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At least 19 recordsLinked to original sources
PubMed2003

Plastic iodophor drape during liver surgery operative use of the iodophor-impregnated adhesive drape to prevent wound infection during high risk surgery.

We retrospectively investigated factors associated with wound infection after liver resection for hepatocellular carcinoma (HCC), with special reference to use of a plastic adhesive drape impregnated with iodophor. The subjects were 296 patients undergoing liver resection for HCC. Wound infection was defined as purulent drainage from the superficial incision with or without laboratory confirmation. One or more of the following signs was required: pain or tenderness, localized swelling, or redness or heat. Wound infection developed in 25 patients. Regression analysis indicated that low body mass index (BMI), smoking, long preoperative hospital stay, and nonuse of iodophor drapes were risk factors for wound infection. Wound infection was significantly less likely with the use of iodophor drapes (3.1%) than for surgery without iodophor drapes (12.1%). By multivariate regression analysis, BMI, smoking, and lack of drape use were independent risk factors. Most of the bacteria isolated were skin bacteria, including Staphylococcus aureus and Staphylococcus epidermidis. In conclusion, low BMI, smoking, a long preoperative hospital stay, and the lack of iodophor drape use were risk factors for wound infection after liver resection for HCC. The drapes presumably prevented contamination from the skin during the operation.

Adult↗
PubMed1990

Comparison of a one-step iodophor skin preparation versus traditional preparation in total joint surgery.

The purpose of this study was to compare a traditional two-step method of preoperative skin preparation using aqueous iodophors with a one-step method using an iodophor-in-alcohol solution. Sixty patients having clean total joint surgery were randomly divided into two preoperative skin preparation groups (30 in each). In one group, the skin was prepared with a traditional five-minute aqueous iodophor scrub followed by the application of an aqueous iodophor solution as a paint. In the other group, the skin was prepared with a one-step application of a water-insoluble iodophor-in-alcohol solution applied as a paint. Bacterial colony counts were made by sampling the incision area with culture plates before skin preparation and just prior to wound closure. The one-step application of a water-insoluble iodophor-in-alcohol solution was equally as effective as the traditional scrub-and-paint preparation in reducing the number of bacteria about the operative site. The water-insoluble preparation also resulted in significantly improved drape adhesion as compared to the standard scrub-and-paint procedure. The one-step water-insoluble iodophor-in-alcohol solution fulfills the requirements for an operative site skin preparation and significantly improves drape adhesion. It is more convenient, easier to apply, less time consuming, and potentially less expensive than the traditional scrub-and-paint method.

Administration, Cutaneous↗
PubMed1986

Milk iodine residues in herds practicing iodophor premilking teat disinfection.

The objective was to determine effects of different concentrations of iodophor teat dips on milk iodine residues, when teat dips were used both premilking and postmilking. Eighty cows in each of seven herds were assigned to one of four treatments. Each treatment received postmilking teat dip at .1 or 1% iodophor concentration. Two groups received no premilking dip, and the other two groups received premilking teat dip at the same concentration as the postmilking teat dip. Premilking teat dipping was followed by manual drying of teats. Noniodophor postmilking dips and no premilking inodophor udder sanitizers were used during an 8-d adjustment period. Milk was collected for milk iodine determination from each cow from weigh jars or milk meters at p.m. milkings during the last 3 d of the adjustment period and d 4, 6, and 8 of the treatment period. Premilking and postmilking teat dipping with .1% iodophor dip did not significantly increase milk iodine residue above postmilking teat dipping with .1% iodophor dip alone. However, 1% iodophor postmilking teat dip significantly increased milk iodine residue over use of .1% iodophor dip used as a premilking and postmilking teat dip. Adding a 1% iodophor premilking teat dip significantly increased iodine residues.

Animals↗
PubMed2006

[Comparative study on the resistance of Bacteriophage phi chi 174D, T4 and f2 to an iodophor in laboratory].

BACKGROUND: To screen for the most resistant bacteriophage as indicator in disinfection tests, the resistance of bacteriophage phi chi 174D, T4 and f2 to iodophor were observed in laboratory. METHODS: The virucidal activity of iodophor against bacteriophage phi chi 174D, T4, and f2 were assessed by suspension test. The neutralizer is selected and appraised by testing with neutralizer. Bacteriophage phi chi 174D, T4, and f2 were detected and enumerated by the double-agar-layer plaque technique. RESULTS: (1) With 500 mg/L of available iodine of iodophor solution, within a contact time of 40 min, or 750 mg/L, 10 min, or 1000 mg/L, 5 min, the reduction of bacteriophage phi chi 174D could achieve the "disinfection" level [log10 inactivation value (LIV) or log10 reduction value (LRV) of bacteriophage phi chi 174D (log10 No-log10 Nt) was > or = 4.00 log10]. (2) With 600 mg/L of available iodine of iodophor solution, within a contact time of 40 min, or 700 mg/L, 5 min, the reductions of bacteriophage T4 could achieve the "disinfection" level. (3) With 50 mg/L of available iodine of iodophor solution, within a contact time of 10 min, or 75 mg/L, 10 min, the reductions of bacteriophage f2 could achieve the "disinfection" level. CONCLUSION: The order of resistance of the above three bacteriophages to iodophor from greatest to smallest is as follows: bacteriophage phi chi 174D greater than bacteriophage T4 > bacteriophage f2.

Bacteriophage T4↗
PubMed1991

Interactions between Pseudomonas aeruginosa and iodophor germicides in milking parlor udder wash water systems.

In a field study of 29 dairy farms, Pseudomonas aeruginosa was isolated more frequently (P = 0.05) from milking parlor udder wash water systems containing iodophor germicides than from those with no germicide. Most available iodine (AI2) concentrations were below the recommended level of 25 ppm (25 microgram/ml). Rubber and polyvinyl chloride hoses caused rapid decreases in the AI2 concentrations of 25 ppm iodophor solutions. AI2 dropped from 25 ppm to 6 ppm or less in 240 min for solutions contained in either polyvinyl chloride or rubber, compared with solutions in glass, which were unchanged in 240 min. Addition of inactivated iodophor solution to aqueous cultures resulted in significantly higher (P less than 0.05) numbers of P. aeruginosa at 10 and 24 h postinoculation. P. aeruginosa was grown in polyvinyl chloride tubing and exposed twice daily to 0, 10, or 25 ppm of AI2. None of the exposure concentrations eliminated the bacteria from the hoses, and bacterial numbers were not significantly different in hoses exposed to 0 and 10 ppm by the eighth treatment day. Bacteria taken from the water in these hoses were exposed to different concentrations of iodophor solution. Iodophor concentrations which will kill 50% of P. aeruginosa cultures previously exposed to 0, 10, and 25 ppm of AI2 were predicted to be 3.0, 11.8, and 20.8 ppm, respectively.

Animals↗
PubMed2003

[The clinical effectiveness of a post milking teat disinfection method with a foaming iodophor teat dip].

The effect of postmilking teat dipping with a foaming iodophor agent on incidence of intramammary infections (IMI), incidence of clinical mastitis, somatic cell count and the characteristics of udder tissue and teat was investigated in a positively controlled field study. Two groups of animals were compared. Teats were dipped with a foaming iodophor in the treatment group (TG, 122 animals) while teats in the control group (CG, 121 animals) were dipped with a conventional iodophor teat dip with the same iodine content. A bacteriological examination of quarter milk samples divided the study period in two parts. The incidence of new IMI did not differ between the groups (1st part of trial: TG vs. CG: 6.84% vs. 9.16%, 2nd part of trial: 7.78% vs. 7.82%). There were no differences between the treatment groups regarding incidence of clinical mastitis. We detected 0.64 clinical cases per 100 days in the treatment group vs. 0.50 in the control group. The development of SCC was comparable in both groups. Teat skin and teat duct conditions showed variation during the study period. Clinical efficacy of postmilking teat disinfection with a foaming iodophor was comparable to the treatment with a conventional iodophor product.

Administration, Topical↗
PubMed2003

[Effects of iodophor on the thyroid glands of female medical workers].

OBJECTIVE: To investigate the long-term effects of iodophor on thyroid function and autoimmunity in females. METHODS: 119 medical personnel who have been using iodophor as preoperative skin disinfectant more for than 2 years and 123 medical personnel who have not exposed to iodophor were studied. The urinary iodine, thyroid-stimulating hormone (TSH), free triiodothyronine (FT(3)), free thyroxine (FT(4)), thyroid peroxydase antibody (TPO-Ab) and TG-Ab in serum were measured and the thyroid were examined by B mode ultrasound apparatus. RESULTS: The median urinary iodine (MUI) was 300.4 micro g/L in the exposed group, not significantly higher than that in the non-exposed group (269.1 micro g/L, P > 0.05). The TSH levels of the exposed group and non-exposed group were 1.66 mU/L and 1.62 mU/L (P = 0.84). B mode ultrasound examination showed that the prevalence rate of thyroid disorders was 3.36% in the exposed group, not significantly different from that in the non-exposed group (2.44%). The thyroid autoantibody positive rate was not significantly different between these two groups too. The titer of autoantibody in the exposed group was 29.5 IU/L, significantly higher than that in the non-exposed group (22.4 IU/L, P = 0.048). The titer of TG-Ab in the exposed group was 21.85 IU/L, not significantly different from that in the non-exposed group (18.7 IU/L, P = 0.542). The mean titer of TPO-Ab in exposed group was 29.5 IU/L, significantly higher than that in non-exposed group (22.4 IU/L, P = 0.048). The total prevalence rate of all sorts of thyroid disorders in the exposed group was 11.76%, significantly higher than that in non-exposed group (4.07%, P = 0.026). The thyroid disorders discovered included clinical hyperthyroidism and subclinical hypothyroidism. CONCLUSION: Using iodophor as preoperative skin disinfectant may result in an increased incidence of thyroid disorders in female medical personnel. Medical personnel with iodophor exposure history should have their thyroid function and thyroid autoimmune status examined regularly.

Adult↗
PubMed1967

Microbial destruction by low concentrations of hypochlorite and iodophor germicides in alkaline and acidified water.

Hypochlorite and iodophor germicides were evaluated for their ability to destroy a variety of organisms at levels approximating those used for final sanitizing rinse for dairy and food equipment and beverage bottles (3 to 50 ppm). Test organisms included Escherichia coli, Streptococcus lactis, Lactobacillus plantarum, Pediococcus cerevisiae, and Saccharomyces cerevisiae. The hypochlorites and iodophors demonstrated approximate rates of destruction at equivalent concentrations for the bacterial species tested, except where the hypochlorite contained excess alkalinity. The hypochlorite responded more readily to a downward shift to a pH of 5.0 than did the iodophor. Excess alkalinity of the hypochlorite significantly affected its bactericidal activity. The iodophor exhibited a consistently greater rate of destruction of yeast cells than the hypochlorite. Successive treatment with low levels of iodophor (6 ppm) followed by a hypochlorite (12 to 25 ppm) resulted in a high level of destruction of all test organisms. Possibilities for employing these measures in a sanitizing rinse of bottles for maximal destruction of organisms were discussed. Among the test organisms, S. lactis showed a comparatively high resistance and was a useful organism for comparing the halogen preparations.

Chlorine↗
PubMed1993

Effect of iodophor vs iodine tincture skin preparation on blood culture contamination rate.

OBJECTIVE: To determine if iodine tincture is a more effective skin antiseptic for blood culture collection than povidone-iodine, an iodophor. DESIGN: Pairwise comparisons across phases. In phases 1 and 3, blood culture skin preparation was performed with the iodophor; in phases 2 and 4, skin preparation was performed with iodine tincture. SETTING: Emergency department of a large urban teaching hospital. PATIENTS: All adult patients seen in the emergency department who had blood cultures collected because a systemic bacterial infection was suspected. MAIN OUTCOME MEASURE: The blood culture contamination rate for the iodophor and iodine tincture skin preparations. RESULTS: A total of 8467 blood cultures were collected during the study, and 421 (4.97%) were classified as contaminated. The contamination rate for the blood cultures collected using the iodophor was 6.25%, and the contamination rate for the cultures using iodine tincture was 3.74%; this difference is statistically significant (P < .00001). CONCLUSIONS: The effectiveness of the skin antiseptic may be an important factor in determining contamination rate in blood culturing. If these results are confirmed by others, then institutions that have a high blood culture contamination rate when using an iodophor for skin preparation should consider changing to iodine tincture.

Anti-Infective Agents, Local↗
PubMed1984

[Metabolism of iodine iodophor in the thyroid gland].

As evidenced by animal experiments (Wistar rats), the iodophore iodine of the commercial product Jodonal-M is bound by the thyroid gland, if administered with the drinking water. When drinking water containing 2 mg/l iodophore iodine was given, the thyroid glands of the experimental animals bound 1.19%; and those of the control animals, 4.68% 131I. When drinking water containing 1 mg/l iodophore iodine was administered, the thyroid glands of the experimental animals bound 1.90%; and those of the control animals, 6.77% 131I. It is concluded that the iodophore iodine which passes over to the milk during teat disinfection is bound by the thyroid glands in a similar manner and takes part in the formation of the thyroid hormones just as the "native" iodine of the milk.

Animals↗
PubMed1986

Evaluation of .5% and 1% iodophor teat dips on commercial dairies.

Two postmilking teat dips containing .5 and 1% iodine were evaluated for approximately 8 mo under conditions of natural exposure to mastitis pathogens on four commercial dairy farms. In the two herds using .5% iodophor, incidence of intramammary infection with Staphylococcus aureus and Streptococcus agalactiae was reduced 68.3 and 46.2%, respectively. When numbers of new infections with both pathogens were combined, efficacy for the .5% iodophor was 62.3%. In the two herds using 1% iodophor, incidence of intramammary infection with Staph. aureus and Strep. agalactiae was reduced 52.4 and 70.7%, respectively. When numbers of new infections with both pathogens were combined, efficacy for the 1% iodophor was 64.3%. Efficacy of teat dips was variable against coagulase-negative staphylococci and Corynebacterium bovis.

Animals↗
PubMed1991

Effects of a 1.94% sulfonic acid teat dip and a 1% iodophor teat dip on teat canal infections in lactating dairy cows.

Sixty-three cows were used in a natural exposure trial for 1 yr to determine the effects of a 1.94% linear dodecyl benzene sulfonic acid and a 1% iodophor teat dip on teat canal and intramammary infections. Overall, total teat canal infections increased 28.9% and total intramammary infections increased 30% in quarters dipped with the linear dodecyl benzene sulfonic acid compared with a 14.3% increase in teat canal infections and a 17.4% decrease in intramammary infections for the iodophor group. Higher frequencies were observed for teat canal and intramammary infections caused by Staphylococcus epidermidis in the linear dodecyl benzene sulfonic acid group. Staphylococcus hyicus was the predominant organism isolated from teat canal and intramammary infections in the iodophor group. No difference was observed between the two teat dips in the persistence of Staphylococcus aureus teat canal infections. A greater number of S. hyicus teat canal infections persisted in the iodophor group, whereas teat canal infections produced by S. epidermidis and Staphylococcus xylosus persisted longer in the sulfonic acid group. Results of this study indicated that use of a linear dodecyl benzene sulfonic acid teat dip for 1 yr was not associated with increased S. aureus teat canal infections and intramammary infections. However, linear dodecyl benzene sulfonic acid appeared to affect the distribution of coagulase-negative staphylococci isolated from teat canal infections and intramammary infections.

Administration, Topical↗
PubMed1985

Efficacy of low-concentration iodophors for germicidal hand washing.

The efficacy of iodophor germicides containing different concentrations of available iodine against transient (inoculated) bacteria and the natural hand microflora was compared with chlorhexidine gluconate (2 and 4%) liquid detergent (Hibitane), non-germicidal soap and a tap water rinse. The tap water rinse was ineffective compared with all other treatments. Only 4% chlorhexidine gluconate liquid detergent and iodophor containing 0.75% available iodine were significantly better than the non-germicidal soap for reduction of transient bacteria, Escherichia coli and Pseudomonas fluorescens, that had been inoculated onto hands. These agents also caused a significant reduction in the number of 'natural' microorganisms released from hands after a standard 15 s hand wash. The low-concentration iodophor products and the product containing 2% chlorhexidine gluconate failed to give results significantly better than the non-germicidal control soap. Baird-Parker medium and standard aerobic plate counts were highly correlated (r = 0.82), so that for studies of Gram-negative bacteria inoculated onto hands as a transient microflora, counts on Baird-Parker medium give a reasonable indication of the natural (residual) hand microflora.

Chlorhexidine↗
PubMed1987

The use of an iodophor-impregnated plastic incise drape in abdominal surgery--a controlled clinical trial.

A prospective randomized clinical trial comparing the use of a new iodophor-impregnated incise drape with a standard skin preparation technique in 1102 patients undergoing abdominal surgical procedures is reported. The effect of the incise drape on wound bacterial contamination and subsequent wound infections is compared. The iodophor-impregnated plastic incise drape reduced the contamination of the wound. In particular, isolates of normal skin organisms were less frequent when the drape was used in clean and clean contaminated procedures. However, no difference was found between the wound infection rates for the patients on whom the iodophor drape was used and those patients on whom the drape was not used.

Abdomen↗