. In 5 subjects receiving dtc the ratio between the reduced two leg and one leg extension forces (75 +/- 2.3%) did not change. During administration of C10, however, this ratio decreased by 16 +/- 3.1%. Partial blocking with dtc caused a two component curve during tension development with a first maximum at 0.22 s, and another maximum at 1.03 s of a 3 s attempt to reach MVC. During partial blocking with C10 results in muscle contractions where a relatively large amount of type I muscle fibres are contributing to the force developed. The experiment suggests that type I fibre recruitment is restricted during severe static exercise in normal muscles. Furthermore, it demonstrates that fibre recruitment can vary in the same muscle function performed with one leg or two legs.

Adult↗
PubMed1979

The painful chronic anterior lower leg syndrome. A prospective clinical and experimental study.

A presumed painful chronic anterior lower leg syndrome was diagnosed in 51 patients (73 legs), 30 women and 21 men, aged 11 to 70 years, over a 2-year period. The duration of the syndrome varied from 1 month to 10 years. The patients' main complaint was pain when walking located in the medial ventral muscle compartment of the lower leg. In addition 10 of the patients (15 legs) had leg pain at rest as well and 12 (15 legs) had paresis of the extensor muscles. Thirty-four paired intracompartmental pressure recordings with the wick technique in 6 patients suggest that the more severe the syndrome the lower the pressure in the tibialis anterior muscle. Blind diathermic fasciotomy in 25 patients (36 legs) with a typical history relieved the pain and paresis completely or partly in 33 (92 per cent) out of 36 legs. No postoperative complications worth mentioning were observed. It is concluded that: 1) a chronic painful anterior lower leg syndrome should be suspected in patients with pain on walking and at rest located in the ventral part of the lower leg; 2) intracompartmental pressure measurements seem to be of little preoperative diagnostic value in non-selected patients; 3) blind diathermic fasciotomy of the anterior, medial compartment of the lower leg, including the extensor retinaculum, gives relief from pain and paresis in most patients with a typical history.

Adolescent↗
PubMed1978

Effects of leg exercise on insulin absorption in diabetic patients.

To examine the effects of leg exercise on insulin absorption from various injection sites, 125I-labelled rapid actin insulin (9 units) was injected subcutaneously into the leg, arm or abdomen of patients with insulin-dependent diabetes before one hour of intermittent leg (bicycle) exercise and on a resting, control day. Insulin disappearance from the leg increased by 135 per cent during the first 10 minutes of leg exercise (P less than 0.05) and remained 50 per cent above resting levels after 60 minutes (P less than 0.02). Leg exercise had no effect on insulin disappearance from the arm, but insulin disappearance from the abdomen was reduced during the post-exercise recovery period (P less than 0.02). As compared to leg injection, arm or abdominal injection reduced the hypoglycemic effect of exercise by 57 per cent (P less than 0.02) and 89 per cent (P less than 0.005), respectively. Leg exercise accelerates insulin absorption from the leg. Arm or abdominal injection avoids this acceleration during leg exercise and reduces exercise-induced hypoglycemia.

Abdomen↗
PubMed1977

Forces applied to cranks of a bicycle ergometer during one- and two-leg cycling.

An examination was made of the comparability of one- and two-leg exercise performed pedaling a stationary bicycle ergometer. The pattern of force exerted on both cranks was examined by means of a specially adapted ergometer which is described. The mean of the peak force in each cycle (MPF) was linearly related to work load (W) in both forms of exercise, and if account was taken of the doubled work output in two-leg cycling there was no significant difference between the MPF/W relationships; these are given by the equations one-leg: MPF (kg) = 11.23 + 0.065 (W in kpm/min) two-leg MPF (kg) = 10.76 + 0.032 (W in kpm/min). Calculation from the force records of the work performed on the cranks (WCR net) showed good agreement (r = 0.98, P less than 0.001) with the work load set on the ergometer. Analysis of the proportion of work done in leg extension and flexion phases of cycling revealed no differences between one- and two-leg exercise or between the right and left legs. The majority (approximately 80%) of Wer net being performed in leg extension is described by: Wer net (extension)) = 10.6 +/- 0.8 (W cr net total). In one-leg exercise (W greater than 900 kpm/min) the variation in rotation speed during a normal cycle ranged from +20 to --30% of the mean speed compared with +/- 10% in two-leg exercise.

Adult↗
PubMed1976

[Adult leg development of Tenebrio molitor: I. Experimental analysis of the restoration process during morphogenesis (author's transl)].

The leg of the last instar larva, and especially the pharate pupa, of Tenebrio molitor (Coleoptera) shows considerable restoration ability. Restoration refers to the regeneration of leg structures removed during the last larval instar. This process involves only those tissues adjacent to the cut surface. At each level of the leg, amputation before a characteristic time leads to the restoration of a complete leg, but thereafter the new segments formed are hypomorphic or just lobes. After an amputation close to the pupal ecdysis, fragments are obtained, and these incomplete structures show that the restoration process has ceased. Just before the pupal ecdysis the leg is withdrawn from the cuticle, so a very late amputation does not effect the leg tissue and a complete pupal and adult leg is formed. The whole of the larval leg participates in adult leg morphogenesis, and histological techniques demonstrate a great correspondence between larval and adult leg segments. The larval trochanter, however, forms the adult trochanter and the proximal part of the femur. The larval tibia forms the adult tibia plus tarsus, except for the adult claws which develop from the larval tarsal claw.

Amputation, Surgical↗
PubMed1978

[Influence of dihydroergotamine and leg compression on the blood volume in different regions of the body (author's transl)].

After intravenous injection of 99mTc labelled autologous erythrocytes the radioactivity of a definite body-region is proportional to the local blood volume. By whole body scintigraphy it is possible to assess simultaneous changes of blood volume in different interesting regions. By this method the influence of 1 mg dihydroergotamine i.v. was investigated in 10 patients and of compression of both legs by inflatable leg cuffs (Jobst) with pressures of 25 and 40 mmHg (3,3 and 5,3 kPa) in 7 patients. After dihydroergotamine statistically significant decreases of blood volume were found in the legs and arms and increases in the thorax and liver. Over the abdominal region there was a statistically not significant decrease of blood volume. After leg compression a statistically significant decrease of blood volume in the legs and an increase in thorax, liver and abdomen were found. The arms showed a statistically not significant blood volume increase. The blood volume diminishing effect of dihydroergotamine in the legs was 20,4% in average, of a leg compression (25 mmHg=3,3 kPa) 33,4%. Contrary to the general opinion a reduction of blood volume was also found in legs with severe varicosis. The diminution of blood volume is even more intense in such cases than in normal legs. The results after dihydroergotamine are explained by its well known constrictor effect on the capacitance vessels in the extremities.

Abdomen↗
PubMed1979

Influence of beta-adrenoceptor blockade on leg blood flow and lactate release in man.

Nine healthy male volunteers were studied at rest and during exercise before and after acute local beta-blockade in one leg. Oxygen uptake, arterial pressure, heart rate, leg blood flow and arterial-femoral venous differences for oxygen and lactate were determined. In addition, five subjects were studied at rest during adrenaline infusion to test the blockade; in this situation the increase in leg blood flow and decrease in resistance seen in the control leg were prevented in the blocked leg. During exercise, the beta-blockade did not influence leg blood flow. At rest, lactate release was abolished from the blocked leg, and during exercise the release was reduced by 50%. These findings demonstrate that acute betareceptor blockade does not interfere with the exercise-induced vasadilation but has metabolic consequences reflected by a reduction in the release of lactate from the leg.

Adrenergic beta-Antagonists↗
PubMed1977

Central and regional circulatory effects of adding arm exercise to leg exercise.

7 young, healthy, male subjects performed exercise on bicycle ergometers in two 20 min periods with an interval of 1 h. The first 10 min of each 20 min period consisted of arm exercise (38--62% of Vo2 max for arm exercise) or leg exercise (58--78% of Vo2 max for leg exercise). During the last 10 min the subjects performed combined arm and leg exercise (71--83% of Vo2 max for this type of exercise). The following variables were measured during each type of exercise: oxygen uptake, heart rate, mean arterial blood pressure, cardiac output, leg blood flow (only during leg exercise and combined exercise), arterio-venous concentration differences for O2 and lactate at the levels of the axillary and the external iliac vessels. Superimposing a sufficiently strenuous arm exercise (oxygen uptake for arm exercise greater than 40% of oxygen uptake for combined exercise) on leg exercise caused a reduction in blood flow and oxygen uptake in the exercising legs with unchanged mean arterial blood pressure. Superimposing leg exercise on arm exercise caused a decrease in mean arterial blood pressure and an increased axillary arterio-venous oxygen difference. These findings indicate that the oxygen supply to one large group of exercising muscles may be limited by vasoconstriction or by a fall in arterial pressure, when another large group of muscles is exercising simultaneously.

Adult↗