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At least 19 recordsLinked to original sources
PubMed1975

A study of biological chemistry on the nature of jaw cysts. On the maintainance of homoeostasis in jaw cyst fluid.

Jaw cyst lining cells have an active transporting mechanism for Na+ ion and K+ion, a secreting mechanism and a selecting mechanism, and they allow permeation of electrolytes, lipids and protein into cysts. The components within the cysts have a controlling metabolism, and keep the system stable. Tumour wall cells of cystic ameloblastoma have only a passive transporting mechanism for various substances. Their nature differs from that of jaw cyst lining cells.

Ameloblastoma↗
PubMed1988

A biochemical study on the nature of jaw cysts (III). Instrumental analysis of the viscous component of fluids in ciliated cysts of the maxilla.

Cyst fluids are composed of electrolytes, proteins, lipids and viscous components. These substances affect the state of jaw cysts. Jaw cysts whose inner wall layer is ciliated epithelium contain high-viscosity fluids. This study comprised 30 cases of the following types of jaw cysts: nasopalatine, mucosal and ciliated cysts of the maxilla. And the author chiefly investigated ciliated cysts of the maxilla. Their fluid contents were extracted and pre-treated for analysis. It was concluded that hyaluronidase in cyst fluids causes cyst walls to decompose hyaluronic acid in the cellular interstitium of cyst walls or in the basement membrane of the cellular layer and convert it into cyst fluid, hence it is confirmed that the main component of viscous cyst fluid is hyaluronic acid.

Chondroitin Sulfates↗
PubMed1995

Identification and characterization of gelatinases/type IV collagenases in jaw cysts.

The molecular mechanisms of jaw cyst expansion probably involve interactions of matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). In this study, molecular species of gelatinases present in neutral salt extracts of cyst walls and cyst fluids were characterized by functional activity measurements (type I gelatin and alpha-casein zymography) and immunologically (Western-blotting). The effects of various protein thiol-group or cysteine-switch reactants involved in the activation of collagenases were studied on cyst gelatinases and a gelatinases purified from human gingival fibroblasts (72 kD MMP-2), gingival keratinocytes (92 kD MMP-9) and polymorphonuclear neutrophilic leukocytes (92 kD MMP-9). Western-blotting revealed the presence of both 92 kD (MMP-9) and 72 kD (MMP-2) gelatinases in cyst wall extracts and cyst fluids. Western-blot studies further suggested that jaw cyst gelatinases were only in part complexed with and thus inhibited by TIMP-1 or TIMP-2, suggesting that both MMP-9 and MMP-2 may participate in cyst expansion. MMP-2 was also partially fragmented to a 68 kD form and additional lower molecular weight proteinases (< 60 kD) were detected by alpha-casein zymography and by Western-blotting, suggesting proteolytic fragmentation. MMP-9 was at least partially activated by all protein-thiol group reactants and rather resistant to oxidative inhibition by hypochlorite (NaOCl); in contrast, MMP-2 was activated by APMA but not at all by gold thioglucose (GTG) and was clearly inactivated by hypochlorite (NaOCl).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

A biochemical study of the nature of jaw cysts (II). The role of lipids in the enlargement of cysts.

It is believed that cysts in jaws enlarge when the permeability of the cyst wall changes, that the proteins of cyst fluid increase, and that the intracystic fluid pressure on the jaw bone increases because of inflammation. On the other hand, it is also believed that cysts enlarge when a prostaglandin-like substance, which is generated in the wall, acts chemically in the resorption of the jaw bone. This investigation comprised 97 cases of various jaw cysts. The author attempted to treat 91 of these cases by the irrigation method. Lipids and related substances in cyst walls removed at operation in 15 cases, and cyst fluid were examined in all cases as follows. Their identification with IR, analyses of fatty acids with GC, and estimation of the free radical concentration by ESR were carried out. As a result, it was found that in an infected cyst wall the values of phospholipids, TBA and the free radical concentration increased, and that the value of arachidonic acid decreased. In cyst fluid there was no LCAT activity, the value of HDL-cholesterol decreased, and free cholesterol crystals were detected. After irrigation of cyst cavities, cholesterol esters were detected. In infected cyst fluid, the values for white corpuscles, TBA, and the free radical concentration increased, whereas the values of PO2, arachidonic acid, and SOD decreased. As the infection disappeared, these values were reversed. Finally the cysts diminished in size. The author assumes that jaw cyst enlargement is related to LPO and PG-like substances produced by lipid peroxidation of the cyst wall and fluid.

Cholesterol↗
PubMed1982

Treatment of jaw cysts with an irrigational method. On the significance of the method and the progress of cysts.

It is held that cysts in jaws enlarge as the cyst fluids increase and that the intracystic fluid pressure on the jaw bones increases because of inflammation. According to this investigation, cysts enlarge in the following manner: when a cyst is infected, the cyst wall becomes almost bloodless; cell membranes of the wall are destroyed, and unsaturated fatty acids depart from the membranes; these unsaturated fatty acids generate prostaglandins and lipoperoxides which lower the reaction of cyclic AMP; the result is resorption of the jawbone; therefore, control of the cyst inflammation is the first requirement in the treatment of the cyst. For control of the inflammation, exchanges of cyst fluids for liquids, including antibiotics, were carried out once a week. As a result, the volume of cyst fluids decreased, the cysts diminished in size, and clearing tissues were scarcely seen. It can be maintained that this irrigational method is effective for the treatment of cysts in jaws.

Anti-Bacterial Agents↗
PubMed2000

Detection of human alpha-defensin-1, an antimicrobial peptide, in the fluid of jaw cysts.

OBJECTIVE: The purpose of this study was to isolate and to identify an antimicrobial peptide, human alpha-defensin-1 (HNP-1) in jaw cyst fluid. STUDY DESIGN: We collected jaw cyst fluid from 22 patients with various jaw cysts and analyzed the peptide components of them by reversed-phase high-performance liquid chromatography (HPLC). HNP-1 in the jaw cyst fluid was identified by the amino acid sequence and the molecular weight. The concentration of HNP-1 in the fluid of various jaw cysts was quantified by HPLC. RESULTS: HNP-1 in the jaw cyst fluid was isolated, purified, and identified. The concentrations of HNP-1 in the jaw cyst fluid ranged from 27.0 to 3725.4 microg/mL. CONCLUSION: HNP-1 was detected in the fluid of various types of jaw cysts.

Adolescent↗
PubMed1977

[Lipid analysis in jaw cysts].

In patients with jaw cysts, cyst content and blood serum are examined by means of thin section chromatography with regard to their contents of cholesterol, free fatty acids, triglycerides and cholesterol esters. The increase in lipid content found in the cyst is primarily due to the increase in free cholesterol. Since the serum values are within normal ranges, it is unlikely that cysts are the result of endogenous causes. Our examinations showed that they are primarily due to local processes.

Cholesterol↗
PubMed1999

Statistical observations on jaw cysts in Enugu, Nigeria, 1987-1996.

Cases of jaw cysts treated at the Department of Oral and Maxillofacial Surgery in the University of Nigeria Teaching Hospital, Enugu during the 10 year period between 1987 and 1996 were studied clinically. A diagnosis of jaw cyst was established in 20 patients during the above period. According to pathological classification by the WHO method, these patients included 10 (50%) with dentigerous cyst, 3 (15%) with radicular cyst, 3 (15%) with odontogenic keratocyst, 3 (15%) with fissural cyst (nasopalatine duct cyst, nasoalveolar cyst, globulomaxillary cyst), 1 (5%) with dermoid cyst. Patients with dentigerous cyst, which was found at relatively high frequency, were further analyzed with regard to age, sex, and anatomical distribution. Among patients with dentigerous cyst, those aged between 21 and 40 years accounted for 60%. Males outnumbered females in a ratio of 1.5:1. Dentigerous cyst occurred most frequently in the region of the mandibular wisdom teeth. The relatively very small number of cases, the need for more research on the subject and the need to educate the general public on oral hygiene are highlighted.

Adolescent↗
PubMed1990

Free radicals and SOD activity of jaw cyst. Direct measurement and spin trapping studies by ESR.

Free radicals produced in the fluid of jaw cysts were directly measured at room temperature using ESR. With these samples, SOD activity of the cyst fluid was measured by the ESR spin trapping method with DMPO as a trapping agent. Freeze-dried samples of cyst fluid showed a broad ESR signal at g = 2.005. Relative signal intensity of samples from jaw cysts with inflammation was higher than jaw cysts without inflammation. SOD activity of cyst fluid with high viscosity showed higher values than that of cyst fluid with low viscosity. We suggest that free radicals produced in jaw cyst damage tissues while higher SOD activity of cyst fluid play a role in a self-defense mechanism against free radicals.

Body Fluids↗
PubMed1985

Scanning electron microscopic observations on the inner surface of jaw cysts.

The cavity surface of 9 jaw cysts was studied in the scanning electron microscope. The material comprised 5 radicular, 2 residual, 1 dentigerous and 1 globulomaxillary cyst. The surface morphology varied from smooth to ruffled within the same cyst, and between cysts. Interepithelial spaces, some of which contained migrating leukocytes, were frequently observed. Bacteria occurred in 1 cyst (dentigerous) only, and included rods, filaments and spirochetes. Crystals of various morphology were seen in 6 of the cysts.

Adolescent↗
PubMed1998

Characteristics of bone formation following marsupialization of jaw cysts.

OBJECTIVES: To assess bone regeneration following marsupialization of jaw cysts. METHODS: CT with multiplanar reconstruction (MPR) was performed on 23 patients with cysts of the jaws pre-operatively and 3-4 months after marsupialization. The two images were compared for the three-dimensional outline of the cyst, the distance between the cyst and adjacent structures (vital teeth, maxillary sinus, nasal cavity and mandibular canal) and the integrity of the cortex and mandibular canal. The characteristics of the new bone formation were also determined. RESULTS: The outline of the cyst was changed and partially reduced. The distance between cyst wall and adjacent structures was increased. There was remodelling of the cortex and mandibular canal. The new bone formed in the periphery of the cyst showed either a ground glass appearance or radial bone spicules. CONCLUSION: CT with MPR is useful for evaluation of morphological changes and bone formation following marsupialization of jaw cysts. CT with MPR is the technique of choice for the maxilla and the entire body of the mandible and coronal CT for cysts in mandibular angle and ascending ramus. Cysts can be enucleated safely as early as 3 months after marsupialization.

Adult↗
PubMed1996

Epithelial jaw cysts: analysis of 126 Nigerian cases.

One hundred and twenty-six Nigerian cases of epithelial jaw cysts were retrieved from case notes and biopsy records of the Department of Oral and Maxillofacial Surgery and Department of Oral Pathology and Oral Biology of the Lagos University Teaching Hospital. The cases were analysed for age, sex, site and methods of management. Results show that developmental odontogenic cysts (57.14%) were more common than inflammatory odontogenic cysts (26.94%). Dentigerous cyst (22.22%) was the most common epithelial jaw cyst, followed by radicular cyst (21.43%). Developmental non-odontogenic cysts were more than twice as common in females as in males. Sixty-eight per cent of epithelial jaw cysts were treated by enucleation, 10% by marsupialisation, 13% by jaw resection and 9% by surgical excision.

Adolescent↗
PubMedDate not supplied

Jaw cysts: diagnosis and treatment.

The classification, embryology, histopathology, clinical features, and treatment of benign jaw cysts are presented. Emphasis is placed on the differentiation of benign cysts from malignant radiolucent lesions of the jaws. Preservation of adjacent teeth and over vital structures is of paramount importance in the management of jaw cysts.

Bone Cysts↗
PubMed1985

Treatment of jaw cysts with an irrigational method. (II). The effect on the nature of cyst walls and surrounding bone.

Cysts in jaws are generally excised by Partsch II when they are small. When they are large, they are excised by Partsch I to form a paranasal sinus in an oral cavity, or by an operation based on Caldwell-Luc's method to form it from nostrils, as Partsch II forms dead space after the operation and the cyst increases by the pressure of intracystic fluid. However, with Partsch I, the bone needs many days to regenerate, and since a surgical ciliated cyst of the maxilla is often formed after an operation of the maxillary sinus, Partsch I is not necessarily a good method. Therefore, in order to control cyst inflammation, the irrigation of cyst cavities was repeated, as it is held that prostaglandin-like (PG-like) substances are generated in the cyst walls when a cyst is inflamed by bacterial infection; prostaglandin E2 (PGE2) especially acts on the resorption of bone and enlarges the cyst. As a result of repeated irrigations, infection of the cyst cavities disappeared simultaneously with decreasing the pressure of intracystic cavities, the values of thiobarbituric acid, Prostaglandin E, Prostaglandin F2 alpha (TBA, PGE, PGF2 alpha), and the free radical intensity at g = 2.003 decreased. The bone regenerated around the cyst walls, and finally the cyst diminished in size. In the case of the viscous cyst fluids, a solution containing hyaluronidase enabled complete disappearance. It would be better to apply Partsch II after the cyst has become smaller through irrigation. After the irrigational method, irregular formation and tendency toward malignancy could be found in none of the cyst wall cells.

Adult↗
PubMed1976

Intracystic fluid pressure in non-keratinizing jaw cysts.

The technique for registration of fluid pressure in jaw cysts by means of pressure transducer and cannulation of the cyst cavity or cementation of a two-way valve into a tooth communicating with the cyst is described. Twenty-six closed cysts were subjected to registration of intracystic pressure. Subsequent histologic examination showed that all cysts were non-keratinized. Initial pressure values in apical periodontal cysts averaged +47 mmHg, in follicular cysts +44 mmHg, and in residual cysts +38 mmHg. A median palatine cyst exhibited a pressure of +81 mmHg. Most cysts showed intracystic pulsation corresponding to the number of heart beats on electrocardiograms obtained simultaneously. The intracystic pulsation disappeared when the intracystic pressure was experimentally increased and reappeared when it was lowered. In three cases in which registration of pressure was performed 7-14 days after the aspiration of the cyst fluid, an intracystic pressure in the same range as the initial one was found. The findings indicate deficient lymphatic drainage of non-keratinizing jaw cysts.

Bone Cysts↗
PubMed1989

Lectin-binding patterns in epithelial lining of jaw cysts.

Lectin-binding patterns were examined in epithelial walls of 65 jaw cysts (30 post-operative maxillary cysts: POMCs, 20 radicular and 15 follicular cysts), and characteristic lectin staining for each kind of jaw cysts is presented. Between squamous and columnar epithelia, the staining intensity of WGA, Con A and UEA-I was not different, but SBA bound more remarkably to squamous than to columnar epithelia. In both epithelia the outer layers did react more strongly with the lectins examined. Concerning odontogenic cysts, the lectin-binding affinities of outer and intermediate layer cells were nearly the same in both follicular and radicular cysts. Basal cells of radicular cyst walls were however, more markedly positive for lectin binding than of follicular cysts. Furthermore, basal cells of keratinized (RKSE 60 keratin-positive) epithelium were inferior to those of non-keratinized linings in the bindings. Lectin-binding patterns of metaplastic squamose epithelia of POMCs which were positive for RGE53-keratin (principally columnar epithelium-specific keratin) were similar to originally squamous linings of odontogenic cysts. Columnar linings of unusual radicular cysts were positively stained with SBA. By these results, lectin-binding sugar residues of the epithelium seem to be related to the epithelial morphology.

Antibodies↗