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At least 19 recordsLinked to original sources
PubMed2001

Comparison of liver cytology and biopsy diagnoses in dogs and cats: 56 cases.

The results of liver cytology and corresponding biopsy specimens submitted to the Pathology Department at Angell Memorial Animal Hospital during 1998 were retrospectively reviewed to objectively assess the diagnostic value of liver cytology. A "corresponding" biopsy was defined as a biopsy specimen obtained within 1 day of the cytology specimen. Fifty-six cases were reviewed, including 25 from dogs and 31 from cats. Results were in complete agreement in 34 cases, in partial agreement in 11 cases, and in disagreement in 11 cases. Agreement occurred most often in cases of fatty change (10 cases) and neoplasia (7 cases of lymphoma and 3 cases of epithelial tumor). Disagreement was most common in cases of hepatitis (6 cases) in which inflammation was not seen in cytologic specimens. Other causes for disagreement included fibrosis (2 cases), and 1 case each of amyloidosis, hemangiosarcoma, and lymphoma. Three cytologic specimens were considered suggestive of hepatitis because of leukocytosis in the background, although clinicians were advised to compare cytologic observation to CBC results. Cytologic evaluation of the liver was useful for determining disease processes, especially when disease distribution was diffuse.

Journal Article↗
PubMed1986

Wash off liver cytology: a complementary diagnostic tool to liver biopsy.

Parenchymal and non-parenchymal cells were harvested by washing the liver tissue core and needle after percutaneous biopsy. The cytological material obtained was suitable for morphological analysis, including showing the presence of surface and cytoplasmic antigens using labelled antibody techniques. This technique provides a combined cytological and histological approach to the diagnosis of liver disease.

Antigens↗
PubMed2002

Liver cytology.

Physical examination, clinical laboratory testing, and medical imaging are effective in establishing the presence of liver disease; however, they infrequently establish a definitive diagnosis. Morphologic evaluation of liver tissue is generally accepted as a valuable diagnostic tool in establishing a diagnosis in liver disease. Clinicians have several options for obtaining specimens for morphologic evaluation, including surgically obtained wedge biopsies, percutaneous core biopsies, and fine-needle aspiration specimens. Surgical and core biopsy procedures require anesthesia or sedation and have a substantial risk of bleeding complications. Fine-needle aspiration usually does not require sedation and is rarely associated with hemorrhage; thus, it is frequently chosen for animals that are poor anesthetic risks or have coagulopathies. Diseases like malignant lymphoma, hepatic lipidosis, and suppurative hepatitis are readily diagnosed cytologically, whereas hepatocellular adenomas, hyperplastic nodules, fibrosis, and chronic inflammation are more difficult to identify cytologically.

Animal Diseases↗
PubMed1978

Histologic and cytologic liver changes in 120 patients with malignant lymphomas.

The purpose of this study was to determine the frequency of liver involvement in malignant lymphomas. Non-specific liver changes were also registered. Percutaneous liver biopsy was performed on 120 patients with untreated malignant lymphomas. There were 38 patients with Hodgkin's disease, 42 with histiocytic and 40 with lymphocytic lymphomas. All the biopsy specimens were histologically and cytologically analyzed. Positive liver findings (lymphomatous infiltration) were observed in 27.5% of patients with lymphocytic, 23.8% with histiocytic lymphomas, and 7.8% with Hodgkin's disease. Liver involvement in non-Hodgkin's lymphomas was significantly higher (P less than 0.025) than in Hodgkin's disease. In the whole group of patients, there were non-specific liver changes: 23 chronic persistent hepatitis, 5 aggressive hepatitis, 9 liver steatosis and 4 liver hemosiderosis. Based on these results, it can be concluded that liver involvement with lymphomatous tissue is more common in non-Hodgkin's lymphomas. Knowledge of this is relevant for clinical staging and the treatment program. These findings also confirm that percutaneous liver biopsy is a valuable diagnostic procedure in the staging of malignant lymphomas.

Hodgkin Disease↗
PubMed1987

[Fine-needle cyto-puncture. Apropos of 138 liver cytologies and 66 pancreas cytologies].

In this report, we examined the sensitivity and specificity of 138 hepatic and 66 pancreatic fine needle aspiration cytology. Aspiration cytodiagnosis was performed using a fine needle, percutaneously, with ultrasonic or tomodensitometric guidance. Sensitivity of hepatic and pancreatic aspiration cytodiagnosis was 86.73% et 83.3%; specificity was respectively 97.72% an 100%. These results are compared with literature review and confirm the interest of fine needle aspiration cytology in tumoral pathology.

Adenocarcinoma↗
PubMed1994

Focal fatty change of the liver: cytologic findings in a radiographic mimic of metastases.

Fine-needle aspiration (FNA) is being increasingly utilized for the workup of patients with suspected metastatic disease. In the course of these biopsies, cytologists are being confronted by a variety of nonneoplastic lesions which radiographically simulate metastatic deposits. Some of these lesions will predominately reveal hepatocytes. One of these cytologically poorly characterized lesions is focal fatty change. Aspirates show a population of benign hepatocytes with single or multiple clear cytoplasmic vacuoles. Recognition of the entity along with accurate needle placement in the nodule can establish the diagnosis of focal fatty infiltration and negate the need for further biopsies.

Adult↗
PubMed2002

The influence of age on the cytology of the liver in healthy dogs.

Liver cytology was evaluated in 28 healthy dogs 1-14 years of age with normal liver structure and function. Smears were stained with May-Grünwald-Giemsa. Hepatocytes had distinct cell borders, and cells did not overlap. Cells with two nuclei and cells with intranuclear crystalloid structures were observed regularly. Cytoplasm contained small numbers of vacuoles characteristic of glycogen and lipid and small amounts of pigment consistent with ceroid or bile. Nuclei were uniform. Small numbers of biliary epithelial cells were seen in most samples. Lymphocytes and neutrophils occurred in small numbers, with lipocytes, mast cells, fibrocytes, mesothelial cells, eosinophils, and Kupffer macrophages seen less frequently. Mean parenchymal cell sizes were significantly greater in older dogs, but no age-related differences were observed in nuclear size. Older dogs also had a significantly increased number of nuclei per cell. There were more neutrophils in young and old dogs than in middle-aged dogs.

Aging↗
PubMedDate not supplied

Application of silver stains to cytologic specimens of neuroendocrine tumors metastatic to the liver.

Cytologic specimens of neuroendocrine tumors metastatic to the liver were examined with regard to their silver staining properties after the application of argentaffin and argyrophil staining techniques (Masson, Grimelius and Sevier-Munger). In tumors with a content of serotonin (small intestine carcinoids), the presence of this substance was demonstrated cytologically as an argentaffin reaction in individual tumor cells; however, formalin fixation was a prerequisite for positive staining. Melanin in malignant melanoma cells displayed a positive argentaffin reaction, irrespective of the fixation used (air drying, formalin, Bouin's fluid or acetone-alcohol). Thus, serotonin and melanin can be distinguished in cytologic samples of neuroendocrine tumors by the use of the Masson argentaffin reaction with different fixatives. The nonargentaffin-positive neuroendocrine tumor cells were weakly stained or unreactive with the Grimelius argyrophil technique. The Sevier-Munger argyrophil technique was negative or gave a disturbing nonspecific background staining reaction that was difficult to interpret in the cytologic samples. Thus, the Grimelius method appears to be the most useful silver stain for identifying neuroendocrine tumor cells in cytologic material, irrespective of their hormone content, since both argentaffin-positive and argentaffin-negative cell samples were stained at least to some degree.

Adenocarcinoma↗
PubMed1986

[Fine needle aspiration cytology of liver and pancreas tumors].

The authors' experience on the liver and pancreas tumours diagnosis by fine needle aspiration biopsy (FNB) performed percutaneously with ultrasound guidance (partly on blind) or intraoperatively is reported. Two hundred and eleven patients in total have been investigated. In 82 patients a FNB of the liver was performed and in 70 patients a FNB of the pancreas was done and for comparison 59 "macrobiopsies" (MB) of the liver were examined cytologically. The FNB made success fully permitted a complete cytologic investigation to be done and approached the possibilities of the MB. By FNB 67 out of 71 liver neoplasms and 29 out of 30 neoplasms of the pancreas have been diagnosed, i.e. the diagnostic sensitivity was 0.94 and 0.97 respectively. No false positive results were established and the diagnostic accuracy was 0.95 for liver tumours and 0.99 for pancreatic tumours. The possibilities for typification of the neoplasms by means of the FNB are enormous. The liver and the pancreas FNB proved to be a most helpful method for diagnosing the tumorous processes and could save a number of invasive, expensive and labour-consuming examinations.

Adolescent↗
PubMedDate not supplied

Fine needle aspiration cytology of liver tumors.

Fine needle aspiration cytology has undergone increasing utilization in the evaluation of hepatic neoplasms. Experience with liver aspirates has demonstrated that problems in differential diagnosis require thorough understanding of criteria for distinguishing different tumor types. The present report describes the cytologic presentation of primary and metastatic hepatic tumors with emphasis on characteristic nuclear and cytoplasmic features encountered in fine needle aspiration biopsy specimens.

Adenocarcinoma↗