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At least 19 recordsLinked to original sources
PubMed2003

Palladium-mediated three-component synthesis of furo[2,3-b]pyridones by one-pot coupling of 3-iodopyridones, alkynes, and organic halides.

[reaction: see text] The one-pot assembly of 4-alkoxy-3-iodo-2-pyridones, terminal alkynes, and organic halides has been achieved by integration of two sequential palladium-mediated cross-coupling reactions--Sonogashira and Wacker-type heteroannulation processes--and subsequent deprotection of the alkoxy group to afford furo[2,3-b]pyridones.

Journal Article↗
PubMedDate not supplied

Solution phase synthesis of libraries of polycyclic natural product analogues by cascade radical annulation: synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues.

An improved cascade radical annulation route to (+/-)-mappicine, (S)-mappicine, and mappicine ketone is reported. The route is used to prepare libraries of mappicine and mappicine ketone analogues in a semiautomated fashion. Key diversity generating steps include the addition of an aldehyde to a Grignard reagent derived from a D-ring iodopyridine, N-propargylation of a subsequently derived iodopyridone, and cascade radical annulation with an isonitrile to form a mappicine analogue. Parallel oxidation of mappicine analogues produced mappicine ketones. The route is general and flexible and could be used to make very large libraries. It is also illustrative of how late stage cascade reactions can be employed strategically to generate libraries of polycyclic natural product analogues.

Alkaloids↗
PubMed1965

HYTRAST: A NEW CONTRAST MEDIUM FOR BRONCHOGRAPHY.

In 1962 Hytrast, an aqueous suspension containing 50% w/v of combined iodine as a mixture of N-(2,3-dihydroxypropyl)-3,5-diiodopyridone-4 and 3,5-diiodopyridone-4, was introduced as a contrast medium for bronchography. Extensive clinical trials had suggested that this agent was superior to products usually employed for this purpose. At the Nova Scotia Sanatorium, Hytrast was used as a bronchographic contrast medium in 31 consecutive cases. For comparison purposes, the records of the first 50 patients in whom another contrast medium, Dionosil Oily, was used were reviewed. In all cases the contrast medium was introduced through a catheter passed into the bronchus with the aid of a laryngeal mirror, after local anesthesia was induced by pontocaine 2%. Experience in this limited number of cases was at variance with most published results. Hytrast was more irritating than Dionosil Oily, had a greater tendency to produce alveolarization, caused more frequent undesirable sequelae, and was retained in the lung for prolonged periods.

Adolescent↗