Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Intestinal dysbiosis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Association of Candida albicans fungi with some opportunistic microorganisms in intestinal dysbiosis in patients of different age groups].

The occurrence of C. albicans in association with opportunistic microorganisms (Staphylococcus aureus and Klebsiella) in intestinal dysbiosis in patents of different age groups (from 6 days to 31 years) was analyzed. The data on the comparative evaluation of the results of the bacteriological examination of patients with intestinal dysbiosis, carried out during the periods of 2000-2001 and 2001-2002 (388 and 467 patients respectively), are presented. During the period of 2000-2001 the detection rate of C. albicans in monoculture was 6-33% of cases (in the examined group). A higher detection rate was registered with respect to the association of C. albicans with staphylococci (42-65% of cases). The associations of C. albicans with staphylococci and Klebsiella were observed in 13-46% of cases. Similar results were registered during the period of 2001-2002, but during this period a reliable decrease in the detection rate of the association of C. albicans with staphylococci (practically by 20% in the group of infants) and the 1 1/2-fold increase of the detection rate of C. albicans in monooulture (in all age groups) were observed.

Adult↗
PubMed2004

The causes of intestinal dysbiosis: a review.

Alterations in the bowel flora and its activities are now believed to be contributing factors to many chronic and degenerative diseases. Irritable bowel syndrome, inflammatory bowel disease, rheumatoid arthritis, and ankylosing spondylitis have all been linked to alterations in the intestinal microflora. The intestinal dysbiosis hypothesis suggests a number of factors associated with modern Western living have a detrimental impact on the microflora of the gastrointestinal tract. Factors such as antibiotics, psychological and physical stress, and certain dietary components have been found to contribute to intestinal dysbiosis. If these causes can be eliminated or at least attenuated then treatments aimed at manipulating the microflora may be more successful

Anti-Bacterial Agents↗
PubMedDate not supplied

[The screening diagnosis of intestinal dysbiosis].

A screening method for the evaluation of the state of intestinal microbiocenosis by monitoring the persistence sign of bacteria, their anti-interferon activity, was proposed. The examination of patients with dysbiosis of the intestine has shown that their intestinal microflora was found capable of inactivating the preparation of human leukocytic interferon at a definite concentration 8.7 times more often than the intestinal microflora of healthy persons. The number of interferon-active colonies correlated with the severity of changes in intestinal microbiocenosis and the degree of clinical manifestations of the disease.

Adult↗
PubMed2003

Tissue hypoxia and intestinal dysbiosis in children with tuberculosis.

We studied the role of autochthonous microflora from body cavities in the development of tissue hypoxia and instability of cell membranes. In children with tuberculosis dysbiosis manifested in nonspecific quantitative changes in the intestinal microflora and the presence of coxsackievirus antigens in the urine. DNA-containing viruses with pronounced immunosuppressive activity (e.g., herpesvirus, measles virus, and rubella virus) were found in most children. Microbiological and virological changes were accompanied by the appearance of laboratory signs for tissue hypoxia, which included inhibition of Krebs cycle dehydrogenases and alpha-glycerophosphate pathway in blood lymphocytes. Regression analysis revealed a relationship between the content of extraintestinal coxsackieviruses and inactivation of alpha-glycerophosphate dehydrogenase, succinate dehydrogenase and ratio of facultatively anaerobic bacteria in microbiocenosis, and expression of acid phosphatase and total population of malonate-positive enterobacteria, staphylococci, yeasts, and enterococci.

Acid Phosphatase↗
PubMedDate not supplied

[The persistence factors of the enterobacteria in the fecal flora in intestinal dysbiosis].

The persistence properties of 188 enterobacterial strains of the fecal flora, isolated from 100 patients with the pathology of the intestine and bile ducts in cases of enteric dysbiosis, were determined. The occurrence of this sign was found to decrease in the row of anticomplementary activity (ACA)-antilysozyme activity (ALA)-"anti-interferon" activity. High levels of ACA and ALA (in comparison with their background levels) in opportunistic bacteria confirmed their role in the development of enteric dysbiosis.

Adult↗
PubMed2025

Colorectal cancer-associated Streptococcus gallolyticus: a hidden diversity expose.

Streptococcus gallolyticus subsp. gallolyticus (SGG) is a bacterial pathogen implicated in bacteremia and endocarditis and is often associated with colon tumors in elderly individuals. The development of colorectal cancer (CRC) has been linked to intestinal dysbiosis, characterized by increased proportions of SGG and other intestinal microbes. In this study, we present the complete nucleotide sequence of five novel clinical isolates of SGG associated with colorectal cancer, revealing unexpected genetic diversity. Sequencing an additional 30 SGG clinical isolates provided a more comprehensive description of this genetic diversity. We did not identify a pathogenicity island specific to CRC-associated SGG isolates. Most of these human-derived SGG isolates exhibit resistance to multiple antibiotics. Our findings also offer additional insights into multilocus sequence typing (MLST), capsular loci, and pilus organization. Analysis of the repertoire of surface proteins reveals high potential for binding and foraging complex polysaccharides. Finally, comparative genomics with the phylogenetically closest non-pathogenic subspecies S. gallolyticus subsp. macedonicus confirmed that SGG pathogenicity-associated factors mostly rely on a large repertoire of surface proteins involved in host colonization, presence of C5a peptidase to avoid innate immunity, bile salt hydrolase to persist in the gut, and of specific bacteriocin and type VII-dependent effectors to colonize the host colon. Additionally, the presence of extracellular polysaccharides in SGG probably helps the bacterium survive in harsher conditions.IMPORTANCEStreptococcus gallolyticus subsp. gallolyticus (SGG) was the first intestinal bacterium associated with colorectal cancer. It is now widely accepted that colonic microbiota dysbiosis contributes to oncogenesis, with a higher relative abundance of several potentially pro-carcinogenic bacteria. For example, the oncogenic role of Escherichia coli pks+ and enterotoxinogenic Bacteroides fragilis in colorectal cancer has been well established, identifying the role of genetic loci encoding toxins. Through the sequencing and analysis of 11 clinical SGG isolates from CRC patients and comparisons with non-CRC isolates, we uncovered a significant diversity among CRC-associated strains. Our findings suggest that SGG association with CRC is complex and is not linked to a specific strain or pathogenicity island, thus highlighting the opportunistic and versatile nature of SGG.

Humans↗
PubMedDate not supplied

[Bacterial endotoxinemia in children with intestinal dysbacteriosis].

34 children with gastrointestinal diseases of infectious, allergic and mixed etiology were examined. The state of normal microflora in the large intestine as indicated by fecal bacterial charts and the level of secretory immunoglobulin A (sIgA) in the contents of the intestine as indicated by the results of radial immunodiffusion were studied. In addition, the content of endotoxin in the children's plasma was determined with the use of the Limulus (LAL) test. The presence of endotoxin in the plasma of children with intestinal dysbiosis was determined in 71.1% of cases. The frequency of the detection of antigenemia was found to be related to the severity of manifestations of dysbiotic changes in the intestine and to the level of sIgA in fecal supernatants. The inclusion of the probiotic preparation Bifidumbacterin forte containing live bifidobacteria adsorbed on activated charcoal into the complex therapy of digestive tract diseases ensured a decrease in the detection rate of endotoxinemia, which correlated with the tendency towards the normalization of defective intestinal microflora.

Adolescent↗
PubMed2005

[Experience of pediatric application of bifidumbacterin multi, a biologically active food supplement].

The article is dedicated to a clinical trial of Bifidumbacterin Multi-1, a biologically active food supplement (BAFS) for children aged 0 to 3 years. The study showed that application of BAFS in children with intestinal dysbiosis helped to cope with the symptoms of alimentary disturbances, promoted improvement of body mass index, increase of hemoglobin end erythrocyte level, suppression of zymotic and putrefactive dyspepsia, decrease of inflammation of the intestinal mucosa, elimination of bibidobacterial deficit, and reduction of conditionally pathogenic microflora. Bifidumbacterin Multi-1 was well tolerated and highly effective according to clinical and laboratory data. This preparation may be recommended as a component of complex therapy in children aged 0 to 3 years old.

Anti-Infective Agents↗
PubMed1997

[Clinical and bacteriological features of intestinal dysbacteriosis in patients with pulmonary tuberculosis].

In patients with pulmonary tuberculosis, intestinal dysbacteriosis has clinical and bacteriological features characterized by the short-age of bifidobacteria (in 88-92%), by changes in the composition of Escherichia coli strains (in 38-42%), by the presence of Candida (in 58-62%), Proteus in half the patients, and by associated dysbacteriosis. Most (75%) patients show Stage III-IV intestinal dysbiosis formed after 3-4 months of continuous chemotherapy. There is a direct relationship between the magnitude of dysbiotic disorders and the duration of chemotherapy.

Antitubercular Agents↗
PubMedDate not supplied

[Use of zinc sulfate and sodium thiosulfate electrophoresis in treating patients with intestinal dysbacteriosis].

Electrophoresis of 2% zinc sulfate solution and 3% sodium thiosulfate solution was used in combined treatment of intestinal dysbiosis with high Candida proliferation in 79 patients. 77 controls received standard therapy. It is shown that such electrophoresis produced positive changes in the clinical picture of the disease, significantly suppressed growth of Candida fulgi, improved function of the liver as shown by a rise in the amount of total protein and hemoglobin, lower bilirubin concentrations in the blood.

Electrophoresis↗
PubMedDate not supplied

[The use of Smecta for the treatment of the basic digestive tract diseases].

The indices for the gastric contents aggression and protection ratio returned to normal in patients with peptic ulcer and preulcerous condition during the treatment with smekta due to a decrease in proteolytic activity and increase in the synthesis of the mucus protective proteins. Monitoring of intragastric pH in the body of the stomach throughout 24 hours in patients with peptic ulcer of duodenal location revealed significant acid-neutralizing effect of smekta. Patients with nonspecific ulcerous colitis enjoyed freedom of side effects as a result of the use of salofalk and derived full therapeutic benefit from this treatment. Under the effect of smekta there occurred suppression of the growth of pathogenic proteolytic flora, improvement of qualitative properties of coli flora and growth of sugar-lytic flora in patients with intestinal dysbiosis. According to the data available, smekta strengthens the mucous barrier by improving the conformation of the mucus structural elements.

Aminosalicylic Acids↗
PubMedDate not supplied

[The role of persisting opportunistic intestinal microflora in dysbiosis in the occurrence of hepatobiliary system diseases].

The state of microbiocenosis in the intestine of 89 patients with surgical pathology of biliary ducts was determined. Dysbiotic disturbances of different severity were detected in 96.6% of the examined persons. High occurrence of dysbiosis of the large intestine and the presence of the capacity for inactivating natural host resistance factors in different representatives of intestinal microflora were regarded as the cause of the development and maintenance of the inflammatory processes of the biliary ducts.

Adult↗
PubMed2026

Interkingdom remodeling of the intestinal bacteriome and virome during Toxoplasma gondii infection in rats.

Toxoplasma gondii infection is associated with intestinal microbiome disruption, but its effects on genome-resolved bacterial populations, the gut virome, and bacteriome-virome relationships remain poorly understood. Using previously generated shotgun metagenomic datasets from 36 intestinal samples collected from 18 Sprague-Dawley rats across control, acute, and chronic infection groups, we reconstructed 294 quality-filtered, non-redundant bacterial metagenome-assembled genomes (MAGs) and identified 899 medium-to-high-quality viral operational taxonomic units (vOTUs) from assembled metagenomic contigs. Infection was associated with reduced bacterial richness in the small intestine during both acute and chronic stages and lower Shannon diversity during chronic infection. In contrast, large-intestinal α-diversity remained stable despite significant compositional reorganization. Taxonomic changes included increased Lactobacillus intestinalis, Limosilactobacillus reuteri, and Prevotella sp900547005, together with decreased Rothia sp002492045 and Akkermansia muciniphila. Functional profiling revealed region- and stage-specific changes in predicted bacterial metabolic potential, including reduced energy-related pathways and carbohydrate-active enzyme abundance. The virome also showed significant compositional changes in both intestinal regions. Quimbyviridae and Podoviridae_crAss-like viruses decreased in the small intestine during chronic infection, while Quimbyviridae, Flandersviridae, and Podoviridae_crAss-like viruses showed stage-specific decreases in the large intestine. Predicted bacterial hosts were assigned to 48.39% of vOTUs, with Lachnospiraceae and Ruminococcaceae being the most frequently linked families. Trans-kingdom networks further revealed region-specific positive and negative abundance correlations between bacterial and viral taxa. These findings extend previous microbiota-metabolome observations by integrating genome-resolved bacteriome analysis with contig-based virome profiling, providing a foundation for future mechanistic studies of toxoplasmosis-associated microbiome remodeling.

Gut virome↗