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[Larva migrans "saxoniae": larva migrans infection in Saxony].

A 38 year old woman from Dresden presented in September 2002, about four weeks after the Elbe River flooding with signs of cutaneous larva migrans on the back of her hand. There was no history of travel to tropical or subtropical regions in the last few years. Cryotherapy as well as systemic ivermectin (Stromectol) therapy were not successful in stopping progress of the lesions. Combination therapy with systemic ivermectin and topical tiabendazole (Lombristop) induced full remission. Cutaneous larva migrans normally occurs in German patients only after recent visits to tropical or subtropical regions. In our patient, however, it was most likely due to the unusual climatic conditions in the summer of 2002 in the Elbe region: Heavy rainfalls and inundation by regional rivers soaked the ground, followed by a period of unusually hot and sunny weather.

Adult↗

Raccoon ascarid larvae (Baylisascaris procyonis) as a cause of ocular larva migrans.

Larvae of the common raccoon roundworm, Baylisascaris procyonis, are known causes of visceral larva migrans and CNS disease in animals and human beings. In the present experiments we examined the ability of B. procyonis to cause ocular larva migrans (OLM) in subhuman primates, as an indication of its possible ocular zoonotic importance. Squirrel monkeys given 5,000 or 10,000 infective B. procyonis eggs per os and cynomolgus monkeys given 20,000 eggs had clinical and histologic evidence of OLM, beginning 7 days after inoculation. Clinically, multifocal retinal hemorrhages, white spots, chorioretinitis, inflammatory tracks, vascular sheathing, diffuse retinal degeneration, and motile intraretinal larvae were seen. Histologically, primarily subretinal larvae caused varying degrees of retinal disruption, degeneration and necrosis, retinitis, vasculitis, and perivascular sheathing, primarily with eosinophils. Larvae were also present in choroidal granulomas. It was concluded that B. procyonis larvae have marked ability to produce OLM in subhuman primates following oral infection and should be considered as a possible etiology in human ocular disease.

Animals↗

[Cutaneous larva migrans].

Larva migrans is a rare cutaneous parasitic infestation, whose incidence in Israel has increased over the past few years. This is mainly due to the growing number of Israelis traveling to the Far East and to Central and South America. We present 4 such cases. The treatment of choice for this parasite is thiabendazole, an imidazole with anthelminthic properties.

Adult↗

Two imported cases of cutaneous larva migrans.

Cutaneous larva migrans (CLM) is a rare serpiginous cutaneous eruption caused by accidental penetration and migration in the skin with infective larvae of nematode that normally do not have the human as their host. Although CLM has a worldwide distribution, the infection is most frequent in warmer climates. More recently, they have been increasingly imported from the tropics or subtropics by travelers. We experienced two patients who had pruritic serpiginous linear eruption in their skin for a few weeks after traveling to the endemic areas (Brazil and Thailand, respectively). After the treatment with albendazole, the skin lesions resolved with post-inflammatory hyperpigmentation. We report herein two cases of cutaneous larva migrans successfully treated with albendazole.

Adult↗

Oral albendazole for the treatment of cutaneous larva migrans.

Cutaneous larva migrans is becoming more common in the U.K. with the popularity of tropical countries as holiday destinations. We describe the increasing use of a new benzimidazole derivative, albendazole, which is very effective in the treatment of cutaneous larva migrans. In contrast to thiabendazole, it is virtually free from side-effects and should, we feel, become the treatment of choice for this condition.

Administration, Oral↗

Treatment of cutaneous larva migrans.

Cutaneous larva migrans caused by the larvae of animal hookworms is the most frequent skin disease among travelers returning from tropical countries. Complications (impetigo and allergic reactions), together with the intense pruritus and the significant duration of the disease, make treatment mandatory. Freezing the leading edge of the skin track rarely works. Topical treatment of the affected area with 10%-15% thiabendazole solution or ointment has limited value for multiple lesions and hookworm folliculitis, and requires applications 3 times a day for at least 15 days. Oral thiabendazole is poorly effective when given as a single dose (cure rate, 68%-84%) and is less well tolerated than either albendazole or ivermectin. Treatment with a single 400-mg oral dose of albendazole gives cure rates of 46%-100%; a single 12-mg oral dose of ivermectin gives cure rates of 81%-100%.

Antinematodal Agents↗

Cutaneous larva migrans.

Cutaneous larva migrans, or creeping eruption, is an infection caused by certain nematode larvae and, occasionally, fly maggots. After penetrating human skin, the larvae remain in the epidermis and wander aimlessly. The burrows may be intensely pruritic. Systemic reactions may include profound eosinophilia. Oral or topical thiabendazole is effective therapy.

Adult↗

[Cutaneous larva migrans].

Cutaneous larva migrans (CLM) is a parasitic disease of the skin produced by skin-penetrating larvae, mainly the filariform larvae of cat and dog hookworms. Three cases of CLM diagnosed in Copenhagen are reported and the clinical manifestations, pathogenesis, diagnosis and treatment are described.

Adult↗

Cutaneous larva migrans.

Cutaneous larva migrans is occasionally seen in pediatric emergency outpatient care settings. It results from infestation of hookworm larvae into the epidermis. The infestation is self-limited but may produce severe discomfort. The diagnosis relies entirely on clinical findings. Laboratory findings only support the clinical diagnosis but do not confirm it. Treatment is typically with topical thiabendazole, but oral thiabendazole may be indicated in severe cases.

Adolescent↗

Massive infestation of cutanea larva migrans.

Cutaneous larva migrans is a tropical disease that typically is acquired on exposed surfaces in patients who have been sitting or lying on moist ground or other surfaces which have been contaminated by dog or cat feces. A patient is reported who presented with typical, severely pruritic, migratory plaques after sleeping on a wet, bus station floor.

Animals↗

Neuropathological observation of rabbits (Oryctolagus cuniculus) affected with raccoon roundworm (Baylisascaris procyonis) larva migrans in Japan.

Larvae of the raccoon roundworm, Baylisascaris procyonis (B. procyonis) are a known cause of cerebrospinal larva migrans in animals and humans. The present paper described details of the central nervous lesion in the rabbits (Oryctolagus cuniculus) affected with B. procyonis larva migrans in Japan. Clinically affected animals showed neurological signs including circling, torticollis, tremor of head, or ataxic gait. The most characteristic pathological alterations were large malacic lesions associated with an activated astroglial proliferation which was seen at the corpus medullare in the cerebellum including the cerebellar peduncle. Moreover, focal malacic lesions with perivascular cuffing and infiltration by lymphocytes and heterophiles were scattered everywhere throughout the brain. In these lesions or normal-appearing areas away from obvious lesions, ascarid larvae, about a maximum 65-75 micro m in diameter, were recognized. Other prominent features were minute lesions (we call them migration tract-like lesions) composed of lymphocytes, hemosiderin-laden macrophages and reactive astrocytes scattering throughout the cerebrum. In this study, we demonstrated ascarid larvae in only eight out of 23 animals diagnosed as B. procyonis larva migrans. Since it is not always possible to detect the larvae, the possibility of B. procyonis larva migrans must be given serious consideration to the characteristic lesions described above.

Animals↗

Management of complex pedal cutaneous larva migrans.

Although cutaneous larva migrans is more commonly seen in the southeastern US and tropical regions of the world, patients with such parasitic involvement may present in other non-endemic areas for various reasons, particularly travelers returning from tropical vacations. Awareness of the clinical presentation and symptomatology of cutaneous larva migrans is important for all physicians, including those practicing in northern climates, for prompt recognition and effective treatment of the disease. Furthermore, cutaneous larva migrans should be of particular interest to podiatrists, because the infestation commonly involves the feet, and a patient may initially present for treatment of secondary manifestations, ie, dermatitis, pruritus, or infection, as in this case report.

Adult↗

Cutaneous larva migrans with parts of the larva in the epidermis.

Creeping eruption is usually caused by hookworms, most commonly Ancylostoma braziliensis and Ancylostoma caninum. Because lesions of cutaneous larva migrans have a typical clinical appearance, they are rarely biopsied. Specimens usually show spongiotic dermatitis with spongiotic vesicles containing neutrophils and eosinophils and a mixed-cell dermal infiltrate with numerous eosinophils. We report a case with parts of the larva migrans in the epidermis on histologic examination.

Adult↗

[Larva migrans].

Larbish, cutaneous larva migrans or creeping eruption, is a serpiginous cutaneous eruption caused by skin penetration of infective larva from various animal nematodes. Hookworms (Ancylostoma brasiliense, A. caninum) are the most common causative parasites. They live in the intestines of dogs and cats where their ova are deposited in the animal feces. In sandy and shady soil, when temperature and moisture are elevated, the ova hatch and mature into infective larva. Infection occurs when humans have contact with the infected soil. Infective larva penetrate the exposed skin of the body, commonly around the feet, hands and buttocks. In humans, the larva are not able to complete their natural cycle and remain trapped in the upper dermis of the skin. The disease is widespread in tropical or subtropical regions, especially along the coast on sandy beaches. The diagnosis is easy for the patient who is returning from a tropical or subtropical climate and gives a history of beach exposure. The characteristic skin lesion is a fissure or erythematous cord which is displaced a few millimeters each day in a serpiginous track. Scabies, the larva currens syndrome due to Strongyloides stercoralis, must be distinguished from other creeping eruptions and subcutaneous swelling lesions caused by other nematodes or myiasis. Medical treatments are justified because it shortens the duration of the natural evolution of the disease. Topical tiabendazole is safe for localized invasions, but prolonged treatment may be necessary. Oral thiabendazole treatment for three days is effective, but sometimes is associated with adverse effects. Trials using albendazole for one or four consecutive days appear more efficacious. More recent trials using ivermectine showed that a single oral dose can cure 100% of the patients; thus, this drug looks very promising as a new form of therapy. Individual prophylaxis consists of avoiding skin contact with soil which has been contaminated with dog or cat feces. Keeping dogs and cats off the beaches is illusory in tropical countries.

Animals↗

Neuroimaging studies of cerebral "visceral larva migrans" syndrome.

"Visceral larva migrans" syndrome is a zoonotic disease caused by the migration or presence in human tissue of nematode larva from lower-order animals. This syndrome includes generalized illness, eosinophilia, and symptoms arising from larval invasions of different organs including the liver, lungs, eyes, and central nervous system. There has been only one case report of the computed tomographic (CT) and magnetic resonance imaging (MRI) appearances of cerebral toxocaral disease. Described here is a patient with cerebral toxocaral disease with a high eosinophil count and toxocaral titer in the serum and abnormal CT and MRI findings who had spontaneous recovery of the clinical symptoms.

Brain Diseases↗

[Cutaneous larva migrans--an unusual case].

Cutaneous larva migrans is the result of human skin infestation by nematode larvae, which penetrate through the epidermis. The case of 21-year-old woman with serpiginous, erythematosus, and linear stripes was reported. The skin lesions lasted for five months. The diagnosis of cutaneous larva migrans was established based on the typical clinical picture of infestation. Thus, it is important for infestation to be recognized clinically, so that effective treatment may be instituted. Various therapeutic modalities, including cryotherapy, topical and systemic chemotherapy, can be used in the treatment of cutaneous larva migrans. It was demonstrated, that cryosurgery is a fast and effective method in the therapy of cutaneous larva migrans infestation.

Adult↗

Cutaneous larva migrans--a case report.

Cutaneous larva migrans or creeping eruption is an uncommon parasitic skin infection caused by the filariform larvae of dog or cat hook worms. We report a case of larva migrans on the anterior abdominal wall, in a 52 year old lady, who did gardening as a hobby.

Abdomen↗