[Physiological basis of differential diagnosis of polyuria and disorders of the kidney concentrating ability].
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In non-renal (diabetic) glucosuria we did not find any statistically real relations between the concentration of glucose in the urine and cryoscopically measured osmolality in children with healthy kidneys. The close negative correlation of the conductance of the urine to the concentration of glucose is not only to be explained by changes of the viscosity, but is an expression of an increased re-absorption of sodium as a result of a compensatory hyperaldosteronism. In renal insufficiency the electrolytic conductibility of the urine is lower than the borderline area of the normal, even when under influence of the glucose excretion the osmolality of the urine is still to be found normal. Thus also on the conditions of a considerable glucosuria we can further judge the concentrating ability of the kidney in diabetes mellitus with the help of the measurement of the conductance of the urine.
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Post-natal development of plasma and urine osmolality, as well as plasma renin activity, aldosterone and cortisol levels were studied in calves between 1 and 9 months of age. The ratio of urine to plasma osmolality rose from 0.8 at an early post-natal age to 3.8 at the end of the study period. Plasma renin activity, plasma aldosterone and cortisol levels did not show any change during the post-natal development period. The plasma concentrations of these hormones were in the same range as is found in the adult.
The naked mole-rat (Heterocephalus glaber) is a strictly subterranean mammal inhabiting the arid zones of north-east Africa. These animals have no access to free water and water balance thus might be facilitated by regulating renal water loss. The urinary concentrating ability of the naked mole-rat was determined using five dietary manipulations in which both water and salt content were altered. "Control" animals (n = 7) received a high quality protein cereal mixed to a thin paste with water (1 g cereal: 8.5 g water). Water stress was induced by reducing the water content of the diet by either 50% (n = 7) or 65% (n = 7). Salt loading was facilitated by replacing the water with the same volume of either 0.9% salt (n = 7) or 3.0% salt (n = 4) solutions. Changes in body mass, food consumption and urine volume were measured daily. The effect of diet on osmolality and electrolyte concentrations of urine and plasma were determined on termination of the diet trials. Although energy intake was not reduced, naked mole-rats lost body weight with both water stress treatments. Urine volume voided per day decreased significantly with both water stress treatments (P < 0.05), such that the most extreme water stress led to an 80% reduction in urine volume. Mildly salt-loaded animals gained weight, yet underwent a sodium diuresis, as indicated by a 1.3-fold increase in the daily volume of urine voided (P < 0.05). Maximum urine concentration (1521 +/- 250 mmol.kg-1) was achieved with mild water stress and was 4.6 +/- 0.9 times that of plasma.(ABSTRACT TRUNCATED AT 250 WORDS)
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